Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDK2_LEIDO

TriTrypDb:

LdBPK_260110.1 , LdCL_260006000 , LdCL_260006300 , LdCL_260006600 , LDHU3_26.0180

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

A0A3Q8IDK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDK2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004175	endopeptidase activity	4	3
GO:0004252	serine-type endopeptidase activity	5	3
GO:0008233	peptidase activity	3	4
GO:0008236	serine-type peptidase activity	4	3
GO:0016787	hydrolase activity	2	4
GO:0017171	serine hydrolase activity	3	3
GO:0140096	catalytic activity, acting on a protein	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	184	186	PF00675	0.493
CLV_NRD_NRD_1	213	215	PF00675	0.732
CLV_NRD_NRD_1	220	222	PF00675	0.715
CLV_PCSK_KEX2_1	155	157	PF00082	0.461
CLV_PCSK_KEX2_1	183	185	PF00082	0.448
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.474
CLV_PCSK_PC7_1	179	185	PF00082	0.544
CLV_PCSK_SKI1_1	221	225	PF00082	0.726
CLV_PCSK_SKI1_1	47	51	PF00082	0.649
CLV_PCSK_SKI1_1	85	89	PF00082	0.712
DOC_MAPK_gen_1	183	191	PF00069	0.658
DOC_MAPK_MEF2A_6	94	101	PF00069	0.311
DOC_USP7_MATH_1	115	119	PF00917	0.714
DOC_WW_Pin1_4	174	179	PF00397	0.729
LIG_Actin_WH2_2	139	157	PF00022	0.733
LIG_BRCT_BRCA1_1	206	210	PF00533	0.420
LIG_eIF4E_1	100	106	PF01652	0.414
LIG_eIF4E_1	139	145	PF01652	0.728
LIG_eIF4E_1	175	181	PF01652	0.732
LIG_FHA_1	139	145	PF00498	0.682
LIG_FHA_1	19	25	PF00498	0.403
LIG_FHA_1	6	12	PF00498	0.527
LIG_FHA_1	69	75	PF00498	0.483
LIG_FHA_1	86	92	PF00498	0.511
LIG_FHA_2	169	175	PF00498	0.684
LIG_FHA_2	211	217	PF00498	0.442
LIG_LIR_Apic_2	173	178	PF02991	0.646
LIG_LIR_Apic_2	55	61	PF02991	0.453
LIG_LIR_Gen_1	107	117	PF02991	0.335
LIG_LIR_Gen_1	203	211	PF02991	0.414
LIG_LIR_Gen_1	3	12	PF02991	0.574
LIG_LIR_Nem_3	107	112	PF02991	0.335
LIG_LIR_Nem_3	171	175	PF02991	0.671
LIG_LIR_Nem_3	203	209	PF02991	0.414
LIG_LIR_Nem_3	21	26	PF02991	0.245
LIG_LIR_Nem_3	3	7	PF02991	0.706
LIG_MLH1_MIPbox_1	207	211	PF16413	0.443
LIG_Pex14_2	109	113	PF04695	0.337
LIG_PTB_Apo_2	190	197	PF02174	0.488
LIG_REV1ctd_RIR_1	208	219	PF16727	0.664
LIG_SH2_CRK	139	143	PF00017	0.727
LIG_SH2_CRK	206	210	PF00017	0.411
LIG_SH2_NCK_1	4	8	PF00017	0.663
LIG_SH2_PTP2	175	178	PF00017	0.660
LIG_SH2_SRC	4	7	PF00017	0.665
LIG_SH2_STAP1	172	176	PF00017	0.643
LIG_SH2_STAP1	206	210	PF00017	0.414
LIG_SH2_STAT5	100	103	PF00017	0.358
LIG_SH2_STAT5	111	114	PF00017	0.277
LIG_SH2_STAT5	150	153	PF00017	0.644
LIG_SH2_STAT5	166	169	PF00017	0.634
LIG_SH2_STAT5	175	178	PF00017	0.652
LIG_SH2_STAT5	66	69	PF00017	0.442
LIG_SH3_3	80	86	PF00018	0.500
LIG_SUMO_SIM_anti_2	141	146	PF11976	0.687
LIG_SUMO_SIM_par_1	34	41	PF11976	0.479
LIG_TYR_ITIM	204	209	PF00017	0.451
LIG_WRC_WIRS_1	106	111	PF05994	0.327
MOD_CDK_SPK_2	174	179	PF00069	0.681
MOD_CK2_1	168	174	PF00069	0.613
MOD_GlcNHglycan	54	57	PF01048	0.705
MOD_GSK3_1	115	122	PF00069	0.668
MOD_GSK3_1	14	21	PF00069	0.385
MOD_GSK3_1	200	207	PF00069	0.375
MOD_N-GLC_1	128	133	PF02516	0.666
MOD_N-GLC_1	68	73	PF02516	0.649
MOD_NEK2_1	105	110	PF00069	0.343
MOD_NEK2_1	204	209	PF00069	0.328
MOD_NEK2_1	210	215	PF00069	0.558
MOD_NEK2_1	25	30	PF00069	0.623
MOD_NEK2_1	37	42	PF00069	0.553
MOD_NEK2_1	65	70	PF00069	0.544
MOD_PIKK_1	121	127	PF00454	0.638
MOD_PKA_2	38	44	PF00069	0.640
MOD_PKA_2	52	58	PF00069	0.655
MOD_Plk_1	18	24	PF00069	0.435
MOD_Plk_1	215	221	PF00069	0.571
MOD_Plk_4	140	146	PF00069	0.589
MOD_Plk_4	18	24	PF00069	0.330
MOD_Plk_4	205	211	PF00069	0.321
MOD_Plk_4	7	13	PF00069	0.355
MOD_ProDKin_1	174	180	PF00069	0.682
TRG_ENDOCYTIC_2	139	142	PF00928	0.677
TRG_ENDOCYTIC_2	206	209	PF00928	0.411
TRG_ENDOCYTIC_2	4	7	PF00928	0.591
TRG_ER_diArg_1	183	185	PF00400	0.690
TRG_ER_diArg_1	211	214	PF00400	0.594
TRG_NES_CRM1_1	6	19	PF08389	0.440
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z5	Leptomonas seymouri	78%	99%
A0A0S4INS6	Bodo saltans	45%	100%
A0A1X0NU17	Trypanosomatidae	60%	100%
A0A422N342	Trypanosoma rangeli	61%	100%
A4HEL7	Leishmania braziliensis	87%	100%
A4I1V0	Leishmania infantum	100%	100%
C9ZS72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AXZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q9H9	Leishmania major	97%	100%
Q4Q9I2	Leishmania major	97%	100%
V5B9I6	Trypanosoma cruzi	61%	100%