Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IDK6_LEIDO

TriTrypDb:

LdBPK_260220.1 , LdCL_260007700 , LDHU3_26.0330

Length:

378

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IDK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDK6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.612
CLV_C14_Caspase3-7	183	187	PF00656	0.657
CLV_NRD_NRD_1	136	138	PF00675	0.694
CLV_NRD_NRD_1	366	368	PF00675	0.670
CLV_NRD_NRD_1	57	59	PF00675	0.630
CLV_NRD_NRD_1	68	70	PF00675	0.457
CLV_PCSK_KEX2_1	337	339	PF00082	0.705
CLV_PCSK_KEX2_1	366	368	PF00082	0.670
CLV_PCSK_KEX2_1	57	59	PF00082	0.572
CLV_PCSK_KEX2_1	68	70	PF00082	0.406
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.700
CLV_PCSK_SKI1_1	199	203	PF00082	0.744
CLV_PCSK_SKI1_1	361	365	PF00082	0.557
DEG_APCC_DBOX_1	85	93	PF00400	0.577
DEG_COP1_1	108	117	PF00400	0.709
DEG_Nend_UBRbox_2	1	3	PF02207	0.733
DOC_CKS1_1	326	331	PF01111	0.670
DOC_CYCLIN_RxL_1	196	205	PF00134	0.707
DOC_CYCLIN_yCln2_LP_2	320	326	PF00134	0.775
DOC_MAPK_gen_1	65	73	PF00069	0.623
DOC_PP1_RVXF_1	75	82	PF00149	0.539
DOC_PP1_RVXF_1	88	95	PF00149	0.620
DOC_PP2B_LxvP_1	211	214	PF13499	0.586
DOC_PP4_FxxP_1	259	262	PF00568	0.536
DOC_PP4_FxxP_1	94	97	PF00568	0.698
DOC_USP7_MATH_1	164	168	PF00917	0.617
DOC_USP7_MATH_1	174	178	PF00917	0.662
DOC_USP7_MATH_1	308	312	PF00917	0.702
DOC_USP7_MATH_1	314	318	PF00917	0.721
DOC_USP7_MATH_1	47	51	PF00917	0.665
DOC_WW_Pin1_4	109	114	PF00397	0.736
DOC_WW_Pin1_4	172	177	PF00397	0.797
DOC_WW_Pin1_4	200	205	PF00397	0.717
DOC_WW_Pin1_4	209	214	PF00397	0.577
DOC_WW_Pin1_4	258	263	PF00397	0.540
DOC_WW_Pin1_4	325	330	PF00397	0.622
DOC_WW_Pin1_4	338	343	PF00397	0.805
DOC_WW_Pin1_4	35	40	PF00397	0.547
DOC_WW_Pin1_4	93	98	PF00397	0.613
LIG_14-3-3_CanoR_1	236	241	PF00244	0.506
LIG_14-3-3_CanoR_1	345	349	PF00244	0.732
LIG_14-3-3_CanoR_1	370	374	PF00244	0.608
LIG_14-3-3_CanoR_1	86	90	PF00244	0.567
LIG_Actin_WH2_1	345	363	PF00022	0.703
LIG_Actin_WH2_2	146	162	PF00022	0.624
LIG_Clathr_ClatBox_1	248	252	PF01394	0.611
LIG_FHA_1	1	7	PF00498	0.683
LIG_FHA_1	109	115	PF00498	0.647
LIG_FHA_1	160	166	PF00498	0.612
LIG_FHA_1	264	270	PF00498	0.457
LIG_FHA_1	28	34	PF00498	0.686
LIG_FHA_1	61	67	PF00498	0.625
LIG_FHA_2	210	216	PF00498	0.647
LIG_FHA_2	351	357	PF00498	0.645
LIG_FHA_2	80	86	PF00498	0.543
LIG_LIR_Apic_2	258	262	PF02991	0.465
LIG_LIR_Gen_1	185	194	PF02991	0.746
LIG_LIR_Gen_1	353	360	PF02991	0.713
LIG_LIR_Nem_3	13	19	PF02991	0.525
LIG_LIR_Nem_3	185	191	PF02991	0.756
LIG_LIR_Nem_3	286	292	PF02991	0.576
LIG_LIR_Nem_3	321	325	PF02991	0.740
LIG_LIR_Nem_3	353	357	PF02991	0.717
LIG_PAM2_1	200	212	PF00658	0.640
LIG_RPA_C_Fungi	63	75	PF08784	0.593
LIG_SH2_CRK	198	202	PF00017	0.684
LIG_SH2_CRK	289	293	PF00017	0.513
LIG_SH2_STAP1	188	192	PF00017	0.739
LIG_SH2_STAP1	23	27	PF00017	0.565
LIG_SH2_STAP1	354	358	PF00017	0.725
LIG_SH2_STAT3	23	26	PF00017	0.573
LIG_SH2_STAT5	284	287	PF00017	0.495
LIG_SH3_1	95	101	PF00018	0.523
LIG_SH3_3	111	117	PF00018	0.736
LIG_SH3_3	266	272	PF00018	0.514
LIG_SH3_3	285	291	PF00018	0.508
LIG_SH3_3	320	326	PF00018	0.700
LIG_SH3_3	94	100	PF00018	0.622
LIG_SUMO_SIM_par_1	264	271	PF11976	0.530
LIG_TRAF2_1	18	21	PF00917	0.631
LIG_TRAF2_1	353	356	PF00917	0.734
LIG_TRAF2_1	82	85	PF00917	0.669
LIG_TRFH_1	209	213	PF08558	0.667
LIG_TYR_ITIM	352	357	PF00017	0.691
MOD_CDK_SPxxK_3	338	345	PF00069	0.802
MOD_CK1_1	121	127	PF00069	0.678
MOD_CK1_1	177	183	PF00069	0.697
MOD_CK1_1	261	267	PF00069	0.550
MOD_CK1_1	283	289	PF00069	0.599
MOD_CK1_1	341	347	PF00069	0.746
MOD_CK1_1	350	356	PF00069	0.736
MOD_CK2_1	350	356	PF00069	0.742
MOD_CK2_1	79	85	PF00069	0.547
MOD_GlcNHglycan	126	129	PF01048	0.671
MOD_GlcNHglycan	182	185	PF01048	0.767
MOD_GlcNHglycan	263	266	PF01048	0.554
MOD_GlcNHglycan	310	313	PF01048	0.675
MOD_GlcNHglycan	316	319	PF01048	0.619
MOD_GlcNHglycan	50	53	PF01048	0.653
MOD_GSK3_1	105	112	PF00069	0.633
MOD_GSK3_1	118	125	PF00069	0.827
MOD_GSK3_1	174	181	PF00069	0.771
MOD_GSK3_1	308	315	PF00069	0.693
MOD_GSK3_1	340	347	PF00069	0.770
MOD_GSK3_1	369	376	PF00069	0.691
MOD_N-GLC_1	121	126	PF02516	0.605
MOD_NEK2_1	107	112	PF00069	0.805
MOD_NEK2_1	159	164	PF00069	0.639
MOD_PIKK_1	174	180	PF00454	0.745
MOD_PIKK_1	347	353	PF00454	0.751
MOD_PIKK_1	79	85	PF00454	0.584
MOD_PK_1	236	242	PF00069	0.503
MOD_PKA_2	159	165	PF00069	0.567
MOD_PKA_2	344	350	PF00069	0.732
MOD_PKA_2	369	375	PF00069	0.672
MOD_PKA_2	85	91	PF00069	0.568
MOD_PKB_1	338	346	PF00069	0.721
MOD_Plk_1	12	18	PF00069	0.579
MOD_Plk_1	277	283	PF00069	0.451
MOD_Plk_1	77	83	PF00069	0.591
MOD_Plk_4	149	155	PF00069	0.591
MOD_Plk_4	236	242	PF00069	0.546
MOD_Plk_4	263	269	PF00069	0.534
MOD_Plk_4	280	286	PF00069	0.440
MOD_Plk_4	344	350	PF00069	0.771
MOD_ProDKin_1	109	115	PF00069	0.736
MOD_ProDKin_1	172	178	PF00069	0.798
MOD_ProDKin_1	200	206	PF00069	0.717
MOD_ProDKin_1	209	215	PF00069	0.576
MOD_ProDKin_1	258	264	PF00069	0.538
MOD_ProDKin_1	325	331	PF00069	0.624
MOD_ProDKin_1	338	344	PF00069	0.801
MOD_ProDKin_1	35	41	PF00069	0.543
MOD_ProDKin_1	93	99	PF00069	0.618
MOD_SUMO_for_1	336	339	PF00179	0.699
MOD_SUMO_rev_2	355	363	PF00179	0.724
TRG_DiLeu_BaEn_1	146	151	PF01217	0.582
TRG_DiLeu_BaEn_4	355	361	PF01217	0.723
TRG_DiLeu_BaEn_4	84	90	PF01217	0.666
TRG_DiLeu_BaLyEn_6	196	201	PF01217	0.624
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.566
TRG_DiLeu_BaLyEn_6	288	293	PF01217	0.511
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.688
TRG_ENDOCYTIC_2	188	191	PF00928	0.743
TRG_ENDOCYTIC_2	198	201	PF00928	0.578
TRG_ENDOCYTIC_2	289	292	PF00928	0.486
TRG_ENDOCYTIC_2	354	357	PF00928	0.732
TRG_ER_diArg_1	365	367	PF00400	0.746
TRG_ER_diArg_1	56	58	PF00400	0.639
TRG_ER_diArg_1	68	70	PF00400	0.435
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	57	62	PF00026	0.666

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P503	Leptomonas seymouri	39%	94%
A4HEN2	Leishmania braziliensis	71%	100%
A4I1W0	Leishmania infantum	100%	100%
E9AY05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q9G8	Leishmania major	88%	99%