Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDK5_LEIDO

TriTrypDb:

LdBPK_200670.1 , LdCL_200011400 , LDHU3_20.0810

Length:

406

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8IDK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDK5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006396	RNA processing	6	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0031123	RNA 3'-end processing	7	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071076	RNA 3' uridylation	8	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016779	nucleotidyltransferase activity	4	10
GO:0050265	RNA uridylyltransferase activity	4	10
GO:0070569	uridylyltransferase activity	5	10
GO:0140098	catalytic activity, acting on RNA	3	10
GO:0140640	catalytic activity, acting on a nucleic acid	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	62	66	PF00656	0.521
CLV_C14_Caspase3-7	83	87	PF00656	0.536
CLV_NRD_NRD_1	270	272	PF00675	0.366
CLV_NRD_NRD_1	289	291	PF00675	0.279
CLV_NRD_NRD_1	347	349	PF00675	0.378
CLV_NRD_NRD_1	5	7	PF00675	0.451
CLV_PCSK_KEX2_1	270	272	PF00082	0.374
CLV_PCSK_KEX2_1	291	293	PF00082	0.431
CLV_PCSK_KEX2_1	347	349	PF00082	0.378
CLV_PCSK_KEX2_1	362	364	PF00082	0.367
CLV_PCSK_KEX2_1	5	7	PF00082	0.407
CLV_PCSK_KEX2_1	91	93	PF00082	0.395
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.417
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.440
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.395
CLV_PCSK_SKI1_1	177	181	PF00082	0.431
CLV_PCSK_SKI1_1	217	221	PF00082	0.521
CLV_PCSK_SKI1_1	377	381	PF00082	0.526
DEG_Nend_UBRbox_3	1	3	PF02207	0.496
DEG_SPOP_SBC_1	304	308	PF00917	0.665
DOC_ANK_TNKS_1	346	353	PF00023	0.530
DOC_MAPK_gen_1	353	361	PF00069	0.513
DOC_MAPK_HePTP_8	39	51	PF00069	0.492
DOC_MAPK_MEF2A_6	353	361	PF00069	0.519
DOC_MAPK_MEF2A_6	42	51	PF00069	0.473
DOC_PIKK_1	24	32	PF02985	0.370
DOC_PP2B_LxvP_1	211	214	PF13499	0.436
DOC_PP4_FxxP_1	223	226	PF00568	0.405
DOC_USP7_MATH_1	175	179	PF00917	0.383
DOC_USP7_MATH_1	305	309	PF00917	0.659
DOC_USP7_MATH_1	313	317	PF00917	0.496
DOC_USP7_MATH_1	372	376	PF00917	0.521
DOC_USP7_UBL2_3	164	168	PF12436	0.332
DOC_WW_Pin1_4	73	78	PF00397	0.407
LIG_14-3-3_CanoR_1	270	276	PF00244	0.383
LIG_14-3-3_CanoR_1	303	313	PF00244	0.639
LIG_Actin_WH2_2	236	251	PF00022	0.446
LIG_AP2alpha_1	376	380	PF02296	0.501
LIG_BRCT_BRCA1_1	308	312	PF00533	0.651
LIG_BRCT_BRCA1_1	68	72	PF00533	0.437
LIG_FHA_1	185	191	PF00498	0.314
LIG_FHA_1	220	226	PF00498	0.493
LIG_FHA_1	261	267	PF00498	0.333
LIG_FHA_1	330	336	PF00498	0.464
LIG_FHA_1	381	387	PF00498	0.534
LIG_FHA_2	20	26	PF00498	0.555
LIG_FHA_2	205	211	PF00498	0.404
LIG_FHA_2	60	66	PF00498	0.518
LIG_LIR_Apic_2	221	226	PF02991	0.383
LIG_LIR_Gen_1	178	188	PF02991	0.366
LIG_LIR_Gen_1	252	259	PF02991	0.415
LIG_LIR_Gen_1	274	284	PF02991	0.386
LIG_LIR_Nem_3	154	159	PF02991	0.315
LIG_LIR_Nem_3	178	183	PF02991	0.381
LIG_LIR_Nem_3	205	211	PF02991	0.352
LIG_LIR_Nem_3	241	247	PF02991	0.350
LIG_LIR_Nem_3	252	257	PF02991	0.316
LIG_LIR_Nem_3	274	279	PF02991	0.386
LIG_LIR_Nem_3	294	298	PF02991	0.199
LIG_LIR_Nem_3	309	315	PF02991	0.531
LIG_LIR_Nem_3	31	37	PF02991	0.470
LIG_LIR_Nem_3	337	342	PF02991	0.316
LIG_LIR_Nem_3	360	364	PF02991	0.356
LIG_LIR_Nem_3	375	379	PF02991	0.399
LIG_LIR_Nem_3	69	75	PF02991	0.360
LIG_Pex14_2	376	380	PF04695	0.401
LIG_SH2_CRK	276	280	PF00017	0.450
LIG_SH2_GRB2like	342	345	PF00017	0.334
LIG_SH2_PTP2	159	162	PF00017	0.315
LIG_SH2_STAP1	276	280	PF00017	0.373
LIG_SH2_STAT5	159	162	PF00017	0.317
LIG_SH2_STAT5	244	247	PF00017	0.369
LIG_SH2_STAT5	298	301	PF00017	0.484
LIG_SH2_STAT5	342	345	PF00017	0.357
LIG_SH3_3	169	175	PF00018	0.368
LIG_SH3_3	389	395	PF00018	0.603
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.430
LIG_SUMO_SIM_anti_2	263	268	PF11976	0.332
LIG_SUMO_SIM_anti_2	80	86	PF11976	0.506
LIG_SUMO_SIM_par_1	35	41	PF11976	0.455
LIG_TRAF2_1	316	319	PF00917	0.547
LIG_TRFH_1	223	227	PF08558	0.436
LIG_WRC_WIRS_1	180	185	PF05994	0.339
LIG_WRC_WIRS_1	220	225	PF05994	0.492
LIG_WRC_WIRS_1	399	404	PF05994	0.504
LIG_WW_1	226	229	PF00397	0.418
MOD_CK1_1	19	25	PF00069	0.565
MOD_CK1_1	306	312	PF00069	0.642
MOD_CK1_1	54	60	PF00069	0.356
MOD_CK2_1	204	210	PF00069	0.508
MOD_CK2_1	313	319	PF00069	0.574
MOD_CK2_1	394	400	PF00069	0.654
MOD_CK2_1	77	83	PF00069	0.506
MOD_Cter_Amidation	3	6	PF01082	0.532
MOD_Cter_Amidation	345	348	PF01082	0.367
MOD_GlcNHglycan	124	127	PF01048	0.413
MOD_GlcNHglycan	294	298	PF01048	0.524
MOD_GlcNHglycan	79	82	PF01048	0.495
MOD_GSK3_1	16	23	PF00069	0.551
MOD_GSK3_1	175	182	PF00069	0.368
MOD_GSK3_1	303	310	PF00069	0.661
MOD_GSK3_1	313	320	PF00069	0.475
MOD_GSK3_1	394	401	PF00069	0.636
MOD_GSK3_1	54	61	PF00069	0.470
MOD_GSK3_1	73	80	PF00069	0.327
MOD_N-GLC_1	260	265	PF02516	0.394
MOD_N-GLC_1	372	377	PF02516	0.506
MOD_N-GLC_1	73	78	PF02516	0.370
MOD_NEK2_1	179	184	PF00069	0.357
MOD_NEK2_1	317	322	PF00069	0.471
MOD_NEK2_1	380	385	PF00069	0.561
MOD_NEK2_1	51	56	PF00069	0.384
MOD_NEK2_1	59	64	PF00069	0.381
MOD_NEK2_1	68	73	PF00069	0.266
MOD_NEK2_2	175	180	PF00069	0.460
MOD_NEK2_2	372	377	PF00069	0.489
MOD_PIKK_1	16	22	PF00454	0.455
MOD_PKA_2	16	22	PF00069	0.404
MOD_PKA_2	352	358	PF00069	0.535
MOD_Plk_1	129	135	PF00069	0.338
MOD_Plk_1	175	181	PF00069	0.366
MOD_Plk_1	209	215	PF00069	0.402
MOD_Plk_1	293	299	PF00069	0.504
MOD_Plk_1	317	323	PF00069	0.530
MOD_Plk_1	372	378	PF00069	0.558
MOD_Plk_1	66	72	PF00069	0.314
MOD_Plk_4	175	181	PF00069	0.488
MOD_Plk_4	186	192	PF00069	0.390
MOD_Plk_4	262	268	PF00069	0.332
MOD_ProDKin_1	73	79	PF00069	0.401
MOD_SUMO_rev_2	355	364	PF00179	0.516
TRG_DiLeu_BaEn_1	106	111	PF01217	0.485
TRG_DiLeu_LyEn_5	106	111	PF01217	0.337
TRG_ENDOCYTIC_2	159	162	PF00928	0.315
TRG_ENDOCYTIC_2	208	211	PF00928	0.478
TRG_ENDOCYTIC_2	229	232	PF00928	0.380
TRG_ENDOCYTIC_2	244	247	PF00928	0.324
TRG_ENDOCYTIC_2	254	257	PF00928	0.356
TRG_ENDOCYTIC_2	276	279	PF00928	0.353
TRG_ENDOCYTIC_2	365	368	PF00928	0.472
TRG_ER_diArg_1	269	271	PF00400	0.362
TRG_ER_diArg_1	347	349	PF00400	0.378
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	273	278	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	362	366	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7H1	Leptomonas seymouri	64%	99%
A0A0S4J0S6	Bodo saltans	56%	100%
A0A1X0NX27	Trypanosomatidae	55%	100%
A0A422NJM7	Trypanosoma rangeli	54%	88%
A4HYQ1	Leishmania infantum	100%	100%
C7AJA4	Trypanosoma brucei brucei	54%	100%
C9ZI80	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AUK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QCY0	Leishmania major	96%	100%
Q6DFA8	Xenopus laevis	25%	80%