Vacuolar protein sorting-associated protein 33, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vacuolar protein sorting-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IDK4_LEIDO

TriTrypDb:

LdBPK_252280.1 , LdCL_250028600 , LDHU3_25.2760

Length:

597

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005773	vacuole	5	1
GO:0032991	protein-containing complex	1	1
GO:0033263	CORVET complex	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0099023	vesicle tethering complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IDK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDK4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0016192	vesicle-mediated transport	4	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	324	326	PF00675	0.268
CLV_NRD_NRD_1	370	372	PF00675	0.251
CLV_NRD_NRD_1	398	400	PF00675	0.391
CLV_NRD_NRD_1	467	469	PF00675	0.239
CLV_PCSK_KEX2_1	324	326	PF00082	0.245
CLV_PCSK_KEX2_1	372	374	PF00082	0.267
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.339
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.287
CLV_PCSK_SKI1_1	156	160	PF00082	0.397
CLV_PCSK_SKI1_1	167	171	PF00082	0.249
CLV_PCSK_SKI1_1	183	187	PF00082	0.179
CLV_PCSK_SKI1_1	286	290	PF00082	0.310
CLV_PCSK_SKI1_1	302	306	PF00082	0.209
CLV_PCSK_SKI1_1	332	336	PF00082	0.245
CLV_PCSK_SKI1_1	372	376	PF00082	0.361
CLV_PCSK_SKI1_1	423	427	PF00082	0.411
CLV_PCSK_SKI1_1	588	592	PF00082	0.516
DEG_APCC_KENBOX_2	428	432	PF00400	0.305
DEG_SCF_FBW7_1	245	250	PF00400	0.249
DOC_CKS1_1	244	249	PF01111	0.245
DOC_CYCLIN_RxL_1	180	190	PF00134	0.299
DOC_CYCLIN_RxL_1	370	377	PF00134	0.221
DOC_CYCLIN_RxL_1	402	414	PF00134	0.314
DOC_CYCLIN_RxL_1	585	594	PF00134	0.393
DOC_MAPK_gen_1	421	428	PF00069	0.310
DOC_MAPK_gen_1	585	593	PF00069	0.453
DOC_MAPK_gen_1	60	67	PF00069	0.310
DOC_MAPK_JIP1_4	111	117	PF00069	0.391
DOC_MAPK_MEF2A_6	156	164	PF00069	0.391
DOC_PP1_RVXF_1	370	377	PF00149	0.266
DOC_PP2B_LxvP_1	115	118	PF13499	0.382
DOC_PP4_FxxP_1	244	247	PF00568	0.310
DOC_USP7_UBL2_3	335	339	PF12436	0.245
DOC_WW_Pin1_4	243	248	PF00397	0.312
DOC_WW_Pin1_4	5	10	PF00397	0.392
LIG_14-3-3_CanoR_1	142	147	PF00244	0.266
LIG_14-3-3_CanoR_1	563	570	PF00244	0.382
LIG_14-3-3_CanoR_1	585	591	PF00244	0.391
LIG_Actin_WH2_2	377	393	PF00022	0.452
LIG_Actin_WH2_2	542	560	PF00022	0.339
LIG_APCC_ABBA_1	1	6	PF00400	0.418
LIG_BRCT_BRCA1_1	134	138	PF00533	0.391
LIG_BRCT_BRCA1_1	240	244	PF00533	0.467
LIG_BRCT_BRCA1_1	366	370	PF00533	0.274
LIG_BRCT_BRCA1_2	366	372	PF00533	0.366
LIG_Clathr_ClatBox_1	235	239	PF01394	0.260
LIG_Clathr_ClatBox_1	590	594	PF01394	0.498
LIG_eIF4E_2	493	499	PF01652	0.310
LIG_FHA_1	157	163	PF00498	0.467
LIG_FHA_1	232	238	PF00498	0.294
LIG_FHA_1	33	39	PF00498	0.424
LIG_FHA_1	5	11	PF00498	0.506
LIG_FHA_1	538	544	PF00498	0.245
LIG_FHA_1	575	581	PF00498	0.286
LIG_FHA_2	548	554	PF00498	0.260
LIG_GBD_Chelix_1	405	413	PF00786	0.372
LIG_LIR_Apic_2	241	247	PF02991	0.391
LIG_LIR_Gen_1	147	158	PF02991	0.337
LIG_LIR_Gen_1	21	30	PF02991	0.461
LIG_LIR_Gen_1	293	304	PF02991	0.271
LIG_LIR_Gen_1	401	411	PF02991	0.282
LIG_LIR_Nem_3	135	141	PF02991	0.299
LIG_LIR_Nem_3	147	153	PF02991	0.325
LIG_LIR_Nem_3	165	169	PF02991	0.171
LIG_LIR_Nem_3	190	196	PF02991	0.245
LIG_LIR_Nem_3	21	25	PF02991	0.458
LIG_LIR_Nem_3	253	257	PF02991	0.279
LIG_LIR_Nem_3	293	299	PF02991	0.245
LIG_LIR_Nem_3	301	307	PF02991	0.245
LIG_LIR_Nem_3	401	406	PF02991	0.282
LIG_LIR_Nem_3	443	448	PF02991	0.381
LIG_LIR_Nem_3	462	467	PF02991	0.149
LIG_LIR_Nem_3	487	493	PF02991	0.211
LIG_LYPXL_yS_3	464	467	PF13949	0.212
LIG_MYND_1	518	522	PF01753	0.266
LIG_NRBOX	408	414	PF00104	0.391
LIG_PCNA_yPIPBox_3	584	597	PF02747	0.417
LIG_Pex14_2	166	170	PF04695	0.391
LIG_Rb_pABgroove_1	256	264	PF01858	0.244
LIG_SH2_CRK	436	440	PF00017	0.252
LIG_SH2_CRK	493	497	PF00017	0.299
LIG_SH2_NCK_1	493	497	PF00017	0.244
LIG_SH2_PTP2	150	153	PF00017	0.391
LIG_SH2_SRC	488	491	PF00017	0.255
LIG_SH2_SRC	493	496	PF00017	0.267
LIG_SH2_STAP1	103	107	PF00017	0.310
LIG_SH2_STAT3	116	119	PF00017	0.391
LIG_SH2_STAT5	103	106	PF00017	0.150
LIG_SH2_STAT5	116	119	PF00017	0.339
LIG_SH2_STAT5	150	153	PF00017	0.391
LIG_SH2_STAT5	219	222	PF00017	0.442
LIG_SH2_STAT5	392	395	PF00017	0.272
LIG_SH2_STAT5	76	79	PF00017	0.310
LIG_SH2_STAT5	84	87	PF00017	0.455
LIG_SH3_2	592	597	PF14604	0.483
LIG_SH3_3	266	272	PF00018	0.273
LIG_SH3_3	589	595	PF00018	0.497
LIG_SUMO_SIM_anti_2	21	27	PF11976	0.383
LIG_SUMO_SIM_anti_2	233	239	PF11976	0.288
LIG_SUMO_SIM_par_1	233	239	PF11976	0.286
LIG_SUMO_SIM_par_1	408	414	PF11976	0.305
LIG_SUMO_SIM_par_1	424	430	PF11976	0.305
LIG_TRAF2_1	18	21	PF00917	0.383
LIG_TRFH_1	84	88	PF08558	0.339
LIG_TYR_ITIM	148	153	PF00017	0.355
LIG_TYR_ITIM	252	257	PF00017	0.260
LIG_UBA3_1	295	302	PF00899	0.309
LIG_UBA3_1	425	429	PF00899	0.310
MOD_CK1_1	110	116	PF00069	0.257
MOD_CK1_1	165	171	PF00069	0.391
MOD_CK1_1	176	182	PF00069	0.391
MOD_CK1_1	24	30	PF00069	0.388
MOD_CK1_1	362	368	PF00069	0.391
MOD_CK1_1	46	52	PF00069	0.475
MOD_CK1_1	463	469	PF00069	0.381
MOD_CK1_1	476	482	PF00069	0.319
MOD_CK1_1	552	558	PF00069	0.444
MOD_CK1_1	92	98	PF00069	0.396
MOD_CK2_1	227	233	PF00069	0.309
MOD_CK2_1	271	277	PF00069	0.339
MOD_CK2_1	424	430	PF00069	0.352
MOD_CK2_1	474	480	PF00069	0.316
MOD_CK2_1	547	553	PF00069	0.260
MOD_GlcNHglycan	239	243	PF01048	0.190
MOD_GlcNHglycan	277	281	PF01048	0.348
MOD_GlcNHglycan	45	48	PF01048	0.424
MOD_GlcNHglycan	457	460	PF01048	0.378
MOD_GlcNHglycan	553	557	PF01048	0.279
MOD_GlcNHglycan	565	568	PF01048	0.245
MOD_GlcNHglycan	581	584	PF01048	0.201
MOD_GlcNHglycan	77	80	PF01048	0.335
MOD_GSK3_1	158	165	PF00069	0.244
MOD_GSK3_1	223	230	PF00069	0.307
MOD_GSK3_1	243	250	PF00069	0.129
MOD_GSK3_1	271	278	PF00069	0.291
MOD_GSK3_1	302	309	PF00069	0.277
MOD_GSK3_1	352	359	PF00069	0.260
MOD_GSK3_1	361	368	PF00069	0.248
MOD_GSK3_1	455	462	PF00069	0.303
MOD_GSK3_1	470	477	PF00069	0.203
MOD_GSK3_1	533	540	PF00069	0.257
MOD_GSK3_1	575	582	PF00069	0.240
MOD_GSK3_1	88	95	PF00069	0.381
MOD_N-GLC_1	176	181	PF02516	0.310
MOD_N-GLC_1	289	294	PF02516	0.314
MOD_N-GLC_1	474	479	PF02516	0.317
MOD_NEK2_1	101	106	PF00069	0.285
MOD_NEK2_1	107	112	PF00069	0.287
MOD_NEK2_1	132	137	PF00069	0.314
MOD_NEK2_1	158	163	PF00069	0.450
MOD_NEK2_1	188	193	PF00069	0.170
MOD_NEK2_1	275	280	PF00069	0.329
MOD_NEK2_1	500	505	PF00069	0.339
MOD_NEK2_1	586	591	PF00069	0.299
MOD_PIKK_1	101	107	PF00454	0.339
MOD_PIKK_1	247	253	PF00454	0.245
MOD_PIKK_1	362	368	PF00454	0.250
MOD_PKA_2	562	568	PF00069	0.382
MOD_Plk_1	176	182	PF00069	0.319
MOD_Plk_1	300	306	PF00069	0.312
MOD_Plk_1	474	480	PF00069	0.317
MOD_Plk_1	484	490	PF00069	0.305
MOD_Plk_1	552	558	PF00069	0.245
MOD_Plk_1	88	94	PF00069	0.266
MOD_Plk_2-3	227	233	PF00069	0.391
MOD_Plk_2-3	424	430	PF00069	0.352
MOD_Plk_4	110	116	PF00069	0.375
MOD_Plk_4	118	124	PF00069	0.355
MOD_Plk_4	165	171	PF00069	0.331
MOD_Plk_4	176	182	PF00069	0.264
MOD_Plk_4	21	27	PF00069	0.290
MOD_Plk_4	231	237	PF00069	0.269
MOD_Plk_4	306	312	PF00069	0.251
MOD_Plk_4	411	417	PF00069	0.263
MOD_Plk_4	500	506	PF00069	0.357
MOD_Plk_4	516	522	PF00069	0.391
MOD_ProDKin_1	243	249	PF00069	0.312
MOD_ProDKin_1	5	11	PF00069	0.381
MOD_SUMO_for_1	18	21	PF00179	0.377
MOD_SUMO_rev_2	125	135	PF00179	0.310
MOD_SUMO_rev_2	149	158	PF00179	0.391
MOD_SUMO_rev_2	327	337	PF00179	0.245
TRG_DiLeu_BaEn_1	231	236	PF01217	0.339
TRG_DiLeu_BaEn_1	346	351	PF01217	0.245
TRG_DiLeu_BaEn_1	430	435	PF01217	0.344
TRG_DiLeu_BaEn_1	449	454	PF01217	0.193
TRG_DiLeu_BaEn_1	524	529	PF01217	0.288
TRG_DiLeu_BaEn_2	332	338	PF01217	0.245
TRG_DiLeu_BaLyEn_6	180	185	PF01217	0.391
TRG_DiLeu_BaLyEn_6	405	410	PF01217	0.260
TRG_DiLeu_LyEn_5	346	351	PF01217	0.245
TRG_ENDOCYTIC_2	150	153	PF00928	0.345
TRG_ENDOCYTIC_2	254	257	PF00928	0.275
TRG_ENDOCYTIC_2	464	467	PF00928	0.281
TRG_ER_diArg_1	370	373	PF00400	0.245
TRG_NES_CRM1_1	227	239	PF08389	0.289
TRG_Pf-PMV_PEXEL_1	332	336	PF00026	0.250
TRG_Pf-PMV_PEXEL_1	339	343	PF00026	0.239
TRG_Pf-PMV_PEXEL_1	373	377	PF00026	0.375
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKV5	Leptomonas seymouri	78%	100%
A0A0S4IXS0	Bodo saltans	46%	99%
A0A1X0NZL8	Trypanosomatidae	50%	99%
A0A3R7P4L0	Trypanosoma rangeli	48%	100%
A4HEC2	Leishmania braziliensis	86%	100%
A4I1R7	Leishmania infantum	100%	100%
C9ZKC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AXV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P20795	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	86%
P34260	Caenorhabditis elegans	24%	99%
P59016	Mus musculus	26%	97%
Q18891	Caenorhabditis elegans	22%	97%
Q28288	Canis lupus familiaris	21%	100%
Q2HJ18	Bos taurus	27%	97%
Q4Q9L9	Leishmania major	94%	100%
Q58EN8	Danio rerio	27%	97%
Q63615	Rattus norvegicus	34%	100%
Q63616	Rattus norvegicus	26%	97%
Q64324	Mus musculus	21%	100%
Q94KJ7	Arabidopsis thaliana	31%	100%
Q96AX1	Homo sapiens	33%	100%
Q9D2N9	Mus musculus	33%	100%
Q9H267	Homo sapiens	26%	97%
Q9P7V6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q9Y1I2	Drosophila melanogaster	27%	97%
V5D8I9	Trypanosoma cruzi	50%	100%