39S ribosomal protein L24, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDE3_LEIDO

TriTrypDb:

LdBPK_251700.1 , LdCL_250022700 , LDHU3_25.2140

Length:

465

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	8
GO:0043226	organelle	2	8
GO:0043228	non-membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043232	intracellular non-membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8
GO:0005739	mitochondrion	5	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8IDE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDE3

PDB structure(s): 7aih_O , 7am2_O , 7ane_O

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	8
GO:0006518	peptide metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009058	biosynthetic process	2	8
GO:0009059	macromolecule biosynthetic process	4	8
GO:0009987	cellular process	1	8
GO:0019538	protein metabolic process	3	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	8
GO:0043043	peptide biosynthetic process	5	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043603	amide metabolic process	3	8
GO:0043604	amide biosynthetic process	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044249	cellular biosynthetic process	3	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0044271	cellular nitrogen compound biosynthetic process	4	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:1901566	organonitrogen compound biosynthetic process	4	8
GO:1901576	organic substance biosynthetic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003735	structural constituent of ribosome	2	8
GO:0005198	structural molecule activity	1	8
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	229	231	PF00675	0.451
CLV_NRD_NRD_1	279	281	PF00675	0.472
CLV_NRD_NRD_1	292	294	PF00675	0.465
CLV_NRD_NRD_1	428	430	PF00675	0.564
CLV_PCSK_KEX2_1	229	231	PF00082	0.392
CLV_PCSK_KEX2_1	279	281	PF00082	0.413
CLV_PCSK_KEX2_1	38	40	PF00082	0.421
CLV_PCSK_KEX2_1	428	430	PF00082	0.564
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.412
CLV_PCSK_SKI1_1	315	319	PF00082	0.502
CLV_PCSK_SKI1_1	42	46	PF00082	0.503
DEG_APCC_DBOX_1	77	85	PF00400	0.413
DEG_Kelch_Keap1_1	220	225	PF01344	0.496
DOC_MAPK_gen_1	11	19	PF00069	0.442
DOC_MAPK_gen_1	161	168	PF00069	0.353
DOC_MAPK_gen_1	269	278	PF00069	0.493
DOC_MAPK_gen_1	76	83	PF00069	0.478
DOC_MAPK_MEF2A_6	11	19	PF00069	0.444
DOC_MAPK_MEF2A_6	269	278	PF00069	0.510
DOC_PP1_RVXF_1	14	20	PF00149	0.437
DOC_PP2B_LxvP_1	239	242	PF13499	0.423
DOC_PP2B_LxvP_1	54	57	PF13499	0.517
DOC_USP7_MATH_1	348	352	PF00917	0.692
DOC_USP7_MATH_1	361	365	PF00917	0.518
DOC_USP7_UBL2_3	217	221	PF12436	0.427
DOC_USP7_UBL2_3	359	363	PF12436	0.633
DOC_USP7_UBL2_3	38	42	PF12436	0.462
DOC_WW_Pin1_4	123	128	PF00397	0.458
DOC_WW_Pin1_4	47	52	PF00397	0.486
LIG_14-3-3_CanoR_1	16	20	PF00244	0.483
LIG_14-3-3_CanoR_1	229	234	PF00244	0.433
LIG_14-3-3_CanoR_1	293	297	PF00244	0.420
LIG_14-3-3_CanoR_1	381	389	PF00244	0.600
LIG_Actin_WH2_2	277	295	PF00022	0.440
LIG_Actin_WH2_2	49	67	PF00022	0.438
LIG_CaM_IQ_9	307	322	PF13499	0.460
LIG_eIF4E_1	162	168	PF01652	0.408
LIG_FHA_1	139	145	PF00498	0.483
LIG_FHA_1	205	211	PF00498	0.450
LIG_FHA_1	221	227	PF00498	0.373
LIG_FHA_1	320	326	PF00498	0.493
LIG_FHA_1	363	369	PF00498	0.670
LIG_FHA_1	436	442	PF00498	0.526
LIG_FHA_2	181	187	PF00498	0.444
LIG_HCF-1_HBM_1	98	101	PF13415	0.423
LIG_LIR_Apic_2	34	40	PF02991	0.409
LIG_LIR_Gen_1	401	406	PF02991	0.515
LIG_LIR_Nem_3	401	405	PF02991	0.514
LIG_PCNA_yPIPBox_3	163	177	PF02747	0.375
LIG_SH2_GRB2like	101	104	PF00017	0.415
LIG_SH2_PTP2	402	405	PF00017	0.493
LIG_SH2_SRC	296	299	PF00017	0.431
LIG_SH2_SRC	96	99	PF00017	0.431
LIG_SH2_STAT3	101	104	PF00017	0.415
LIG_SH2_STAT5	124	127	PF00017	0.472
LIG_SH2_STAT5	287	290	PF00017	0.403
LIG_SH2_STAT5	402	405	PF00017	0.493
LIG_SH2_STAT5	68	71	PF00017	0.478
LIG_SH3_3	173	179	PF00018	0.413
LIG_SH3_3	386	392	PF00018	0.633
LIG_SH3_3	438	444	PF00018	0.546
LIG_SUMO_SIM_anti_2	140	146	PF11976	0.413
LIG_SUMO_SIM_anti_2	401	410	PF11976	0.471
LIG_SUMO_SIM_anti_2	79	86	PF11976	0.473
LIG_SUMO_SIM_par_1	140	146	PF11976	0.374
LIG_SUMO_SIM_par_1	364	370	PF11976	0.602
LIG_TRAF2_1	243	246	PF00917	0.550
LIG_UBA3_1	53	60	PF00899	0.545
LIG_UBA3_1	63	72	PF00899	0.416
LIG_WRC_WIRS_1	310	315	PF05994	0.455
MOD_CK1_1	232	238	PF00069	0.422
MOD_CK1_1	342	348	PF00069	0.642
MOD_CK1_1	364	370	PF00069	0.524
MOD_CK1_1	401	407	PF00069	0.595
MOD_CK2_1	180	186	PF00069	0.445
MOD_CK2_1	401	407	PF00069	0.526
MOD_GlcNHglycan	145	148	PF01048	0.485
MOD_GlcNHglycan	234	237	PF01048	0.421
MOD_GlcNHglycan	345	348	PF01048	0.641
MOD_GlcNHglycan	455	458	PF01048	0.672
MOD_GSK3_1	288	295	PF00069	0.433
MOD_GSK3_1	339	346	PF00069	0.601
MOD_N-GLC_1	453	458	PF02516	0.556
MOD_N-GLC_1	47	52	PF02516	0.486
MOD_NEK2_1	254	259	PF00069	0.571
MOD_NEK2_1	288	293	PF00069	0.398
MOD_NEK2_1	349	354	PF00069	0.568
MOD_NEK2_1	398	403	PF00069	0.623
MOD_NEK2_1	83	88	PF00069	0.465
MOD_PIKK_1	339	345	PF00454	0.599
MOD_PIKK_1	349	355	PF00454	0.569
MOD_PKA_1	229	235	PF00069	0.403
MOD_PKA_2	15	21	PF00069	0.482
MOD_PKA_2	229	235	PF00069	0.403
MOD_PKA_2	292	298	PF00069	0.434
MOD_PKA_2	319	325	PF00069	0.488
MOD_PKB_1	29	37	PF00069	0.408
MOD_Plk_1	244	250	PF00069	0.562
MOD_Plk_1	263	269	PF00069	0.397
MOD_Plk_1	409	415	PF00069	0.470
MOD_Plk_1	97	103	PF00069	0.421
MOD_Plk_2-3	263	269	PF00069	0.462
MOD_Plk_2-3	409	415	PF00069	0.493
MOD_Plk_4	367	373	PF00069	0.513
MOD_Plk_4	398	404	PF00069	0.511
MOD_ProDKin_1	123	129	PF00069	0.455
MOD_ProDKin_1	47	53	PF00069	0.487
MOD_SUMO_for_1	376	379	PF00179	0.682
MOD_SUMO_rev_2	126	133	PF00179	0.415
TRG_DiLeu_BaEn_1	234	239	PF01217	0.419
TRG_DiLeu_BaEn_1	272	277	PF01217	0.424
TRG_DiLeu_BaEn_1	79	84	PF01217	0.471
TRG_DiLeu_BaLyEn_6	271	276	PF01217	0.490
TRG_ENDOCYTIC_2	122	125	PF00928	0.384
TRG_ENDOCYTIC_2	402	405	PF00928	0.493
TRG_ER_diArg_1	10	13	PF00400	0.475
TRG_ER_diArg_1	198	201	PF00400	0.545
TRG_ER_diArg_1	229	231	PF00400	0.451
TRG_ER_diArg_1	278	280	PF00400	0.483
TRG_ER_diArg_1	30	33	PF00400	0.404
TRG_ER_diArg_1	4	7	PF00400	0.497
TRG_NES_CRM1_1	209	222	PF08389	0.492
TRG_NES_CRM1_1	308	323	PF08389	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I882	Leptomonas seymouri	73%	100%
A0A1X0NY95	Trypanosomatidae	74%	100%
A4HEI0	Leishmania braziliensis	83%	98%
A4I1L0	Leishmania infantum	100%	100%
E9AXP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q9S7	Leishmania major	92%	100%