LeishMANIAdb
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Molybdenum cofactor biosynthesis protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Molybdenum cofactor biosynthesis protein, putative
Gene product:
molybdenum cofactor biosynthesis protein, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IDC7_LEIDO
TriTrypDb:
LdBPK_282840.1 * , LdCL_280033500 , LDHU3_28.3830
Length:
756

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IDC7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDC7

Function

Biological processes
Term Name Level Count
GO:0006777 Mo-molybdopterin cofactor biosynthetic process 5 6
GO:0006793 phosphorus metabolic process 3 6
GO:0006796 phosphate-containing compound metabolic process 4 6
GO:0006807 nitrogen compound metabolic process 2 6
GO:0008152 metabolic process 1 6
GO:0009058 biosynthetic process 2 6
GO:0009987 cellular process 1 6
GO:0018130 heterocycle biosynthetic process 4 6
GO:0019637 organophosphate metabolic process 3 6
GO:0019720 Mo-molybdopterin cofactor metabolic process 4 6
GO:0032324 molybdopterin cofactor biosynthetic process 4 6
GO:0043545 molybdopterin cofactor metabolic process 3 6
GO:0044237 cellular metabolic process 2 6
GO:0044249 cellular biosynthetic process 3 6
GO:0046483 heterocycle metabolic process 3 6
GO:0051189 prosthetic group metabolic process 2 6
GO:0071704 organic substance metabolic process 2 6
GO:0090407 organophosphate biosynthetic process 4 6
GO:1901360 organic cyclic compound metabolic process 3 6
GO:1901362 organic cyclic compound biosynthetic process 4 6
GO:1901564 organonitrogen compound metabolic process 3 6
GO:1901566 organonitrogen compound biosynthetic process 4 6
GO:1901576 organic substance biosynthetic process 3 6
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016829 lyase activity 2 1
GO:0016830 carbon-carbon lyase activity 3 1
GO:0016849 phosphorus-oxygen lyase activity 3 1
GO:0061798 GTP 3',8'-cyclase activity 4 1
GO:0061799 cyclic pyranopterin monophosphate synthase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 236 240 PF00656 0.591
CLV_C14_Caspase3-7 288 292 PF00656 0.669
CLV_C14_Caspase3-7 702 706 PF00656 0.652
CLV_NRD_NRD_1 277 279 PF00675 0.709
CLV_NRD_NRD_1 318 320 PF00675 0.681
CLV_NRD_NRD_1 404 406 PF00675 0.680
CLV_NRD_NRD_1 428 430 PF00675 0.673
CLV_NRD_NRD_1 499 501 PF00675 0.684
CLV_NRD_NRD_1 573 575 PF00675 0.690
CLV_NRD_NRD_1 585 587 PF00675 0.586
CLV_NRD_NRD_1 603 605 PF00675 0.575
CLV_NRD_NRD_1 613 615 PF00675 0.613
CLV_NRD_NRD_1 664 666 PF00675 0.688
CLV_NRD_NRD_1 697 699 PF00675 0.602
CLV_NRD_NRD_1 740 742 PF00675 0.690
CLV_NRD_NRD_1 76 78 PF00675 0.380
CLV_NRD_NRD_1 96 98 PF00675 0.199
CLV_PCSK_FUR_1 662 666 PF00082 0.539
CLV_PCSK_KEX2_1 167 169 PF00082 0.380
CLV_PCSK_KEX2_1 273 275 PF00082 0.712
CLV_PCSK_KEX2_1 277 279 PF00082 0.673
CLV_PCSK_KEX2_1 310 312 PF00082 0.616
CLV_PCSK_KEX2_1 318 320 PF00082 0.609
CLV_PCSK_KEX2_1 404 406 PF00082 0.655
CLV_PCSK_KEX2_1 428 430 PF00082 0.673
CLV_PCSK_KEX2_1 497 499 PF00082 0.693
CLV_PCSK_KEX2_1 524 526 PF00082 0.688
CLV_PCSK_KEX2_1 585 587 PF00082 0.674
CLV_PCSK_KEX2_1 662 664 PF00082 0.695
CLV_PCSK_KEX2_1 697 699 PF00082 0.639
CLV_PCSK_KEX2_1 749 751 PF00082 0.664
CLV_PCSK_KEX2_1 75 77 PF00082 0.380
CLV_PCSK_KEX2_1 754 756 PF00082 0.613
CLV_PCSK_KEX2_1 95 97 PF00082 0.199
CLV_PCSK_PC1ET2_1 167 169 PF00082 0.380
CLV_PCSK_PC1ET2_1 273 275 PF00082 0.712
CLV_PCSK_PC1ET2_1 310 312 PF00082 0.616
CLV_PCSK_PC1ET2_1 497 499 PF00082 0.693
CLV_PCSK_PC1ET2_1 524 526 PF00082 0.688
CLV_PCSK_PC1ET2_1 749 751 PF00082 0.664
CLV_PCSK_PC1ET2_1 754 756 PF00082 0.613
CLV_PCSK_PC7_1 750 756 PF00082 0.659
CLV_PCSK_PC7_1 91 97 PF00082 0.380
CLV_PCSK_SKI1_1 2 6 PF00082 0.642
CLV_PCSK_SKI1_1 435 439 PF00082 0.690
CLV_PCSK_SKI1_1 742 746 PF00082 0.686
CLV_PCSK_SKI1_1 750 754 PF00082 0.599
CLV_PCSK_SKI1_1 77 81 PF00082 0.380
CLV_PCSK_SKI1_1 91 95 PF00082 0.253
DEG_Nend_UBRbox_1 1 4 PF02207 0.589
DEG_SCF_FBW7_1 7 13 PF00400 0.664
DEG_SPOP_SBC_1 472 476 PF00917 0.706
DOC_CKS1_1 334 339 PF01111 0.645
DOC_CKS1_1 4 9 PF01111 0.646
DOC_CKS1_1 63 68 PF01111 0.346
DOC_CYCLIN_yCln2_LP_2 327 330 PF00134 0.666
DOC_CYCLIN_yCln2_LP_2 4 10 PF00134 0.679
DOC_MAPK_FxFP_2 61 64 PF00069 0.346
DOC_MAPK_gen_1 585 594 PF00069 0.632
DOC_PP2B_LxvP_1 327 330 PF13499 0.666
DOC_PP2B_LxvP_1 80 83 PF13499 0.380
DOC_PP4_FxxP_1 61 64 PF00568 0.346
DOC_USP7_MATH_1 103 107 PF00917 0.346
DOC_USP7_MATH_1 22 26 PF00917 0.636
DOC_USP7_MATH_1 222 226 PF00917 0.665
DOC_USP7_MATH_1 350 354 PF00917 0.658
DOC_USP7_MATH_1 431 435 PF00917 0.663
DOC_USP7_MATH_1 437 441 PF00917 0.659
DOC_USP7_MATH_1 443 447 PF00917 0.612
DOC_USP7_MATH_1 516 520 PF00917 0.624
DOC_USP7_MATH_1 595 599 PF00917 0.595
DOC_USP7_UBL2_3 666 670 PF12436 0.701
DOC_USP7_UBL2_3 742 746 PF12436 0.693
DOC_WW_Pin1_4 220 225 PF00397 0.716
DOC_WW_Pin1_4 3 8 PF00397 0.644
DOC_WW_Pin1_4 328 333 PF00397 0.690
DOC_WW_Pin1_4 336 341 PF00397 0.630
DOC_WW_Pin1_4 427 432 PF00397 0.594
DOC_WW_Pin1_4 609 614 PF00397 0.668
DOC_WW_Pin1_4 62 67 PF00397 0.378
LIG_14-3-3_CanoR_1 234 239 PF00244 0.643
LIG_14-3-3_CanoR_1 377 381 PF00244 0.605
LIG_14-3-3_CanoR_1 498 508 PF00244 0.639
LIG_14-3-3_CanoR_1 574 582 PF00244 0.595
LIG_14-3-3_CanoR_1 617 625 PF00244 0.675
LIG_14-3-3_CanoR_1 69 75 PF00244 0.380
LIG_14-3-3_CanoR_1 95 101 PF00244 0.380
LIG_BIR_III_4 239 243 PF00653 0.679
LIG_BRCT_BRCA1_1 12 16 PF00533 0.702
LIG_BRCT_BRCA1_1 595 599 PF00533 0.617
LIG_BRCT_BRCA1_1 70 74 PF00533 0.380
LIG_deltaCOP1_diTrp_1 689 695 PF00928 0.694
LIG_Dynein_DLC8_1 522 528 PF01221 0.653
LIG_FHA_1 173 179 PF00498 0.597
LIG_FHA_1 394 400 PF00498 0.691
LIG_FHA_1 407 413 PF00498 0.577
LIG_FHA_1 41 47 PF00498 0.380
LIG_FHA_2 139 145 PF00498 0.380
LIG_FHA_2 226 232 PF00498 0.618
LIG_FHA_2 234 240 PF00498 0.581
LIG_FHA_2 283 289 PF00498 0.670
LIG_FHA_2 476 482 PF00498 0.659
LIG_FHA_2 541 547 PF00498 0.600
LIG_FHA_2 720 726 PF00498 0.688
LIG_LIR_Gen_1 109 116 PF02991 0.380
LIG_LIR_Gen_1 141 150 PF02991 0.380
LIG_LIR_Gen_1 173 182 PF02991 0.611
LIG_LIR_Nem_3 109 113 PF02991 0.380
LIG_LIR_Nem_3 141 146 PF02991 0.380
LIG_LIR_Nem_3 173 177 PF02991 0.576
LIG_NRP_CendR_1 754 756 PF00754 0.670
LIG_Pex14_1 691 695 PF04695 0.701
LIG_RPA_C_Fungi 659 671 PF08784 0.664
LIG_SH2_CRK 110 114 PF00017 0.380
LIG_SH2_CRK 143 147 PF00017 0.380
LIG_SH2_STAP1 110 114 PF00017 0.380
LIG_SH2_STAT5 114 117 PF00017 0.382
LIG_SH2_STAT5 33 36 PF00017 0.519
LIG_SH2_STAT5 533 536 PF00017 0.701
LIG_SH3_1 326 332 PF00018 0.665
LIG_SH3_2 674 679 PF14604 0.665
LIG_SH3_2 737 742 PF14604 0.678
LIG_SH3_3 179 185 PF00018 0.657
LIG_SH3_3 18 24 PF00018 0.531
LIG_SH3_3 210 216 PF00018 0.651
LIG_SH3_3 326 332 PF00018 0.665
LIG_SH3_3 334 340 PF00018 0.603
LIG_SH3_3 4 10 PF00018 0.655
LIG_SH3_3 671 677 PF00018 0.665
LIG_SH3_3 732 738 PF00018 0.685
LIG_SH3_3 76 82 PF00018 0.380
LIG_SUMO_SIM_anti_2 25 31 PF11976 0.628
LIG_TRAF2_1 258 261 PF00917 0.710
LIG_TRAF2_1 418 421 PF00917 0.665
LIG_TRAF2_1 462 465 PF00917 0.680
LIG_TRAF2_1 468 471 PF00917 0.616
LIG_TRAF2_1 483 486 PF00917 0.594
LIG_TRAF2_1 543 546 PF00917 0.661
LIG_TRAF2_1 557 560 PF00917 0.607
LIG_TRAF2_1 633 636 PF00917 0.663
LIG_WW_3 738 742 PF00397 0.655
LIG_WW_3 81 85 PF00397 0.380
MOD_CDC14_SPxK_1 430 433 PF00782 0.588
MOD_CDK_SPK_2 609 614 PF00069 0.668
MOD_CDK_SPxK_1 427 433 PF00069 0.595
MOD_CDK_SPxK_1 609 615 PF00069 0.671
MOD_CDK_SPxxK_3 336 343 PF00069 0.646
MOD_CDK_SPxxK_3 62 69 PF00069 0.346
MOD_CK1_1 225 231 PF00069 0.698
MOD_CK1_1 233 239 PF00069 0.622
MOD_CK1_1 339 345 PF00069 0.693
MOD_CK1_1 351 357 PF00069 0.579
MOD_CK1_1 376 382 PF00069 0.678
MOD_CK1_1 510 516 PF00069 0.639
MOD_CK1_1 519 525 PF00069 0.621
MOD_CK1_1 696 702 PF00069 0.689
MOD_CK2_1 103 109 PF00069 0.346
MOD_CK2_1 155 161 PF00069 0.431
MOD_CK2_1 177 183 PF00069 0.688
MOD_CK2_1 24 30 PF00069 0.628
MOD_CK2_1 303 309 PF00069 0.627
MOD_CK2_1 353 359 PF00069 0.667
MOD_CK2_1 443 449 PF00069 0.665
MOD_CK2_1 540 546 PF00069 0.585
MOD_CK2_1 629 635 PF00069 0.672
MOD_CK2_1 719 725 PF00069 0.686
MOD_Cter_Amidation 522 525 PF01082 0.690
MOD_Cter_Amidation 583 586 PF01082 0.691
MOD_Cter_Amidation 602 605 PF01082 0.517
MOD_GlcNHglycan 12 15 PF01048 0.661
MOD_GlcNHglycan 188 191 PF01048 0.750
MOD_GlcNHglycan 192 195 PF01048 0.744
MOD_GlcNHglycan 204 207 PF01048 0.634
MOD_GlcNHglycan 224 227 PF01048 0.773
MOD_GlcNHglycan 244 247 PF01048 0.539
MOD_GlcNHglycan 269 272 PF01048 0.664
MOD_GlcNHglycan 291 295 PF01048 0.677
MOD_GlcNHglycan 350 353 PF01048 0.676
MOD_GlcNHglycan 355 358 PF01048 0.638
MOD_GlcNHglycan 386 389 PF01048 0.663
MOD_GlcNHglycan 439 442 PF01048 0.695
MOD_GlcNHglycan 445 448 PF01048 0.643
MOD_GlcNHglycan 521 524 PF01048 0.668
MOD_GlcNHglycan 601 604 PF01048 0.668
MOD_GlcNHglycan 618 621 PF01048 0.562
MOD_GlcNHglycan 630 634 PF01048 0.598
MOD_GlcNHglycan 656 659 PF01048 0.642
MOD_GSK3_1 186 193 PF00069 0.675
MOD_GSK3_1 225 232 PF00069 0.669
MOD_GSK3_1 339 346 PF00069 0.679
MOD_GSK3_1 427 434 PF00069 0.671
MOD_GSK3_1 471 478 PF00069 0.709
MOD_GSK3_1 498 505 PF00069 0.685
MOD_GSK3_1 507 514 PF00069 0.627
MOD_GSK3_1 519 526 PF00069 0.571
MOD_GSK3_1 580 587 PF00069 0.652
MOD_GSK3_1 595 602 PF00069 0.584
MOD_GSK3_1 6 13 PF00069 0.722
MOD_GSK3_1 696 703 PF00069 0.587
MOD_N-GLC_1 431 436 PF02516 0.686
MOD_NEK2_1 136 141 PF00069 0.346
MOD_NEK2_1 186 191 PF00069 0.673
MOD_NEK2_1 40 45 PF00069 0.380
MOD_NEK2_1 599 604 PF00069 0.633
MOD_NEK2_2 138 143 PF00069 0.380
MOD_NEK2_2 70 75 PF00069 0.380
MOD_PIKK_1 523 529 PF00454 0.650
MOD_PKA_1 498 504 PF00069 0.692
MOD_PKA_1 95 101 PF00069 0.380
MOD_PKA_2 233 239 PF00069 0.603
MOD_PKA_2 303 309 PF00069 0.593
MOD_PKA_2 376 382 PF00069 0.565
MOD_PKA_2 498 504 PF00069 0.692
MOD_PKA_2 573 579 PF00069 0.605
MOD_PKA_2 584 590 PF00069 0.597
MOD_PKA_2 616 622 PF00069 0.706
MOD_PKA_2 68 74 PF00069 0.380
MOD_PKA_2 696 702 PF00069 0.643
MOD_PKA_2 95 101 PF00069 0.380
MOD_PKB_1 343 351 PF00069 0.673
MOD_PKB_1 698 706 PF00069 0.593
MOD_Plk_1 108 114 PF00069 0.380
MOD_Plk_1 431 437 PF00069 0.686
MOD_Plk_1 629 635 PF00069 0.593
MOD_Plk_2-3 155 161 PF00069 0.380
MOD_Plk_4 108 114 PF00069 0.380
MOD_Plk_4 138 144 PF00069 0.380
MOD_Plk_4 24 30 PF00069 0.628
MOD_Plk_4 376 382 PF00069 0.656
MOD_Plk_4 54 60 PF00069 0.380
MOD_ProDKin_1 220 226 PF00069 0.716
MOD_ProDKin_1 3 9 PF00069 0.649
MOD_ProDKin_1 328 334 PF00069 0.690
MOD_ProDKin_1 336 342 PF00069 0.632
MOD_ProDKin_1 427 433 PF00069 0.595
MOD_ProDKin_1 609 615 PF00069 0.671
MOD_ProDKin_1 62 68 PF00069 0.378
MOD_SUMO_rev_2 449 458 PF00179 0.607
TRG_ENDOCYTIC_2 110 113 PF00928 0.380
TRG_ENDOCYTIC_2 143 146 PF00928 0.380
TRG_ER_diArg_1 276 278 PF00400 0.712
TRG_ER_diArg_1 317 319 PF00400 0.671
TRG_ER_diArg_1 404 406 PF00400 0.655
TRG_ER_diArg_1 433 436 PF00400 0.682
TRG_ER_diArg_1 498 500 PF00400 0.604
TRG_ER_diArg_1 662 665 PF00400 0.662
TRG_ER_diArg_1 697 700 PF00400 0.642
TRG_ER_diArg_1 74 77 PF00400 0.380
TRG_ER_diArg_1 94 97 PF00400 0.199
TRG_NES_CRM1_1 130 144 PF08389 0.380
TRG_NLS_Bipartite_1 604 618 PF00514 0.705
TRG_NLS_MonoCore_2 495 500 PF00514 0.699
TRG_NLS_MonoExtC_3 495 500 PF00514 0.609
TRG_NLS_MonoExtC_3 740 745 PF00514 0.693
TRG_NLS_MonoExtN_4 496 501 PF00514 0.693
TRG_NLS_MonoExtN_4 613 618 PF00514 0.712
TRG_NLS_MonoExtN_4 738 745 PF00514 0.680
TRG_Pf-PMV_PEXEL_1 184 188 PF00026 0.726
TRG_Pf-PMV_PEXEL_1 310 314 PF00026 0.617

Homologs

Protein Taxonomy Sequence identity Coverage
A4HGW7 Leishmania braziliensis 69% 100%
A4I3Z7 Leishmania infantum 99% 100%
E9B087 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4Q7Z8 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS