Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDG9_LEIDO

TriTrypDb:

LdBPK_251250.1 , LdCL_250018300 , LDHU3_25.1590

Length:

611

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005846	nuclear cap binding complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0034518	RNA cap binding complex	2	12
GO:0140535	intracellular protein-containing complex	2	12
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IDG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDG9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	306	310	PF00656	0.262
CLV_C14_Caspase3-7	373	377	PF00656	0.398
CLV_C14_Caspase3-7	474	478	PF00656	0.492
CLV_C14_Caspase3-7	508	512	PF00656	0.479
CLV_NRD_NRD_1	124	126	PF00675	0.492
CLV_NRD_NRD_1	175	177	PF00675	0.375
CLV_NRD_NRD_1	274	276	PF00675	0.262
CLV_NRD_NRD_1	311	313	PF00675	0.427
CLV_NRD_NRD_1	370	372	PF00675	0.397
CLV_NRD_NRD_1	428	430	PF00675	0.389
CLV_NRD_NRD_1	44	46	PF00675	0.402
CLV_NRD_NRD_1	90	92	PF00675	0.447
CLV_PCSK_FUR_1	42	46	PF00082	0.413
CLV_PCSK_KEX2_1	177	179	PF00082	0.346
CLV_PCSK_KEX2_1	274	276	PF00082	0.383
CLV_PCSK_KEX2_1	311	313	PF00082	0.428
CLV_PCSK_KEX2_1	369	371	PF00082	0.394
CLV_PCSK_KEX2_1	428	430	PF00082	0.407
CLV_PCSK_KEX2_1	44	46	PF00082	0.420
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.336
CLV_PCSK_PC7_1	173	179	PF00082	0.449
CLV_PCSK_PC7_1	365	371	PF00082	0.449
CLV_PCSK_SKI1_1	114	118	PF00082	0.491
CLV_PCSK_SKI1_1	199	203	PF00082	0.363
CLV_PCSK_SKI1_1	209	213	PF00082	0.363
CLV_PCSK_SKI1_1	311	315	PF00082	0.449
CLV_PCSK_SKI1_1	352	356	PF00082	0.449
CLV_PCSK_SKI1_1	365	369	PF00082	0.413
CLV_PCSK_SKI1_1	44	48	PF00082	0.328
CLV_PCSK_SKI1_1	441	445	PF00082	0.357
CLV_PCSK_SKI1_1	600	604	PF00082	0.403
DEG_APCC_DBOX_1	351	359	PF00400	0.398
DEG_APCC_DBOX_1	599	607	PF00400	0.385
DEG_Nend_UBRbox_1	1	4	PF02207	0.449
DEG_SCF_TRCP1_1	376	382	PF00400	0.262
DEG_SPOP_SBC_1	390	394	PF00917	0.437
DOC_CKS1_1	527	532	PF01111	0.475
DOC_CYCLIN_RxL_1	196	206	PF00134	0.448
DOC_CYCLIN_RxL_1	39	51	PF00134	0.346
DOC_MAPK_gen_1	39	48	PF00069	0.449
DOC_MAPK_gen_1	91	98	PF00069	0.475
DOC_MAPK_MEF2A_6	398	406	PF00069	0.423
DOC_MAPK_MEF2A_6	91	100	PF00069	0.368
DOC_PP2B_LxvP_1	410	413	PF13499	0.344
DOC_PP2B_LxvP_1	563	566	PF13499	0.449
DOC_USP7_MATH_1	283	287	PF00917	0.410
DOC_USP7_MATH_1	31	35	PF00917	0.459
DOC_USP7_MATH_1	374	378	PF00917	0.484
DOC_USP7_MATH_1	388	392	PF00917	0.387
DOC_USP7_MATH_1	450	454	PF00917	0.398
DOC_WW_Pin1_4	210	215	PF00397	0.475
DOC_WW_Pin1_4	324	329	PF00397	0.328
DOC_WW_Pin1_4	384	389	PF00397	0.443
DOC_WW_Pin1_4	391	396	PF00397	0.481
DOC_WW_Pin1_4	526	531	PF00397	0.374
DOC_WW_Pin1_4	545	550	PF00397	0.484
DOC_WW_Pin1_4	82	87	PF00397	0.367
LIG_14-3-3_CanoR_1	292	296	PF00244	0.405
LIG_14-3-3_CanoR_1	347	355	PF00244	0.449
LIG_14-3-3_CanoR_1	441	449	PF00244	0.353
LIG_14-3-3_CanoR_1	493	502	PF00244	0.415
LIG_APCC_ABBA_1	56	61	PF00400	0.377
LIG_BRCT_BRCA1_1	285	289	PF00533	0.428
LIG_CtBP_PxDLS_1	134	140	PF00389	0.344
LIG_eIF4E_1	437	443	PF01652	0.449
LIG_FHA_1	130	136	PF00498	0.427
LIG_FHA_1	333	339	PF00498	0.449
LIG_FHA_1	380	386	PF00498	0.262
LIG_FHA_1	401	407	PF00498	0.404
LIG_FHA_1	418	424	PF00498	0.209
LIG_FHA_1	460	466	PF00498	0.262
LIG_FHA_1	527	533	PF00498	0.475
LIG_FHA_2	325	331	PF00498	0.328
LIG_FHA_2	506	512	PF00498	0.371
LIG_Integrin_RGD_1	568	570	PF01839	0.398
LIG_LIR_Gen_1	259	267	PF02991	0.475
LIG_LIR_Gen_1	3	12	PF02991	0.331
LIG_LIR_Gen_1	37	48	PF02991	0.328
LIG_LIR_Gen_1	558	567	PF02991	0.357
LIG_LIR_Nem_3	110	116	PF02991	0.449
LIG_LIR_Nem_3	155	161	PF02991	0.475
LIG_LIR_Nem_3	221	227	PF02991	0.415
LIG_LIR_Nem_3	259	263	PF02991	0.475
LIG_LIR_Nem_3	3	7	PF02991	0.331
LIG_LIR_Nem_3	37	43	PF02991	0.328
LIG_LIR_Nem_3	558	563	PF02991	0.375
LIG_LYPXL_yS_3	93	96	PF13949	0.413
LIG_MYND_3	248	252	PF01753	0.300
LIG_NRBOX	42	48	PF00104	0.344
LIG_PCNA_PIPBox_1	194	203	PF02747	0.398
LIG_PCNA_yPIPBox_3	189	202	PF02747	0.427
LIG_PDZ_Class_3	606	611	PF00595	0.398
LIG_RPA_C_Fungi	269	281	PF08784	0.262
LIG_SH2_CRK	260	264	PF00017	0.475
LIG_SH2_CRK	437	441	PF00017	0.449
LIG_SH2_CRK	560	564	PF00017	0.417
LIG_SH2_PTP2	224	227	PF00017	0.385
LIG_SH2_PTP2	594	597	PF00017	0.363
LIG_SH2_SRC	224	227	PF00017	0.405
LIG_SH2_STAP1	334	338	PF00017	0.475
LIG_SH2_STAP1	560	564	PF00017	0.407
LIG_SH2_STAP1	65	69	PF00017	0.328
LIG_SH2_STAT5	224	227	PF00017	0.385
LIG_SH2_STAT5	334	337	PF00017	0.449
LIG_SH2_STAT5	411	414	PF00017	0.432
LIG_SH2_STAT5	422	425	PF00017	0.380
LIG_SH2_STAT5	594	597	PF00017	0.355
LIG_SH3_1	103	109	PF00018	0.449
LIG_SH3_2	86	91	PF14604	0.475
LIG_SH3_3	103	109	PF00018	0.367
LIG_SH3_3	524	530	PF00018	0.371
LIG_SH3_3	535	541	PF00018	0.458
LIG_SH3_3	590	596	PF00018	0.433
LIG_SH3_3	83	89	PF00018	0.413
LIG_Sin3_3	452	459	PF02671	0.475
LIG_SUMO_SIM_anti_2	230	236	PF11976	0.335
LIG_SUMO_SIM_anti_2	51	58	PF11976	0.385
LIG_SUMO_SIM_par_1	540	546	PF11976	0.403
LIG_TRAF2_1	228	231	PF00917	0.449
LIG_TRAF2_1	479	482	PF00917	0.475
LIG_TRAF2_1	553	556	PF00917	0.354
LIG_TRFH_1	13	17	PF08558	0.344
LIG_TYR_ITIM	38	43	PF00017	0.449
LIG_UBA3_1	14	23	PF00899	0.449
LIG_UBA3_1	55	63	PF00899	0.449
LIG_WRC_WIRS_1	1	6	PF05994	0.385
LIG_WRPW_2	113	116	PF00400	0.398
MOD_CDK_SPxxK_3	324	331	PF00069	0.328
MOD_CDK_SPxxK_3	391	398	PF00069	0.391
MOD_CDK_SPxxK_3	545	552	PF00069	0.475
MOD_CK1_1	244	250	PF00069	0.435
MOD_CK1_1	304	310	PF00069	0.475
MOD_CK1_1	391	397	PF00069	0.399
MOD_CK1_1	494	500	PF00069	0.427
MOD_CK1_1	558	564	PF00069	0.449
MOD_CK1_1	575	581	PF00069	0.465
MOD_CK2_1	200	206	PF00069	0.427
MOD_CK2_1	225	231	PF00069	0.363
MOD_CK2_1	324	330	PF00069	0.328
MOD_CK2_1	598	604	PF00069	0.398
MOD_CK2_1	69	75	PF00069	0.344
MOD_Cter_Amidation	309	312	PF01082	0.475
MOD_Cter_Amidation	426	429	PF01082	0.449
MOD_Cter_Amidation	89	92	PF01082	0.475
MOD_GlcNHglycan	203	206	PF01048	0.472
MOD_GlcNHglycan	227	230	PF01048	0.487
MOD_GlcNHglycan	24	28	PF01048	0.378
MOD_GlcNHglycan	244	247	PF01048	0.239
MOD_GlcNHglycan	306	309	PF01048	0.335
MOD_GlcNHglycan	349	352	PF01048	0.455
MOD_GlcNHglycan	376	379	PF01048	0.484
MOD_GlcNHglycan	444	447	PF01048	0.378
MOD_GlcNHglycan	450	453	PF01048	0.385
MOD_GlcNHglycan	473	476	PF01048	0.362
MOD_GlcNHglycan	496	499	PF01048	0.421
MOD_GlcNHglycan	51	54	PF01048	0.344
MOD_GlcNHglycan	545	548	PF01048	0.453
MOD_GlcNHglycan	574	577	PF01048	0.395
MOD_GSK3_1	379	386	PF00069	0.459
MOD_GSK3_1	390	397	PF00069	0.230
MOD_GSK3_1	444	451	PF00069	0.475
MOD_GSK3_1	505	512	PF00069	0.453
MOD_GSK3_1	555	562	PF00069	0.449
MOD_N-GLC_2	346	348	PF02516	0.449
MOD_NEK2_1	129	134	PF00069	0.344
MOD_NEK2_1	159	164	PF00069	0.387
MOD_NEK2_1	358	363	PF00069	0.449
MOD_NEK2_1	442	447	PF00069	0.368
MOD_NEK2_1	448	453	PF00069	0.356
MOD_NEK2_1	491	496	PF00069	0.482
MOD_NEK2_1	559	564	PF00069	0.480
MOD_NEK2_1	598	603	PF00069	0.425
MOD_OFUCOSY	157	163	PF10250	0.385
MOD_PIKK_1	233	239	PF00454	0.398
MOD_PIKK_1	332	338	PF00454	0.449
MOD_PIKK_1	586	592	PF00454	0.449
MOD_PKA_1	369	375	PF00069	0.451
MOD_PKA_2	188	194	PF00069	0.399
MOD_PKA_2	291	297	PF00069	0.411
MOD_PKA_2	369	375	PF00069	0.451
MOD_Plk_1	220	226	PF00069	0.379
MOD_Plk_1	301	307	PF00069	0.332
MOD_Plk_1	400	406	PF00069	0.449
MOD_Plk_1	417	423	PF00069	0.357
MOD_Plk_1	555	561	PF00069	0.364
MOD_Plk_1	583	589	PF00069	0.421
MOD_Plk_4	220	226	PF00069	0.430
MOD_Plk_4	444	450	PF00069	0.441
MOD_Plk_4	555	561	PF00069	0.393
MOD_ProDKin_1	210	216	PF00069	0.475
MOD_ProDKin_1	324	330	PF00069	0.328
MOD_ProDKin_1	384	390	PF00069	0.443
MOD_ProDKin_1	391	397	PF00069	0.481
MOD_ProDKin_1	526	532	PF00069	0.374
MOD_ProDKin_1	545	551	PF00069	0.484
MOD_ProDKin_1	82	88	PF00069	0.367
TRG_DiLeu_BaEn_1	230	235	PF01217	0.344
TRG_DiLeu_BaEn_4	230	236	PF01217	0.475
TRG_DiLeu_BaLyEn_6	309	314	PF01217	0.437
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.413
TRG_ENDOCYTIC_2	113	116	PF00928	0.145
TRG_ENDOCYTIC_2	224	227	PF00928	0.385
TRG_ENDOCYTIC_2	260	263	PF00928	0.475
TRG_ENDOCYTIC_2	40	43	PF00928	0.328
TRG_ENDOCYTIC_2	437	440	PF00928	0.449
TRG_ENDOCYTIC_2	469	472	PF00928	0.413
TRG_ENDOCYTIC_2	560	563	PF00928	0.435
TRG_ENDOCYTIC_2	594	597	PF00928	0.338
TRG_ENDOCYTIC_2	93	96	PF00928	0.385
TRG_ER_diArg_1	139	142	PF00400	0.344
TRG_ER_diArg_1	175	178	PF00400	0.342
TRG_ER_diArg_1	311	313	PF00400	0.374
TRG_ER_diArg_1	314	317	PF00400	0.351
TRG_ER_diArg_1	368	371	PF00400	0.393
TRG_ER_diArg_1	42	45	PF00400	0.400
TRG_ER_diArg_1	428	431	PF00400	0.449
TRG_ER_diArg_1	96	99	PF00400	0.382
TRG_NLS_MonoCore_2	176	181	PF00514	0.344
TRG_NLS_MonoExtC_3	175	180	PF00514	0.364
TRG_NLS_MonoExtN_4	173	180	PF00514	0.393
TRG_Pf-PMV_PEXEL_1	150	155	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	311	316	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	552	556	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II50	Leptomonas seymouri	57%	93%
A0A0S4J8F6	Bodo saltans	34%	100%
A0A1X0NNM1	Trypanosomatidae	38%	98%
A0A422P1X4	Trypanosoma rangeli	43%	100%
A4HE65	Leishmania braziliensis	81%	100%
A4I1G5	Leishmania infantum	100%	100%
C9ZK06	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AXK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q9X1	Leishmania major	93%	100%
V5D8Y9	Trypanosoma cruzi	44%	100%