Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDC8_LEIDO

TriTrypDb:

LdBPK_191220.1 , LdCL_190017300 , LDHU3_19.1470

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IDC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDC8

PDB structure(s): 7aih_Aq , 7ane_Aq

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	67	71	PF00656	0.697
CLV_NRD_NRD_1	178	180	PF00675	0.638
CLV_NRD_NRD_1	321	323	PF00675	0.572
CLV_PCSK_FUR_1	176	180	PF00082	0.451
CLV_PCSK_KEX2_1	178	180	PF00082	0.638
CLV_PCSK_KEX2_1	321	323	PF00082	0.563
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.563
DEG_Nend_Nbox_1	1	3	PF02207	0.461
DEG_SPOP_SBC_1	64	68	PF00917	0.559
DOC_CYCLIN_yCln2_LP_2	159	165	PF00134	0.475
DOC_CYCLIN_yCln2_LP_2	247	253	PF00134	0.533
DOC_MAPK_gen_1	129	137	PF00069	0.405
DOC_MAPK_MEF2A_6	120	128	PF00069	0.424
DOC_MAPK_MEF2A_6	35	42	PF00069	0.493
DOC_MAPK_NFAT4_5	35	43	PF00069	0.490
DOC_PP2B_LxvP_1	26	29	PF13499	0.549
DOC_USP7_MATH_1	190	194	PF00917	0.673
DOC_USP7_MATH_1	257	261	PF00917	0.639
DOC_USP7_MATH_1	295	299	PF00917	0.550
DOC_USP7_MATH_1	64	68	PF00917	0.712
LIG_14-3-3_CanoR_1	100	108	PF00244	0.691
LIG_14-3-3_CanoR_1	129	137	PF00244	0.441
LIG_14-3-3_CanoR_1	273	282	PF00244	0.566
LIG_14-3-3_CanoR_1	322	328	PF00244	0.570
LIG_FHA_1	111	117	PF00498	0.566
LIG_FHA_1	130	136	PF00498	0.478
LIG_FHA_1	202	208	PF00498	0.665
LIG_FHA_1	221	227	PF00498	0.313
LIG_LIR_Apic_2	160	164	PF02991	0.438
LIG_LIR_Apic_2	180	186	PF02991	0.474
LIG_LIR_Gen_1	169	177	PF02991	0.548
LIG_LIR_Nem_3	169	174	PF02991	0.543
LIG_LIR_Nem_3	276	282	PF02991	0.594
LIG_SH2_CRK	171	175	PF00017	0.537
LIG_SH2_CRK	183	187	PF00017	0.516
LIG_SH2_CRK	51	55	PF00017	0.660
LIG_SH2_NCK_1	183	187	PF00017	0.720
LIG_SH2_NCK_1	51	55	PF00017	0.631
LIG_SH2_STAT3	10	13	PF00017	0.549
LIG_SH2_STAT5	10	13	PF00017	0.549
LIG_SH3_3	247	253	PF00018	0.645
LIG_SH3_3	298	304	PF00018	0.470
LIG_SH3_3	9	15	PF00018	0.547
LIG_SUMO_SIM_anti_2	217	223	PF11976	0.502
LIG_TRAF2_1	197	200	PF00917	0.576
MOD_CK1_1	166	172	PF00069	0.481
MOD_CK1_1	217	223	PF00069	0.468
MOD_CK1_1	233	239	PF00069	0.520
MOD_CK1_1	265	271	PF00069	0.640
MOD_CK1_1	293	299	PF00069	0.567
MOD_GlcNHglycan	192	195	PF01048	0.590
MOD_GlcNHglycan	232	235	PF01048	0.741
MOD_GlcNHglycan	260	263	PF01048	0.664
MOD_GlcNHglycan	264	267	PF01048	0.654
MOD_GlcNHglycan	269	272	PF01048	0.588
MOD_GlcNHglycan	292	295	PF01048	0.489
MOD_GlcNHglycan	298	301	PF01048	0.422
MOD_GSK3_1	258	265	PF00069	0.628
MOD_N-GLC_1	102	107	PF02516	0.694
MOD_N-GLC_1	290	295	PF02516	0.486
MOD_NEK2_2	281	286	PF00069	0.478
MOD_PIKK_1	166	172	PF00454	0.532
MOD_PIKK_1	273	279	PF00454	0.595
MOD_PKA_1	321	327	PF00069	0.548
MOD_PKA_2	230	236	PF00069	0.679
MOD_PKA_2	296	302	PF00069	0.462
MOD_PKA_2	321	327	PF00069	0.548
MOD_Plk_1	102	108	PF00069	0.691
MOD_Plk_1	217	223	PF00069	0.560
MOD_Plk_1	64	70	PF00069	0.669
MOD_Plk_2-3	65	71	PF00069	0.667
MOD_Plk_4	217	223	PF00069	0.457
MOD_Plk_4	27	33	PF00069	0.517
MOD_SUMO_rev_2	311	318	PF00179	0.523
TRG_ENDOCYTIC_2	171	174	PF00928	0.535
TRG_ENDOCYTIC_2	51	54	PF00928	0.656
TRG_ER_diArg_1	128	131	PF00400	0.415
TRG_ER_diArg_1	135	138	PF00400	0.403
TRG_ER_diArg_1	176	179	PF00400	0.446
TRG_NLS_MonoExtC_3	320	325	PF00514	0.549
TRG_NLS_MonoExtN_4	321	326	PF00514	0.546
TRG_Pf-PMV_PEXEL_1	278	283	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM80	Leptomonas seymouri	65%	96%
A0A1X0P627	Trypanosomatidae	37%	100%
A0A3R7NH36	Trypanosoma rangeli	44%	100%
A4HA69	Leishmania braziliensis	84%	100%
A4HYE1	Leishmania infantum	100%	100%
D0A0S6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AS74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QD92	Leishmania major	94%	99%
V5AZ17	Trypanosoma cruzi	43%	100%