cAMP response protein 1, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cAMP response protein 1, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDJ1_LEIDO

TriTrypDb:

LdBPK_324120.1 , LdCL_320047200 , LDHU3_32.5290

Length:

699

Annotations

LeishMANIAdb annotations

A protein related to animal PKA regulatory subunits. Likely binds cAMP.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IDJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDJ1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	1
GO:0017076	purine nucleotide binding	4	1
GO:0030551	cyclic nucleotide binding	4	1
GO:0030552	cAMP binding	4	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0032553	ribonucleotide binding	3	1
GO:0032555	purine ribonucleotide binding	4	1
GO:0032559	adenyl ribonucleotide binding	5	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.458
CLV_NRD_NRD_1	152	154	PF00675	0.427
CLV_NRD_NRD_1	160	162	PF00675	0.433
CLV_NRD_NRD_1	180	182	PF00675	0.364
CLV_NRD_NRD_1	198	200	PF00675	0.377
CLV_NRD_NRD_1	207	209	PF00675	0.435
CLV_NRD_NRD_1	215	217	PF00675	0.384
CLV_NRD_NRD_1	258	260	PF00675	0.342
CLV_NRD_NRD_1	285	287	PF00675	0.363
CLV_NRD_NRD_1	293	295	PF00675	0.305
CLV_NRD_NRD_1	365	367	PF00675	0.422
CLV_NRD_NRD_1	439	441	PF00675	0.404
CLV_NRD_NRD_1	517	519	PF00675	0.419
CLV_NRD_NRD_1	697	699	PF00675	0.655
CLV_PCSK_FUR_1	204	208	PF00082	0.553
CLV_PCSK_FUR_1	290	294	PF00082	0.328
CLV_PCSK_KEX2_1	136	138	PF00082	0.451
CLV_PCSK_KEX2_1	151	153	PF00082	0.399
CLV_PCSK_KEX2_1	180	182	PF00082	0.469
CLV_PCSK_KEX2_1	198	200	PF00082	0.326
CLV_PCSK_KEX2_1	206	208	PF00082	0.439
CLV_PCSK_KEX2_1	215	217	PF00082	0.265
CLV_PCSK_KEX2_1	258	260	PF00082	0.245
CLV_PCSK_KEX2_1	292	294	PF00082	0.308
CLV_PCSK_KEX2_1	364	366	PF00082	0.422
CLV_PCSK_KEX2_1	370	372	PF00082	0.421
CLV_PCSK_KEX2_1	461	463	PF00082	0.302
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.545
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.308
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.482
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.317
CLV_PCSK_PC7_1	366	372	PF00082	0.472
CLV_PCSK_SKI1_1	198	202	PF00082	0.515
CLV_PCSK_SKI1_1	271	275	PF00082	0.407
CLV_PCSK_SKI1_1	358	362	PF00082	0.448
CLV_PCSK_SKI1_1	370	374	PF00082	0.426
CLV_PCSK_SKI1_1	392	396	PF00082	0.423
CLV_PCSK_SKI1_1	440	444	PF00082	0.428
CLV_PCSK_SKI1_1	478	482	PF00082	0.294
CLV_PCSK_SKI1_1	511	515	PF00082	0.531
CLV_PCSK_SKI1_1	549	553	PF00082	0.497
CLV_PCSK_SKI1_1	67	71	PF00082	0.571
CLV_PCSK_SKI1_1	74	78	PF00082	0.483
DEG_APCC_DBOX_1	214	222	PF00400	0.443
DEG_APCC_DBOX_1	477	485	PF00400	0.303
DEG_APCC_DBOX_1	528	536	PF00400	0.416
DEG_APCC_KENBOX_2	295	299	PF00400	0.420
DEG_Nend_UBRbox_2	1	3	PF02207	0.722
DOC_CYCLIN_RxL_1	62	73	PF00134	0.569
DOC_MAPK_FxFP_2	223	226	PF00069	0.495
DOC_MAPK_gen_1	159	168	PF00069	0.451
DOC_MAPK_gen_1	215	223	PF00069	0.528
DOC_MAPK_gen_1	3	11	PF00069	0.672
DOC_MAPK_gen_1	370	377	PF00069	0.452
DOC_MAPK_gen_1	440	450	PF00069	0.428
DOC_MAPK_gen_1	461	468	PF00069	0.376
DOC_MAPK_gen_1	475	484	PF00069	0.220
DOC_MAPK_gen_1	518	525	PF00069	0.371
DOC_MAPK_HePTP_8	552	564	PF00069	0.483
DOC_MAPK_MEF2A_6	370	379	PF00069	0.427
DOC_MAPK_MEF2A_6	475	484	PF00069	0.312
DOC_MAPK_MEF2A_6	555	564	PF00069	0.478
DOC_MAPK_RevD_3	191	207	PF00069	0.450
DOC_MAPK_RevD_3	274	288	PF00069	0.443
DOC_PP1_RVXF_1	269	275	PF00149	0.409
DOC_PP2B_LxvP_1	192	195	PF13499	0.528
DOC_PP4_FxxP_1	223	226	PF00568	0.384
DOC_PP4_FxxP_1	38	41	PF00568	0.543
DOC_PP4_FxxP_1	525	528	PF00568	0.420
DOC_USP7_MATH_1	352	356	PF00917	0.528
DOC_USP7_MATH_1	46	50	PF00917	0.593
DOC_USP7_MATH_1	460	464	PF00917	0.434
DOC_USP7_MATH_1	521	525	PF00917	0.463
DOC_USP7_MATH_1	58	62	PF00917	0.748
DOC_USP7_UBL2_3	247	251	PF12436	0.496
DOC_USP7_UBL2_3	288	292	PF12436	0.319
DOC_WW_Pin1_4	335	340	PF00397	0.351
DOC_WW_Pin1_4	347	352	PF00397	0.442
DOC_WW_Pin1_4	537	542	PF00397	0.502
LIG_14-3-3_CanoR_1	3	11	PF00244	0.686
LIG_14-3-3_CanoR_1	45	55	PF00244	0.628
LIG_14-3-3_CanoR_1	529	533	PF00244	0.423
LIG_14-3-3_CanoR_1	582	590	PF00244	0.470
LIG_14-3-3_CanoR_1	596	601	PF00244	0.617
LIG_14-3-3_CanoR_1	62	66	PF00244	0.664
LIG_Actin_WH2_2	242	260	PF00022	0.506
LIG_APCC_ABBA_1	505	510	PF00400	0.476
LIG_APCC_ABBAyCdc20_2	67	73	PF00400	0.438
LIG_BRCT_BRCA1_1	420	424	PF00533	0.317
LIG_BRCT_BRCA1_1	598	602	PF00533	0.592
LIG_BRCT_BRCA1_1	6	10	PF00533	0.706
LIG_eIF4E_1	142	148	PF01652	0.525
LIG_FHA_1	278	284	PF00498	0.301
LIG_FHA_1	393	399	PF00498	0.488
LIG_FHA_1	420	426	PF00498	0.428
LIG_FHA_1	538	544	PF00498	0.414
LIG_FHA_1	578	584	PF00498	0.495
LIG_FHA_2	233	239	PF00498	0.492
LIG_LIR_Apic_2	220	226	PF02991	0.510
LIG_LIR_Apic_2	524	528	PF02991	0.521
LIG_LIR_Gen_1	187	197	PF02991	0.424
LIG_LIR_Gen_1	313	321	PF02991	0.301
LIG_LIR_Gen_1	340	349	PF02991	0.337
LIG_LIR_Gen_1	467	476	PF02991	0.317
LIG_LIR_Gen_1	49	58	PF02991	0.596
LIG_LIR_Gen_1	520	528	PF02991	0.334
LIG_LIR_Gen_1	682	690	PF02991	0.445
LIG_LIR_Nem_3	138	142	PF02991	0.560
LIG_LIR_Nem_3	187	192	PF02991	0.431
LIG_LIR_Nem_3	313	317	PF02991	0.301
LIG_LIR_Nem_3	331	337	PF02991	0.301
LIG_LIR_Nem_3	340	345	PF02991	0.274
LIG_LIR_Nem_3	467	473	PF02991	0.317
LIG_LIR_Nem_3	49	55	PF02991	0.673
LIG_LIR_Nem_3	520	525	PF02991	0.336
LIG_LIR_Nem_3	599	605	PF02991	0.487
LIG_LIR_Nem_3	682	686	PF02991	0.456
LIG_MLH1_MIPbox_1	420	424	PF16413	0.317
LIG_Pex14_2	236	240	PF04695	0.373
LIG_Pex14_2	379	383	PF04695	0.415
LIG_PTB_Apo_2	379	386	PF02174	0.477
LIG_PTB_Phospho_1	379	385	PF10480	0.482
LIG_Rb_LxCxE_1	313	331	PF01857	0.301
LIG_SH2_NCK_1	342	346	PF00017	0.313
LIG_SH2_PTP2	52	55	PF00017	0.717
LIG_SH2_SRC	342	345	PF00017	0.337
LIG_SH2_STAP1	342	346	PF00017	0.337
LIG_SH2_STAP1	621	625	PF00017	0.374
LIG_SH2_STAT3	107	110	PF00017	0.556
LIG_SH2_STAT3	385	388	PF00017	0.484
LIG_SH2_STAT3	423	426	PF00017	0.317
LIG_SH2_STAT5	107	110	PF00017	0.437
LIG_SH2_STAT5	256	259	PF00017	0.343
LIG_SH2_STAT5	262	265	PF00017	0.328
LIG_SH2_STAT5	348	351	PF00017	0.537
LIG_SH2_STAT5	385	388	PF00017	0.360
LIG_SH2_STAT5	411	414	PF00017	0.384
LIG_SH2_STAT5	423	426	PF00017	0.256
LIG_SH2_STAT5	470	473	PF00017	0.337
LIG_SH2_STAT5	52	55	PF00017	0.674
LIG_SH3_3	31	37	PF00018	0.577
LIG_SH3_3	38	44	PF00018	0.541
LIG_SUMO_SIM_anti_2	164	169	PF11976	0.448
LIG_SUMO_SIM_anti_2	280	285	PF11976	0.313
LIG_SUMO_SIM_anti_2	548	554	PF11976	0.501
LIG_SUMO_SIM_par_1	274	280	PF11976	0.362
LIG_SUMO_SIM_par_1	402	408	PF11976	0.361
LIG_SUMO_SIM_par_1	565	571	PF11976	0.495
LIG_TRAF2_1	132	135	PF00917	0.462
LIG_TRAF2_1	338	341	PF00917	0.328
LIG_TRFH_1	191	195	PF08558	0.518
LIG_TYR_ITIM	332	337	PF00017	0.435
LIG_TYR_ITIM	468	473	PF00017	0.435
LIG_UBA3_1	244	253	PF00899	0.379
LIG_UBA3_1	77	83	PF00899	0.555
LIG_WRC_WIRS_1	186	191	PF05994	0.529
LIG_WRC_WIRS_1	522	527	PF05994	0.422
MOD_CK1_1	390	396	PF00069	0.493
MOD_CK1_1	464	470	PF00069	0.356
MOD_CK1_1	539	545	PF00069	0.471
MOD_CK1_1	588	594	PF00069	0.628
MOD_CK1_1	61	67	PF00069	0.693
MOD_CK1_1	616	622	PF00069	0.390
MOD_CK1_1	656	662	PF00069	0.574
MOD_CK2_1	129	135	PF00069	0.485
MOD_CK2_1	22	28	PF00069	0.738
MOD_CK2_1	232	238	PF00069	0.493
MOD_CK2_1	335	341	PF00069	0.328
MOD_CK2_1	570	576	PF00069	0.534
MOD_GlcNHglycan	131	134	PF01048	0.341
MOD_GlcNHglycan	299	302	PF01048	0.376
MOD_GlcNHglycan	322	325	PF01048	0.301
MOD_GlcNHglycan	564	567	PF01048	0.420
MOD_GlcNHglycan	58	61	PF01048	0.705
MOD_GlcNHglycan	598	601	PF01048	0.621
MOD_GlcNHglycan	655	658	PF01048	0.369
MOD_GSK3_1	228	235	PF00069	0.433
MOD_GSK3_1	292	299	PF00069	0.468
MOD_GSK3_1	460	467	PF00069	0.390
MOD_GSK3_1	5	12	PF00069	0.711
MOD_GSK3_1	558	565	PF00069	0.463
MOD_GSK3_1	56	63	PF00069	0.612
MOD_GSK3_1	624	631	PF00069	0.368
MOD_N-GLC_1	14	19	PF02516	0.704
MOD_N-GLC_1	297	302	PF02516	0.420
MOD_N-GLC_1	5	10	PF02516	0.717
MOD_N-GLC_1	596	601	PF02516	0.605
MOD_N-GLC_2	469	471	PF02516	0.299
MOD_NEK2_1	232	237	PF00069	0.393
MOD_NEK2_1	274	279	PF00069	0.317
MOD_NEK2_1	443	448	PF00069	0.428
MOD_NEK2_1	451	456	PF00069	0.315
MOD_NEK2_1	536	541	PF00069	0.462
MOD_NEK2_1	553	558	PF00069	0.364
MOD_NEK2_1	568	573	PF00069	0.285
MOD_NEK2_1	614	619	PF00069	0.487
MOD_NEK2_1	653	658	PF00069	0.515
MOD_NEK2_1	681	686	PF00069	0.448
MOD_NEK2_1	76	81	PF00069	0.574
MOD_PIKK_1	392	398	PF00454	0.523
MOD_PIKK_1	616	622	PF00454	0.427
MOD_PK_1	161	167	PF00069	0.456
MOD_PK_1	322	328	PF00069	0.301
MOD_PK_1	461	467	PF00069	0.393
MOD_PK_1	5	11	PF00069	0.675
MOD_PKA_1	161	167	PF00069	0.456
MOD_PKA_1	292	298	PF00069	0.337
MOD_PKA_1	461	467	PF00069	0.317
MOD_PKA_2	292	298	PF00069	0.421
MOD_PKA_2	461	467	PF00069	0.335
MOD_PKA_2	474	480	PF00069	0.306
MOD_PKA_2	528	534	PF00069	0.423
MOD_PKA_2	61	67	PF00069	0.502
MOD_PKA_2	94	100	PF00069	0.509
MOD_PKB_1	159	167	PF00069	0.457
MOD_Plk_1	153	159	PF00069	0.570
MOD_Plk_1	390	396	PF00069	0.493
MOD_Plk_1	418	424	PF00069	0.337
MOD_Plk_1	5	11	PF00069	0.718
MOD_Plk_1	568	574	PF00069	0.401
MOD_Plk_2-3	689	695	PF00069	0.497
MOD_Plk_4	232	238	PF00069	0.417
MOD_Plk_4	279	285	PF00069	0.337
MOD_Plk_4	322	328	PF00069	0.374
MOD_Plk_4	419	425	PF00069	0.428
MOD_Plk_4	461	467	PF00069	0.310
MOD_Plk_4	5	11	PF00069	0.711
MOD_Plk_4	539	545	PF00069	0.436
MOD_Plk_4	558	564	PF00069	0.230
MOD_ProDKin_1	335	341	PF00069	0.351
MOD_ProDKin_1	347	353	PF00069	0.435
MOD_ProDKin_1	537	543	PF00069	0.496
MOD_SUMO_rev_2	434	443	PF00179	0.362
MOD_SUMO_rev_2	454	463	PF00179	0.395
MOD_SUMO_rev_2	637	646	PF00179	0.428
TRG_DiLeu_BaEn_1	488	493	PF01217	0.465
TRG_DiLeu_BaEn_1	548	553	PF01217	0.497
TRG_DiLeu_BaEn_1	670	675	PF01217	0.564
TRG_DiLeu_BaEn_1	73	78	PF01217	0.409
TRG_DiLeu_BaEn_3	134	140	PF01217	0.374
TRG_ENDOCYTIC_2	334	337	PF00928	0.367
TRG_ENDOCYTIC_2	342	345	PF00928	0.301
TRG_ENDOCYTIC_2	470	473	PF00928	0.323
TRG_ENDOCYTIC_2	52	55	PF00928	0.599
TRG_ENDOCYTIC_2	522	525	PF00928	0.349
TRG_ENDOCYTIC_2	687	690	PF00928	0.493
TRG_ER_diArg_1	180	182	PF00400	0.459
TRG_ER_diArg_1	197	199	PF00400	0.328
TRG_ER_diArg_1	203	206	PF00400	0.448
TRG_ER_diArg_1	257	259	PF00400	0.245
TRG_ER_diArg_1	363	366	PF00400	0.428
TRG_NES_CRM1_1	472	483	PF08389	0.339
TRG_NLS_MonoExtC_3	285	290	PF00514	0.341
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	261	266	PF00026	0.278
TRG_Pf-PMV_PEXEL_1	650	655	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	691	696	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAZ4	Leptomonas seymouri	64%	100%
A0A0S4JPP7	Bodo saltans	33%	69%
A0A1X0NTP9	Trypanosomatidae	47%	98%
A0A422NHV4	Trypanosoma rangeli	47%	99%
A4HL34	Leishmania braziliensis	80%	100%
A4I8L5	Leishmania infantum	100%	100%
D0AAJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	99%
E9B3H5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q4M5	Leishmania major	96%	100%
V5BDD3	Trypanosoma cruzi	47%	99%