Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDE0_LEIDO

TriTrypDb:

LdBPK_150610.1 , LdCL_150011200 , LDHU3_15.0760

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IDE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDE0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.667
CLV_NRD_NRD_1	2	4	PF00675	0.499
CLV_NRD_NRD_1	210	212	PF00675	0.735
CLV_NRD_NRD_1	216	218	PF00675	0.500
CLV_PCSK_KEX2_1	209	211	PF00082	0.762
CLV_PCSK_PC7_1	206	212	PF00082	0.638
CLV_PCSK_SKI1_1	152	156	PF00082	0.572
CLV_PCSK_SKI1_1	5	9	PF00082	0.627
DEG_SPOP_SBC_1	117	121	PF00917	0.648
DOC_USP7_MATH_1	117	121	PF00917	0.785
DOC_USP7_MATH_1	142	146	PF00917	0.692
DOC_USP7_MATH_1	193	197	PF00917	0.668
DOC_WW_Pin1_4	118	123	PF00397	0.737
DOC_WW_Pin1_4	200	205	PF00397	0.679
DOC_WW_Pin1_4	230	235	PF00397	0.613
LIG_14-3-3_CanoR_1	149	155	PF00244	0.602
LIG_14-3-3_CanoR_1	164	169	PF00244	0.475
LIG_14-3-3_CanoR_1	192	198	PF00244	0.755
LIG_14-3-3_CanoR_1	21	31	PF00244	0.533
LIG_FHA_2	124	130	PF00498	0.691
LIG_LIR_Apic_2	85	90	PF02991	0.706
LIG_LIR_Nem_3	202	208	PF02991	0.576
LIG_LIR_Nem_3	98	104	PF02991	0.479
LIG_Pex14_1	55	59	PF04695	0.570
LIG_SH2_CRK	101	105	PF00017	0.631
LIG_SH2_CRK	205	209	PF00017	0.566
LIG_SH2_GRB2like	87	90	PF00017	0.673
LIG_SH2_PTP2	87	90	PF00017	0.699
LIG_SH2_SRC	59	62	PF00017	0.525
LIG_SH2_SRC	87	90	PF00017	0.699
LIG_SH2_STAT5	158	161	PF00017	0.565
LIG_SH2_STAT5	17	20	PF00017	0.461
LIG_SH2_STAT5	232	235	PF00017	0.503
LIG_SH2_STAT5	87	90	PF00017	0.684
LIG_SH3_3	170	176	PF00018	0.672
LIG_TYR_ITIM	99	104	PF00017	0.485
MOD_CDC14_SPxK_1	203	206	PF00782	0.636
MOD_CDK_SPK_2	230	235	PF00069	0.596
MOD_CDK_SPxK_1	200	206	PF00069	0.638
MOD_CK1_1	150	156	PF00069	0.728
MOD_CK1_1	194	200	PF00069	0.694
MOD_CK1_1	34	40	PF00069	0.606
MOD_CK2_1	123	129	PF00069	0.720
MOD_CK2_1	193	199	PF00069	0.762
MOD_GlcNHglycan	144	147	PF01048	0.705
MOD_GlcNHglycan	149	152	PF01048	0.661
MOD_GlcNHglycan	173	176	PF01048	0.764
MOD_GlcNHglycan	193	196	PF01048	0.511
MOD_GSK3_1	113	120	PF00069	0.749
MOD_GSK3_1	132	139	PF00069	0.741
MOD_GSK3_1	171	178	PF00069	0.642
MOD_GSK3_1	187	194	PF00069	0.514
MOD_GSK3_1	30	37	PF00069	0.678
MOD_NEK2_1	132	137	PF00069	0.678
MOD_NEK2_1	147	152	PF00069	0.532
MOD_NEK2_1	198	203	PF00069	0.669
MOD_NEK2_1	31	36	PF00069	0.558
MOD_PIKK_1	152	158	PF00454	0.612
MOD_PIKK_1	31	37	PF00454	0.651
MOD_PKA_2	191	197	PF00069	0.769
MOD_PKB_1	162	170	PF00069	0.737
MOD_Plk_4	95	101	PF00069	0.524
MOD_ProDKin_1	118	124	PF00069	0.736
MOD_ProDKin_1	200	206	PF00069	0.680
TRG_ENDOCYTIC_2	101	104	PF00928	0.638
TRG_ENDOCYTIC_2	205	208	PF00928	0.568
TRG_ER_diArg_1	208	211	PF00400	0.762
TRG_NLS_MonoExtN_4	2	7	PF00514	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7F5	Leptomonas seymouri	47%	100%
A0A3R7KEI8	Trypanosoma rangeli	31%	100%
A4H831	Leishmania braziliensis	75%	100%
A4HWF7	Leishmania infantum	100%	100%
C9ZNZ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AQ56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QFC6	Leishmania major	92%	100%