TLP18.3_Psb32_and_MOLO-1_founding_proteins_of_pho sphatase_putative/Pfam:PF04536

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDD5_LEIDO

TriTrypDb:

LdBPK_251940.1 , LdCL_250025100 , LDHU3_25.2400

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3Q8IDD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDD5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.496
CLV_NRD_NRD_1	41	43	PF00675	0.446
CLV_NRD_NRD_1	91	93	PF00675	0.362
CLV_PCSK_KEX2_1	107	109	PF00082	0.294
CLV_PCSK_KEX2_1	3	5	PF00082	0.481
CLV_PCSK_KEX2_1	378	380	PF00082	0.660
CLV_PCSK_KEX2_1	41	43	PF00082	0.446
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.294
CLV_PCSK_PC1ET2_1	378	380	PF00082	0.660
CLV_PCSK_PC7_1	103	109	PF00082	0.365
CLV_PCSK_SKI1_1	103	107	PF00082	0.357
CLV_PCSK_SKI1_1	180	184	PF00082	0.353
CLV_PCSK_SKI1_1	206	210	PF00082	0.217
CLV_PCSK_SKI1_1	242	246	PF00082	0.385
CLV_PCSK_SKI1_1	311	315	PF00082	0.608
CLV_PCSK_SKI1_1	384	388	PF00082	0.493
CLV_PCSK_SKI1_1	397	401	PF00082	0.509
CLV_PCSK_SKI1_1	405	409	PF00082	0.575
DEG_APCC_DBOX_1	396	404	PF00400	0.324
DEG_Nend_Nbox_1	1	3	PF02207	0.716
DEG_SPOP_SBC_1	28	32	PF00917	0.672
DOC_CYCLIN_yClb3_PxF_3	33	41	PF00134	0.632
DOC_CYCLIN_yCln2_LP_2	403	409	PF00134	0.402
DOC_MAPK_gen_1	106	115	PF00069	0.541
DOC_MAPK_gen_1	239	247	PF00069	0.661
DOC_MAPK_MEF2A_6	136	143	PF00069	0.541
DOC_PP1_RVXF_1	250	256	PF00149	0.543
DOC_PP2B_LxvP_1	245	248	PF13499	0.566
DOC_PP4_FxxP_1	200	203	PF00568	0.455
DOC_USP7_MATH_1	28	32	PF00917	0.696
DOC_USP7_UBL2_3	370	374	PF12436	0.311
DOC_WW_Pin1_4	29	34	PF00397	0.737
DOC_WW_Pin1_4	47	52	PF00397	0.608
LIG_14-3-3_CanoR_1	108	116	PF00244	0.396
LIG_14-3-3_CanoR_1	3	9	PF00244	0.694
LIG_14-3-3_CanoR_1	92	100	PF00244	0.573
LIG_BRCT_BRCA1_1	151	155	PF00533	0.437
LIG_BRCT_BRCA1_1	157	161	PF00533	0.427
LIG_BRCT_BRCA1_1	34	38	PF00533	0.669
LIG_deltaCOP1_diTrp_1	412	418	PF00928	0.343
LIG_FHA_1	108	114	PF00498	0.541
LIG_FHA_1	181	187	PF00498	0.462
LIG_FHA_1	22	28	PF00498	0.666
LIG_FHA_1	220	226	PF00498	0.452
LIG_FHA_1	279	285	PF00498	0.298
LIG_FHA_1	351	357	PF00498	0.341
LIG_FHA_1	363	369	PF00498	0.310
LIG_FHA_2	83	89	PF00498	0.575
LIG_LIR_Apic_2	197	203	PF02991	0.454
LIG_LIR_Gen_1	137	147	PF02991	0.419
LIG_LIR_Gen_1	79	86	PF02991	0.570
LIG_LIR_Nem_3	137	143	PF02991	0.419
LIG_LIR_Nem_3	207	212	PF02991	0.431
LIG_LIR_Nem_3	412	418	PF02991	0.379
LIG_MLH1_MIPbox_1	157	161	PF16413	0.541
LIG_PDZ_Class_2	430	435	PF00595	0.448
LIG_Pex14_2	196	200	PF04695	0.431
LIG_PTB_Apo_2	154	161	PF02174	0.487
LIG_RPA_C_Insects	54	69	PF08784	0.464
LIG_SH2_CRK	404	408	PF00017	0.510
LIG_SH2_CRK	416	420	PF00017	0.400
LIG_SH2_NCK_1	388	392	PF00017	0.482
LIG_SH2_PTP2	140	143	PF00017	0.247
LIG_SH2_SRC	227	230	PF00017	0.280
LIG_SH2_STAP1	364	368	PF00017	0.303
LIG_SH2_STAP1	416	420	PF00017	0.456
LIG_SH2_STAT5	140	143	PF00017	0.256
LIG_SH2_STAT5	149	152	PF00017	0.293
LIG_SH2_STAT5	195	198	PF00017	0.324
LIG_SH2_STAT5	269	272	PF00017	0.326
LIG_SH2_STAT5	318	321	PF00017	0.303
LIG_SH2_STAT5	364	367	PF00017	0.347
LIG_SH3_3	139	145	PF00018	0.268
LIG_SH3_3	205	211	PF00018	0.420
LIG_SH3_3	30	36	PF00018	0.681
LIG_SH3_3	396	402	PF00018	0.412
LIG_SH3_3	8	14	PF00018	0.668
LIG_SUMO_SIM_par_1	140	146	PF11976	0.268
LIG_SUMO_SIM_par_1	243	249	PF11976	0.507
LIG_SUMO_SIM_par_1	405	412	PF11976	0.410
LIG_TRAF2_1	191	194	PF00917	0.290
LIG_UBA3_1	244	252	PF00899	0.505
LIG_UBA3_1	372	378	PF00899	0.403
LIG_UBA3_1	48	54	PF00899	0.500
LIG_WRC_WIRS_1	77	82	PF05994	0.458
MOD_CDK_SPxxK_3	47	54	PF00069	0.511
MOD_CK1_1	188	194	PF00069	0.366
MOD_CK1_1	19	25	PF00069	0.680
MOD_CK1_1	219	225	PF00069	0.296
MOD_CK1_1	31	37	PF00069	0.641
MOD_CK1_1	50	56	PF00069	0.592
MOD_CK2_1	188	194	PF00069	0.376
MOD_CK2_1	374	380	PF00069	0.424
MOD_CK2_1	82	88	PF00069	0.526
MOD_GlcNHglycan	187	190	PF01048	0.378
MOD_GSK3_1	130	137	PF00069	0.348
MOD_GSK3_1	143	150	PF00069	0.213
MOD_GSK3_1	27	34	PF00069	0.606
MOD_GSK3_1	422	429	PF00069	0.542
MOD_N-GLC_1	22	27	PF02516	0.723
MOD_N-GLC_2	323	325	PF02516	0.352
MOD_NEK2_1	155	160	PF00069	0.268
MOD_NEK2_1	275	280	PF00069	0.304
MOD_NEK2_1	288	293	PF00069	0.389
MOD_NEK2_1	37	42	PF00069	0.594
MOD_NEK2_1	386	391	PF00069	0.481
MOD_OFUCOSY	361	366	PF10250	0.334
MOD_PIKK_1	216	222	PF00454	0.420
MOD_PIKK_1	283	289	PF00454	0.480
MOD_PIKK_1	420	426	PF00454	0.509
MOD_PIKK_1	91	97	PF00454	0.453
MOD_PKA_1	107	113	PF00069	0.268
MOD_PKA_1	3	9	PF00069	0.540
MOD_PKA_1	384	390	PF00069	0.479
MOD_PKA_2	107	113	PF00069	0.285
MOD_PKA_2	3	9	PF00069	0.633
MOD_PKA_2	91	97	PF00069	0.415
MOD_Plk_1	180	186	PF00069	0.268
MOD_Plk_1	22	28	PF00069	0.680
MOD_Plk_1	305	311	PF00069	0.435
MOD_Plk_4	155	161	PF00069	0.277
MOD_Plk_4	338	344	PF00069	0.508
MOD_ProDKin_1	29	35	PF00069	0.694
MOD_ProDKin_1	47	53	PF00069	0.512
MOD_SUMO_rev_2	58	67	PF00179	0.460
TRG_ENDOCYTIC_2	140	143	PF00928	0.247
TRG_ENDOCYTIC_2	318	321	PF00928	0.350
TRG_ENDOCYTIC_2	327	330	PF00928	0.435
TRG_ENDOCYTIC_2	404	407	PF00928	0.517
TRG_ENDOCYTIC_2	416	419	PF00928	0.452
TRG_ER_diArg_1	2	4	PF00400	0.625
TRG_ER_FFAT_2	360	369	PF00635	0.403
TRG_NLS_Bipartite_1	92	110	PF00514	0.402
TRG_NLS_MonoExtC_3	105	111	PF00514	0.369
TRG_NLS_MonoExtN_4	103	110	PF00514	0.373
TRG_Pf-PMV_PEXEL_1	405	410	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	59	64	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMC6	Leptomonas seymouri	83%	99%
A0A0S4JYA2	Bodo saltans	63%	100%
A0A1X0NZJ4	Trypanosomatidae	66%	88%
A0A3R7N4K9	Trypanosoma rangeli	69%	94%
A4HE88	Leishmania braziliensis	89%	100%
A4I1N4	Leishmania infantum	100%	100%
C9ZK83	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
C9ZK84	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9AXR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q9Q3	Leishmania major	97%	100%
V5BHX3	Trypanosoma cruzi	68%	99%