LeishMANIAdb
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Protein_kinase_putative/GeneDB:LmjF.27.2470

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein_kinase_putative/GeneDB:LmjF.27.2470
Gene product:
protein kinase, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IDK8_LEIDO
TriTrypDb:
LdBPK_272420.1 , LdCL_270032600 , LDHU3_27.3650
Length:
560

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 21
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 27
NetGPI no yes: 0, no: 27
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 2
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 3
GO:0016020 membrane 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1

Expansion

Sequence features

A0A3Q8IDK8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDK8

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 28
GO:0006793 phosphorus metabolic process 3 28
GO:0006796 phosphate-containing compound metabolic process 4 28
GO:0006807 nitrogen compound metabolic process 2 28
GO:0008152 metabolic process 1 28
GO:0009987 cellular process 1 28
GO:0016310 phosphorylation 5 28
GO:0019538 protein metabolic process 3 28
GO:0036211 protein modification process 4 28
GO:0043170 macromolecule metabolic process 3 28
GO:0043412 macromolecule modification 4 28
GO:0044237 cellular metabolic process 2 28
GO:0044238 primary metabolic process 2 28
GO:0071704 organic substance metabolic process 2 28
GO:1901564 organonitrogen compound metabolic process 3 28
GO:0007165 signal transduction 2 2
GO:0018105 peptidyl-serine phosphorylation 6 2
GO:0018193 peptidyl-amino acid modification 5 2
GO:0018209 peptidyl-serine modification 6 2
GO:0035556 intracellular signal transduction 3 2
GO:0046777 protein autophosphorylation 6 1
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0065007 biological regulation 1 2
GO:0000281 mitotic cytokinesis 4 1
GO:0000910 cytokinesis 3 1
GO:0022402 cell cycle process 2 1
GO:0061640 cytoskeleton-dependent cytokinesis 4 1
GO:1903047 mitotic cell cycle process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 28
GO:0003824 catalytic activity 1 28
GO:0004672 protein kinase activity 3 28
GO:0005488 binding 1 28
GO:0005524 ATP binding 5 28
GO:0016301 kinase activity 4 28
GO:0016740 transferase activity 2 28
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 28
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 28
GO:0017076 purine nucleotide binding 4 28
GO:0030554 adenyl nucleotide binding 5 28
GO:0032553 ribonucleotide binding 3 28
GO:0032555 purine ribonucleotide binding 4 28
GO:0032559 adenyl ribonucleotide binding 5 28
GO:0035639 purine ribonucleoside triphosphate binding 4 28
GO:0036094 small molecule binding 2 28
GO:0043167 ion binding 2 28
GO:0043168 anion binding 3 28
GO:0097159 organic cyclic compound binding 2 28
GO:0097367 carbohydrate derivative binding 2 28
GO:0140096 catalytic activity, acting on a protein 2 28
GO:1901265 nucleoside phosphate binding 3 28
GO:1901363 heterocyclic compound binding 2 28
GO:0004674 protein serine/threonine kinase activity 4 21
GO:0008270 zinc ion binding 6 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1
GO:0046914 transition metal ion binding 5 1
GO:0004683 calmodulin-dependent protein kinase activity 5 1
GO:0005515 protein binding 2 1
GO:0005516 calmodulin binding 3 1
GO:0009931 calcium-dependent protein serine/threonine kinase activity 5 1
GO:0010857 calcium-dependent protein kinase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 202 204 PF00675 0.410
CLV_NRD_NRD_1 436 438 PF00675 0.444
CLV_NRD_NRD_1 52 54 PF00675 0.334
CLV_NRD_NRD_1 558 560 PF00675 0.602
CLV_NRD_NRD_1 90 92 PF00675 0.291
CLV_PCSK_KEX2_1 404 406 PF00082 0.510
CLV_PCSK_KEX2_1 438 440 PF00082 0.425
CLV_PCSK_KEX2_1 52 54 PF00082 0.437
CLV_PCSK_KEX2_1 545 547 PF00082 0.617
CLV_PCSK_KEX2_1 558 560 PF00082 0.589
CLV_PCSK_KEX2_1 90 92 PF00082 0.291
CLV_PCSK_PC1ET2_1 404 406 PF00082 0.524
CLV_PCSK_PC1ET2_1 438 440 PF00082 0.425
CLV_PCSK_PC1ET2_1 52 54 PF00082 0.437
CLV_PCSK_PC1ET2_1 545 547 PF00082 0.617
CLV_PCSK_SKI1_1 124 128 PF00082 0.347
CLV_PCSK_SKI1_1 141 145 PF00082 0.475
CLV_PCSK_SKI1_1 305 309 PF00082 0.531
CLV_PCSK_SKI1_1 310 314 PF00082 0.622
CLV_PCSK_SKI1_1 486 490 PF00082 0.533
CLV_PCSK_SKI1_1 545 549 PF00082 0.621
DEG_APCC_DBOX_1 123 131 PF00400 0.405
DEG_APCC_DBOX_1 436 444 PF00400 0.428
DEG_SCF_FBW7_1 533 538 PF00400 0.621
DEG_SPOP_SBC_1 178 182 PF00917 0.405
DEG_SPOP_SBC_1 528 532 PF00917 0.621
DOC_CYCLIN_yCln2_LP_2 283 289 PF00134 0.323
DOC_MAPK_gen_1 141 150 PF00069 0.404
DOC_MAPK_gen_1 309 318 PF00069 0.595
DOC_MAPK_gen_1 39 49 PF00069 0.311
DOC_MAPK_gen_1 90 98 PF00069 0.347
DOC_MAPK_JIP1_4 144 150 PF00069 0.362
DOC_MAPK_JIP1_4 276 282 PF00069 0.301
DOC_MAPK_MEF2A_6 90 98 PF00069 0.354
DOC_MAPK_NFAT4_5 91 99 PF00069 0.370
DOC_SPAK_OSR1_1 91 95 PF12202 0.288
DOC_USP7_MATH_1 154 158 PF00917 0.395
DOC_USP7_MATH_1 423 427 PF00917 0.570
DOC_USP7_MATH_1 535 539 PF00917 0.775
DOC_USP7_MATH_1 541 545 PF00917 0.871
DOC_USP7_UBL2_3 309 313 PF12436 0.511
DOC_USP7_UBL2_3 48 52 PF12436 0.404
DOC_USP7_UBL2_3 536 540 PF12436 0.630
DOC_USP7_UBL2_3 54 58 PF12436 0.404
DOC_WW_Pin1_4 152 157 PF00397 0.320
DOC_WW_Pin1_4 183 188 PF00397 0.395
DOC_WW_Pin1_4 255 260 PF00397 0.359
DOC_WW_Pin1_4 329 334 PF00397 0.535
DOC_WW_Pin1_4 512 517 PF00397 0.702
DOC_WW_Pin1_4 529 534 PF00397 0.708
DOC_WW_Pin1_4 547 552 PF00397 0.613
LIG_14-3-3_CanoR_1 16 22 PF00244 0.390
LIG_14-3-3_CanoR_1 246 250 PF00244 0.474
LIG_14-3-3_CanoR_1 340 348 PF00244 0.577
LIG_14-3-3_CanoR_1 475 479 PF00244 0.630
LIG_14-3-3_CanoR_1 546 551 PF00244 0.596
LIG_14-3-3_CterR_2 558 560 PF00244 0.617
LIG_APCC_ABBA_1 409 414 PF00400 0.533
LIG_APCC_ABBAyCdc20_2 136 142 PF00400 0.300
LIG_deltaCOP1_diTrp_1 330 338 PF00928 0.568
LIG_EH1_1 92 100 PF00400 0.300
LIG_eIF4E_1 93 99 PF01652 0.310
LIG_FHA_1 218 224 PF00498 0.349
LIG_FHA_1 236 242 PF00498 0.310
LIG_FHA_1 320 326 PF00498 0.494
LIG_FHA_1 39 45 PF00498 0.367
LIG_FHA_1 62 68 PF00498 0.307
LIG_FHA_2 200 206 PF00498 0.325
LIG_FHA_2 258 264 PF00498 0.372
LIG_FHA_2 276 282 PF00498 0.497
LIG_LIR_Apic_2 186 192 PF02991 0.404
LIG_LIR_Apic_2 330 334 PF02991 0.586
LIG_LIR_Gen_1 220 229 PF02991 0.317
LIG_LIR_Gen_1 237 243 PF02991 0.374
LIG_LIR_Gen_1 251 261 PF02991 0.303
LIG_LIR_Gen_1 332 339 PF02991 0.549
LIG_LIR_Gen_1 342 349 PF02991 0.521
LIG_LIR_Gen_1 398 407 PF02991 0.439
LIG_LIR_Nem_3 220 224 PF02991 0.346
LIG_LIR_Nem_3 237 242 PF02991 0.420
LIG_LIR_Nem_3 251 257 PF02991 0.341
LIG_LIR_Nem_3 270 274 PF02991 0.292
LIG_LIR_Nem_3 332 338 PF02991 0.465
LIG_LIR_Nem_3 342 348 PF02991 0.430
LIG_LIR_Nem_3 398 402 PF02991 0.416
LIG_LIR_Nem_3 408 413 PF02991 0.514
LIG_LIR_Nem_3 477 482 PF02991 0.658
LIG_LIR_Nem_3 89 95 PF02991 0.444
LIG_LYPXL_S_1 409 413 PF13949 0.422
LIG_LYPXL_yS_3 410 413 PF13949 0.415
LIG_Pex14_1 331 335 PF04695 0.571
LIG_Pex14_2 235 239 PF04695 0.428
LIG_SH2_CRK 30 34 PF00017 0.355
LIG_SH2_NCK_1 271 275 PF00017 0.295
LIG_SH2_NCK_1 30 34 PF00017 0.310
LIG_SH2_PTP2 189 192 PF00017 0.341
LIG_SH2_PTP2 221 224 PF00017 0.380
LIG_SH2_PTP2 93 96 PF00017 0.494
LIG_SH2_SRC 177 180 PF00017 0.405
LIG_SH2_SRC 271 274 PF00017 0.295
LIG_SH2_STAP1 30 34 PF00017 0.310
LIG_SH2_STAP1 45 49 PF00017 0.405
LIG_SH2_STAT5 177 180 PF00017 0.390
LIG_SH2_STAT5 189 192 PF00017 0.382
LIG_SH2_STAT5 221 224 PF00017 0.380
LIG_SH2_STAT5 399 402 PF00017 0.402
LIG_SH2_STAT5 445 448 PF00017 0.385
LIG_SH2_STAT5 85 88 PF00017 0.390
LIG_SH2_STAT5 93 96 PF00017 0.403
LIG_SH3_3 271 277 PF00018 0.363
LIG_SH3_4 536 543 PF00018 0.608
LIG_SUMO_SIM_anti_2 278 284 PF11976 0.301
LIG_SUMO_SIM_anti_2 66 71 PF11976 0.358
LIG_SUMO_SIM_par_1 94 100 PF11976 0.445
LIG_TYR_ITIM 219 224 PF00017 0.424
LIG_TYR_ITIM 269 274 PF00017 0.295
LIG_UBA3_1 104 112 PF00899 0.380
MOD_CDK_SPK_2 531 536 PF00069 0.623
MOD_CDK_SPxK_1 552 558 PF00069 0.611
MOD_CDK_SPxxK_3 255 262 PF00069 0.348
MOD_CDK_SPxxK_3 529 536 PF00069 0.791
MOD_CDK_SPxxK_3 552 559 PF00069 0.595
MOD_CK1_1 117 123 PF00069 0.321
MOD_CK1_1 155 161 PF00069 0.316
MOD_CK1_1 162 168 PF00069 0.304
MOD_CK1_1 248 254 PF00069 0.594
MOD_CK1_1 300 306 PF00069 0.531
MOD_CK1_1 474 480 PF00069 0.579
MOD_CK1_1 515 521 PF00069 0.618
MOD_CK1_1 531 537 PF00069 0.627
MOD_CK1_1 539 545 PF00069 0.675
MOD_CK2_1 199 205 PF00069 0.325
MOD_CK2_1 231 237 PF00069 0.383
MOD_CK2_1 275 281 PF00069 0.300
MOD_CK2_1 492 498 PF00069 0.553
MOD_Cter_Amidation 402 405 PF01082 0.468
MOD_GlcNHglycan 127 130 PF01048 0.383
MOD_GlcNHglycan 224 227 PF01048 0.336
MOD_GlcNHglycan 99 102 PF01048 0.369
MOD_GSK3_1 152 159 PF00069 0.353
MOD_GSK3_1 179 186 PF00069 0.483
MOD_GSK3_1 231 238 PF00069 0.337
MOD_GSK3_1 241 248 PF00069 0.384
MOD_GSK3_1 253 260 PF00069 0.382
MOD_GSK3_1 339 346 PF00069 0.579
MOD_GSK3_1 359 366 PF00069 0.403
MOD_GSK3_1 482 489 PF00069 0.578
MOD_GSK3_1 515 522 PF00069 0.604
MOD_GSK3_1 527 534 PF00069 0.825
MOD_GSK3_1 535 542 PF00069 0.724
MOD_N-GLC_1 117 122 PF02516 0.295
MOD_N-GLC_1 162 167 PF02516 0.442
MOD_NEK2_1 241 246 PF00069 0.588
MOD_NEK2_1 319 324 PF00069 0.499
MOD_NEK2_1 471 476 PF00069 0.577
MOD_NEK2_1 482 487 PF00069 0.560
MOD_PIKK_1 319 325 PF00454 0.661
MOD_PIKK_1 350 356 PF00454 0.482
MOD_PKA_1 545 551 PF00069 0.599
MOD_PKA_2 245 251 PF00069 0.454
MOD_PKA_2 275 281 PF00069 0.334
MOD_PKA_2 339 345 PF00069 0.538
MOD_PKA_2 38 44 PF00069 0.334
MOD_PKA_2 474 480 PF00069 0.649
MOD_PKA_2 545 551 PF00069 0.598
MOD_Plk_1 117 123 PF00069 0.383
MOD_Plk_1 423 429 PF00069 0.474
MOD_Plk_4 117 123 PF00069 0.327
MOD_Plk_4 185 191 PF00069 0.340
MOD_Plk_4 321 327 PF00069 0.511
MOD_Plk_4 344 350 PF00069 0.401
MOD_Plk_4 474 480 PF00069 0.602
MOD_ProDKin_1 152 158 PF00069 0.320
MOD_ProDKin_1 183 189 PF00069 0.395
MOD_ProDKin_1 255 261 PF00069 0.359
MOD_ProDKin_1 329 335 PF00069 0.528
MOD_ProDKin_1 512 518 PF00069 0.705
MOD_ProDKin_1 529 535 PF00069 0.707
MOD_ProDKin_1 547 553 PF00069 0.614
MOD_SUMO_for_1 143 146 PF00179 0.404
MOD_SUMO_rev_2 353 360 PF00179 0.614
MOD_SUMO_rev_2 364 374 PF00179 0.539
TRG_DiLeu_BaEn_1 237 242 PF01217 0.295
TRG_DiLeu_BaEn_2 407 413 PF01217 0.540
TRG_ENDOCYTIC_2 221 224 PF00928 0.424
TRG_ENDOCYTIC_2 271 274 PF00928 0.297
TRG_ENDOCYTIC_2 30 33 PF00928 0.369
TRG_ENDOCYTIC_2 399 402 PF00928 0.421
TRG_ENDOCYTIC_2 410 413 PF00928 0.420
TRG_ENDOCYTIC_2 93 96 PF00928 0.412
TRG_ER_diArg_1 200 203 PF00400 0.454
TRG_ER_diArg_1 437 440 PF00400 0.429
TRG_ER_diArg_1 90 92 PF00400 0.288
TRG_NLS_MonoExtC_3 308 313 PF00514 0.479
TRG_NLS_MonoExtN_4 309 314 PF00514 0.501
TRG_Pf-PMV_PEXEL_1 141 146 PF00026 0.385

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PE80 Leptomonas seymouri 71% 99%
A0A0S4J7K4 Bodo saltans 60% 100%
A0A1X0NJV4 Trypanosomatidae 60% 100%
A0A1X0P1A2 Trypanosomatidae 60% 100%
A0A2I0BVG8 Plasmodium falciparum (isolate NF54) 28% 100%
A0A3Q8IC87 Leishmania donovani 33% 100%
A0A3Q8IFK8 Leishmania donovani 27% 100%
A0A3Q8INQ4 Leishmania donovani 30% 100%
A0A3Q8IVR8 Leishmania donovani 26% 100%
A0A3S5H5G0 Leishmania donovani 28% 100%
A0A3S5H5U5 Leishmania donovani 23% 100%
A0A3S7WTN9 Leishmania donovani 25% 100%
A0A3S7X9R4 Leishmania donovani 28% 100%
A0A509AHB6 Plasmodium berghei (strain Anka) 28% 100%
A4H459 Leishmania braziliensis 29% 100%
A4H4S9 Leishmania braziliensis 25% 100%
A4H8C4 Leishmania braziliensis 26% 100%
A4HC27 Leishmania braziliensis 24% 100%
A4HCD7 Leishmania braziliensis 33% 100%
A4HED7 Leishmania braziliensis 29% 100%
A4HG27 Leishmania braziliensis 84% 100%
A4HJT5 Leishmania braziliensis 27% 100%
A4HJW2 Leishmania braziliensis 24% 100%
A4HN71 Leishmania braziliensis 27% 100%
A4HNT2 Leishmania braziliensis 26% 100%
A4HP12 Leishmania braziliensis 27% 100%
A4HSE2 Leishmania infantum 28% 100%
A4HWP5 Leishmania infantum 25% 100%
A4HZV1 Leishmania infantum 33% 100%
A4I1T4 Leishmania infantum 30% 100%
A4I349 Leishmania infantum 100% 100%
A4I7A1 Leishmania infantum 27% 100%
A4IBT4 Leishmania infantum 27% 100%
A4IBT9 Leishmania infantum 27% 100%
A4ICR2 Leishmania infantum 26% 100%
C9ZN29 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 100%
E9ACW7 Leishmania major 92% 100%
E9AG71 Leishmania infantum 23% 100%
E9AKB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AKZ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9AQF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9AVR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9AXW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9AZF6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B6S4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B6S9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
P62343 Plasmodium falciparum (isolate K1 / Thailand) 28% 100%
P62344 Plasmodium falciparum (isolate 3D7) 28% 100%
Q4Q204 Leishmania major 26% 100%
Q4Q5W2 Leishmania major 28% 100%
Q4Q9K2 Leishmania major 31% 100%
Q4QBR6 Leishmania major 33% 100%
Q4QF23 Leishmania major 25% 100%
Q4QIV8 Leishmania major 25% 100%
Q4QJJ0 Leishmania major 28% 100%
Q6C7U0 Yarrowia lipolytica (strain CLIB 122 / E 150) 27% 79%
Q7RAH3 Plasmodium yoelii yoelii 28% 100%
Q9GNR4 Leishmania major 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS