Leucine-rich repeat protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDD1_LEIDO

TriTrypDb:

LdBPK_323200.1 , LdCL_320038000 , LDHU3_32.4060

Length:

875

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

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Expansion

Sequence features

A0A3Q8IDD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDD1

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	570	574	PF00656	0.350
CLV_NRD_NRD_1	24	26	PF00675	0.431
CLV_NRD_NRD_1	579	581	PF00675	0.385
CLV_NRD_NRD_1	677	679	PF00675	0.386
CLV_NRD_NRD_1	7	9	PF00675	0.618
CLV_PCSK_KEX2_1	677	679	PF00082	0.404
CLV_PCSK_KEX2_1	681	683	PF00082	0.514
CLV_PCSK_KEX2_1	7	9	PF00082	0.617
CLV_PCSK_KEX2_1	727	729	PF00082	0.613
CLV_PCSK_KEX2_1	81	83	PF00082	0.423

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IME5	Leptomonas seymouri	79%	90%
A0A0S4II95	Bodo saltans	53%	100%
A0A1X0NRQ9	Trypanosomatidae	61%	90%
A0A422NYS0	Trypanosoma rangeli	61%	95%
A4HKU6	Leishmania braziliensis	83%	100%
A4I8C5	Leishmania infantum	100%	100%
D0AAU7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	90%
E9B384	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q4X1	Leishmania major	96%	100%
V5BQQ6	Trypanosoma cruzi	62%	96%

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