Acylphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Acylphosphatase

Gene product:

acylphosphatase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDK0_LEIDO

TriTrypDb:

LdCL_250026200 , LDHU3_25.2510

Length:

173

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IDK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDK0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0003998	acylphosphatase activity	6	6
GO:0016462	pyrophosphatase activity	5	6
GO:0016787	hydrolase activity	2	6
GO:0016817	hydrolase activity, acting on acid anhydrides	3	6
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	7	11	PF00656	0.585
CLV_NRD_NRD_1	84	86	PF00675	0.506
CLV_PCSK_SKI1_1	16	20	PF00082	0.550
CLV_PCSK_SKI1_1	22	26	PF00082	0.524
DOC_ANK_TNKS_1	101	108	PF00023	0.506
DOC_WW_Pin1_4	128	133	PF00397	0.506
DOC_WW_Pin1_4	38	43	PF00397	0.569
DOC_WW_Pin1_4	8	13	PF00397	0.645
LIG_14-3-3_CanoR_1	66	72	PF00244	0.549
LIG_Actin_WH2_2	75	93	PF00022	0.506
LIG_FHA_1	143	149	PF00498	0.418
LIG_FHA_1	31	37	PF00498	0.608
LIG_FHA_1	68	74	PF00498	0.506
LIG_FHA_1	96	102	PF00498	0.430
LIG_FHA_2	135	141	PF00498	0.506
LIG_FHA_2	48	54	PF00498	0.616
LIG_LIR_Nem_3	70	74	PF02991	0.506
LIG_PCNA_yPIPBox_3	159	170	PF02747	0.507
LIG_SH2_CRK	87	91	PF00017	0.506
LIG_SH2_GRB2like	30	33	PF00017	0.571
LIG_SH2_STAP1	69	73	PF00017	0.418
LIG_SH2_STAT5	30	33	PF00017	0.583
LIG_SH2_STAT5	67	70	PF00017	0.592
LIG_SH2_STAT5	87	90	PF00017	0.199
LIG_SH3_3	144	150	PF00018	0.515
LIG_SH3_3	55	61	PF00018	0.531
LIG_Sin3_3	55	62	PF02671	0.531
LIG_SUMO_SIM_par_1	2	8	PF11976	0.615
MOD_CDK_SPK_2	128	133	PF00069	0.418
MOD_CK1_1	8	14	PF00069	0.743
MOD_GlcNHglycan	150	153	PF01048	0.729
MOD_GlcNHglycan	166	169	PF01048	0.596
MOD_GlcNHglycan	75	78	PF01048	0.506
MOD_GSK3_1	4	11	PF00069	0.659
MOD_N-GLC_1	162	167	PF02516	0.526
MOD_NEK2_1	162	167	PF00069	0.526
MOD_NEK2_1	4	9	PF00069	0.607
MOD_NEK2_1	62	67	PF00069	0.620
MOD_NEK2_1	95	100	PF00069	0.414
MOD_PIKK_1	142	148	PF00454	0.477
MOD_PKA_1	85	91	PF00069	0.506
MOD_Plk_1	14	20	PF00069	0.564
MOD_Plk_1	142	148	PF00069	0.462
MOD_Plk_1	162	168	PF00069	0.515
MOD_Plk_1	62	68	PF00069	0.654
MOD_ProDKin_1	128	134	PF00069	0.506
MOD_ProDKin_1	38	44	PF00069	0.568
MOD_ProDKin_1	8	14	PF00069	0.640
TRG_ENDOCYTIC_2	71	74	PF00928	0.506
TRG_ENDOCYTIC_2	87	90	PF00928	0.297
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HE98	Leishmania braziliensis	77%	86%
A4I1P4	Leishmania infantum	100%	100%
E9AXS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q9P3	Leishmania major	86%	100%