Hypothetical_protein_conserved

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic translation initiation factor 3 subunit F

Species:

Leishmania donovani

UniProt:

A0A3Q8IDI4_LEIDO

TriTrypDb:

LdBPK_251670.1 , LdCL_250022400 , LDHU3_25.2110

Length:

326

Annotations

Annotations by Jardim et al.

Translation, Eukaryotic translation initiation factor 3 subunit F

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005852	eukaryotic translation initiation factor 3 complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IDI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDI4

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	3
GO:0006796	phosphate-containing compound metabolic process	4	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0016310	phosphorylation	5	3
GO:0044237	cellular metabolic process	2	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008233	peptidase activity	3	2
GO:0008237	metallopeptidase activity	4	2
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0016787	hydrolase activity	2	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.618
CLV_NRD_NRD_1	214	216	PF00675	0.687
CLV_NRD_NRD_1	22	24	PF00675	0.490
CLV_NRD_NRD_1	286	288	PF00675	0.501
CLV_NRD_NRD_1	305	307	PF00675	0.610
CLV_NRD_NRD_1	68	70	PF00675	0.581
CLV_NRD_NRD_1	73	75	PF00675	0.608
CLV_PCSK_KEX2_1	214	216	PF00082	0.692
CLV_PCSK_KEX2_1	22	24	PF00082	0.465
CLV_PCSK_KEX2_1	256	258	PF00082	0.694
CLV_PCSK_KEX2_1	286	288	PF00082	0.518
CLV_PCSK_KEX2_1	305	307	PF00082	0.453
CLV_PCSK_KEX2_1	67	69	PF00082	0.561
CLV_PCSK_KEX2_1	72	74	PF00082	0.536
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.465
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.694
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.547
CLV_PCSK_PC7_1	68	74	PF00082	0.545
CLV_PCSK_SKI1_1	145	149	PF00082	0.633
CLV_PCSK_SKI1_1	273	277	PF00082	0.497
CLV_PCSK_SKI1_1	69	73	PF00082	0.579
DEG_APCC_DBOX_1	152	160	PF00400	0.623
DEG_APCC_DBOX_1	184	192	PF00400	0.676
DEG_ODPH_VHL_1	156	168	PF01847	0.599
DOC_CKS1_1	8	13	PF01111	0.503
DOC_PP1_RVXF_1	128	134	PF00149	0.578
DOC_PP4_FxxP_1	139	142	PF00568	0.609
DOC_USP7_MATH_1	228	232	PF00917	0.740
DOC_WW_Pin1_4	125	130	PF00397	0.680
DOC_WW_Pin1_4	7	12	PF00397	0.509
LIG_14-3-3_CanoR_1	153	157	PF00244	0.607
LIG_14-3-3_CanoR_1	73	83	PF00244	0.557
LIG_APCC_ABBA_1	115	120	PF00400	0.516
LIG_BIR_II_1	1	5	PF00653	0.577
LIG_BRCT_BRCA1_1	105	109	PF00533	0.507
LIG_BRCT_BRCA1_1	135	139	PF00533	0.556
LIG_BRCT_BRCA1_1	268	272	PF00533	0.633
LIG_eIF4E_1	75	81	PF01652	0.586
LIG_FHA_1	126	132	PF00498	0.599
LIG_FHA_1	170	176	PF00498	0.599
LIG_FHA_1	204	210	PF00498	0.636
LIG_FHA_1	41	47	PF00498	0.404
LIG_FHA_1	75	81	PF00498	0.493
LIG_FHA_2	240	246	PF00498	0.663
LIG_FHA_2	308	314	PF00498	0.780
LIG_FHA_2	47	53	PF00498	0.535
LIG_FHA_2	74	80	PF00498	0.565
LIG_FHA_2	92	98	PF00498	0.572
LIG_LIR_Apic_2	136	142	PF02991	0.586
LIG_LIR_Nem_3	245	250	PF02991	0.555
LIG_OCRL_FandH_1	108	120	PF00620	0.568
LIG_SH2_STAT3	75	78	PF00017	0.604
LIG_SH2_STAT5	196	199	PF00017	0.632
LIG_SH2_STAT5	30	33	PF00017	0.370
LIG_SH2_STAT5	75	78	PF00017	0.499
LIG_TRAF2_1	222	225	PF00917	0.704
MOD_CDK_SPK_2	125	130	PF00069	0.630
MOD_CK1_1	169	175	PF00069	0.605
MOD_CK2_1	239	245	PF00069	0.665
MOD_CK2_1	307	313	PF00069	0.770
MOD_GlcNHglycan	230	233	PF01048	0.613
MOD_GlcNHglycan	84	87	PF01048	0.520
MOD_GSK3_1	166	173	PF00069	0.555
MOD_GSK3_1	46	53	PF00069	0.490
MOD_N-GLC_1	307	312	PF02516	0.714
MOD_NEK2_2	143	148	PF00069	0.644
MOD_PIKK_1	266	272	PF00454	0.630
MOD_PIKK_1	74	80	PF00454	0.602
MOD_PKA_1	73	79	PF00069	0.584
MOD_PKA_2	152	158	PF00069	0.625
MOD_PKA_2	73	79	PF00069	0.520
MOD_PKB_1	257	265	PF00069	0.693
MOD_Plk_1	143	149	PF00069	0.598
MOD_Plk_4	103	109	PF00069	0.494
MOD_Plk_4	133	139	PF00069	0.505
MOD_Plk_4	170	176	PF00069	0.574
MOD_Plk_4	280	286	PF00069	0.569
MOD_Plk_4	294	300	PF00069	0.603
MOD_ProDKin_1	125	131	PF00069	0.670
MOD_ProDKin_1	7	13	PF00069	0.507
MOD_SUMO_rev_2	199	205	PF00179	0.646
TRG_DiLeu_BaEn_4	211	217	PF01217	0.686
TRG_DiLeu_BaEn_4	95	101	PF01217	0.520
TRG_ER_diArg_1	214	216	PF00400	0.707
TRG_ER_diArg_1	285	287	PF00400	0.525
TRG_ER_diArg_1	67	69	PF00400	0.541
TRG_ER_diArg_1	73	75	PF00400	0.582
TRG_NLS_MonoCore_2	21	26	PF00514	0.485
TRG_NLS_MonoExtN_4	22	27	PF00514	0.553
TRG_NLS_MonoExtN_4	69	76	PF00514	0.582
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.624
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8X4	Leptomonas seymouri	73%	99%
A0A1X0NYA8	Trypanosomatidae	34%	94%
A0A3R7MHX6	Trypanosoma rangeli	33%	99%
A4I1K7	Leishmania infantum	100%	100%
C9ZK49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	96%
E9AXP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q9T0	Leishmania major	99%	100%
V5DIT1	Trypanosoma cruzi	30%	94%