DUF2012 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2012), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDJ8_LEIDO

TriTrypDb:

LdBPK_260650.1 , LdCL_260012200 , LDHU3_26.0860

Length:

225

Annotations

Annotations by Jardim et al.

ER/Golgi Proteins, ER Membrane complex EMC7 Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0032991	protein-containing complex	1	1
GO:0072546	EMC complex	3	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1

Expansion

Sequence features

A0A3Q8IDJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDJ8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0030246	carbohydrate binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	73	77	PF00656	0.272
CLV_PCSK_SKI1_1	206	210	PF00082	0.469
DEG_Nend_Nbox_1	1	3	PF02207	0.580
DOC_CYCLIN_yCln2_LP_2	167	173	PF00134	0.380
DOC_MAPK_FxFP_2	98	101	PF00069	0.290
DOC_MAPK_MEF2A_6	168	177	PF00069	0.346
DOC_PP2B_LxvP_1	36	39	PF13499	0.362
DOC_PP4_FxxP_1	69	72	PF00568	0.314
DOC_PP4_FxxP_1	98	101	PF00568	0.290
DOC_SPAK_OSR1_1	68	72	PF12202	0.297
DOC_USP7_UBL2_3	205	209	PF12436	0.656
DOC_USP7_UBL2_3	215	219	PF12436	0.705
DOC_WW_Pin1_4	139	144	PF00397	0.312
DOC_WW_Pin1_4	166	171	PF00397	0.463
LIG_14-3-3_CanoR_1	122	130	PF00244	0.331
LIG_APCC_ABBA_1	185	190	PF00400	0.662
LIG_DCNL_PONY_1	1	4	PF03556	0.553
LIG_FHA_1	100	106	PF00498	0.214
LIG_FHA_1	86	92	PF00498	0.317
LIG_FHA_2	110	116	PF00498	0.297
LIG_FHA_2	71	77	PF00498	0.279
LIG_HP1_1	170	174	PF01393	0.420
LIG_LIR_Apic_2	80	85	PF02991	0.343
LIG_LIR_Gen_1	47	57	PF02991	0.342
LIG_LIR_Gen_1	94	103	PF02991	0.274
LIG_LIR_Nem_3	149	154	PF02991	0.356
LIG_LIR_Nem_3	31	36	PF02991	0.362
LIG_LIR_Nem_3	47	52	PF02991	0.411
LIG_LIR_Nem_3	76	82	PF02991	0.314
LIG_LIR_Nem_3	94	100	PF02991	0.274
LIG_PCNA_yPIPBox_3	158	167	PF02747	0.314
LIG_SH2_CRK	33	37	PF00017	0.331
LIG_SH2_CRK	82	86	PF00017	0.315
LIG_SH2_GRB2like	151	154	PF00017	0.240
LIG_SH2_STAT3	32	35	PF00017	0.388
LIG_SH2_STAT3	63	66	PF00017	0.320
LIG_SH2_STAT3	89	92	PF00017	0.348
LIG_SH2_STAT5	155	158	PF00017	0.274
LIG_SH2_STAT5	42	45	PF00017	0.427
LIG_SH2_STAT5	89	92	PF00017	0.300
LIG_SH2_STAT5	97	100	PF00017	0.307
LIG_SUMO_SIM_anti_2	162	169	PF11976	0.372
LIG_SUMO_SIM_anti_2	178	183	PF11976	0.238
LIG_SUMO_SIM_par_1	173	178	PF11976	0.382
LIG_SUMO_SIM_par_1	19	24	PF11976	0.575
LIG_TRAF2_1	189	192	PF00917	0.682
LIG_TRAF2_1	24	27	PF00917	0.537
LIG_TRAF2_2	157	162	PF00917	0.342
LIG_UBA3_1	181	186	PF00899	0.379
LIG_WW_1	39	42	PF00397	0.410
MOD_CK1_1	210	216	PF00069	0.697
MOD_CK2_1	21	27	PF00069	0.564
MOD_GlcNHglycan	123	126	PF01048	0.585
MOD_GlcNHglycan	134	138	PF01048	0.522
MOD_GlcNHglycan	148	151	PF01048	0.447
MOD_GlcNHglycan	23	26	PF01048	0.667
MOD_GSK3_1	116	123	PF00069	0.307
MOD_GSK3_1	162	169	PF00069	0.311
MOD_GSK3_1	193	200	PF00069	0.671
MOD_GSK3_1	209	216	PF00069	0.615
MOD_NEK2_1	120	125	PF00069	0.309
MOD_NEK2_1	133	138	PF00069	0.252
MOD_NEK2_1	175	180	PF00069	0.302
MOD_NEK2_1	2	7	PF00069	0.623
MOD_NEK2_1	207	212	PF00069	0.663
MOD_NEK2_2	77	82	PF00069	0.380
MOD_PIKK_1	193	199	PF00454	0.663
MOD_PKA_2	109	115	PF00069	0.323
MOD_PKA_2	121	127	PF00069	0.338
MOD_PKA_2	193	199	PF00069	0.672
MOD_PKA_2	2	8	PF00069	0.600
MOD_Plk_4	116	122	PF00069	0.344
MOD_Plk_4	162	168	PF00069	0.284
MOD_Plk_4	177	183	PF00069	0.383
MOD_Plk_4	28	34	PF00069	0.370
MOD_Plk_4	38	44	PF00069	0.382
MOD_Plk_4	56	62	PF00069	0.280
MOD_Plk_4	85	91	PF00069	0.296
MOD_ProDKin_1	139	145	PF00069	0.312
MOD_ProDKin_1	166	172	PF00069	0.463
MOD_SUMO_rev_2	111	119	PF00179	0.297
TRG_DiLeu_BaEn_2	93	99	PF01217	0.299
TRG_ENDOCYTIC_2	33	36	PF00928	0.324
TRG_ENDOCYTIC_2	95	98	PF00928	0.290

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU9	Leptomonas seymouri	66%	98%
A0A0S4JJC6	Bodo saltans	32%	90%
A0A1X0NSE7	Trypanosomatidae	40%	90%
A0A422N2I9	Trypanosoma rangeli	40%	96%
A4HES3	Leishmania braziliensis	78%	100%
A4I200	Leishmania infantum	100%	100%
C9ZS15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	93%
E9AY47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q9C6	Leishmania major	96%	100%