Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDI0_LEIDO

TriTrypDb:

LdBPK_290420.1 , LdCL_290009000 , LDHU3_29.0570

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IDI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDI0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.788
CLV_NRD_NRD_1	441	443	PF00675	0.761
CLV_NRD_NRD_1	534	536	PF00675	0.734
CLV_PCSK_FUR_1	439	443	PF00082	0.723
CLV_PCSK_KEX2_1	392	394	PF00082	0.660
CLV_PCSK_KEX2_1	441	443	PF00082	0.761
CLV_PCSK_KEX2_1	534	536	PF00082	0.738
CLV_PCSK_KEX2_1	573	575	PF00082	0.697
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.761
CLV_PCSK_PC1ET2_1	573	575	PF00082	0.697
CLV_PCSK_SKI1_1	393	397	PF00082	0.603
CLV_PCSK_SKI1_1	447	451	PF00082	0.807
CLV_PCSK_SKI1_1	482	486	PF00082	0.793
CLV_Separin_Metazoa	507	511	PF03568	0.845
DEG_APCC_DBOX_1	450	458	PF00400	0.731
DEG_APCC_DBOX_1	563	571	PF00400	0.795
DEG_Nend_Nbox_1	1	3	PF02207	0.605
DEG_SCF_FBW7_1	74	80	PF00400	0.634
DEG_SCF_FBW7_2	402	408	PF00400	0.682
DOC_CKS1_1	340	345	PF01111	0.619
DOC_CKS1_1	402	407	PF01111	0.680
DOC_CKS1_1	489	494	PF01111	0.735
DOC_CKS1_1	74	79	PF01111	0.739
DOC_CYCLIN_yCln2_LP_2	200	206	PF00134	0.788
DOC_MAPK_RevD_3	558	574	PF00069	0.733
DOC_PP2B_LxvP_1	200	203	PF13499	0.796
DOC_PP2B_LxvP_1	450	453	PF13499	0.735
DOC_PP2B_LxvP_1	54	57	PF13499	0.776
DOC_USP7_MATH_1	11	15	PF00917	0.716
DOC_USP7_MATH_1	124	128	PF00917	0.825
DOC_USP7_MATH_1	272	276	PF00917	0.747
DOC_USP7_MATH_1	359	363	PF00917	0.620
DOC_USP7_MATH_1	430	434	PF00917	0.719
DOC_USP7_MATH_1	543	547	PF00917	0.797
DOC_USP7_MATH_1	75	79	PF00917	0.792
DOC_USP7_UBL2_3	157	161	PF12436	0.743
DOC_WW_Pin1_4	130	135	PF00397	0.830
DOC_WW_Pin1_4	183	188	PF00397	0.744
DOC_WW_Pin1_4	223	228	PF00397	0.727
DOC_WW_Pin1_4	265	270	PF00397	0.790
DOC_WW_Pin1_4	314	319	PF00397	0.737
DOC_WW_Pin1_4	329	334	PF00397	0.762
DOC_WW_Pin1_4	336	341	PF00397	0.683
DOC_WW_Pin1_4	377	382	PF00397	0.835
DOC_WW_Pin1_4	39	44	PF00397	0.786
DOC_WW_Pin1_4	401	406	PF00397	0.688
DOC_WW_Pin1_4	409	414	PF00397	0.702
DOC_WW_Pin1_4	488	493	PF00397	0.739
DOC_WW_Pin1_4	520	525	PF00397	0.771
DOC_WW_Pin1_4	73	78	PF00397	0.744
LIG_14-3-3_CanoR_1	360	368	PF00244	0.782
LIG_14-3-3_CanoR_1	375	382	PF00244	0.760
LIG_14-3-3_CanoR_1	385	394	PF00244	0.750
LIG_14-3-3_CanoR_1	441	450	PF00244	0.805
LIG_14-3-3_CanoR_1	475	479	PF00244	0.756
LIG_14-3-3_CanoR_1	534	540	PF00244	0.740
LIG_BRCT_BRCA1_1	215	219	PF00533	0.591
LIG_DCNL_PONY_1	1	4	PF03556	0.704
LIG_deltaCOP1_diTrp_1	212	219	PF00928	0.733
LIG_FHA_1	179	185	PF00498	0.789
LIG_FHA_1	293	299	PF00498	0.715
LIG_FHA_1	329	335	PF00498	0.730
LIG_FHA_1	362	368	PF00498	0.680
LIG_FHA_1	402	408	PF00498	0.739
LIG_FHA_1	547	553	PF00498	0.754
LIG_FHA_1	74	80	PF00498	0.852
LIG_FHA_2	311	317	PF00498	0.786
LIG_FHA_2	502	508	PF00498	0.753
LIG_FHA_2	63	69	PF00498	0.745
LIG_LIR_Apic_2	465	470	PF02991	0.601
LIG_LIR_Gen_1	396	407	PF02991	0.563
LIG_LIR_Nem_3	129	135	PF02991	0.790
LIG_LIR_Nem_3	396	402	PF02991	0.553
LIG_MLH1_MIPbox_1	215	219	PF16413	0.591
LIG_MYND_1	568	572	PF01753	0.694
LIG_NRBOX	110	116	PF00104	0.717
LIG_NRBOX	88	94	PF00104	0.608
LIG_Pex14_2	390	394	PF04695	0.642
LIG_RPA_C_Fungi	355	367	PF08784	0.780
LIG_SH2_CRK	467	471	PF00017	0.600
LIG_SH2_NCK_1	399	403	PF00017	0.584
LIG_SH2_STAT5	218	221	PF00017	0.747
LIG_SH3_1	337	343	PF00018	0.661
LIG_SH3_1	513	519	PF00018	0.670
LIG_SH3_2	508	513	PF14604	0.681
LIG_SH3_3	181	187	PF00018	0.698
LIG_SH3_3	191	197	PF00018	0.644
LIG_SH3_3	202	208	PF00018	0.594
LIG_SH3_3	266	272	PF00018	0.817
LIG_SH3_3	293	299	PF00018	0.818
LIG_SH3_3	330	336	PF00018	0.809
LIG_SH3_3	337	343	PF00018	0.734
LIG_SH3_3	399	405	PF00018	0.670
LIG_SH3_3	505	511	PF00018	0.774
LIG_SH3_3	513	519	PF00018	0.696
LIG_SH3_3	566	572	PF00018	0.767
LIG_SH3_3	71	77	PF00018	0.719
LIG_SH3_4	157	164	PF00018	0.753
LIG_Sin3_3	148	155	PF02671	0.714
LIG_SUMO_SIM_anti_2	474	480	PF11976	0.604
LIG_SUMO_SIM_anti_2	556	562	PF11976	0.781
LIG_SUMO_SIM_par_1	294	300	PF11976	0.712
LIG_TRAF2_1	28	31	PF00917	0.636
LIG_TRAF2_1	471	474	PF00917	0.740
MOD_CDC14_SPxK_1	133	136	PF00782	0.830
MOD_CDK_SPxK_1	130	136	PF00069	0.831
MOD_CDK_SPxK_1	329	335	PF00069	0.733
MOD_CDK_SPxK_1	78	84	PF00069	0.711
MOD_CK1_1	240	246	PF00069	0.821
MOD_CK1_1	258	264	PF00069	0.717
MOD_CK1_1	300	306	PF00069	0.636
MOD_CK1_1	445	451	PF00069	0.806
MOD_CK1_1	546	552	PF00069	0.773
MOD_CK1_1	78	84	PF00069	0.712
MOD_CK2_1	300	306	PF00069	0.716
MOD_CK2_1	310	316	PF00069	0.746
MOD_CK2_1	501	507	PF00069	0.694
MOD_CK2_1	62	68	PF00069	0.744
MOD_Cter_Amidation	439	442	PF01082	0.767
MOD_DYRK1A_RPxSP_1	265	269	PF00069	0.789
MOD_GlcNHglycan	191	194	PF01048	0.809
MOD_GlcNHglycan	239	242	PF01048	0.683
MOD_GlcNHglycan	272	275	PF01048	0.781
MOD_GlcNHglycan	361	364	PF01048	0.668
MOD_GlcNHglycan	432	435	PF01048	0.714
MOD_GlcNHglycan	528	531	PF01048	0.768
MOD_GlcNHglycan	541	544	PF01048	0.680
MOD_GlcNHglycan	546	549	PF01048	0.619
MOD_GSK3_1	179	186	PF00069	0.758
MOD_GSK3_1	30	37	PF00069	0.769
MOD_GSK3_1	310	317	PF00069	0.720
MOD_GSK3_1	371	378	PF00069	0.725
MOD_GSK3_1	381	388	PF00069	0.725
MOD_GSK3_1	39	46	PF00069	0.696
MOD_GSK3_1	441	448	PF00069	0.697
MOD_GSK3_1	535	542	PF00069	0.814
MOD_GSK3_1	73	80	PF00069	0.751
MOD_N-GLC_1	130	135	PF02516	0.704
MOD_N-GLC_1	258	263	PF02516	0.623
MOD_NEK2_1	178	183	PF00069	0.659
MOD_NEK2_1	328	333	PF00069	0.737
MOD_NEK2_1	457	462	PF00069	0.720
MOD_PIKK_1	43	49	PF00454	0.812
MOD_PKA_1	441	447	PF00069	0.753
MOD_PKA_1	534	540	PF00069	0.735
MOD_PKA_2	359	365	PF00069	0.776
MOD_PKA_2	441	447	PF00069	0.753
MOD_PKA_2	474	480	PF00069	0.734
MOD_PKA_2	534	540	PF00069	0.738
MOD_PKB_1	439	447	PF00069	0.715
MOD_Plk_1	124	130	PF00069	0.656
MOD_Plk_1	445	451	PF00069	0.722
MOD_Plk_1	84	90	PF00069	0.625
MOD_Plk_4	214	220	PF00069	0.738
MOD_Plk_4	292	298	PF00069	0.760
MOD_Plk_4	474	480	PF00069	0.707
MOD_ProDKin_1	130	136	PF00069	0.831
MOD_ProDKin_1	183	189	PF00069	0.745
MOD_ProDKin_1	223	229	PF00069	0.728
MOD_ProDKin_1	265	271	PF00069	0.787
MOD_ProDKin_1	314	320	PF00069	0.739
MOD_ProDKin_1	329	335	PF00069	0.760
MOD_ProDKin_1	336	342	PF00069	0.684
MOD_ProDKin_1	377	383	PF00069	0.833
MOD_ProDKin_1	39	45	PF00069	0.783
MOD_ProDKin_1	401	407	PF00069	0.689
MOD_ProDKin_1	409	415	PF00069	0.701
MOD_ProDKin_1	488	494	PF00069	0.737
MOD_ProDKin_1	520	526	PF00069	0.771
MOD_ProDKin_1	73	79	PF00069	0.741
MOD_SUMO_rev_2	277	287	PF00179	0.711
MOD_SUMO_rev_2	322	331	PF00179	0.798
TRG_DiLeu_BaEn_1	474	479	PF01217	0.707
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.683
TRG_ENDOCYTIC_2	399	402	PF00928	0.585
TRG_ER_diArg_1	334	337	PF00400	0.771
TRG_ER_diArg_1	439	442	PF00400	0.726
TRG_ER_diArg_1	533	535	PF00400	0.735
TRG_ER_diArg_1	563	566	PF00400	0.679
TRG_NLS_MonoCore_2	572	577	PF00514	0.758
TRG_NLS_MonoExtN_4	572	577	PF00514	0.758

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFI2	Leptomonas seymouri	30%	100%
A4HH42	Leishmania braziliensis	58%	99%
A4I495	Leishmania infantum	100%	100%
E9ADP2	Leishmania major	88%	100%
E9AM38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%