Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDF7_LEIDO

TriTrypDb:

LdBPK_271320.1 , LdCL_270019900 , LDHU3_27.2030

Length:

375

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IDF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDF7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.519
CLV_C14_Caspase3-7	15	19	PF00656	0.472
CLV_NRD_NRD_1	172	174	PF00675	0.406
CLV_NRD_NRD_1	69	71	PF00675	0.512
CLV_PCSK_KEX2_1	172	174	PF00082	0.514
CLV_PCSK_KEX2_1	69	71	PF00082	0.512
CLV_PCSK_SKI1_1	204	208	PF00082	0.414
CLV_PCSK_SKI1_1	223	227	PF00082	0.277
CLV_PCSK_SKI1_1	349	353	PF00082	0.442
CLV_PCSK_SKI1_1	63	67	PF00082	0.537
DEG_APCC_DBOX_1	348	356	PF00400	0.344
DEG_Nend_UBRbox_2	1	3	PF02207	0.488
DEG_SPOP_SBC_1	128	132	PF00917	0.666
DEG_SPOP_SBC_1	134	138	PF00917	0.611
DOC_ANK_TNKS_1	302	309	PF00023	0.395
DOC_CKS1_1	224	229	PF01111	0.455
DOC_CYCLIN_yCln2_LP_2	94	100	PF00134	0.452
DOC_MAPK_gen_1	172	178	PF00069	0.330
DOC_MAPK_gen_1	50	58	PF00069	0.518
DOC_MAPK_MEF2A_6	342	350	PF00069	0.366
DOC_MAPK_MEF2A_6	50	58	PF00069	0.550
DOC_PP1_RVXF_1	175	182	PF00149	0.321
DOC_PP2B_LxvP_1	299	302	PF13499	0.479
DOC_PP4_FxxP_1	31	34	PF00568	0.507
DOC_USP7_MATH_1	127	131	PF00917	0.781
DOC_USP7_MATH_1	133	137	PF00917	0.607
DOC_USP7_MATH_1	285	289	PF00917	0.475
DOC_USP7_MATH_2	317	323	PF00917	0.474
DOC_WW_Pin1_4	129	134	PF00397	0.691
DOC_WW_Pin1_4	223	228	PF00397	0.497
DOC_WW_Pin1_4	236	241	PF00397	0.339
DOC_WW_Pin1_4	30	35	PF00397	0.512
LIG_14-3-3_CanoR_1	109	113	PF00244	0.433
LIG_14-3-3_CanoR_1	141	147	PF00244	0.527
LIG_14-3-3_CanoR_1	162	171	PF00244	0.519
LIG_14-3-3_CanoR_1	177	182	PF00244	0.462
LIG_14-3-3_CanoR_1	204	213	PF00244	0.443
LIG_14-3-3_CanoR_1	342	346	PF00244	0.455
LIG_APCC_ABBA_1	274	279	PF00400	0.574
LIG_BRCT_BRCA1_1	23	27	PF00533	0.561
LIG_FHA_1	191	197	PF00498	0.425
LIG_FHA_1	236	242	PF00498	0.427
LIG_FHA_1	269	275	PF00498	0.457
LIG_FHA_1	287	293	PF00498	0.467
LIG_FHA_1	53	59	PF00498	0.679
LIG_FHA_1	60	66	PF00498	0.482
LIG_FHA_2	153	159	PF00498	0.454
LIG_FHA_2	88	94	PF00498	0.349
LIG_LIR_Apic_2	29	34	PF02991	0.503
LIG_LIR_Gen_1	111	120	PF02991	0.551
LIG_LIR_Gen_1	183	192	PF02991	0.400
LIG_LIR_Gen_1	310	317	PF02991	0.487
LIG_LIR_Gen_1	43	51	PF02991	0.433
LIG_LIR_Nem_3	111	116	PF02991	0.494
LIG_LIR_Nem_3	183	188	PF02991	0.378
LIG_LIR_Nem_3	310	316	PF02991	0.440
LIG_LIR_Nem_3	43	47	PF02991	0.388
LIG_NRP_CendR_1	374	375	PF00754	0.670
LIG_Pex14_2	181	185	PF04695	0.445
LIG_Pex14_2	188	192	PF04695	0.486
LIG_Pex14_2	27	31	PF04695	0.495
LIG_SH2_CRK	144	148	PF00017	0.459
LIG_SH2_CRK	313	317	PF00017	0.452
LIG_SH2_NCK_1	358	362	PF00017	0.512
LIG_SH2_SRC	358	361	PF00017	0.517
LIG_SH2_STAT3	365	368	PF00017	0.543
LIG_SH2_STAT5	13	16	PF00017	0.415
LIG_SH2_STAT5	144	147	PF00017	0.500
LIG_SH2_STAT5	266	269	PF00017	0.342
LIG_SH2_STAT5	365	368	PF00017	0.614
LIG_SH3_3	221	227	PF00018	0.485
LIG_SH3_3	53	59	PF00018	0.515
LIG_SUMO_SIM_par_1	114	119	PF11976	0.552
LIG_SUMO_SIM_par_1	54	60	PF11976	0.662
LIG_SUMO_SIM_par_1	89	96	PF11976	0.516
LIG_TRAF2_1	166	169	PF00917	0.390
LIG_TYR_ITIM	257	262	PF00017	0.401
LIG_UBA3_1	5	12	PF00899	0.291
LIG_WRC_WIRS_1	143	148	PF05994	0.505
LIG_WRC_WIRS_1	178	183	PF05994	0.461
MOD_CDK_SPxK_1	223	229	PF00069	0.454
MOD_CK1_1	122	128	PF00069	0.758
MOD_CK1_1	137	143	PF00069	0.567
MOD_CK1_1	180	186	PF00069	0.493
MOD_CK1_1	190	196	PF00069	0.376
MOD_CK1_1	21	27	PF00069	0.554
MOD_CK1_1	215	221	PF00069	0.560
MOD_CK2_1	152	158	PF00069	0.461
MOD_CK2_1	162	168	PF00069	0.428
MOD_CK2_1	312	318	PF00069	0.516
MOD_CK2_1	319	325	PF00069	0.440
MOD_CK2_1	341	347	PF00069	0.388
MOD_CK2_1	87	93	PF00069	0.417
MOD_DYRK1A_RPxSP_1	223	227	PF00069	0.454
MOD_GlcNHglycan	121	124	PF01048	0.635
MOD_GlcNHglycan	165	168	PF01048	0.495
MOD_GlcNHglycan	173	176	PF01048	0.453
MOD_GlcNHglycan	23	26	PF01048	0.622
MOD_GlcNHglycan	79	82	PF01048	0.567
MOD_GSK3_1	114	121	PF00069	0.624
MOD_GSK3_1	129	136	PF00069	0.743
MOD_GSK3_1	17	24	PF00069	0.604
MOD_GSK3_1	177	184	PF00069	0.358
MOD_GSK3_1	59	66	PF00069	0.548
MOD_N-GLC_1	370	375	PF02516	0.682
MOD_NEK2_1	116	121	PF00069	0.634
MOD_NEK2_1	171	176	PF00069	0.456
MOD_NEK2_1	181	186	PF00069	0.341
MOD_NEK2_1	195	200	PF00069	0.252
MOD_NEK2_1	312	317	PF00069	0.509
MOD_NEK2_1	42	47	PF00069	0.372
MOD_NEK2_2	152	157	PF00069	0.434
MOD_OFUCOSY	212	219	PF10250	0.396
MOD_PIKK_1	283	289	PF00454	0.494
MOD_PKA_2	108	114	PF00069	0.427
MOD_PKA_2	171	177	PF00069	0.511
MOD_PKA_2	341	347	PF00069	0.456
MOD_PKA_2	49	55	PF00069	0.617
MOD_Plk_1	17	23	PF00069	0.604
MOD_Plk_1	42	48	PF00069	0.383
MOD_Plk_2-3	319	325	PF00069	0.470
MOD_Plk_4	108	114	PF00069	0.450
MOD_Plk_4	142	148	PF00069	0.514
MOD_Plk_4	177	183	PF00069	0.363
MOD_Plk_4	319	325	PF00069	0.470
MOD_Plk_4	87	93	PF00069	0.438
MOD_ProDKin_1	129	135	PF00069	0.689
MOD_ProDKin_1	223	229	PF00069	0.502
MOD_ProDKin_1	236	242	PF00069	0.350
MOD_ProDKin_1	30	36	PF00069	0.507
MOD_SUMO_rev_2	80	88	PF00179	0.510
TRG_DiLeu_BaEn_1	319	324	PF01217	0.536
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.446
TRG_ENDOCYTIC_2	144	147	PF00928	0.454
TRG_ENDOCYTIC_2	259	262	PF00928	0.344
TRG_ENDOCYTIC_2	313	316	PF00928	0.445
TRG_ENDOCYTIC_2	358	361	PF00928	0.469
TRG_ER_diArg_1	171	173	PF00400	0.324
TRG_ER_diArg_1	302	305	PF00400	0.437
TRG_ER_diArg_1	68	70	PF00400	0.525
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R9	Leptomonas seymouri	59%	96%
A0A0S4JR94	Bodo saltans	28%	100%
A0A422NFS8	Trypanosoma rangeli	36%	100%
A4HFR8	Leishmania braziliensis	78%	100%
A4I2U3	Leishmania infantum	100%	100%
D0A609	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9ADC2	Leishmania major	95%	100%
E9AZ46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5B0Z1	Trypanosoma cruzi	37%	100%