LeishMANIAdb
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Hypothetical_protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein
Gene product:
hypothetical protein
Species:
Leishmania donovani
UniProt:
A0A3Q8IDI7_LEIDO
TriTrypDb:
LdCL_250030700 , LDHU3_25.2980
Length:
129

Annotations

LeishMANIAdb annotations

The TM segment is conserved among Kinetoplastids. Unknown function.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A0A3Q8IDI7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDI7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 4 6 PF00675 0.475
CLV_NRD_NRD_1 60 62 PF00675 0.434
CLV_PCSK_FUR_1 58 62 PF00082 0.349
CLV_PCSK_KEX2_1 4 6 PF00082 0.475
CLV_PCSK_KEX2_1 60 62 PF00082 0.455
CLV_PCSK_KEX2_1 87 89 PF00082 0.392
CLV_PCSK_PC1ET2_1 87 89 PF00082 0.371
CLV_PCSK_PC7_1 56 62 PF00082 0.439
CLV_PCSK_SKI1_1 123 127 PF00082 0.479
CLV_PCSK_SKI1_1 87 91 PF00082 0.469
DOC_CYCLIN_RxL_1 84 93 PF00134 0.562
DOC_PP2B_LxvP_1 38 41 PF13499 0.570
DOC_USP7_MATH_1 16 20 PF00917 0.678
DOC_USP7_MATH_1 25 29 PF00917 0.685
DOC_USP7_MATH_1 8 12 PF00917 0.664
DOC_USP7_MATH_1 92 96 PF00917 0.603
DOC_WW_Pin1_4 21 26 PF00397 0.750
DOC_WW_Pin1_4 32 37 PF00397 0.707
LIG_BRCT_BRCA1_1 81 85 PF00533 0.700
LIG_BRCT_BRCA1_2 81 87 PF00533 0.567
LIG_FHA_1 97 103 PF00498 0.466
LIG_LIR_Nem_3 115 119 PF02991 0.231
LIG_MYND_1 36 40 PF01753 0.601
LIG_SH2_STAT5 113 116 PF00017 0.207
LIG_SH3_3 33 39 PF00018 0.613
LIG_WW_3 1 5 PF00397 0.631
MOD_CDK_SPK_2 21 26 PF00069 0.738
MOD_CK1_1 17 23 PF00069 0.694
MOD_CK1_1 74 80 PF00069 0.625
MOD_CK2_1 90 96 PF00069 0.655
MOD_GlcNHglycan 14 17 PF01048 0.457
MOD_GlcNHglycan 19 22 PF01048 0.432
MOD_GlcNHglycan 27 30 PF01048 0.384
MOD_GlcNHglycan 73 76 PF01048 0.396
MOD_GlcNHglycan 81 84 PF01048 0.371
MOD_GlcNHglycan 90 93 PF01048 0.505
MOD_GSK3_1 108 115 PF00069 0.300
MOD_GSK3_1 16 23 PF00069 0.695
MOD_GSK3_1 6 13 PF00069 0.629
MOD_GSK3_1 69 76 PF00069 0.656
MOD_GSK3_1 79 86 PF00069 0.616
MOD_GSK3_1 88 95 PF00069 0.604
MOD_N-GLC_1 6 11 PF02516 0.378
MOD_NEK2_1 105 110 PF00069 0.149
MOD_NEK2_1 90 95 PF00069 0.619
MOD_PIKK_1 14 20 PF00454 0.666
MOD_PKA_1 60 66 PF00069 0.571
MOD_PKA_2 25 31 PF00069 0.706
MOD_PKA_2 60 66 PF00069 0.653
MOD_PKB_1 58 66 PF00069 0.564
MOD_Plk_1 123 129 PF00069 0.296
MOD_ProDKin_1 21 27 PF00069 0.750
MOD_ProDKin_1 32 38 PF00069 0.705
TRG_DiLeu_BaLyEn_6 45 50 PF01217 0.576
TRG_ENDOCYTIC_2 122 125 PF00928 0.290
TRG_ER_diArg_1 3 5 PF00400 0.636
TRG_Pf-PMV_PEXEL_1 48 52 PF00026 0.332

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3R4 Leptomonas seymouri 52% 92%
A0A0S4J168 Bodo saltans 32% 92%
A0A1X0NDT0 Trypanosomatidae 39% 100%
A0A422P4M2 Trypanosoma rangeli 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS