Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDH2_LEIDO

TriTrypDb:

LdBPK_151380.1 , LdCL_150019100 , LDHU3_15.1700

Length:

303

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IDH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDH2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.696
CLV_NRD_NRD_1	65	67	PF00675	0.585
CLV_PCSK_KEX2_1	171	173	PF00082	0.695
CLV_PCSK_KEX2_1	65	67	PF00082	0.564
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.663
CLV_PCSK_SKI1_1	57	61	PF00082	0.595
CLV_PCSK_SKI1_1	65	69	PF00082	0.549
DEG_SPOP_SBC_1	184	188	PF00917	0.712
DOC_CKS1_1	14	19	PF01111	0.672
DOC_CYCLIN_RxL_1	62	72	PF00134	0.577
DOC_PP2B_LxvP_1	228	231	PF13499	0.491
DOC_USP7_MATH_1	129	133	PF00917	0.625
DOC_USP7_MATH_1	164	168	PF00917	0.639
DOC_USP7_MATH_1	176	180	PF00917	0.722
DOC_USP7_MATH_1	231	235	PF00917	0.534
DOC_USP7_MATH_1	28	32	PF00917	0.502
DOC_USP7_MATH_1	70	74	PF00917	0.569
DOC_WW_Pin1_4	10	15	PF00397	0.493
DOC_WW_Pin1_4	118	123	PF00397	0.748
DOC_WW_Pin1_4	187	192	PF00397	0.762
DOC_WW_Pin1_4	2	7	PF00397	0.755
DOC_WW_Pin1_4	73	78	PF00397	0.500
LIG_14-3-3_CanoR_1	166	170	PF00244	0.587
LIG_14-3-3_CanoR_1	199	207	PF00244	0.533
LIG_BRCT_BRCA1_1	287	291	PF00533	0.588
LIG_FHA_1	14	20	PF00498	0.754
LIG_FHA_1	202	208	PF00498	0.684
LIG_FHA_1	62	68	PF00498	0.598
LIG_FHA_2	105	111	PF00498	0.761
LIG_Integrin_RGD_1	279	281	PF01839	0.692
LIG_MYND_1	118	122	PF01753	0.692
LIG_RPA_C_Fungi	208	220	PF08784	0.548
LIG_RPA_C_Fungi	48	60	PF08784	0.537
LIG_SH2_STAP1	287	291	PF00017	0.610
LIG_SH3_1	11	17	PF00018	0.610
LIG_SH3_3	11	17	PF00018	0.634
LIG_SH3_3	148	154	PF00018	0.616
LIG_SH3_3	189	195	PF00018	0.712
LIG_SH3_3	22	28	PF00018	0.627
LIG_SUMO_SIM_par_1	204	210	PF11976	0.542
LIG_TRAF2_1	212	215	PF00917	0.602
LIG_TRAF2_1	267	270	PF00917	0.738
LIG_WW_2	17	20	PF00397	0.678
LIG_WW_3	196	200	PF00397	0.703
MOD_CDK_SPxxK_3	2	9	PF00069	0.698
MOD_CK1_1	116	122	PF00069	0.707
MOD_CK1_1	13	19	PF00069	0.615
MOD_CK1_1	165	171	PF00069	0.659
MOD_CK1_1	179	185	PF00069	0.754
MOD_CK1_1	186	192	PF00069	0.705
MOD_CK1_1	236	242	PF00069	0.614
MOD_CK1_1	285	291	PF00069	0.658
MOD_CK1_1	295	301	PF00069	0.563
MOD_CK1_1	73	79	PF00069	0.574
MOD_CK2_1	139	145	PF00069	0.561
MOD_CK2_1	209	215	PF00069	0.605
MOD_CK2_1	223	229	PF00069	0.402
MOD_CK2_1	263	269	PF00069	0.601
MOD_GlcNHglycan	115	118	PF01048	0.742
MOD_GlcNHglycan	130	134	PF01048	0.595
MOD_GlcNHglycan	141	144	PF01048	0.495
MOD_GlcNHglycan	177	181	PF01048	0.662
MOD_GlcNHglycan	2	5	PF01048	0.822
MOD_GlcNHglycan	209	212	PF01048	0.625
MOD_GlcNHglycan	225	228	PF01048	0.616
MOD_GlcNHglycan	235	238	PF01048	0.650
MOD_GlcNHglycan	263	268	PF01048	0.698
MOD_GlcNHglycan	298	301	PF01048	0.719
MOD_GSK3_1	112	119	PF00069	0.751
MOD_GSK3_1	154	161	PF00069	0.730
MOD_GSK3_1	179	186	PF00069	0.764
MOD_GSK3_1	197	204	PF00069	0.476
MOD_GSK3_1	281	288	PF00069	0.622
MOD_GSK3_1	292	299	PF00069	0.704
MOD_N-GLC_1	70	75	PF02516	0.515
MOD_NEK2_1	207	212	PF00069	0.556
MOD_NEK2_1	233	238	PF00069	0.654
MOD_NEK2_1	61	66	PF00069	0.513
MOD_PKA_2	165	171	PF00069	0.744
MOD_PKA_2	198	204	PF00069	0.552
MOD_PKA_2	61	67	PF00069	0.549
MOD_Plk_1	70	76	PF00069	0.591
MOD_Plk_1	87	93	PF00069	0.518
MOD_ProDKin_1	10	16	PF00069	0.492
MOD_ProDKin_1	118	124	PF00069	0.749
MOD_ProDKin_1	187	193	PF00069	0.762
MOD_ProDKin_1	2	8	PF00069	0.756
MOD_ProDKin_1	73	79	PF00069	0.492
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.601
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.376
TRG_ER_diArg_1	50	53	PF00400	0.494
TRG_ER_diArg_1	65	67	PF00400	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEC2	Leptomonas seymouri	40%	88%
A4H899	Leishmania braziliensis	62%	100%
A4HWM1	Leishmania infantum	100%	100%
E9AQC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QF47	Leishmania major	89%	100%