Glycerol-3-phosphate dehydrogenase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycerol-3-phosphate dehydrogenase-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IDJ7_LEIDO

TriTrypDb:

LdBPK_200500.1 , LdCL_200009700 , LDHU3_20.0590

Length:

791

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0009331	glycerol-3-phosphate dehydrogenase complex	4	10
GO:0032991	protein-containing complex	1	10
GO:1902494	catalytic complex	2	10
GO:1990204	oxidoreductase complex	3	10
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IDJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDJ7

Function

Biological processes
Term	Name	Level	Count
GO:0006072	glycerol-3-phosphate metabolic process	5	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0019637	organophosphate metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0052646	alditol phosphate metabolic process	4	10
GO:0071704	organic substance metabolic process	2	10
GO:1901135	carbohydrate derivative metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004368	glycerol-3-phosphate dehydrogenase (quinone) activity	5	10
GO:0016491	oxidoreductase activity	2	10
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	10
GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor	4	10
GO:0052590	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity	6	6
GO:0052591	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	7	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	357	361	PF00656	0.591
CLV_C14_Caspase3-7	397	401	PF00656	0.511
CLV_C14_Caspase3-7	669	673	PF00656	0.406
CLV_C14_Caspase3-7	708	712	PF00656	0.480
CLV_C14_Caspase3-7	88	92	PF00656	0.290
CLV_NRD_NRD_1	168	170	PF00675	0.531
CLV_NRD_NRD_1	27	29	PF00675	0.613
CLV_NRD_NRD_1	5	7	PF00675	0.386
CLV_NRD_NRD_1	647	649	PF00675	0.686
CLV_NRD_NRD_1	664	666	PF00675	0.497
CLV_NRD_NRD_1	686	688	PF00675	0.663
CLV_NRD_NRD_1	739	741	PF00675	0.505
CLV_NRD_NRD_1	772	774	PF00675	0.518
CLV_NRD_NRD_1	781	783	PF00675	0.564
CLV_PCSK_KEX2_1	168	170	PF00082	0.531
CLV_PCSK_KEX2_1	27	29	PF00082	0.613
CLV_PCSK_KEX2_1	618	620	PF00082	0.613
CLV_PCSK_KEX2_1	647	649	PF00082	0.686
CLV_PCSK_KEX2_1	664	666	PF00082	0.497
CLV_PCSK_KEX2_1	739	741	PF00082	0.527
CLV_PCSK_KEX2_1	772	774	PF00082	0.518
CLV_PCSK_KEX2_1	781	783	PF00082	0.564
CLV_PCSK_PC1ET2_1	618	620	PF00082	0.613
CLV_PCSK_SKI1_1	359	363	PF00082	0.359
CLV_PCSK_SKI1_1	437	441	PF00082	0.244
CLV_PCSK_SKI1_1	98	102	PF00082	0.508
DEG_APCC_DBOX_1	717	725	PF00400	0.336
DEG_SCF_FBW7_1	218	223	PF00400	0.238
DEG_SPOP_SBC_1	220	224	PF00917	0.261
DEG_SPOP_SBC_1	341	345	PF00917	0.466
DEG_SPOP_SBC_1	414	418	PF00917	0.551
DOC_CDC14_PxL_1	532	540	PF14671	0.495
DOC_CDC14_PxL_1	752	760	PF14671	0.361
DOC_CKS1_1	474	479	PF01111	0.705
DOC_CKS1_1	700	705	PF01111	0.460
DOC_CYCLIN_RxL_1	691	702	PF00134	0.406
DOC_CYCLIN_yCln2_LP_2	461	467	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	700	706	PF00134	0.406
DOC_MAPK_DCC_7	647	655	PF00069	0.441
DOC_MAPK_gen_1	3	12	PF00069	0.629
DOC_MAPK_gen_1	647	655	PF00069	0.441
DOC_MAPK_gen_1	692	700	PF00069	0.405
DOC_MAPK_gen_1	781	789	PF00069	0.370
DOC_MAPK_MEF2A_6	297	305	PF00069	0.563
DOC_MAPK_MEF2A_6	3	12	PF00069	0.636
DOC_MAPK_MEF2A_6	307	316	PF00069	0.501
DOC_MAPK_MEF2A_6	647	655	PF00069	0.441
DOC_MAPK_MEF2A_6	782	791	PF00069	0.386
DOC_MAPK_RevD_3	650	665	PF00069	0.405
DOC_PP1_RVXF_1	508	514	PF00149	0.444
DOC_PP2B_LxvP_1	258	261	PF13499	0.536
DOC_PP2B_LxvP_1	461	464	PF13499	0.508
DOC_PP4_FxxP_1	250	253	PF00568	0.401
DOC_PP4_FxxP_1	506	509	PF00568	0.444
DOC_USP7_MATH_1	228	232	PF00917	0.313
DOC_USP7_MATH_1	341	345	PF00917	0.466
DOC_USP7_MATH_1	375	379	PF00917	0.590
DOC_USP7_MATH_1	478	482	PF00917	0.791
DOC_USP7_MATH_1	488	492	PF00917	0.562
DOC_USP7_MATH_1	57	61	PF00917	0.469
DOC_USP7_UBL2_3	685	689	PF12436	0.486
DOC_WW_Pin1_4	117	122	PF00397	0.303
DOC_WW_Pin1_4	216	221	PF00397	0.333
DOC_WW_Pin1_4	272	277	PF00397	0.511
DOC_WW_Pin1_4	278	283	PF00397	0.488
DOC_WW_Pin1_4	337	342	PF00397	0.563
DOC_WW_Pin1_4	371	376	PF00397	0.582
DOC_WW_Pin1_4	391	396	PF00397	0.383
DOC_WW_Pin1_4	401	406	PF00397	0.569
DOC_WW_Pin1_4	408	413	PF00397	0.541
DOC_WW_Pin1_4	473	478	PF00397	0.755
DOC_WW_Pin1_4	505	510	PF00397	0.428
DOC_WW_Pin1_4	51	56	PF00397	0.477
DOC_WW_Pin1_4	656	661	PF00397	0.388
DOC_WW_Pin1_4	699	704	PF00397	0.461
DOC_WW_Pin1_4	744	749	PF00397	0.290
LIG_14-3-3_CanoR_1	140	146	PF00244	0.317
LIG_14-3-3_CanoR_1	297	302	PF00244	0.536
LIG_14-3-3_CanoR_1	346	355	PF00244	0.536
LIG_14-3-3_CanoR_1	510	514	PF00244	0.444
LIG_14-3-3_CanoR_1	537	543	PF00244	0.449
LIG_14-3-3_CanoR_1	560	565	PF00244	0.472
LIG_14-3-3_CanoR_1	578	587	PF00244	0.238
LIG_14-3-3_CanoR_1	67	74	PF00244	0.447
LIG_14-3-3_CanoR_1	739	748	PF00244	0.328
LIG_14-3-3_CanoR_1	782	788	PF00244	0.358
LIG_Actin_WH2_2	124	142	PF00022	0.300
LIG_Actin_WH2_2	83	100	PF00022	0.290
LIG_AP2alpha_2	72	74	PF02296	0.401
LIG_BIR_II_1	1	5	PF00653	0.684
LIG_BIR_III_4	637	641	PF00653	0.524
LIG_Clathr_ClatBox_1	213	217	PF01394	0.363
LIG_CSL_BTD_1	409	412	PF09270	0.438
LIG_deltaCOP1_diTrp_1	135	138	PF00928	0.327
LIG_eIF4E_1	656	662	PF01652	0.428
LIG_eIF4E_1	676	682	PF01652	0.290
LIG_FHA_1	142	148	PF00498	0.351
LIG_FHA_1	195	201	PF00498	0.327
LIG_FHA_1	220	226	PF00498	0.356
LIG_FHA_1	230	236	PF00498	0.317
LIG_FHA_1	298	304	PF00498	0.600
LIG_FHA_1	415	421	PF00498	0.499
LIG_FHA_1	597	603	PF00498	0.383
LIG_FHA_1	657	663	PF00498	0.295
LIG_FHA_1	693	699	PF00498	0.380
LIG_FHA_2	306	312	PF00498	0.595
LIG_FHA_2	332	338	PF00498	0.504
LIG_FHA_2	706	712	PF00498	0.484
LIG_FHA_2	726	732	PF00498	0.400
LIG_FHA_2	86	92	PF00498	0.290
LIG_Integrin_RGD_1	619	621	PF01839	0.619
LIG_LIR_Apic_2	248	253	PF02991	0.401
LIG_LIR_Apic_2	743	748	PF02991	0.270
LIG_LIR_Gen_1	135	146	PF02991	0.359
LIG_LIR_Gen_1	512	520	PF02991	0.375
LIG_LIR_Gen_1	59	70	PF02991	0.401
LIG_LIR_Gen_1	695	704	PF02991	0.304
LIG_LIR_Gen_1	72	79	PF02991	0.293
LIG_LIR_Gen_1	84	93	PF02991	0.299
LIG_LIR_Nem_3	135	139	PF02991	0.331
LIG_LIR_Nem_3	149	155	PF02991	0.250
LIG_LIR_Nem_3	318	322	PF02991	0.533
LIG_LIR_Nem_3	491	495	PF02991	0.640
LIG_LIR_Nem_3	512	516	PF02991	0.375
LIG_LIR_Nem_3	59	65	PF02991	0.380
LIG_LIR_Nem_3	695	700	PF02991	0.375
LIG_LIR_Nem_3	72	77	PF02991	0.322
LIG_LIR_Nem_3	84	90	PF02991	0.299
LIG_MYND_1	211	215	PF01753	0.308
LIG_MYND_1	270	274	PF01753	0.536
LIG_NRBOX	382	388	PF00104	0.438
LIG_PCNA_yPIPBox_3	618	629	PF02747	0.501
LIG_PDZ_Class_2	786	791	PF00595	0.478
LIG_Rb_pABgroove_1	434	442	PF01858	0.543
LIG_SH2_CRK	319	323	PF00017	0.492
LIG_SH2_CRK	458	462	PF00017	0.561
LIG_SH2_CRK	745	749	PF00017	0.331
LIG_SH2_NCK_1	319	323	PF00017	0.492
LIG_SH2_NCK_1	745	749	PF00017	0.244
LIG_SH2_NCK_1	87	91	PF00017	0.280
LIG_SH2_SRC	319	322	PF00017	0.561
LIG_SH2_SRC	460	463	PF00017	0.591
LIG_SH2_STAP1	458	462	PF00017	0.552
LIG_SH2_STAP1	607	611	PF00017	0.402
LIG_SH2_STAP1	729	733	PF00017	0.308
LIG_SH2_STAT3	556	559	PF00017	0.405
LIG_SH2_STAT5	126	129	PF00017	0.293
LIG_SH2_STAT5	237	240	PF00017	0.437
LIG_SH2_STAT5	421	424	PF00017	0.495
LIG_SH2_STAT5	460	463	PF00017	0.494
LIG_SH2_STAT5	697	700	PF00017	0.299
LIG_SH2_STAT5	745	748	PF00017	0.354
LIG_SH2_STAT5	87	90	PF00017	0.290
LIG_SH3_2	372	377	PF14604	0.508
LIG_SH3_3	157	163	PF00018	0.371
LIG_SH3_3	212	218	PF00018	0.238
LIG_SH3_3	250	256	PF00018	0.355
LIG_SH3_3	325	331	PF00018	0.536
LIG_SH3_3	369	375	PF00018	0.565
LIG_SH3_3	406	412	PF00018	0.508
LIG_SH3_3	471	477	PF00018	0.486
LIG_SH3_3	533	539	PF00018	0.488
LIG_SH3_3	587	593	PF00018	0.431
LIG_SH3_3	611	617	PF00018	0.395
LIG_SUMO_SIM_anti_2	515	520	PF11976	0.403
LIG_SUMO_SIM_anti_2	626	633	PF11976	0.515
LIG_SUMO_SIM_anti_2	75	80	PF11976	0.308
LIG_SUMO_SIM_par_1	143	151	PF11976	0.351
LIG_SUMO_SIM_par_1	299	304	PF11976	0.591
LIG_SUMO_SIM_par_1	354	360	PF11976	0.551
LIG_SUMO_SIM_par_1	626	633	PF11976	0.487
LIG_TRAF2_1	308	311	PF00917	0.591
LIG_TRAF2_1	324	327	PF00917	0.402
LIG_TYR_ITIM	317	322	PF00017	0.508
MOD_CDC14_SPxK_1	281	284	PF00782	0.438
MOD_CDC14_SPxK_1	374	377	PF00782	0.508
MOD_CDK_SPK_2	401	406	PF00069	0.438
MOD_CDK_SPK_2	505	510	PF00069	0.444
MOD_CDK_SPxK_1	278	284	PF00069	0.438
MOD_CDK_SPxK_1	371	377	PF00069	0.508
MOD_CDK_SPxxK_3	51	58	PF00069	0.475
MOD_CK1_1	111	117	PF00069	0.336
MOD_CK1_1	2	8	PF00069	0.666
MOD_CK1_1	203	209	PF00069	0.280
MOD_CK1_1	339	345	PF00069	0.515
MOD_CK1_1	35	41	PF00069	0.447
MOD_CK1_1	390	396	PF00069	0.572
MOD_CK1_1	401	407	PF00069	0.461
MOD_CK1_1	512	518	PF00069	0.342
MOD_CK1_1	531	537	PF00069	0.287
MOD_CK1_1	549	555	PF00069	0.430
MOD_CK1_1	570	576	PF00069	0.360
MOD_CK1_1	581	587	PF00069	0.281
MOD_CK1_1	630	636	PF00069	0.492
MOD_CK1_1	683	689	PF00069	0.417
MOD_CK1_1	705	711	PF00069	0.525
MOD_CK2_1	179	185	PF00069	0.391
MOD_CK2_1	305	311	PF00069	0.560
MOD_CK2_1	331	337	PF00069	0.514
MOD_CK2_1	620	626	PF00069	0.456
MOD_CK2_1	725	731	PF00069	0.377
MOD_CK2_1	744	750	PF00069	0.169
MOD_CK2_1	772	778	PF00069	0.394
MOD_CMANNOS	170	173	PF00535	0.591
MOD_GlcNHglycan	110	113	PF01048	0.512
MOD_GlcNHglycan	181	184	PF01048	0.536
MOD_GlcNHglycan	204	209	PF01048	0.526
MOD_GlcNHglycan	327	331	PF01048	0.375
MOD_GlcNHglycan	34	37	PF01048	0.589
MOD_GlcNHglycan	39	42	PF01048	0.575
MOD_GlcNHglycan	390	393	PF01048	0.349
MOD_GlcNHglycan	400	403	PF01048	0.286
MOD_GlcNHglycan	406	409	PF01048	0.345
MOD_GlcNHglycan	569	572	PF01048	0.580
MOD_GlcNHglycan	68	71	PF01048	0.614
MOD_GlcNHglycan	711	714	PF01048	0.742
MOD_GSK3_1	111	118	PF00069	0.322
MOD_GSK3_1	175	182	PF00069	0.308
MOD_GSK3_1	200	207	PF00069	0.315
MOD_GSK3_1	216	223	PF00069	0.269
MOD_GSK3_1	241	248	PF00069	0.389
MOD_GSK3_1	272	279	PF00069	0.552
MOD_GSK3_1	297	304	PF00069	0.579
MOD_GSK3_1	31	38	PF00069	0.396
MOD_GSK3_1	326	333	PF00069	0.498
MOD_GSK3_1	336	343	PF00069	0.531
MOD_GSK3_1	367	374	PF00069	0.547
MOD_GSK3_1	387	394	PF00069	0.461
MOD_GSK3_1	404	411	PF00069	0.465
MOD_GSK3_1	415	422	PF00069	0.436
MOD_GSK3_1	472	479	PF00069	0.698
MOD_GSK3_1	505	512	PF00069	0.368
MOD_GSK3_1	562	569	PF00069	0.424
MOD_GSK3_1	570	577	PF00069	0.351
MOD_GSK3_1	698	705	PF00069	0.383
MOD_GSK3_1	740	747	PF00069	0.287
MOD_GSK3_1	783	790	PF00069	0.394
MOD_GSK3_1	81	88	PF00069	0.290
MOD_N-GLC_1	426	431	PF02516	0.348
MOD_N-GLC_1	442	447	PF02516	0.230
MOD_N-GLC_1	546	551	PF02516	0.618
MOD_NEK2_1	141	146	PF00069	0.367
MOD_NEK2_1	312	317	PF00069	0.569
MOD_NEK2_1	336	341	PF00069	0.602
MOD_NEK2_1	354	359	PF00069	0.508
MOD_NEK2_1	37	42	PF00069	0.419
MOD_NEK2_1	387	392	PF00069	0.572
MOD_NEK2_1	495	500	PF00069	0.653
MOD_NEK2_1	504	509	PF00069	0.335
MOD_NEK2_1	566	571	PF00069	0.394
MOD_NEK2_1	609	614	PF00069	0.410
MOD_NEK2_1	65	70	PF00069	0.367
MOD_NEK2_1	698	703	PF00069	0.364
MOD_NEK2_1	783	788	PF00069	0.368
MOD_NEK2_2	432	437	PF00069	0.591
MOD_PIKK_1	581	587	PF00454	0.440
MOD_PKA_1	772	778	PF00069	0.449
MOD_PKA_2	175	181	PF00069	0.339
MOD_PKA_2	2	8	PF00069	0.595
MOD_PKA_2	31	37	PF00069	0.397
MOD_PKA_2	345	351	PF00069	0.536
MOD_PKA_2	509	515	PF00069	0.471
MOD_PKA_2	567	573	PF00069	0.408
MOD_PKA_2	57	63	PF00069	0.450
MOD_PKA_2	66	72	PF00069	0.461
MOD_PKA_2	738	744	PF00069	0.308
MOD_PKA_2	772	778	PF00069	0.449
MOD_PKB_1	560	568	PF00069	0.473
MOD_PKB_1	718	726	PF00069	0.308
MOD_Plk_1	147	153	PF00069	0.361
MOD_Plk_1	574	580	PF00069	0.416
MOD_Plk_4	141	147	PF00069	0.314
MOD_Plk_4	162	168	PF00069	0.351
MOD_Plk_4	209	215	PF00069	0.349
MOD_Plk_4	221	227	PF00069	0.242
MOD_Plk_4	242	248	PF00069	0.327
MOD_Plk_4	312	318	PF00069	0.591
MOD_Plk_4	456	462	PF00069	0.508
MOD_Plk_4	512	518	PF00069	0.376
MOD_Plk_4	562	568	PF00069	0.432
MOD_Plk_4	627	633	PF00069	0.517
MOD_Plk_4	720	726	PF00069	0.343
MOD_Plk_4	757	763	PF00069	0.336
MOD_ProDKin_1	117	123	PF00069	0.303
MOD_ProDKin_1	216	222	PF00069	0.333
MOD_ProDKin_1	272	278	PF00069	0.511
MOD_ProDKin_1	337	343	PF00069	0.563
MOD_ProDKin_1	371	377	PF00069	0.582
MOD_ProDKin_1	391	397	PF00069	0.383
MOD_ProDKin_1	401	407	PF00069	0.569
MOD_ProDKin_1	408	414	PF00069	0.541
MOD_ProDKin_1	473	479	PF00069	0.760
MOD_ProDKin_1	505	511	PF00069	0.428
MOD_ProDKin_1	51	57	PF00069	0.473
MOD_ProDKin_1	656	662	PF00069	0.384
MOD_ProDKin_1	699	705	PF00069	0.462
MOD_ProDKin_1	744	750	PF00069	0.290
TRG_DiLeu_BaEn_1	627	632	PF01217	0.516
TRG_DiLeu_BaLyEn_6	382	387	PF01217	0.461
TRG_DiLeu_BaLyEn_6	575	580	PF01217	0.418
TRG_DiLeu_BaLyEn_6	648	653	PF01217	0.436
TRG_DiLeu_BaLyEn_6	657	662	PF01217	0.389
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.591
TRG_ENDOCYTIC_2	319	322	PF00928	0.490
TRG_ENDOCYTIC_2	458	461	PF00928	0.495
TRG_ENDOCYTIC_2	697	700	PF00928	0.299
TRG_ENDOCYTIC_2	87	90	PF00928	0.290
TRG_ER_diArg_1	131	134	PF00400	0.278
TRG_ER_diArg_1	167	169	PF00400	0.361
TRG_ER_diArg_1	26	28	PF00400	0.404
TRG_ER_diArg_1	377	380	PF00400	0.544
TRG_ER_diArg_1	664	666	PF00400	0.389
TRG_ER_diArg_1	694	697	PF00400	0.356
TRG_ER_diArg_1	718	721	PF00400	0.355
TRG_ER_diArg_1	772	774	PF00400	0.379
TRG_ER_diArg_1	781	783	PF00400	0.405
TRG_NLS_MonoExtN_4	685	691	PF00514	0.331
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	385	389	PF00026	0.308
TRG_Pf-PMV_PEXEL_1	664	668	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4L0	Leptomonas seymouri	47%	94%
A0A1X0NY01	Trypanosomatidae	32%	100%
A4HYM4	Leishmania infantum	99%	100%
C9ZI64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AIA2	Leishmania braziliensis	76%	100%
E9AUI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QCZ7	Leishmania major	89%	100%
V5BVH7	Trypanosoma cruzi	33%	100%