Epsin, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Epsin, putative

Gene product:

epsin, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDD0_LEIDO

TriTrypDb:

LdBPK_250680.1 , LdCL_250012000 , LDHU3_25.0800

Length:

552

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0030117	membrane coat	3	1
GO:0030118	clathrin coat	4	1
GO:0030120	vesicle coat	4	1
GO:0030125	clathrin vesicle coat	5	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0098796	membrane protein complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IDD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDD0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0005543	phospholipid binding	3	1
GO:0008289	lipid binding	2	1
GO:0030276	clathrin binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	353	357	PF00656	0.432
CLV_C14_Caspase3-7	387	391	PF00656	0.568
CLV_NRD_NRD_1	245	247	PF00675	0.537
CLV_NRD_NRD_1	295	297	PF00675	0.571
CLV_PCSK_FUR_1	293	297	PF00082	0.610
CLV_PCSK_KEX2_1	245	247	PF00082	0.537
CLV_PCSK_KEX2_1	295	297	PF00082	0.585
CLV_PCSK_PC7_1	241	247	PF00082	0.518
CLV_PCSK_SKI1_1	77	81	PF00082	0.245
DEG_Nend_UBRbox_3	1	3	PF02207	0.550
DOC_CYCLIN_RxL_1	73	83	PF00134	0.245
DOC_CYCLIN_yCln2_LP_2	406	412	PF00134	0.497
DOC_MAPK_gen_1	293	301	PF00069	0.623
DOC_MAPK_MEF2A_6	230	239	PF00069	0.567
DOC_PP2B_LxvP_1	330	333	PF13499	0.501
DOC_PP4_FxxP_1	331	334	PF00568	0.579
DOC_PP4_FxxP_1	336	339	PF00568	0.735
DOC_USP7_MATH_1	18	22	PF00917	0.427
DOC_USP7_MATH_1	205	209	PF00917	0.699
DOC_USP7_MATH_1	344	348	PF00917	0.604
DOC_USP7_MATH_1	350	354	PF00917	0.547
DOC_USP7_MATH_1	399	403	PF00917	0.743
DOC_USP7_MATH_1	425	429	PF00917	0.675
DOC_USP7_MATH_1	482	486	PF00917	0.737
DOC_USP7_MATH_1	525	529	PF00917	0.693
DOC_WW_Pin1_4	167	172	PF00397	0.481
DOC_WW_Pin1_4	209	214	PF00397	0.649
DOC_WW_Pin1_4	309	314	PF00397	0.602
LIG_14-3-3_CanoR_1	105	113	PF00244	0.263
LIG_14-3-3_CanoR_1	194	199	PF00244	0.731
LIG_14-3-3_CanoR_1	246	254	PF00244	0.457
LIG_AP2alpha_2	349	351	PF02296	0.407
LIG_AP2alpha_2	465	467	PF02296	0.571
LIG_APCC_Cbox_2	91	97	PF00515	0.358
LIG_BIR_III_4	390	394	PF00653	0.598
LIG_BRCT_BRCA1_1	107	111	PF00533	0.245
LIG_Clathr_ClatBox_1	79	83	PF01394	0.245
LIG_deltaCOP1_diTrp_1	390	398	PF00928	0.539
LIG_EVH1_1	318	322	PF00568	0.495
LIG_FHA_1	2	8	PF00498	0.514
LIG_FHA_1	258	264	PF00498	0.323
LIG_FHA_1	322	328	PF00498	0.560
LIG_FHA_2	17	23	PF00498	0.398
LIG_FHA_2	222	228	PF00498	0.458
LIG_FHA_2	273	279	PF00498	0.594
LIG_FHA_2	29	35	PF00498	0.210
LIG_FHA_2	385	391	PF00498	0.566
LIG_GBD_Chelix_1	132	140	PF00786	0.378
LIG_GBD_Chelix_1	148	156	PF00786	0.534
LIG_LIR_Apic_2	110	116	PF02991	0.378
LIG_LIR_Apic_2	328	334	PF02991	0.544
LIG_LIR_Apic_2	367	371	PF02991	0.574
LIG_LIR_Apic_2	390	395	PF02991	0.740
LIG_LIR_Apic_2	430	436	PF02991	0.740
LIG_LIR_Apic_2	465	470	PF02991	0.671
LIG_LIR_Apic_2	511	517	PF02991	0.664
LIG_LIR_Gen_1	21	30	PF02991	0.249
LIG_LIR_Gen_1	349	355	PF02991	0.424
LIG_LIR_Nem_3	12	16	PF02991	0.378
LIG_LIR_Nem_3	21	26	PF02991	0.211
LIG_LIR_Nem_3	349	354	PF02991	0.413
LIG_LIR_Nem_3	485	491	PF02991	0.638
LIG_Pex14_1	488	492	PF04695	0.517
LIG_Pex14_1	72	76	PF04695	0.245
LIG_SH2_CRK	113	117	PF00017	0.379
LIG_SH2_CRK	492	496	PF00017	0.496
LIG_SH2_CRK	76	80	PF00017	0.245
LIG_SH2_GRB2like	113	116	PF00017	0.378
LIG_SH2_PTP2	23	26	PF00017	0.323
LIG_SH2_STAP1	258	262	PF00017	0.559
LIG_SH2_STAT5	113	116	PF00017	0.249
LIG_SH2_STAT5	23	26	PF00017	0.323
LIG_SH2_STAT5	93	96	PF00017	0.349
LIG_SH3_1	35	41	PF00018	0.309
LIG_SH3_3	296	302	PF00018	0.706
LIG_SH3_3	311	317	PF00018	0.589
LIG_SH3_3	338	344	PF00018	0.614
LIG_SH3_3	35	41	PF00018	0.277
LIG_SH3_3	406	412	PF00018	0.602
LIG_SH3_3	475	481	PF00018	0.521
LIG_SUMO_SIM_anti_2	21	29	PF11976	0.239
LIG_SUMO_SIM_anti_2	78	83	PF11976	0.263
LIG_SUMO_SIM_par_1	78	83	PF11976	0.246
LIG_TRAF2_1	224	227	PF00917	0.462
LIG_TRAF2_1	326	329	PF00917	0.490
LIG_TRAF2_2	460	465	PF00917	0.498
LIG_TRAF2_2	507	512	PF00917	0.565
LIG_WRC_WIRS_1	351	356	PF05994	0.462
MOD_CDK_SPxK_1	309	315	PF00069	0.698
MOD_CK1_1	170	176	PF00069	0.568
MOD_CK1_1	208	214	PF00069	0.576
MOD_CK1_1	247	253	PF00069	0.568
MOD_CK1_1	300	306	PF00069	0.601
MOD_CK1_1	451	457	PF00069	0.724
MOD_CK1_1	484	490	PF00069	0.734
MOD_CK1_1	528	534	PF00069	0.565
MOD_CK2_1	121	127	PF00069	0.245
MOD_CK2_1	16	22	PF00069	0.311
MOD_CK2_1	221	227	PF00069	0.494
MOD_CK2_1	28	34	PF00069	0.245
MOD_CK2_1	6	12	PF00069	0.409
MOD_GlcNHglycan	167	170	PF01048	0.587
MOD_GlcNHglycan	172	175	PF01048	0.660
MOD_GlcNHglycan	182	185	PF01048	0.481
MOD_GlcNHglycan	246	249	PF01048	0.501
MOD_GlcNHglycan	346	349	PF01048	0.633
MOD_GlcNHglycan	358	361	PF01048	0.701
MOD_GlcNHglycan	423	426	PF01048	0.597
MOD_GlcNHglycan	450	453	PF01048	0.638
MOD_GlcNHglycan	503	506	PF01048	0.713
MOD_GlcNHglycan	530	533	PF01048	0.629
MOD_GSK3_1	103	110	PF00069	0.272
MOD_GSK3_1	154	161	PF00069	0.558
MOD_GSK3_1	18	25	PF00069	0.255
MOD_GSK3_1	205	212	PF00069	0.634
MOD_GSK3_1	217	224	PF00069	0.516
MOD_GSK3_1	303	310	PF00069	0.647
MOD_GSK3_1	350	357	PF00069	0.557
MOD_GSK3_1	421	428	PF00069	0.687
MOD_N-GLC_1	1	6	PF02516	0.532
MOD_N-GLC_1	158	163	PF02516	0.613
MOD_N-GLC_1	448	453	PF02516	0.620
MOD_NEK2_1	1	6	PF00069	0.516
MOD_NEK2_1	103	108	PF00069	0.266
MOD_NEK2_1	111	116	PF00069	0.226
MOD_NEK2_1	257	262	PF00069	0.452
MOD_NEK2_1	354	359	PF00069	0.495
MOD_NEK2_1	510	515	PF00069	0.760
MOD_NEK2_1	526	531	PF00069	0.551
MOD_PIKK_1	1	7	PF00454	0.530
MOD_PIKK_1	334	340	PF00454	0.569
MOD_PIKK_1	438	444	PF00454	0.770
MOD_PKA_2	244	250	PF00069	0.648
MOD_PKA_2	543	549	PF00069	0.457
MOD_PKB_1	192	200	PF00069	0.500
MOD_Plk_1	68	74	PF00069	0.288
MOD_Plk_4	107	113	PF00069	0.294
MOD_Plk_4	214	220	PF00069	0.490
MOD_Plk_4	22	28	PF00069	0.352
MOD_Plk_4	350	356	PF00069	0.499
MOD_Plk_4	75	81	PF00069	0.277
MOD_ProDKin_1	167	173	PF00069	0.479
MOD_ProDKin_1	209	215	PF00069	0.650
MOD_ProDKin_1	309	315	PF00069	0.603
TRG_AP2beta_CARGO_1	349	358	PF09066	0.419
TRG_DiLeu_BaEn_1	96	101	PF01217	0.378
TRG_DiLeu_BaLyEn_6	99	104	PF01217	0.307
TRG_ENDOCYTIC_2	178	181	PF00928	0.559
TRG_ENDOCYTIC_2	23	26	PF00928	0.288
TRG_ENDOCYTIC_2	76	79	PF00928	0.245
TRG_ER_diArg_1	293	296	PF00400	0.525
TRG_ER_diArg_1	61	64	PF00400	0.378
TRG_Pf-PMV_PEXEL_1	92	96	PF00026	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCI1	Leptomonas seymouri	54%	99%
A0A1X0P4K8	Trypanosomatidae	37%	100%
A0A422NX91	Trypanosoma rangeli	44%	100%
A4HDZ7	Leishmania braziliensis	61%	97%
A4I1A8	Leishmania infantum	98%	100%
D0A5J9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AXE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	87%
O95208	Homo sapiens	26%	86%
Q4QA28	Leishmania major	75%	97%
Q8CHU3	Mus musculus	26%	93%
V5BXH3	Trypanosoma cruzi	43%	100%