TPR repeat/Tetratricopeptide repeat, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDI5_LEIDO

TriTrypDb:

LdBPK_260360.1 , LdCL_260009100 , LDHU3_26.0470

Length:

853

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0000152	nuclear ubiquitin ligase complex	3	1
GO:0005680	anaphase-promoting complex	4	1
GO:0005737	cytoplasm	2	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A0A3Q8IDI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDI5

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007088	regulation of mitotic nuclear division	6	1
GO:0007091	metaphase/anaphase transition of mitotic cell cycle	5	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010638	positive regulation of organelle organization	6	1
GO:0010965	regulation of mitotic sister chromatid separation	6	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0022402	cell cycle process	2	1
GO:0030071	regulation of mitotic metaphase/anaphase transition	7	1
GO:0030163	protein catabolic process	4	1
GO:0031145	anaphase-promoting complex-dependent catabolic process	7	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0033043	regulation of organelle organization	5	1
GO:0033044	regulation of chromosome organization	6	1
GO:0033045	regulation of sister chromatid segregation	5	1
GO:0036211	protein modification process	4	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044770	cell cycle phase transition	3	1
GO:0044772	mitotic cell cycle phase transition	4	1
GO:0044784	metaphase/anaphase transition of cell cycle	4	1
GO:0045787	positive regulation of cell cycle	5	1
GO:0045840	positive regulation of mitotic nuclear division	7	1
GO:0045842	positive regulation of mitotic metaphase/anaphase transition	8	1
GO:0045931	positive regulation of mitotic cell cycle	6	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051130	positive regulation of cellular component organization	5	1
GO:0051301	cell division	2	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051726	regulation of cell cycle	4	1
GO:0051783	regulation of nuclear division	6	1
GO:0051785	positive regulation of nuclear division	7	1
GO:0051983	regulation of chromosome segregation	4	1
GO:0065007	biological regulation	1	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0090068	positive regulation of cell cycle process	6	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901970	positive regulation of mitotic sister chromatid separation	7	1
GO:1901987	regulation of cell cycle phase transition	6	1
GO:1901989	positive regulation of cell cycle phase transition	7	1
GO:1901990	regulation of mitotic cell cycle phase transition	6	1
GO:1901992	positive regulation of mitotic cell cycle phase transition	7	1
GO:1902099	regulation of metaphase/anaphase transition of cell cycle	6	1
GO:1902101	positive regulation of metaphase/anaphase transition of cell cycle	7	1
GO:1903047	mitotic cell cycle process	3	1
GO:1905818	regulation of chromosome separation	5	1
GO:1905820	positive regulation of chromosome separation	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.549
CLV_C14_Caspase3-7	507	511	PF00656	0.741
CLV_C14_Caspase3-7	749	753	PF00656	0.376
CLV_NRD_NRD_1	240	242	PF00675	0.552
CLV_NRD_NRD_1	557	559	PF00675	0.501
CLV_NRD_NRD_1	718	720	PF00675	0.634
CLV_NRD_NRD_1	80	82	PF00675	0.444
CLV_PCSK_FUR_1	240	244	PF00082	0.537
CLV_PCSK_KEX2_1	240	242	PF00082	0.552
CLV_PCSK_KEX2_1	557	559	PF00082	0.501
CLV_PCSK_KEX2_1	718	720	PF00082	0.541
CLV_PCSK_KEX2_1	80	82	PF00082	0.448
CLV_PCSK_KEX2_1	800	802	PF00082	0.640
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.533
CLV_PCSK_PC1ET2_1	800	802	PF00082	0.640
CLV_PCSK_SKI1_1	107	111	PF00082	0.513
CLV_PCSK_SKI1_1	175	179	PF00082	0.498
CLV_PCSK_SKI1_1	792	796	PF00082	0.465
CLV_PCSK_SKI1_1	797	801	PF00082	0.521
DEG_Nend_UBRbox_1	1	4	PF02207	0.698
DEG_SPOP_SBC_1	532	536	PF00917	0.719
DOC_CKS1_1	674	679	PF01111	0.436
DOC_CYCLIN_RxL_1	172	184	PF00134	0.594
DOC_CYCLIN_RxL_1	599	608	PF00134	0.554
DOC_CYCLIN_RxL_1	789	798	PF00134	0.480
DOC_CYCLIN_yCln2_LP_2	228	234	PF00134	0.589
DOC_MAPK_gen_1	172	181	PF00069	0.593
DOC_MAPK_gen_1	265	275	PF00069	0.469
DOC_MAPK_gen_1	393	402	PF00069	0.565
DOC_MAPK_gen_1	557	566	PF00069	0.495
DOC_MAPK_HePTP_8	343	355	PF00069	0.583
DOC_MAPK_HePTP_8	554	566	PF00069	0.591
DOC_MAPK_MEF2A_6	268	277	PF00069	0.483
DOC_MAPK_MEF2A_6	346	355	PF00069	0.574
DOC_MAPK_MEF2A_6	396	404	PF00069	0.627
DOC_MAPK_MEF2A_6	557	566	PF00069	0.597
DOC_PP1_RVXF_1	447	454	PF00149	0.526
DOC_PP1_RVXF_1	600	607	PF00149	0.549
DOC_PP2B_LxvP_1	769	772	PF13499	0.768
DOC_PP2B_LxvP_1	837	840	PF13499	0.527
DOC_USP7_MATH_1	328	332	PF00917	0.535
DOC_USP7_MATH_1	383	387	PF00917	0.591
DOC_USP7_MATH_1	496	500	PF00917	0.748
DOC_USP7_MATH_1	575	579	PF00917	0.636
DOC_USP7_MATH_1	64	68	PF00917	0.591
DOC_USP7_MATH_1	659	663	PF00917	0.411
DOC_USP7_MATH_1	781	785	PF00917	0.606
DOC_USP7_MATH_1	812	816	PF00917	0.637
DOC_WW_Pin1_4	299	304	PF00397	0.762
DOC_WW_Pin1_4	489	494	PF00397	0.720
DOC_WW_Pin1_4	501	506	PF00397	0.550
DOC_WW_Pin1_4	673	678	PF00397	0.389
DOC_WW_Pin1_4	779	784	PF00397	0.558
LIG_14-3-3_CanoR_1	2	11	PF00244	0.630
LIG_14-3-3_CanoR_1	346	352	PF00244	0.362
LIG_14-3-3_CanoR_1	396	404	PF00244	0.697
LIG_14-3-3_CanoR_1	436	444	PF00244	0.523
LIG_14-3-3_CanoR_1	455	463	PF00244	0.473
LIG_14-3-3_CanoR_1	476	485	PF00244	0.722
LIG_14-3-3_CanoR_1	49	53	PF00244	0.570
LIG_14-3-3_CanoR_1	624	633	PF00244	0.541
LIG_14-3-3_CanoR_1	648	654	PF00244	0.436
LIG_14-3-3_CanoR_1	692	700	PF00244	0.436
LIG_14-3-3_CanoR_1	792	797	PF00244	0.459
LIG_14-3-3_CanoR_1	80	86	PF00244	0.439
LIG_BRCT_BRCA1_1	262	266	PF00533	0.371
LIG_eIF4E_1	681	687	PF01652	0.411
LIG_FHA_1	206	212	PF00498	0.534
LIG_FHA_1	338	344	PF00498	0.575
LIG_FHA_1	371	377	PF00498	0.528
LIG_FHA_1	5	11	PF00498	0.634
LIG_FHA_1	568	574	PF00498	0.497
LIG_FHA_1	58	64	PF00498	0.440
LIG_FHA_1	581	587	PF00498	0.641
LIG_FHA_1	662	668	PF00498	0.411
LIG_FHA_1	699	705	PF00498	0.411
LIG_FHA_2	219	225	PF00498	0.578
LIG_FHA_2	287	293	PF00498	0.605
LIG_FHA_2	502	508	PF00498	0.779
LIG_FHA_2	793	799	PF00498	0.485
LIG_FHA_2	823	829	PF00498	0.564
LIG_GBD_Chelix_1	689	697	PF00786	0.513
LIG_LIR_Gen_1	146	155	PF02991	0.526
LIG_LIR_Gen_1	421	432	PF02991	0.618
LIG_LIR_Gen_1	756	765	PF02991	0.543
LIG_LIR_Gen_1	784	794	PF02991	0.525
LIG_LIR_Gen_1	831	840	PF02991	0.558
LIG_LIR_Nem_3	146	152	PF02991	0.514
LIG_LIR_Nem_3	421	427	PF02991	0.627
LIG_LIR_Nem_3	450	456	PF02991	0.547
LIG_LIR_Nem_3	756	760	PF02991	0.494
LIG_LIR_Nem_3	784	789	PF02991	0.628
LIG_LIR_Nem_3	831	837	PF02991	0.573
LIG_REV1ctd_RIR_1	451	459	PF16727	0.498
LIG_SH2_CRK	348	352	PF00017	0.529
LIG_SH2_CRK	683	687	PF00017	0.513
LIG_SH2_CRK	744	748	PF00017	0.558
LIG_SH2_CRK	757	761	PF00017	0.410
LIG_SH2_NCK_1	802	806	PF00017	0.531
LIG_SH2_SRC	244	247	PF00017	0.595
LIG_SH2_SRC	42	45	PF00017	0.586
LIG_SH2_SRC	612	615	PF00017	0.582
LIG_SH2_SRC	681	684	PF00017	0.513
LIG_SH2_SRC	750	753	PF00017	0.587
LIG_SH2_SRC	802	805	PF00017	0.527
LIG_SH2_SRC	99	102	PF00017	0.416
LIG_SH2_STAP1	244	248	PF00017	0.591
LIG_SH2_STAP1	348	352	PF00017	0.402
LIG_SH2_STAP1	424	428	PF00017	0.485
LIG_SH2_STAP1	612	616	PF00017	0.578
LIG_SH2_STAP1	750	754	PF00017	0.482
LIG_SH2_STAP1	802	806	PF00017	0.531
LIG_SH2_STAP1	830	834	PF00017	0.594
LIG_SH2_STAP1	99	103	PF00017	0.490
LIG_SH2_STAT3	643	646	PF00017	0.513
LIG_SH2_STAT5	204	207	PF00017	0.495
LIG_SH2_STAT5	216	219	PF00017	0.491
LIG_SH2_STAT5	42	45	PF00017	0.509
LIG_SH2_STAT5	424	427	PF00017	0.528
LIG_SH2_STAT5	644	647	PF00017	0.411
LIG_SH3_3	487	493	PF00018	0.805
LIG_SH3_3	762	768	PF00018	0.583
LIG_SH3_3	846	852	PF00018	0.726
LIG_SUMO_SIM_anti_2	235	240	PF11976	0.578
LIG_SUMO_SIM_anti_2	406	411	PF11976	0.467
LIG_SUMO_SIM_par_1	408	413	PF11976	0.445
LIG_TRAF2_1	143	146	PF00917	0.488
LIG_TRAF2_1	294	297	PF00917	0.645
LIG_TRAF2_1	840	843	PF00917	0.584
LIG_TRAF2_1	848	851	PF00917	0.631
LIG_TYR_ITIM	832	837	PF00017	0.572
MOD_CDK_SPxK_1	299	305	PF00069	0.754
MOD_CK1_1	331	337	PF00069	0.551
MOD_CK1_1	395	401	PF00069	0.679
MOD_CK1_1	484	490	PF00069	0.746
MOD_CK1_1	501	507	PF00069	0.805
MOD_CK1_1	515	521	PF00069	0.638
MOD_CK1_1	567	573	PF00069	0.572
MOD_CK1_1	815	821	PF00069	0.657
MOD_CK2_1	286	292	PF00069	0.556
MOD_CK2_1	456	462	PF00069	0.578
MOD_CK2_1	476	482	PF00069	0.402
MOD_CK2_1	501	507	PF00069	0.794
MOD_CK2_1	515	521	PF00069	0.684
MOD_CK2_1	624	630	PF00069	0.639
MOD_CK2_1	659	665	PF00069	0.397
MOD_CK2_1	792	798	PF00069	0.478
MOD_GlcNHglycan	107	110	PF01048	0.404
MOD_GlcNHglycan	326	329	PF01048	0.605
MOD_GlcNHglycan	385	388	PF01048	0.731
MOD_GlcNHglycan	60	63	PF01048	0.487
MOD_GlcNHglycan	656	659	PF01048	0.487
MOD_GlcNHglycan	783	786	PF01048	0.608
MOD_GlcNHglycan	816	820	PF01048	0.568
MOD_GSK3_1	101	108	PF00069	0.411
MOD_GSK3_1	164	171	PF00069	0.470
MOD_GSK3_1	286	293	PF00069	0.613
MOD_GSK3_1	299	306	PF00069	0.709
MOD_GSK3_1	324	331	PF00069	0.523
MOD_GSK3_1	333	340	PF00069	0.577
MOD_GSK3_1	47	54	PF00069	0.448
MOD_GSK3_1	496	503	PF00069	0.796
MOD_GSK3_1	512	519	PF00069	0.763
MOD_GSK3_1	526	533	PF00069	0.711
MOD_GSK3_1	581	588	PF00069	0.642
MOD_GSK3_1	620	627	PF00069	0.530
MOD_GSK3_1	669	676	PF00069	0.389
MOD_GSK3_1	775	782	PF00069	0.691
MOD_N-GLC_1	501	506	PF02516	0.768
MOD_N-GLC_1	515	520	PF02516	0.606
MOD_N-GLC_2	91	93	PF02516	0.474
MOD_NEK2_1	1	6	PF00069	0.629
MOD_NEK2_1	205	210	PF00069	0.567
MOD_NEK2_1	232	237	PF00069	0.483
MOD_NEK2_1	285	290	PF00069	0.636
MOD_NEK2_1	314	319	PF00069	0.516
MOD_NEK2_1	347	352	PF00069	0.354
MOD_NEK2_1	370	375	PF00069	0.574
MOD_NEK2_1	377	382	PF00069	0.633
MOD_NEK2_1	410	415	PF00069	0.555
MOD_NEK2_1	48	53	PF00069	0.464
MOD_NEK2_1	564	569	PF00069	0.533
MOD_NEK2_1	820	825	PF00069	0.580
MOD_PIKK_1	437	443	PF00454	0.580
MOD_PIKK_1	496	502	PF00454	0.773
MOD_PIKK_1	573	579	PF00454	0.583
MOD_PK_1	341	347	PF00069	0.544
MOD_PKA_2	1	7	PF00069	0.645
MOD_PKA_2	218	224	PF00069	0.508
MOD_PKA_2	377	383	PF00069	0.668
MOD_PKA_2	392	398	PF00069	0.537
MOD_PKA_2	437	443	PF00069	0.603
MOD_PKA_2	48	54	PF00069	0.570
MOD_PKA_2	530	536	PF00069	0.737
MOD_PKA_2	691	697	PF00069	0.436
MOD_Plk_1	260	266	PF00069	0.394
MOD_Plk_1	341	347	PF00069	0.544
MOD_Plk_1	64	70	PF00069	0.484
MOD_Plk_1	830	836	PF00069	0.521
MOD_Plk_1	842	848	PF00069	0.602
MOD_Plk_2-3	224	230	PF00069	0.412
MOD_Plk_4	191	197	PF00069	0.483
MOD_Plk_4	206	212	PF00069	0.529
MOD_Plk_4	286	292	PF00069	0.525
MOD_Plk_4	347	353	PF00069	0.355
MOD_Plk_4	38	44	PF00069	0.475
MOD_Plk_4	81	87	PF00069	0.462
MOD_Plk_4	830	836	PF00069	0.467
MOD_ProDKin_1	299	305	PF00069	0.754
MOD_ProDKin_1	489	495	PF00069	0.725
MOD_ProDKin_1	501	507	PF00069	0.553
MOD_ProDKin_1	673	679	PF00069	0.389
MOD_ProDKin_1	779	785	PF00069	0.546
MOD_SUMO_for_1	523	526	PF00179	0.788
MOD_SUMO_rev_2	167	177	PF00179	0.485
MOD_SUMO_rev_2	507	514	PF00179	0.684
TRG_DiLeu_BaEn_1	206	211	PF01217	0.528
TRG_DiLeu_BaEn_4	720	726	PF01217	0.696
TRG_ENDOCYTIC_2	348	351	PF00928	0.530
TRG_ENDOCYTIC_2	424	427	PF00928	0.524
TRG_ENDOCYTIC_2	683	686	PF00928	0.513
TRG_ENDOCYTIC_2	744	747	PF00928	0.486
TRG_ENDOCYTIC_2	757	760	PF00928	0.495
TRG_ENDOCYTIC_2	834	837	PF00928	0.582
TRG_ER_diArg_1	169	172	PF00400	0.520
TRG_ER_diArg_1	239	241	PF00400	0.534
TRG_ER_diArg_1	556	558	PF00400	0.489
TRG_ER_diArg_1	79	81	PF00400	0.469
TRG_NES_CRM1_1	408	421	PF08389	0.526
TRG_NLS_MonoExtC_3	240	246	PF00514	0.539
TRG_NLS_MonoExtN_4	172	179	PF00514	0.498
TRG_NLS_MonoExtN_4	240	245	PF00514	0.539
TRG_Pf-PMV_PEXEL_1	542	547	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P507	Leptomonas seymouri	50%	100%
A4HEP3	Leishmania braziliensis	74%	100%
A4I1X3	Leishmania infantum	100%	100%
E9AY19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q9F4	Leishmania major	93%	100%