Phosphatidate cytidylyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidate cytidylyltransferase-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IDC1_LEIDO

TriTrypDb:

LdBPK_323010.1 , LdCL_320036100 , LDHU3_32.3790

Length:

493

Annotations

LeishMANIAdb annotations

Related to bacterial cytidyltransferase enzymes. Relatively conserved architecture, with the expection of an insertion of 2 helices.. Might have been acquired by horizontal gene transfer in the ancestors of Kinetoplastids.

Annotations by Jardim et al.

Phospholipid biosynthesis, Phosphatidate cytidylyltransferase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A0A3Q8IDC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDC1

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0006644	phospholipid metabolic process	4	7
GO:0006650	glycerophospholipid metabolic process	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0008610	lipid biosynthetic process	4	7
GO:0008654	phospholipid biosynthetic process	5	7
GO:0009058	biosynthetic process	2	7
GO:0009987	cellular process	1	7
GO:0016024	CDP-diacylglycerol biosynthetic process	6	7
GO:0019637	organophosphate metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044255	cellular lipid metabolic process	3	7
GO:0045017	glycerolipid biosynthetic process	4	7
GO:0046341	CDP-diacylglycerol metabolic process	6	7
GO:0046474	glycerophospholipid biosynthetic process	5	7
GO:0046486	glycerolipid metabolic process	4	7
GO:0071704	organic substance metabolic process	2	7
GO:0090407	organophosphate biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004605	phosphatidate cytidylyltransferase activity	6	8
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016779	nucleotidyltransferase activity	4	10
GO:0070567	cytidylyltransferase activity	5	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	463	467	PF00656	0.488
CLV_NRD_NRD_1	345	347	PF00675	0.495
CLV_PCSK_KEX2_1	347	349	PF00082	0.480
CLV_PCSK_KEX2_1	443	445	PF00082	0.290
CLV_PCSK_KEX2_1	70	72	PF00082	0.426
CLV_PCSK_PC1ET2_1	347	349	PF00082	0.480
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.290
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.444
CLV_PCSK_SKI1_1	238	242	PF00082	0.450
CLV_PCSK_SKI1_1	29	33	PF00082	0.397
CLV_PCSK_SKI1_1	316	320	PF00082	0.359
CLV_PCSK_SKI1_1	348	352	PF00082	0.479
CLV_PCSK_SKI1_1	358	362	PF00082	0.440
CLV_PCSK_SKI1_1	71	75	PF00082	0.427
DEG_APCC_DBOX_1	19	27	PF00400	0.687
DEG_MDM2_SWIB_1	272	280	PF02201	0.344
DEG_Nend_UBRbox_2	1	3	PF02207	0.740
DOC_CKS1_1	280	285	PF01111	0.485
DOC_CYCLIN_RxL_1	355	363	PF00134	0.682
DOC_CYCLIN_yCln2_LP_2	470	476	PF00134	0.561
DOC_MAPK_gen_1	70	77	PF00069	0.630
DOC_MAPK_MEF2A_6	464	472	PF00069	0.490
DOC_MAPK_MEF2A_6	70	79	PF00069	0.633
DOC_PP1_RVXF_1	135	142	PF00149	0.444
DOC_PP4_FxxP_1	453	456	PF00568	0.551
DOC_USP7_MATH_1	373	377	PF00917	0.496
DOC_USP7_UBL2_3	347	351	PF12436	0.651
DOC_USP7_UBL2_3	70	74	PF12436	0.647
DOC_WW_Pin1_4	107	112	PF00397	0.763
DOC_WW_Pin1_4	12	17	PF00397	0.743
DOC_WW_Pin1_4	279	284	PF00397	0.466
DOC_WW_Pin1_4	360	365	PF00397	0.615
DOC_WW_Pin1_4	369	374	PF00397	0.453
DOC_WW_Pin1_4	88	93	PF00397	0.749
LIG_14-3-3_CanoR_1	316	321	PF00244	0.527
LIG_14-3-3_CanoR_1	480	486	PF00244	0.649
LIG_Actin_WH2_2	430	445	PF00022	0.351
LIG_Clathr_ClatBox_1	156	160	PF01394	0.485
LIG_Clathr_ClatBox_1	78	82	PF01394	0.710
LIG_FHA_1	152	158	PF00498	0.392
LIG_FHA_1	28	34	PF00498	0.400
LIG_FHA_2	220	226	PF00498	0.739
LIG_FHA_2	330	336	PF00498	0.710
LIG_GSK3_LRP6_1	107	112	PF00069	0.712
LIG_LIR_Apic_2	121	126	PF02991	0.649
LIG_LIR_Apic_2	450	456	PF02991	0.516
LIG_LIR_Gen_1	131	139	PF02991	0.516
LIG_LIR_Gen_1	160	171	PF02991	0.374
LIG_LIR_Gen_1	245	255	PF02991	0.676
LIG_LIR_Gen_1	261	272	PF02991	0.417
LIG_LIR_Gen_1	412	423	PF02991	0.333
LIG_LIR_Nem_3	131	136	PF02991	0.608
LIG_LIR_Nem_3	158	164	PF02991	0.411
LIG_LIR_Nem_3	261	267	PF02991	0.596
LIG_LIR_Nem_3	270	275	PF02991	0.340
LIG_LIR_Nem_3	323	328	PF02991	0.648
LIG_LIR_Nem_3	390	394	PF02991	0.434
LIG_LIR_Nem_3	412	418	PF02991	0.305
LIG_LIR_Nem_3	65	69	PF02991	0.324
LIG_NRBOX	419	425	PF00104	0.447
LIG_NRBOX	437	443	PF00104	0.328
LIG_NRP_CendR_1	492	493	PF00754	0.421
LIG_Pex14_2	272	276	PF04695	0.344
LIG_Pex14_2	56	60	PF04695	0.349
LIG_SH2_CRK	123	127	PF00017	0.635
LIG_SH2_CRK	133	137	PF00017	0.493
LIG_SH2_CRK	325	329	PF00017	0.627
LIG_SH2_STAT5	162	165	PF00017	0.347
LIG_SH2_STAT5	246	249	PF00017	0.700
LIG_SH3_1	105	111	PF00018	0.716
LIG_SH3_1	123	129	PF00018	0.581
LIG_SH3_3	100	106	PF00018	0.642
LIG_SH3_3	114	120	PF00018	0.672
LIG_SH3_3	123	129	PF00018	0.606
LIG_SH3_3	289	295	PF00018	0.423
LIG_SH3_3	407	413	PF00018	0.361
LIG_SH3_3	86	92	PF00018	0.778
LIG_SUMO_SIM_par_1	154	160	PF11976	0.425
LIG_SUMO_SIM_par_1	167	172	PF11976	0.358
LIG_TRAF2_1	332	335	PF00917	0.670
LIG_UBA3_1	437	443	PF00899	0.344
LIG_WRC_WIRS_1	57	62	PF05994	0.435
MOD_CDC14_SPxK_1	15	18	PF00782	0.633
MOD_CDC14_SPxK_1	372	375	PF00782	0.490
MOD_CDK_SPxK_1	12	18	PF00069	0.648
MOD_CDK_SPxK_1	369	375	PF00069	0.490
MOD_CK1_1	193	199	PF00069	0.679
MOD_CK1_1	44	50	PF00069	0.543
MOD_CK1_1	484	490	PF00069	0.668
MOD_CK2_1	329	335	PF00069	0.642
MOD_DYRK1A_RPxSP_1	369	373	PF00069	0.551
MOD_GlcNHglycan	149	152	PF01048	0.640
MOD_GlcNHglycan	193	196	PF01048	0.535
MOD_GlcNHglycan	204	207	PF01048	0.544
MOD_GlcNHglycan	43	46	PF01048	0.555
MOD_GlcNHglycan	488	491	PF01048	0.463
MOD_GlcNHglycan	65	69	PF01048	0.330
MOD_GSK3_1	147	154	PF00069	0.562
MOD_GSK3_1	186	193	PF00069	0.707
MOD_GSK3_1	369	376	PF00069	0.490
MOD_GSK3_1	77	84	PF00069	0.736
MOD_N-GLC_1	373	378	PF02516	0.361
MOD_NEK2_1	297	302	PF00069	0.429
MOD_NEK2_1	41	46	PF00069	0.478
MOD_NEK2_1	423	428	PF00069	0.366
MOD_NEK2_1	437	442	PF00069	0.325
MOD_NEK2_1	483	488	PF00069	0.632
MOD_NEK2_1	56	61	PF00069	0.240
MOD_NEK2_1	81	86	PF00069	0.730
MOD_PIKK_1	186	192	PF00454	0.715
MOD_PIKK_1	193	199	PF00454	0.709
MOD_Plk_1	151	157	PF00069	0.238
MOD_Plk_1	229	235	PF00069	0.750
MOD_Plk_1	373	379	PF00069	0.561
MOD_Plk_1	81	87	PF00069	0.707
MOD_Plk_4	151	157	PF00069	0.318
MOD_Plk_4	297	303	PF00069	0.369
MOD_Plk_4	316	322	PF00069	0.595
MOD_Plk_4	423	429	PF00069	0.369
MOD_Plk_4	437	443	PF00069	0.325
MOD_Plk_4	56	62	PF00069	0.449
MOD_Plk_4	94	100	PF00069	0.719
MOD_ProDKin_1	107	113	PF00069	0.766
MOD_ProDKin_1	12	18	PF00069	0.742
MOD_ProDKin_1	279	285	PF00069	0.466
MOD_ProDKin_1	360	366	PF00069	0.617
MOD_ProDKin_1	369	375	PF00069	0.453
MOD_ProDKin_1	88	94	PF00069	0.751
MOD_SUMO_for_1	179	182	PF00179	0.678
MOD_SUMO_for_1	234	237	PF00179	0.758
TRG_DiLeu_BaEn_1	152	157	PF01217	0.361
TRG_DiLeu_BaEn_1	352	357	PF01217	0.632
TRG_ENDOCYTIC_2	133	136	PF00928	0.554
TRG_ENDOCYTIC_2	162	165	PF00928	0.429
TRG_ENDOCYTIC_2	325	328	PF00928	0.653
TRG_ENDOCYTIC_2	399	402	PF00928	0.342
TRG_ER_diArg_1	18	21	PF00400	0.716
TRG_ER_diArg_1	345	348	PF00400	0.685
TRG_NLS_MonoExtN_4	345	350	PF00514	0.669
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEC8	Leptomonas seymouri	61%	100%
A0A1X0NT53	Trypanosomatidae	31%	100%
A0A422NZP0	Trypanosoma rangeli	33%	100%
A4HKS8	Leishmania braziliensis	69%	96%
E9AHM2	Leishmania infantum	100%	100%
E9B366	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q4Y8	Leishmania major	89%	99%
V5AXY5	Trypanosoma cruzi	32%	100%