Protein phosphatase 2A regulatory subunit, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 2A regulatory subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDF8_LEIDO

TriTrypDb:

LdBPK_150980.1 , LdCL_150015300 , LDHU3_15.1260

Length:

831

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000159	protein phosphatase type 2A complex	5	2
GO:0005737	cytoplasm	2	2
GO:0008287	protein serine/threonine phosphatase complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	2
GO:1903293	phosphatase complex	3	2
GO:0005815	microtubule organizing center	2	1
GO:0005929	cilium	4	1
GO:0036064	ciliary basal body	3	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3Q8IDF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDF8

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016311	dephosphorylation	5	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0019208	phosphatase regulator activity	3	2
GO:0019888	protein phosphatase regulator activity	4	2
GO:0030234	enzyme regulator activity	2	2
GO:0098772	molecular function regulator activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	270	276	PF00089	0.301
CLV_NRD_NRD_1	103	105	PF00675	0.568
CLV_NRD_NRD_1	156	158	PF00675	0.347
CLV_NRD_NRD_1	168	170	PF00675	0.314
CLV_NRD_NRD_1	480	482	PF00675	0.352
CLV_NRD_NRD_1	567	569	PF00675	0.649
CLV_NRD_NRD_1	614	616	PF00675	0.490
CLV_NRD_NRD_1	745	747	PF00675	0.389
CLV_PCSK_KEX2_1	103	105	PF00082	0.568
CLV_PCSK_KEX2_1	156	158	PF00082	0.327
CLV_PCSK_KEX2_1	480	482	PF00082	0.352
CLV_PCSK_KEX2_1	567	569	PF00082	0.649
CLV_PCSK_KEX2_1	616	618	PF00082	0.395
CLV_PCSK_KEX2_1	745	747	PF00082	0.390
CLV_PCSK_PC1ET2_1	616	618	PF00082	0.452
CLV_PCSK_SKI1_1	243	247	PF00082	0.424
CLV_PCSK_SKI1_1	366	370	PF00082	0.334
CLV_PCSK_SKI1_1	387	391	PF00082	0.287
CLV_PCSK_SKI1_1	661	665	PF00082	0.403
CLV_PCSK_SKI1_1	684	688	PF00082	0.522
CLV_Separin_Metazoa	26	30	PF03568	0.500
CLV_Separin_Metazoa	496	500	PF03568	0.352
DEG_APCC_DBOX_1	341	349	PF00400	0.432
DEG_Nend_UBRbox_3	1	3	PF02207	0.721
DEG_SPOP_SBC_1	244	248	PF00917	0.305
DEG_SPOP_SBC_1	382	386	PF00917	0.338
DOC_CKS1_1	277	282	PF01111	0.226
DOC_CKS1_1	38	43	PF01111	0.564
DOC_CYCLIN_RxL_1	363	372	PF00134	0.327
DOC_CYCLIN_RxL_1	383	392	PF00134	0.198
DOC_CYCLIN_yCln2_LP_2	264	270	PF00134	0.319
DOC_MAPK_gen_1	639	647	PF00069	0.372
DOC_MAPK_MEF2A_6	115	124	PF00069	0.566
DOC_MAPK_MEF2A_6	764	772	PF00069	0.526
DOC_PP1_RVXF_1	271	277	PF00149	0.417
DOC_PP2B_LxvP_1	264	267	PF13499	0.287
DOC_USP7_MATH_1	102	106	PF00917	0.536
DOC_USP7_MATH_1	313	317	PF00917	0.395
DOC_USP7_MATH_1	51	55	PF00917	0.631
DOC_USP7_MATH_1	520	524	PF00917	0.340
DOC_USP7_MATH_1	543	547	PF00917	0.584
DOC_USP7_MATH_1	557	561	PF00917	0.581
DOC_USP7_MATH_1	571	575	PF00917	0.582
DOC_USP7_MATH_1	598	602	PF00917	0.609
DOC_USP7_MATH_1	734	738	PF00917	0.379
DOC_USP7_MATH_1	96	100	PF00917	0.691
DOC_USP7_UBL2_3	383	387	PF12436	0.419
DOC_WW_Pin1_4	110	115	PF00397	0.548
DOC_WW_Pin1_4	20	25	PF00397	0.590
DOC_WW_Pin1_4	276	281	PF00397	0.245
DOC_WW_Pin1_4	33	38	PF00397	0.652
DOC_WW_Pin1_4	4	9	PF00397	0.695
DOC_WW_Pin1_4	40	45	PF00397	0.611
DOC_WW_Pin1_4	583	588	PF00397	0.647
DOC_WW_Pin1_4	653	658	PF00397	0.410
DOC_WW_Pin1_4	737	742	PF00397	0.380
DOC_WW_Pin1_4	85	90	PF00397	0.626
LIG_14-3-3_CanoR_1	103	107	PF00244	0.518
LIG_14-3-3_CanoR_1	156	160	PF00244	0.378
LIG_14-3-3_CanoR_1	169	177	PF00244	0.286
LIG_14-3-3_CanoR_1	218	226	PF00244	0.332
LIG_14-3-3_CanoR_1	273	277	PF00244	0.425
LIG_14-3-3_CanoR_1	29	34	PF00244	0.737
LIG_14-3-3_CanoR_1	342	346	PF00244	0.443
LIG_14-3-3_CanoR_1	403	412	PF00244	0.347
LIG_14-3-3_CanoR_1	480	487	PF00244	0.391
LIG_14-3-3_CanoR_1	623	632	PF00244	0.449
LIG_14-3-3_CanoR_1	715	720	PF00244	0.444
LIG_Actin_WH2_2	671	689	PF00022	0.397
LIG_BIR_III_2	474	478	PF00653	0.276
LIG_BRCT_BRCA1_1	131	135	PF00533	0.396
LIG_EH1_1	224	232	PF00400	0.344
LIG_FHA_1	171	177	PF00498	0.350
LIG_FHA_1	218	224	PF00498	0.429
LIG_FHA_1	244	250	PF00498	0.302
LIG_FHA_1	269	275	PF00498	0.398
LIG_FHA_1	277	283	PF00498	0.221
LIG_FHA_1	30	36	PF00498	0.605
LIG_FHA_1	356	362	PF00498	0.414
LIG_FHA_1	625	631	PF00498	0.462
LIG_FHA_1	662	668	PF00498	0.403
LIG_FHA_1	701	707	PF00498	0.387
LIG_FHA_1	712	718	PF00498	0.360
LIG_FHA_1	751	757	PF00498	0.411
LIG_FHA_1	760	766	PF00498	0.399
LIG_FHA_2	114	120	PF00498	0.651
LIG_FHA_2	184	190	PF00498	0.405
LIG_FHA_2	342	348	PF00498	0.365
LIG_FHA_2	5	11	PF00498	0.574
LIG_FHA_2	683	689	PF00498	0.512
LIG_FHA_2	699	705	PF00498	0.283
LIG_FHA_2	784	790	PF00498	0.491
LIG_GBD_Chelix_1	241	249	PF00786	0.383
LIG_GBD_Chelix_1	283	291	PF00786	0.361
LIG_LIR_Apic_2	275	280	PF02991	0.290
LIG_LIR_Apic_2	46	51	PF02991	0.586
LIG_LIR_Gen_1	333	340	PF02991	0.391
LIG_LIR_Gen_1	364	374	PF02991	0.380
LIG_LIR_Nem_3	224	229	PF02991	0.300
LIG_LIR_Nem_3	263	268	PF02991	0.313
LIG_LIR_Nem_3	306	312	PF02991	0.433
LIG_LIR_Nem_3	333	337	PF02991	0.376
LIG_LIR_Nem_3	364	370	PF02991	0.380
LIG_LIR_Nem_3	658	663	PF02991	0.329
LIG_LIR_Nem_3	718	724	PF02991	0.409
LIG_LIR_Nem_3	781	785	PF02991	0.355
LIG_LYPXL_SIV_4	792	800	PF13949	0.426
LIG_MYND_3	528	532	PF01753	0.313
LIG_PCNA_yPIPBox_3	169	181	PF02747	0.292
LIG_Pex14_1	402	406	PF04695	0.306
LIG_Pex14_1	779	783	PF04695	0.397
LIG_Pex3_1	177	188	PF04882	0.336
LIG_RPA_C_Fungi	164	176	PF08784	0.298
LIG_SH2_GRB2like	147	150	PF00017	0.323
LIG_SH2_NCK_1	406	410	PF00017	0.352
LIG_SH2_STAT5	225	228	PF00017	0.361
LIG_SH2_STAT5	290	293	PF00017	0.483
LIG_SH2_STAT5	367	370	PF00017	0.285
LIG_SH2_STAT5	388	391	PF00017	0.286
LIG_SH2_STAT5	406	409	PF00017	0.178
LIG_SH2_STAT5	760	763	PF00017	0.400
LIG_SH3_2	24	29	PF14604	0.493
LIG_SH3_3	21	27	PF00018	0.581
LIG_SH3_3	32	38	PF00018	0.531
LIG_SH3_3	41	47	PF00018	0.519
LIG_SH3_3	597	603	PF00018	0.728
LIG_SH3_3	651	657	PF00018	0.420
LIG_SH3_3	728	734	PF00018	0.381
LIG_SUMO_SIM_anti_2	423	431	PF11976	0.351
LIG_SUMO_SIM_anti_2	805	810	PF11976	0.382
LIG_SUMO_SIM_par_1	31	36	PF11976	0.582
LIG_TRAF2_1	152	155	PF00917	0.449
LIG_TRAF2_1	515	518	PF00917	0.276
LIG_TRFH_1	110	114	PF08558	0.571
LIG_TYR_ITIM	365	370	PF00017	0.282
LIG_WRC_WIRS_1	390	395	PF05994	0.276
LIG_WRC_WIRS_1	622	627	PF05994	0.355
LIG_WW_3	26	30	PF00397	0.727
MOD_CDK_SPK_2	110	115	PF00069	0.541
MOD_CDK_SPK_2	276	281	PF00069	0.245
MOD_CDK_SPK_2	737	742	PF00069	0.354
MOD_CK1_1	113	119	PF00069	0.651
MOD_CK1_1	16	22	PF00069	0.523
MOD_CK1_1	275	281	PF00069	0.318
MOD_CK1_1	3	9	PF00069	0.668
MOD_CK1_1	301	307	PF00069	0.344
MOD_CK1_1	317	323	PF00069	0.336
MOD_CK1_1	355	361	PF00069	0.446
MOD_CK1_1	36	42	PF00069	0.588
MOD_CK1_1	558	564	PF00069	0.733
MOD_CK1_1	624	630	PF00069	0.471
MOD_CK1_1	737	743	PF00069	0.348
MOD_CK1_1	816	822	PF00069	0.418
MOD_CK1_1	83	89	PF00069	0.630
MOD_CK1_1	92	98	PF00069	0.590
MOD_CK2_1	115	121	PF00069	0.650
MOD_CK2_1	149	155	PF00069	0.450
MOD_CK2_1	183	189	PF00069	0.392
MOD_CK2_1	193	199	PF00069	0.461
MOD_CK2_1	20	26	PF00069	0.578
MOD_CK2_1	341	347	PF00069	0.381
MOD_CK2_1	4	10	PF00069	0.568
MOD_CK2_1	512	518	PF00069	0.294
MOD_CK2_1	682	688	PF00069	0.435
MOD_CK2_1	698	704	PF00069	0.195
MOD_CK2_1	737	743	PF00069	0.468
MOD_CK2_1	783	789	PF00069	0.404
MOD_CMANNOS	779	782	PF00535	0.402
MOD_GlcNHglycan	2	5	PF01048	0.614
MOD_GlcNHglycan	235	238	PF01048	0.374
MOD_GlcNHglycan	300	303	PF01048	0.335
MOD_GlcNHglycan	318	322	PF01048	0.336
MOD_GlcNHglycan	481	484	PF01048	0.390
MOD_GlcNHglycan	52	56	PF01048	0.819
MOD_GlcNHglycan	545	548	PF01048	0.547
MOD_GlcNHglycan	550	553	PF01048	0.578
MOD_GlcNHglycan	563	566	PF01048	0.593
MOD_GlcNHglycan	573	576	PF01048	0.563
MOD_GlcNHglycan	594	597	PF01048	0.703
MOD_GlcNHglycan	600	603	PF01048	0.563
MOD_GlcNHglycan	66	69	PF01048	0.623
MOD_GlcNHglycan	78	81	PF01048	0.643
MOD_GlcNHglycan	818	821	PF01048	0.439
MOD_GlcNHglycan	82	85	PF01048	0.654
MOD_GlcNHglycan	94	97	PF01048	0.560
MOD_GlcNHglycan	98	101	PF01048	0.549
MOD_GSK3_1	12	19	PF00069	0.788
MOD_GSK3_1	217	224	PF00069	0.385
MOD_GSK3_1	268	275	PF00069	0.294
MOD_GSK3_1	29	36	PF00069	0.579
MOD_GSK3_1	313	320	PF00069	0.426
MOD_GSK3_1	355	362	PF00069	0.327
MOD_GSK3_1	39	46	PF00069	0.616
MOD_GSK3_1	557	564	PF00069	0.673
MOD_GSK3_1	569	576	PF00069	0.556
MOD_GSK3_1	579	586	PF00069	0.609
MOD_GSK3_1	588	595	PF00069	0.515
MOD_GSK3_1	673	680	PF00069	0.381
MOD_GSK3_1	707	714	PF00069	0.471
MOD_GSK3_1	76	83	PF00069	0.580
MOD_GSK3_1	809	816	PF00069	0.327
MOD_GSK3_1	84	91	PF00069	0.587
MOD_GSK3_1	92	99	PF00069	0.590
MOD_N-GLC_1	221	226	PF02516	0.405
MOD_N-GLC_1	558	563	PF02516	0.732
MOD_N-GLC_1	71	76	PF02516	0.576
MOD_N-GLC_1	809	814	PF02516	0.387
MOD_N-GLC_1	89	94	PF02516	0.671
MOD_NEK2_1	268	273	PF00069	0.275
MOD_NEK2_1	298	303	PF00069	0.456
MOD_NEK2_1	352	357	PF00069	0.418
MOD_NEK2_1	361	366	PF00069	0.362
MOD_NEK2_1	389	394	PF00069	0.272
MOD_NEK2_1	531	536	PF00069	0.458
MOD_NEK2_1	58	63	PF00069	0.576
MOD_NEK2_1	632	637	PF00069	0.413
MOD_NEK2_1	749	754	PF00069	0.414
MOD_NEK2_1	809	814	PF00069	0.431
MOD_NEK2_2	674	679	PF00069	0.465
MOD_NEK2_2	682	687	PF00069	0.369
MOD_PIKK_1	170	176	PF00454	0.350
MOD_PIKK_1	469	475	PF00454	0.448
MOD_PIKK_1	677	683	PF00454	0.408
MOD_PKA_1	169	175	PF00069	0.256
MOD_PKA_2	102	108	PF00069	0.546
MOD_PKA_2	155	161	PF00069	0.436
MOD_PKA_2	217	223	PF00069	0.336
MOD_PKA_2	272	278	PF00069	0.412
MOD_PKA_2	341	347	PF00069	0.419
MOD_PKA_2	404	410	PF00069	0.286
MOD_PKA_2	479	485	PF00069	0.341
MOD_PKA_2	561	567	PF00069	0.571
MOD_PKA_2	579	585	PF00069	0.597
MOD_Plk_1	120	126	PF00069	0.549
MOD_Plk_1	128	134	PF00069	0.614
MOD_Plk_1	16	22	PF00069	0.607
MOD_Plk_1	221	227	PF00069	0.316
MOD_Plk_1	317	323	PF00069	0.418
MOD_Plk_1	71	77	PF00069	0.575
MOD_Plk_4	221	227	PF00069	0.359
MOD_Plk_4	272	278	PF00069	0.324
MOD_Plk_4	29	35	PF00069	0.530
MOD_Plk_4	389	395	PF00069	0.306
MOD_Plk_4	715	721	PF00069	0.429
MOD_Plk_4	778	784	PF00069	0.401
MOD_ProDKin_1	110	116	PF00069	0.547
MOD_ProDKin_1	20	26	PF00069	0.591
MOD_ProDKin_1	276	282	PF00069	0.241
MOD_ProDKin_1	33	39	PF00069	0.653
MOD_ProDKin_1	4	10	PF00069	0.695
MOD_ProDKin_1	40	46	PF00069	0.611
MOD_ProDKin_1	583	589	PF00069	0.637
MOD_ProDKin_1	653	659	PF00069	0.409
MOD_ProDKin_1	737	743	PF00069	0.378
MOD_ProDKin_1	85	91	PF00069	0.628
TRG_DiLeu_BaEn_1	257	262	PF01217	0.289
TRG_DiLeu_BaEn_3	154	160	PF01217	0.439
TRG_DiLeu_BaEn_4	371	377	PF01217	0.383
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.414
TRG_DiLeu_BaLyEn_6	752	757	PF01217	0.442
TRG_ENDOCYTIC_2	147	150	PF00928	0.354
TRG_ENDOCYTIC_2	290	293	PF00928	0.322
TRG_ENDOCYTIC_2	367	370	PF00928	0.303
TRG_ENDOCYTIC_2	487	490	PF00928	0.335
TRG_ENDOCYTIC_2	780	783	PF00928	0.408
TRG_ER_diArg_1	102	104	PF00400	0.580
TRG_ER_diArg_1	402	405	PF00400	0.281
TRG_ER_diArg_1	479	481	PF00400	0.352
TRG_ER_diArg_1	638	641	PF00400	0.357
TRG_ER_diArg_1	744	746	PF00400	0.389
TRG_NES_CRM1_1	250	263	PF08389	0.368
TRG_NES_CRM1_1	359	372	PF08389	0.398
TRG_Pf-PMV_PEXEL_1	366	371	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	506	510	PF00026	0.235
TRG_Pf-PMV_PEXEL_1	684	688	PF00026	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA72	Leptomonas seymouri	66%	84%
A0A3R7N5C8	Trypanosoma rangeli	36%	100%
A4H865	Leishmania braziliensis	83%	100%
A4HWJ0	Leishmania infantum	100%	100%
C9ZXV3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AQ91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q38845	Arabidopsis thaliana	22%	100%
Q4QCX5	Leishmania major	24%	100%
Q4QF92	Leishmania major	96%	100%
Q9UT08	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
V5DL61	Trypanosoma cruzi	38%	100%