LeishMANIAdb
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DUF3586 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Download

Quick info

Protein:
DUF3586 domain-containing protein
Gene product:
Protein of unknown function (DUF3586), putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IDE8_LEIDO
TriTrypDb:
LdCL_190020400
Length:
107

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 1
NetGPI no yes: 0, no: 1
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IDE8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDE8

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0004175 endopeptidase activity 4 2
GO:0004197 cysteine-type endopeptidase activity 5 2
GO:0008233 peptidase activity 3 2
GO:0008234 cysteine-type peptidase activity 4 2
GO:0016787 hydrolase activity 2 2
GO:0140096 catalytic activity, acting on a protein 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 23 25 PF00675 0.199
CLV_PCSK_KEX2_1 23 25 PF00082 0.199
CLV_PCSK_PC1ET2_1 23 25 PF00082 0.199
DEG_Nend_UBRbox_3 1 3 PF02207 0.417
DOC_CYCLIN_yCln2_LP_2 91 97 PF00134 0.374
DOC_MAPK_MEF2A_6 57 64 PF00069 0.341
DOC_PP1_RVXF_1 91 98 PF00149 0.373
DOC_PP4_FxxP_1 97 100 PF00568 0.399
DOC_USP7_MATH_1 47 51 PF00917 0.199
DOC_WW_Pin1_4 43 48 PF00397 0.199
LIG_FHA_1 37 43 PF00498 0.199
LIG_FHA_1 74 80 PF00498 0.413
LIG_LIR_Apic_2 41 47 PF02991 0.199
LIG_LIR_Nem_3 66 70 PF02991 0.365
LIG_Rb_pABgroove_1 38 46 PF01858 0.199
LIG_SH2_CRK 44 48 PF00017 0.199
LIG_SH2_NCK_1 44 48 PF00017 0.199
LIG_SH2_STAT5 70 73 PF00017 0.334
LIG_SUMO_SIM_anti_2 37 46 PF11976 0.199
MOD_GlcNHglycan 28 31 PF01048 0.199
MOD_GlcNHglycan 4 7 PF01048 0.199
MOD_GlcNHglycan 49 52 PF01048 0.199
MOD_GSK3_1 11 18 PF00069 0.199
MOD_GSK3_1 43 50 PF00069 0.199
MOD_N-GLC_1 12 17 PF02516 0.199
MOD_PK_1 75 81 PF00069 0.425
MOD_Plk_1 12 18 PF00069 0.199
MOD_ProDKin_1 43 49 PF00069 0.199
TRG_DiLeu_BaEn_1 38 43 PF01217 0.199
TRG_DiLeu_BaLyEn_6 91 96 PF01217 0.380

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS