NLI_interacting_factor-like_phosphatase_putative/ Pfam:PF03031

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dullard-like phosphatase domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDG4_LEIDO

TriTrypDb:

LdBPK_252110.1 , LdCL_250026900 , LDHU3_25.2580

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IDG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDG4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0016787	hydrolase activity	2	17
GO:0016788	hydrolase activity, acting on ester bonds	3	17
GO:0016791	phosphatase activity	5	17
GO:0042578	phosphoric ester hydrolase activity	4	17
GO:0004721	phosphoprotein phosphatase activity	3	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.599
CLV_C14_Caspase3-7	345	349	PF00656	0.376
CLV_Separin_Metazoa	326	330	PF03568	0.397
DEG_Nend_UBRbox_2	1	3	PF02207	0.744
DEG_SCF_FBW7_1	76	81	PF00400	0.527
DEG_SPOP_SBC_1	39	43	PF00917	0.563
DOC_CDC14_PxL_1	328	336	PF14671	0.353
DOC_CYCLIN_yCln2_LP_2	171	177	PF00134	0.544
DOC_MAPK_gen_1	179	188	PF00069	0.314
DOC_MAPK_gen_1	260	269	PF00069	0.443
DOC_MAPK_MEF2A_6	179	188	PF00069	0.335
DOC_MAPK_MEF2A_6	202	211	PF00069	0.278
DOC_MAPK_MEF2A_6	213	221	PF00069	0.245
DOC_MAPK_NFAT4_5	181	189	PF00069	0.306
DOC_MAPK_RevD_3	168	182	PF00069	0.387
DOC_USP7_MATH_1	126	130	PF00917	0.654
DOC_USP7_MATH_1	166	170	PF00917	0.528
DOC_USP7_MATH_1	314	318	PF00917	0.254
DOC_USP7_MATH_1	39	43	PF00917	0.722
DOC_WW_Pin1_4	157	162	PF00397	0.462
DOC_WW_Pin1_4	298	303	PF00397	0.332
DOC_WW_Pin1_4	48	53	PF00397	0.732
DOC_WW_Pin1_4	60	65	PF00397	0.677
DOC_WW_Pin1_4	68	73	PF00397	0.633
DOC_WW_Pin1_4	7	12	PF00397	0.713
DOC_WW_Pin1_4	74	79	PF00397	0.489
LIG_APCC_ABBA_1	267	272	PF00400	0.364
LIG_FHA_1	141	147	PF00498	0.551
LIG_FHA_1	157	163	PF00498	0.422
LIG_FHA_1	242	248	PF00498	0.264
LIG_FHA_1	277	283	PF00498	0.334
LIG_FHA_1	71	77	PF00498	0.805
LIG_FHA_2	247	253	PF00498	0.274
LIG_FHA_2	340	346	PF00498	0.357
LIG_LIR_Apic_2	248	253	PF02991	0.304
LIG_LIR_Gen_1	341	352	PF02991	0.361
LIG_LIR_Nem_3	12	18	PF02991	0.549
LIG_LIR_Nem_3	341	347	PF02991	0.349
LIG_LIR_Nem_3	348	353	PF02991	0.346
LIG_MYND_1	168	172	PF01753	0.455
LIG_REV1ctd_RIR_1	12	20	PF16727	0.571
LIG_SH2_CRK	350	354	PF00017	0.310
LIG_SH2_GRB2like	197	200	PF00017	0.240
LIG_SH2_STAP1	203	207	PF00017	0.393
LIG_SH2_STAT3	305	308	PF00017	0.304
LIG_SH2_STAT5	151	154	PF00017	0.476
LIG_SH2_STAT5	220	223	PF00017	0.302
LIG_SH2_STAT5	250	253	PF00017	0.315
LIG_SH2_STAT5	281	284	PF00017	0.311
LIG_SH2_STAT5	305	308	PF00017	0.251
LIG_SH3_2	49	54	PF14604	0.570
LIG_SH3_3	202	208	PF00018	0.339
LIG_SH3_3	46	52	PF00018	0.677
LIG_SUMO_SIM_anti_2	284	289	PF11976	0.245
LIG_SUMO_SIM_anti_2	293	299	PF11976	0.234
LIG_SUMO_SIM_par_1	184	191	PF11976	0.329
LIG_SUMO_SIM_par_1	207	212	PF11976	0.432
LIG_UBA3_1	254	260	PF00899	0.339
MOD_CDC14_SPxK_1	51	54	PF00782	0.570
MOD_CDK_SPxK_1	48	54	PF00069	0.572
MOD_CK1_1	110	116	PF00069	0.649
MOD_CK1_1	133	139	PF00069	0.591
MOD_CK1_1	246	252	PF00069	0.265
MOD_CK1_1	41	47	PF00069	0.713
MOD_CK1_1	66	72	PF00069	0.700
MOD_CK1_1	74	80	PF00069	0.573
MOD_CK2_1	319	325	PF00069	0.353
MOD_GlcNHglycan	109	113	PF01048	0.671
MOD_GlcNHglycan	114	118	PF01048	0.722
MOD_GlcNHglycan	163	167	PF01048	0.504
MOD_GlcNHglycan	33	36	PF01048	0.821
MOD_GlcNHglycan	361	365	PF01048	0.562
MOD_GlcNHglycan	66	69	PF01048	0.654
MOD_GlcNHglycan	98	101	PF01048	0.818
MOD_GSK3_1	126	133	PF00069	0.661
MOD_GSK3_1	162	169	PF00069	0.510
MOD_GSK3_1	188	195	PF00069	0.317
MOD_GSK3_1	241	248	PF00069	0.289
MOD_GSK3_1	272	279	PF00069	0.345
MOD_GSK3_1	31	38	PF00069	0.717
MOD_GSK3_1	60	67	PF00069	0.656
MOD_GSK3_1	68	75	PF00069	0.655
MOD_GSK3_1	77	84	PF00069	0.593
MOD_N-GLC_1	157	162	PF02516	0.418
MOD_N-GLC_1	7	12	PF02516	0.764
MOD_NEK2_1	192	197	PF00069	0.324
MOD_NEK2_1	243	248	PF00069	0.326
MOD_PIKK_1	21	27	PF00454	0.596
MOD_PIKK_1	81	87	PF00454	0.597
MOD_PKA_2	212	218	PF00069	0.372
MOD_PKA_2	35	41	PF00069	0.572
MOD_PKA_2	4	10	PF00069	0.599
MOD_Plk_1	188	194	PF00069	0.325
MOD_Plk_1	283	289	PF00069	0.299
MOD_Plk_2-3	339	345	PF00069	0.384
MOD_Plk_4	10	16	PF00069	0.544
MOD_Plk_4	166	172	PF00069	0.402
MOD_Plk_4	188	194	PF00069	0.316
MOD_Plk_4	272	278	PF00069	0.304
MOD_Plk_4	283	289	PF00069	0.271
MOD_Plk_4	314	320	PF00069	0.316
MOD_Plk_4	339	345	PF00069	0.340
MOD_Plk_4	78	84	PF00069	0.650
MOD_ProDKin_1	157	163	PF00069	0.467
MOD_ProDKin_1	298	304	PF00069	0.332
MOD_ProDKin_1	48	54	PF00069	0.735
MOD_ProDKin_1	60	66	PF00069	0.677
MOD_ProDKin_1	68	74	PF00069	0.632
MOD_ProDKin_1	7	13	PF00069	0.709
TRG_DiLeu_BaEn_1	326	331	PF01217	0.310
TRG_DiLeu_LyEn_5	326	331	PF01217	0.339
TRG_ENDOCYTIC_2	220	223	PF00928	0.295
TRG_ENDOCYTIC_2	344	347	PF00928	0.334
TRG_ENDOCYTIC_2	350	353	PF00928	0.344
TRG_ER_diArg_1	137	140	PF00400	0.515
TRG_ER_diArg_1	148	151	PF00400	0.379
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG96	Leptomonas seymouri	68%	100%
A0A0S4IJH3	Bodo saltans	46%	100%
A0A0S4IMS1	Bodo saltans	65%	100%
A0A0S4JCX0	Bodo saltans	46%	100%
A0A3S7WZH2	Leishmania donovani	52%	100%
A0A422P4K3	Trypanosoma rangeli	40%	89%
A4HEA5	Leishmania braziliensis	88%	100%
A4HEM1	Leishmania braziliensis	50%	100%
A4I1Q1	Leishmania infantum	100%	100%
A4I1V3	Leishmania infantum	51%	100%
A4ICB8	Leishmania infantum	27%	100%
C9ZKA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	87%
E9AXT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AXZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
Q4Q9H6	Leishmania major	51%	100%
Q4Q9N6	Leishmania major	96%	100%
V5BAV0	Trypanosoma cruzi	24%	100%