Zinc-finger double-stranded RNA-binding, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDJ2_LEIDO

TriTrypDb:

LdBPK_290630.1 , LdCL_290011100 , LDHU3_29.0860

Length:

631

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IDJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDJ2

Function

Biological processes
Term	Name	Level	Count
GO:0000491	small nucleolar ribonucleoprotein complex assembly	7	1
GO:0000492	box C/D snoRNP assembly	8	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	427	431	PF00656	0.625
CLV_NRD_NRD_1	114	116	PF00675	0.748
CLV_NRD_NRD_1	154	156	PF00675	0.534
CLV_NRD_NRD_1	187	189	PF00675	0.588
CLV_NRD_NRD_1	190	192	PF00675	0.538
CLV_NRD_NRD_1	220	222	PF00675	0.539
CLV_NRD_NRD_1	230	232	PF00675	0.613
CLV_NRD_NRD_1	276	278	PF00675	0.751
CLV_NRD_NRD_1	37	39	PF00675	0.589
CLV_NRD_NRD_1	583	585	PF00675	0.714
CLV_NRD_NRD_1	588	590	PF00675	0.689
CLV_PCSK_FUR_1	188	192	PF00082	0.662
CLV_PCSK_FUR_1	274	278	PF00082	0.775
CLV_PCSK_KEX2_1	189	191	PF00082	0.599
CLV_PCSK_KEX2_1	219	221	PF00082	0.514
CLV_PCSK_KEX2_1	232	234	PF00082	0.624
CLV_PCSK_KEX2_1	276	278	PF00082	0.751
CLV_PCSK_KEX2_1	37	39	PF00082	0.589
CLV_PCSK_KEX2_1	583	585	PF00082	0.714
CLV_PCSK_KEX2_1	588	590	PF00082	0.689
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.668
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.642
CLV_PCSK_PC7_1	584	590	PF00082	0.699
CLV_PCSK_SKI1_1	449	453	PF00082	0.668
CLV_PCSK_SKI1_1	564	568	PF00082	0.700
CLV_PCSK_SKI1_1	622	626	PF00082	0.625
DOC_CYCLIN_RxL_1	69	80	PF00134	0.752
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.704
DOC_CYCLIN_yCln2_LP_2	552	558	PF00134	0.630
DOC_MAPK_gen_1	158	168	PF00069	0.659
DOC_MAPK_gen_1	231	242	PF00069	0.699
DOC_MAPK_MEF2A_6	20	29	PF00069	0.592
DOC_PP1_RVXF_1	433	440	PF00149	0.615
DOC_PP2B_LxvP_1	74	77	PF13499	0.757
DOC_PP4_FxxP_1	305	308	PF00568	0.719
DOC_SPAK_OSR1_1	617	621	PF12202	0.661
DOC_USP7_MATH_1	106	110	PF00917	0.714
DOC_USP7_MATH_1	247	251	PF00917	0.717
DOC_USP7_MATH_1	255	259	PF00917	0.775
DOC_USP7_MATH_1	261	265	PF00917	0.835
DOC_USP7_MATH_1	290	294	PF00917	0.663
DOC_USP7_MATH_1	309	313	PF00917	0.555
DOC_USP7_MATH_1	331	335	PF00917	0.708
DOC_USP7_MATH_1	354	358	PF00917	0.798
DOC_USP7_MATH_1	361	365	PF00917	0.718
DOC_USP7_MATH_1	484	488	PF00917	0.844
DOC_USP7_MATH_1	505	509	PF00917	0.660
DOC_USP7_MATH_1	75	79	PF00917	0.661
DOC_USP7_MATH_2	518	524	PF00917	0.734
DOC_WW_Pin1_4	249	254	PF00397	0.710
DOC_WW_Pin1_4	327	332	PF00397	0.757
DOC_WW_Pin1_4	355	360	PF00397	0.720
DOC_WW_Pin1_4	384	389	PF00397	0.627
DOC_WW_Pin1_4	524	529	PF00397	0.740
DOC_WW_Pin1_4	532	537	PF00397	0.753
DOC_WW_Pin1_4	54	59	PF00397	0.710
DOC_WW_Pin1_4	8	13	PF00397	0.563
LIG_14-3-3_CanoR_1	104	112	PF00244	0.671
LIG_14-3-3_CanoR_1	151	159	PF00244	0.551
LIG_14-3-3_CanoR_1	233	242	PF00244	0.633
LIG_14-3-3_CanoR_1	274	283	PF00244	0.755
LIG_14-3-3_CanoR_1	599	606	PF00244	0.617
LIG_14-3-3_CanoR_1	79	85	PF00244	0.786
LIG_BIR_III_4	297	301	PF00653	0.723
LIG_BIR_III_4	342	346	PF00653	0.757
LIG_FHA_1	339	345	PF00498	0.781
LIG_FHA_1	373	379	PF00498	0.717
LIG_FHA_1	501	507	PF00498	0.721
LIG_FHA_2	29	35	PF00498	0.735
LIG_FHA_2	40	46	PF00498	0.512
LIG_FHA_2	425	431	PF00498	0.577
LIG_FHA_2	593	599	PF00498	0.633
LIG_LIR_Gen_1	141	152	PF02991	0.530
LIG_LIR_Gen_1	45	54	PF02991	0.615
LIG_LIR_Gen_1	595	604	PF02991	0.626
LIG_LIR_Nem_3	141	147	PF02991	0.620
LIG_LIR_Nem_3	45	49	PF02991	0.600
LIG_LIR_Nem_3	595	600	PF02991	0.635
LIG_Pex14_1	36	40	PF04695	0.619
LIG_REV1ctd_RIR_1	616	626	PF16727	0.578
LIG_SH2_CRK	144	148	PF00017	0.636
LIG_SH2_CRK	40	44	PF00017	0.700
LIG_SH2_CRK	578	582	PF00017	0.585
LIG_SH2_SRC	314	317	PF00017	0.758
LIG_SH2_STAP1	135	139	PF00017	0.522
LIG_SH2_STAP1	22	26	PF00017	0.770
LIG_SH2_STAP1	433	437	PF00017	0.753
LIG_SH2_STAT3	184	187	PF00017	0.580
LIG_SH2_STAT5	121	124	PF00017	0.632
LIG_SH2_STAT5	144	147	PF00017	0.472
LIG_SH2_STAT5	184	187	PF00017	0.580
LIG_SH2_STAT5	409	412	PF00017	0.367
LIG_SH3_1	376	382	PF00018	0.672
LIG_SH3_1	588	594	PF00018	0.665
LIG_SH3_3	170	176	PF00018	0.605
LIG_SH3_3	210	216	PF00018	0.552
LIG_SH3_3	280	286	PF00018	0.777
LIG_SH3_3	376	382	PF00018	0.765
LIG_SH3_3	499	505	PF00018	0.819
LIG_SH3_3	512	518	PF00018	0.650
LIG_SH3_3	547	553	PF00018	0.726
LIG_SH3_3	587	593	PF00018	0.675
LIG_SUMO_SIM_anti_2	163	170	PF11976	0.457
LIG_TRAF2_1	130	133	PF00917	0.650
LIG_TRAF2_1	313	316	PF00917	0.793
LIG_TRAF2_1	474	477	PF00917	0.743
LIG_TRAF2_1	517	520	PF00917	0.767
LIG_WW_2	550	553	PF00397	0.618
LIG_WW_3	1	5	PF00397	0.761
MOD_CDK_SPK_2	384	389	PF00069	0.627
MOD_CDK_SPxxK_3	384	391	PF00069	0.619
MOD_CK1_1	254	260	PF00069	0.735
MOD_CK1_1	263	269	PF00069	0.741
MOD_CK1_1	293	299	PF00069	0.785
MOD_CK1_1	310	316	PF00069	0.685
MOD_CK1_1	317	323	PF00069	0.719
MOD_CK1_1	327	333	PF00069	0.645
MOD_CK1_1	357	363	PF00069	0.725
MOD_CK1_1	465	471	PF00069	0.580
MOD_CK1_1	78	84	PF00069	0.815
MOD_CK2_1	266	272	PF00069	0.850
MOD_CK2_1	28	34	PF00069	0.740
MOD_CK2_1	293	299	PF00069	0.730
MOD_CK2_1	310	316	PF00069	0.739
MOD_CK2_1	39	45	PF00069	0.702
MOD_CK2_1	442	448	PF00069	0.809
MOD_CK2_1	484	490	PF00069	0.719
MOD_CK2_1	592	598	PF00069	0.636
MOD_CK2_1	8	14	PF00069	0.776
MOD_GlcNHglycan	108	111	PF01048	0.682
MOD_GlcNHglycan	253	256	PF01048	0.725
MOD_GlcNHglycan	257	260	PF01048	0.747
MOD_GlcNHglycan	363	366	PF01048	0.801
MOD_GlcNHglycan	444	447	PF01048	0.776
MOD_GlcNHglycan	466	470	PF01048	0.696
MOD_GlcNHglycan	486	489	PF01048	0.815
MOD_GlcNHglycan	520	525	PF01048	0.864
MOD_GlcNHglycan	64	68	PF01048	0.604
MOD_GlcNHglycan	81	84	PF01048	0.735
MOD_GSK3_1	247	254	PF00069	0.671
MOD_GSK3_1	255	262	PF00069	0.723
MOD_GSK3_1	263	270	PF00069	0.736
MOD_GSK3_1	310	317	PF00069	0.727
MOD_GSK3_1	327	334	PF00069	0.735
MOD_GSK3_1	357	364	PF00069	0.725
MOD_GSK3_1	420	427	PF00069	0.440
MOD_GSK3_1	478	485	PF00069	0.717
MOD_GSK3_1	520	527	PF00069	0.670
MOD_GSK3_1	75	82	PF00069	0.707
MOD_N-GLC_1	327	332	PF02516	0.725
MOD_N-GLC_1	382	387	PF02516	0.644
MOD_N-GLC_1	462	467	PF02516	0.677
MOD_N-GLC_1	524	529	PF02516	0.667
MOD_NEK2_1	143	148	PF00069	0.556
MOD_NEK2_2	150	155	PF00069	0.521
MOD_NEK2_2	39	44	PF00069	0.703
MOD_PIKK_1	128	134	PF00454	0.567
MOD_PIKK_1	191	197	PF00454	0.572
MOD_PIKK_1	284	290	PF00454	0.630
MOD_PKA_1	276	282	PF00069	0.697
MOD_PKA_2	150	156	PF00069	0.543
MOD_PKA_2	264	270	PF00069	0.761
MOD_PKA_2	275	281	PF00069	0.716
MOD_PKA_2	598	604	PF00069	0.620
MOD_PKA_2	78	84	PF00069	0.702
MOD_PKB_1	231	239	PF00069	0.752
MOD_PKB_1	274	282	PF00069	0.681
MOD_Plk_1	236	242	PF00069	0.649
MOD_Plk_1	429	435	PF00069	0.740
MOD_Plk_1	564	570	PF00069	0.691
MOD_Plk_2-3	543	549	PF00069	0.730
MOD_Plk_2-3	598	604	PF00069	0.620
MOD_Plk_4	236	242	PF00069	0.649
MOD_Plk_4	592	598	PF00069	0.636
MOD_ProDKin_1	249	255	PF00069	0.712
MOD_ProDKin_1	327	333	PF00069	0.756
MOD_ProDKin_1	355	361	PF00069	0.714
MOD_ProDKin_1	384	390	PF00069	0.620
MOD_ProDKin_1	524	530	PF00069	0.741
MOD_ProDKin_1	532	538	PF00069	0.752
MOD_ProDKin_1	54	60	PF00069	0.715
MOD_ProDKin_1	8	14	PF00069	0.560
MOD_SUMO_for_1	200	203	PF00179	0.633
TRG_DiLeu_BaEn_1	164	169	PF01217	0.672
TRG_DiLeu_BaEn_1	608	613	PF01217	0.570
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.733
TRG_ENDOCYTIC_2	144	147	PF00928	0.528
TRG_ENDOCYTIC_2	22	25	PF00928	0.774
TRG_ENDOCYTIC_2	40	43	PF00928	0.690
TRG_ENDOCYTIC_2	578	581	PF00928	0.740
TRG_ENDOCYTIC_2	597	600	PF00928	0.627
TRG_ER_diArg_1	188	191	PF00400	0.664
TRG_ER_diArg_1	219	221	PF00400	0.550
TRG_ER_diArg_1	230	233	PF00400	0.626
TRG_ER_diArg_1	274	277	PF00400	0.836
TRG_ER_diArg_1	3	6	PF00400	0.759
TRG_ER_diArg_1	36	38	PF00400	0.623
TRG_ER_diArg_1	388	391	PF00400	0.586
TRG_ER_diArg_1	588	590	PF00400	0.693
TRG_NLS_Bipartite_1	219	236	PF00514	0.591
TRG_NLS_MonoCore_2	187	192	PF00514	0.659
TRG_NLS_MonoCore_2	231	236	PF00514	0.751
TRG_NLS_MonoExtC_3	154	159	PF00514	0.648
TRG_NLS_MonoExtC_3	188	193	PF00514	0.662
TRG_NLS_MonoExtC_3	230	235	PF00514	0.643
TRG_NLS_MonoExtN_4	188	193	PF00514	0.662
TRG_NLS_MonoExtN_4	231	236	PF00514	0.751

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Y7	Leptomonas seymouri	48%	100%
A4I4B3	Leishmania infantum	99%	100%
E9ADR3	Leishmania major	85%	100%
E9AIT5	Leishmania braziliensis	69%	99%
E9AM17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%