Leucine-rich repeat protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDD1_LEIDO

TriTrypDb:

LdBPK_323200.1 , LdCL_320038000 , LDHU3_32.4060

Length:

875

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

A0A3Q8IDD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDD1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	570	574	PF00656	0.350
CLV_NRD_NRD_1	24	26	PF00675	0.431
CLV_NRD_NRD_1	579	581	PF00675	0.385
CLV_NRD_NRD_1	677	679	PF00675	0.386
CLV_NRD_NRD_1	7	9	PF00675	0.618
CLV_PCSK_KEX2_1	677	679	PF00082	0.404
CLV_PCSK_KEX2_1	681	683	PF00082	0.514
CLV_PCSK_KEX2_1	7	9	PF00082	0.617
CLV_PCSK_KEX2_1	727	729	PF00082	0.613
CLV_PCSK_KEX2_1	81	83	PF00082	0.423
CLV_PCSK_PC1ET2_1	681	683	PF00082	0.574
CLV_PCSK_PC1ET2_1	727	729	PF00082	0.546
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.423
CLV_PCSK_PC7_1	677	683	PF00082	0.503
CLV_PCSK_SKI1_1	32	36	PF00082	0.425
CLV_PCSK_SKI1_1	531	535	PF00082	0.477
CLV_PCSK_SKI1_1	546	550	PF00082	0.380
CLV_PCSK_SKI1_1	628	632	PF00082	0.412
CLV_PCSK_SKI1_1	722	726	PF00082	0.430
CLV_PCSK_SKI1_1	801	805	PF00082	0.511
DEG_APCC_DBOX_1	24	32	PF00400	0.504
DEG_SCF_FBW7_1	805	812	PF00400	0.505
DOC_ANK_TNKS_1	340	347	PF00023	0.290
DOC_CDC14_PxL_1	124	132	PF14671	0.290
DOC_CDC14_PxL_1	143	151	PF14671	0.290
DOC_CKS1_1	438	443	PF01111	0.370
DOC_CYCLIN_RxL_1	749	759	PF00134	0.425
DOC_CYCLIN_yCln2_LP_2	631	637	PF00134	0.388
DOC_MAPK_gen_1	25	36	PF00069	0.457
DOC_MAPK_MEF2A_6	59	68	PF00069	0.377
DOC_MAPK_RevD_3	714	728	PF00069	0.357
DOC_PP2B_LxvP_1	331	334	PF13499	0.290
DOC_USP7_MATH_1	117	121	PF00917	0.338
DOC_USP7_MATH_1	393	397	PF00917	0.567
DOC_USP7_MATH_1	555	559	PF00917	0.551
DOC_USP7_MATH_1	638	642	PF00917	0.405
DOC_USP7_MATH_1	809	813	PF00917	0.530
DOC_USP7_UBL2_3	198	202	PF12436	0.497
DOC_USP7_UBL2_3	581	585	PF12436	0.560
DOC_USP7_UBL2_3	598	602	PF12436	0.515
DOC_WW_Pin1_4	389	394	PF00397	0.486
DOC_WW_Pin1_4	406	411	PF00397	0.329
DOC_WW_Pin1_4	437	442	PF00397	0.344
DOC_WW_Pin1_4	483	488	PF00397	0.415
DOC_WW_Pin1_4	516	521	PF00397	0.355
DOC_WW_Pin1_4	539	544	PF00397	0.524
DOC_WW_Pin1_4	586	591	PF00397	0.498
DOC_WW_Pin1_4	612	617	PF00397	0.332
DOC_WW_Pin1_4	687	692	PF00397	0.573
DOC_WW_Pin1_4	709	714	PF00397	0.348
DOC_WW_Pin1_4	80	85	PF00397	0.392
DOC_WW_Pin1_4	805	810	PF00397	0.391
LIG_14-3-3_CanoR_1	131	136	PF00244	0.290
LIG_14-3-3_CanoR_1	387	393	PF00244	0.376
LIG_Actin_WH2_2	66	83	PF00022	0.425
LIG_AP2alpha_2	498	500	PF02296	0.400
LIG_BIR_II_1	1	5	PF00653	0.653
LIG_BRCT_BRCA1_1	133	137	PF00533	0.290
LIG_BRCT_BRCA1_1	298	302	PF00533	0.362
LIG_Clathr_ClatBox_1	180	184	PF01394	0.355
LIG_Clathr_ClatBox_1	51	55	PF01394	0.470
LIG_Clathr_ClatBox_1	63	67	PF01394	0.442
LIG_FHA_1	108	114	PF00498	0.313
LIG_FHA_1	152	158	PF00498	0.290
LIG_FHA_1	276	282	PF00498	0.486
LIG_FHA_1	309	315	PF00498	0.384
LIG_FHA_1	328	334	PF00498	0.277
LIG_FHA_1	410	416	PF00498	0.376
LIG_FHA_1	533	539	PF00498	0.410
LIG_FHA_1	545	551	PF00498	0.393
LIG_FHA_1	595	601	PF00498	0.416
LIG_FHA_1	654	660	PF00498	0.533
LIG_FHA_1	718	724	PF00498	0.486
LIG_FHA_1	72	78	PF00498	0.429
LIG_FHA_1	81	87	PF00498	0.348
LIG_FHA_1	819	825	PF00498	0.532
LIG_FHA_2	139	145	PF00498	0.491
LIG_FHA_2	409	415	PF00498	0.382
LIG_FHA_2	504	510	PF00498	0.411
LIG_FHA_2	697	703	PF00498	0.400
LIG_FHA_2	762	768	PF00498	0.457
LIG_FHA_2	795	801	PF00498	0.604
LIG_FHA_2	857	863	PF00498	0.747
LIG_Integrin_isoDGR_2	5	7	PF01839	0.625
LIG_LIR_Apic_2	284	289	PF02991	0.389
LIG_LIR_Gen_1	103	113	PF02991	0.368
LIG_LIR_Gen_1	134	143	PF02991	0.290
LIG_LIR_Gen_1	235	246	PF02991	0.528
LIG_LIR_Gen_1	394	403	PF02991	0.461
LIG_LIR_Gen_1	40	51	PF02991	0.344
LIG_LIR_Gen_1	430	441	PF02991	0.374
LIG_LIR_Gen_1	573	582	PF02991	0.404
LIG_LIR_Gen_1	779	789	PF02991	0.430
LIG_LIR_Nem_3	103	108	PF02991	0.374
LIG_LIR_Nem_3	119	124	PF02991	0.312
LIG_LIR_Nem_3	134	140	PF02991	0.283
LIG_LIR_Nem_3	141	146	PF02991	0.290
LIG_LIR_Nem_3	235	241	PF02991	0.557
LIG_LIR_Nem_3	285	291	PF02991	0.393
LIG_LIR_Nem_3	337	343	PF02991	0.306
LIG_LIR_Nem_3	394	400	PF02991	0.455
LIG_LIR_Nem_3	40	46	PF02991	0.353
LIG_LIR_Nem_3	430	436	PF02991	0.389
LIG_LIR_Nem_3	469	474	PF02991	0.465
LIG_LIR_Nem_3	479	485	PF02991	0.333
LIG_LIR_Nem_3	498	503	PF02991	0.264
LIG_LIR_Nem_3	517	521	PF02991	0.341
LIG_LIR_Nem_3	573	579	PF02991	0.396
LIG_LIR_Nem_3	587	591	PF02991	0.445
LIG_LIR_Nem_3	779	785	PF02991	0.433
LIG_LIR_Nem_3	806	810	PF02991	0.394
LIG_LYPXL_S_1	287	291	PF13949	0.428
LIG_LYPXL_yS_3	146	149	PF13949	0.325
LIG_LYPXL_yS_3	288	291	PF13949	0.428
LIG_PDZ_Class_2	870	875	PF00595	0.551
LIG_PTB_Apo_2	425	432	PF02174	0.508
LIG_RPA_C_Fungi	228	240	PF08784	0.473
LIG_SH2_CRK	340	344	PF00017	0.290
LIG_SH2_CRK	43	47	PF00017	0.442
LIG_SH2_CRK	588	592	PF00017	0.534
LIG_SH2_CRK	807	811	PF00017	0.396
LIG_SH2_GRB2like	426	429	PF00017	0.523
LIG_SH2_NCK_1	397	401	PF00017	0.418
LIG_SH2_NCK_1	588	592	PF00017	0.483
LIG_SH2_NCK_1	614	618	PF00017	0.367
LIG_SH2_SRC	286	289	PF00017	0.425
LIG_SH2_SRC	332	335	PF00017	0.295
LIG_SH2_SRC	426	429	PF00017	0.446
LIG_SH2_STAP1	338	342	PF00017	0.306
LIG_SH2_STAP1	39	43	PF00017	0.402
LIG_SH2_STAT5	238	241	PF00017	0.479
LIG_SH2_STAT5	286	289	PF00017	0.400
LIG_SH2_STAT5	326	329	PF00017	0.294
LIG_SH2_STAT5	332	335	PF00017	0.284
LIG_SH2_STAT5	342	345	PF00017	0.271
LIG_SH2_STAT5	408	411	PF00017	0.386
LIG_SH2_STAT5	426	429	PF00017	0.362
LIG_SH2_STAT5	435	438	PF00017	0.333
LIG_SH2_STAT5	45	48	PF00017	0.350
LIG_SH2_STAT5	470	473	PF00017	0.386
LIG_SH2_STAT5	588	591	PF00017	0.422
LIG_SH2_STAT5	599	602	PF00017	0.406
LIG_SH2_STAT5	609	612	PF00017	0.371
LIG_SH2_STAT5	614	617	PF00017	0.365
LIG_SH2_STAT5	663	666	PF00017	0.389
LIG_SH2_STAT5	760	763	PF00017	0.384
LIG_SH2_STAT5	792	795	PF00017	0.400
LIG_SH2_STAT5	807	810	PF00017	0.381
LIG_SH3_3	144	150	PF00018	0.298
LIG_SH3_3	155	161	PF00018	0.274
LIG_SH3_3	438	444	PF00018	0.398
LIG_SH3_3	493	499	PF00018	0.536
LIG_SH3_3	597	603	PF00018	0.574
LIG_SH3_3	731	737	PF00018	0.447
LIG_SH3_3	742	748	PF00018	0.351
LIG_SH3_3	771	777	PF00018	0.484
LIG_SH3_5	334	338	PF00018	0.325
LIG_SUMO_SIM_anti_2	61	67	PF11976	0.379
LIG_SUMO_SIM_anti_2	643	650	PF11976	0.543
LIG_SUMO_SIM_par_1	179	184	PF11976	0.399
LIG_SUMO_SIM_par_1	260	265	PF11976	0.512
LIG_SUMO_SIM_par_1	311	317	PF11976	0.306
LIG_SUMO_SIM_par_1	61	67	PF11976	0.346
LIG_SUMO_SIM_par_1	655	660	PF11976	0.377
LIG_TRAF2_1	375	378	PF00917	0.647
LIG_TRAF2_1	860	863	PF00917	0.715
LIG_TYR_ITAM	573	591	PF00017	0.362
LIG_TYR_ITIM	805	810	PF00017	0.391
LIG_WRC_WIRS_1	118	123	PF05994	0.344
LIG_WRC_WIRS_1	140	145	PF05994	0.268
LIG_WRC_WIRS_1	51	56	PF05994	0.416
MOD_CDK_SPxK_1	437	443	PF00069	0.476
MOD_CDK_SPxK_1	516	522	PF00069	0.357
MOD_CDK_SPxK_1	709	715	PF00069	0.351
MOD_CDK_SPxK_1	805	811	PF00069	0.392
MOD_CDK_SPxxK_3	539	546	PF00069	0.435
MOD_CK1_1	142	148	PF00069	0.313
MOD_CK1_1	355	361	PF00069	0.428
MOD_CK1_1	391	397	PF00069	0.520
MOD_CK1_1	439	445	PF00069	0.466
MOD_CK1_1	532	538	PF00069	0.408
MOD_CK1_1	643	649	PF00069	0.408
MOD_CK1_1	683	689	PF00069	0.533
MOD_CK1_1	849	855	PF00069	0.763
MOD_CK1_1	857	863	PF00069	0.690
MOD_CK1_1	864	870	PF00069	0.699
MOD_CK2_1	138	144	PF00069	0.349
MOD_CK2_1	27	33	PF00069	0.416
MOD_CK2_1	485	491	PF00069	0.495
MOD_CK2_1	66	72	PF00069	0.337
MOD_CK2_1	761	767	PF00069	0.598
MOD_CK2_1	856	862	PF00069	0.709
MOD_CK2_1	866	872	PF00069	0.620
MOD_Cter_Amidation	5	8	PF01082	0.629
MOD_GlcNHglycan	18	21	PF01048	0.486
MOD_GlcNHglycan	294	297	PF01048	0.325
MOD_GlcNHglycan	393	396	PF01048	0.572
MOD_GlcNHglycan	487	490	PF01048	0.530
MOD_GlcNHglycan	591	594	PF01048	0.573
MOD_GlcNHglycan	667	670	PF01048	0.494
MOD_GlcNHglycan	830	835	PF01048	0.720
MOD_GSK3_1	107	114	PF00069	0.338
MOD_GSK3_1	138	145	PF00069	0.412
MOD_GSK3_1	292	299	PF00069	0.356
MOD_GSK3_1	308	315	PF00069	0.428
MOD_GSK3_1	348	355	PF00069	0.428
MOD_GSK3_1	389	396	PF00069	0.423
MOD_GSK3_1	402	409	PF00069	0.391
MOD_GSK3_1	661	668	PF00069	0.608
MOD_GSK3_1	683	690	PF00069	0.483
MOD_GSK3_1	703	710	PF00069	0.431
MOD_GSK3_1	761	768	PF00069	0.453
MOD_GSK3_1	790	797	PF00069	0.498
MOD_GSK3_1	805	812	PF00069	0.418
MOD_GSK3_1	842	849	PF00069	0.679
MOD_GSK3_1	850	857	PF00069	0.654
MOD_GSK3_1	858	865	PF00069	0.701
MOD_N-GLC_1	138	143	PF02516	0.325
MOD_N-GLC_1	308	313	PF02516	0.298
MOD_N-GLC_1	476	481	PF02516	0.500
MOD_N-GLC_1	594	599	PF02516	0.417
MOD_N-GLC_2	416	418	PF02516	0.404
MOD_NEK2_1	282	287	PF00069	0.521
MOD_NEK2_1	327	332	PF00069	0.326
MOD_NEK2_1	436	441	PF00069	0.346
MOD_NEK2_1	452	457	PF00069	0.398
MOD_NEK2_1	66	71	PF00069	0.318
MOD_NEK2_1	803	808	PF00069	0.459
MOD_NEK2_1	848	853	PF00069	0.633
MOD_NEK2_1	866	871	PF00069	0.605
MOD_NEK2_1	89	94	PF00069	0.345
MOD_PIKK_1	555	561	PF00454	0.521
MOD_PIKK_1	851	857	PF00454	0.749
MOD_PKA_1	680	686	PF00069	0.503
MOD_PKA_2	276	282	PF00069	0.502
MOD_PKB_1	231	239	PF00069	0.299
MOD_Plk_1	138	144	PF00069	0.325
MOD_Plk_1	32	38	PF00069	0.421
MOD_Plk_1	402	408	PF00069	0.415
MOD_Plk_1	429	435	PF00069	0.516
MOD_Plk_1	476	482	PF00069	0.449
MOD_Plk_1	66	72	PF00069	0.330
MOD_Plk_1	707	713	PF00069	0.415
MOD_Plk_1	861	867	PF00069	0.691
MOD_Plk_2-3	209	215	PF00069	0.452
MOD_Plk_2-3	312	318	PF00069	0.428
MOD_Plk_2-3	50	56	PF00069	0.468
MOD_Plk_4	282	288	PF00069	0.516
MOD_Plk_4	327	333	PF00069	0.294
MOD_Plk_4	379	385	PF00069	0.462
MOD_Plk_4	476	482	PF00069	0.455
MOD_Plk_4	571	577	PF00069	0.384
MOD_Plk_4	643	649	PF00069	0.538
MOD_Plk_4	765	771	PF00069	0.520
MOD_ProDKin_1	389	395	PF00069	0.491
MOD_ProDKin_1	406	412	PF00069	0.331
MOD_ProDKin_1	437	443	PF00069	0.351
MOD_ProDKin_1	483	489	PF00069	0.418
MOD_ProDKin_1	516	522	PF00069	0.357
MOD_ProDKin_1	539	545	PF00069	0.519
MOD_ProDKin_1	586	592	PF00069	0.503
MOD_ProDKin_1	612	618	PF00069	0.333
MOD_ProDKin_1	687	693	PF00069	0.569
MOD_ProDKin_1	709	715	PF00069	0.351
MOD_ProDKin_1	80	86	PF00069	0.385
MOD_ProDKin_1	805	811	PF00069	0.392
MOD_SUMO_for_1	58	61	PF00179	0.450
MOD_SUMO_for_1	601	604	PF00179	0.424
MOD_SUMO_for_1	770	773	PF00179	0.439
MOD_SUMO_rev_2	524	533	PF00179	0.430
MOD_SUMO_rev_2	53	60	PF00179	0.443
MOD_SUMO_rev_2	733	742	PF00179	0.452
TRG_DiLeu_BaEn_3	251	257	PF01217	0.484
TRG_ENDOCYTIC_2	146	149	PF00928	0.306
TRG_ENDOCYTIC_2	168	171	PF00928	0.349
TRG_ENDOCYTIC_2	238	241	PF00928	0.479
TRG_ENDOCYTIC_2	288	291	PF00928	0.428
TRG_ENDOCYTIC_2	340	343	PF00928	0.296
TRG_ENDOCYTIC_2	397	400	PF00928	0.421
TRG_ENDOCYTIC_2	43	46	PF00928	0.344
TRG_ENDOCYTIC_2	435	438	PF00928	0.333
TRG_ENDOCYTIC_2	576	579	PF00928	0.376
TRG_ENDOCYTIC_2	588	591	PF00928	0.428
TRG_ENDOCYTIC_2	609	612	PF00928	0.402
TRG_ENDOCYTIC_2	807	810	PF00928	0.394
TRG_ER_diArg_1	676	678	PF00400	0.371
TRG_NES_CRM1_1	50	61	PF08389	0.417
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.290

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IME5	Leptomonas seymouri	79%	90%
A0A0S4II95	Bodo saltans	53%	100%
A0A1X0NRQ9	Trypanosomatidae	61%	90%
A0A422NYS0	Trypanosoma rangeli	61%	95%
A4HKU6	Leishmania braziliensis	83%	100%
A4I8C5	Leishmania infantum	100%	100%
D0AAU7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	90%
E9B384	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q4X1	Leishmania major	96%	100%
V5BQQ6	Trypanosoma cruzi	62%	96%