Cyclic nucleotide-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IDB5_LEIDO

TriTrypDb:

LdBPK_270540.1 , LdCL_270011900 , LDHU3_27.0890

Length:

917

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

A0A3Q8IDB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDB5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	863	867	PF00656	0.824
CLV_NRD_NRD_1	16	18	PF00675	0.703
CLV_NRD_NRD_1	186	188	PF00675	0.585
CLV_NRD_NRD_1	361	363	PF00675	0.726
CLV_NRD_NRD_1	517	519	PF00675	0.806
CLV_NRD_NRD_1	537	539	PF00675	0.489
CLV_PCSK_KEX2_1	16	18	PF00082	0.710
CLV_PCSK_KEX2_1	186	188	PF00082	0.573
CLV_PCSK_KEX2_1	361	363	PF00082	0.726
CLV_PCSK_KEX2_1	517	519	PF00082	0.806
CLV_PCSK_SKI1_1	231	235	PF00082	0.633
CLV_PCSK_SKI1_1	286	290	PF00082	0.612
CLV_PCSK_SKI1_1	450	454	PF00082	0.695
CLV_PCSK_SKI1_1	461	465	PF00082	0.666
CLV_PCSK_SKI1_1	651	655	PF00082	0.598
CLV_PCSK_SKI1_1	668	672	PF00082	0.353
CLV_PCSK_SKI1_1	734	738	PF00082	0.578
CLV_PCSK_SKI1_1	740	744	PF00082	0.505
CLV_PCSK_SKI1_1	839	843	PF00082	0.501
CLV_PCSK_SKI1_1	904	908	PF00082	0.544
CLV_Separin_Metazoa	287	291	PF03568	0.361
DEG_APCC_DBOX_1	230	238	PF00400	0.493
DEG_Nend_UBRbox_3	1	3	PF02207	0.466
DEG_SCF_FBW7_1	265	272	PF00400	0.483
DEG_SPOP_SBC_1	316	320	PF00917	0.549
DEG_SPOP_SBC_1	65	69	PF00917	0.405
DOC_ANK_TNKS_1	301	308	PF00023	0.506
DOC_CDC14_PxL_1	751	759	PF14671	0.741
DOC_CKS1_1	266	271	PF01111	0.466
DOC_CYCLIN_yCln2_LP_2	674	680	PF00134	0.437
DOC_MAPK_DCC_7	551	561	PF00069	0.495
DOC_MAPK_MEF2A_6	588	597	PF00069	0.373
DOC_PP1_RVXF_1	666	672	PF00149	0.436
DOC_PP2B_LxvP_1	485	488	PF13499	0.489
DOC_PP2B_LxvP_1	674	677	PF13499	0.474
DOC_PP2B_LxvP_1	752	755	PF13499	0.719
DOC_PP4_FxxP_1	214	217	PF00568	0.537
DOC_USP7_MATH_1	108	112	PF00917	0.614
DOC_USP7_MATH_1	12	16	PF00917	0.504
DOC_USP7_MATH_1	185	189	PF00917	0.686
DOC_USP7_MATH_1	220	224	PF00917	0.427
DOC_USP7_MATH_1	310	314	PF00917	0.560
DOC_USP7_MATH_1	380	384	PF00917	0.500
DOC_USP7_MATH_1	45	49	PF00917	0.578
DOC_USP7_MATH_1	452	456	PF00917	0.475
DOC_USP7_MATH_1	479	483	PF00917	0.537
DOC_USP7_MATH_1	569	573	PF00917	0.459
DOC_USP7_MATH_1	65	69	PF00917	0.322
DOC_USP7_MATH_1	736	740	PF00917	0.775
DOC_WW_Pin1_4	120	125	PF00397	0.524
DOC_WW_Pin1_4	265	270	PF00397	0.495
DOC_WW_Pin1_4	318	323	PF00397	0.547
DOC_WW_Pin1_4	398	403	PF00397	0.548
DOC_WW_Pin1_4	686	691	PF00397	0.763
LIG_14-3-3_CanoR_1	156	164	PF00244	0.737
LIG_14-3-3_CanoR_1	186	194	PF00244	0.710
LIG_14-3-3_CanoR_1	344	353	PF00244	0.534
LIG_14-3-3_CanoR_1	378	388	PF00244	0.615
LIG_14-3-3_CanoR_1	562	568	PF00244	0.509
LIG_14-3-3_CanoR_1	646	651	PF00244	0.463
LIG_14-3-3_CanoR_1	688	697	PF00244	0.689
LIG_14-3-3_CanoR_1	768	777	PF00244	0.778
LIG_14-3-3_CanoR_1	801	805	PF00244	0.667
LIG_14-3-3_CanoR_1	845	854	PF00244	0.659
LIG_14-3-3_CanoR_1	96	101	PF00244	0.509
LIG_APCC_ABBA_1	650	655	PF00400	0.410
LIG_BIR_III_4	219	223	PF00653	0.531
LIG_BRCT_BRCA1_1	68	72	PF00533	0.430
LIG_Clathr_ClatBox_1	339	343	PF01394	0.486
LIG_Clathr_ClatBox_1	793	797	PF01394	0.764
LIG_eIF4E_1	675	681	PF01652	0.513
LIG_FHA_1	136	142	PF00498	0.513
LIG_FHA_1	202	208	PF00498	0.411
LIG_FHA_1	266	272	PF00498	0.432
LIG_FHA_1	324	330	PF00498	0.553
LIG_FHA_1	355	361	PF00498	0.518
LIG_FHA_1	366	372	PF00498	0.551
LIG_FHA_1	387	393	PF00498	0.538
LIG_FHA_1	494	500	PF00498	0.520
LIG_FHA_1	647	653	PF00498	0.491
LIG_FHA_1	65	71	PF00498	0.547
LIG_FHA_1	655	661	PF00498	0.426
LIG_FHA_1	771	777	PF00498	0.720
LIG_FHA_1	788	794	PF00498	0.661
LIG_FHA_1	824	830	PF00498	0.697
LIG_FHA_1	906	912	PF00498	0.697
LIG_FHA_2	124	130	PF00498	0.422
LIG_FHA_2	213	219	PF00498	0.515
LIG_FHA_2	280	286	PF00498	0.433
LIG_FHA_2	309	315	PF00498	0.557
LIG_FHA_2	318	324	PF00498	0.550
LIG_FHA_2	526	532	PF00498	0.470
LIG_FHA_2	587	593	PF00498	0.472
LIG_FHA_2	861	867	PF00498	0.769
LIG_FHA_2	890	896	PF00498	0.715
LIG_LIR_Apic_2	131	137	PF02991	0.411
LIG_LIR_Apic_2	213	217	PF02991	0.530
LIG_LIR_Apic_2	575	581	PF02991	0.486
LIG_LIR_Gen_1	587	597	PF02991	0.524
LIG_LIR_Gen_1	69	79	PF02991	0.426
LIG_LIR_Gen_1	692	702	PF02991	0.758
LIG_LIR_Gen_1	894	903	PF02991	0.691
LIG_LIR_Nem_3	413	419	PF02991	0.540
LIG_LIR_Nem_3	531	537	PF02991	0.452
LIG_LIR_Nem_3	542	548	PF02991	0.454
LIG_LIR_Nem_3	587	593	PF02991	0.506
LIG_LIR_Nem_3	621	626	PF02991	0.583
LIG_LIR_Nem_3	69	75	PF02991	0.424
LIG_LIR_Nem_3	692	697	PF02991	0.763
LIG_LIR_Nem_3	894	899	PF02991	0.692
LIG_NRBOX	142	148	PF00104	0.436
LIG_OCRL_FandH_1	736	748	PF00620	0.776
LIG_PAM2_1	172	184	PF00658	0.738
LIG_PCNA_yPIPBox_3	224	234	PF02747	0.472
LIG_Pex14_1	663	667	PF04695	0.513
LIG_Pex14_2	667	671	PF04695	0.513
LIG_PTB_Apo_2	890	897	PF02174	0.696
LIG_SH2_CRK	678	682	PF00017	0.586
LIG_SH2_CRK	888	892	PF00017	0.711
LIG_SH2_NCK_1	888	892	PF00017	0.784
LIG_SH2_PTP2	134	137	PF00017	0.389
LIG_SH2_SRC	568	571	PF00017	0.528
LIG_SH2_SRC	673	676	PF00017	0.474
LIG_SH2_STAT3	547	550	PF00017	0.517
LIG_SH2_STAT5	134	137	PF00017	0.389
LIG_SH2_STAT5	416	419	PF00017	0.543
LIG_SH2_STAT5	421	424	PF00017	0.536
LIG_SH2_STAT5	547	550	PF00017	0.444
LIG_SH2_STAT5	578	581	PF00017	0.386
LIG_SH2_STAT5	673	676	PF00017	0.474
LIG_SH2_STAT5	74	77	PF00017	0.409
LIG_SH3_3	173	179	PF00018	0.732
LIG_SH3_3	430	436	PF00018	0.538
LIG_SH3_3	465	471	PF00018	0.524
LIG_SH3_3	507	513	PF00018	0.450
LIG_SUMO_SIM_anti_2	784	790	PF11976	0.785
LIG_SUMO_SIM_par_1	138	145	PF11976	0.513
LIG_SUMO_SIM_par_1	244	249	PF11976	0.370
LIG_SUMO_SIM_par_1	272	279	PF11976	0.425
LIG_SUMO_SIM_par_1	580	587	PF11976	0.380
LIG_SUMO_SIM_par_1	741	747	PF11976	0.709
LIG_SUMO_SIM_par_1	792	797	PF11976	0.700
LIG_TRAF2_1	529	532	PF00917	0.447
LIG_TRAF2_1	583	586	PF00917	0.461
LIG_TRAF2_1	892	895	PF00917	0.715
LIG_UBA3_1	616	625	PF00899	0.507
MOD_CK1_1	123	129	PF00069	0.465
MOD_CK1_1	270	276	PF00069	0.408
MOD_CK1_1	317	323	PF00069	0.548
MOD_CK1_1	366	372	PF00069	0.550
MOD_CK1_1	379	385	PF00069	0.546
MOD_CK1_1	386	392	PF00069	0.509
MOD_CK1_1	398	404	PF00069	0.582
MOD_CK1_1	423	429	PF00069	0.581
MOD_CK1_1	48	54	PF00069	0.585
MOD_CK1_1	628	634	PF00069	0.530
MOD_CK1_1	712	718	PF00069	0.751
MOD_CK1_1	756	762	PF00069	0.725
MOD_CK1_1	784	790	PF00069	0.712
MOD_CK1_1	855	861	PF00069	0.739
MOD_CK1_1	889	895	PF00069	0.736
MOD_CK2_1	106	112	PF00069	0.616
MOD_CK2_1	186	192	PF00069	0.665
MOD_CK2_1	229	235	PF00069	0.490
MOD_CK2_1	279	285	PF00069	0.444
MOD_CK2_1	317	323	PF00069	0.553
MOD_CK2_1	32	38	PF00069	0.624
MOD_CK2_1	366	372	PF00069	0.582
MOD_CK2_1	525	531	PF00069	0.467
MOD_CK2_1	580	586	PF00069	0.458
MOD_CK2_1	889	895	PF00069	0.774
MOD_GlcNHglycan	247	251	PF01048	0.605
MOD_GlcNHglycan	346	349	PF01048	0.665
MOD_GlcNHglycan	372	376	PF01048	0.747
MOD_GlcNHglycan	378	381	PF01048	0.704
MOD_GlcNHglycan	403	406	PF01048	0.701
MOD_GlcNHglycan	424	428	PF01048	0.734
MOD_GlcNHglycan	441	444	PF01048	0.562
MOD_GlcNHglycan	488	491	PF01048	0.724
MOD_GlcNHglycan	50	53	PF01048	0.831
MOD_GlcNHglycan	519	522	PF01048	0.743
MOD_GlcNHglycan	58	61	PF01048	0.725
MOD_GlcNHglycan	628	631	PF01048	0.733
MOD_GlcNHglycan	632	636	PF01048	0.753
MOD_GlcNHglycan	691	694	PF01048	0.487
MOD_GlcNHglycan	718	721	PF01048	0.564
MOD_GlcNHglycan	725	728	PF01048	0.502
MOD_GlcNHglycan	783	786	PF01048	0.499
MOD_GlcNHglycan	848	851	PF01048	0.508
MOD_GlcNHglycan	854	857	PF01048	0.528
MOD_GlcNHglycan	888	891	PF01048	0.575
MOD_GSK3_1	12	19	PF00069	0.495
MOD_GSK3_1	265	272	PF00069	0.489
MOD_GSK3_1	310	317	PF00069	0.559
MOD_GSK3_1	362	369	PF00069	0.557
MOD_GSK3_1	376	383	PF00069	0.543
MOD_GSK3_1	386	393	PF00069	0.529
MOD_GSK3_1	394	401	PF00069	0.544
MOD_GSK3_1	415	422	PF00069	0.570
MOD_GSK3_1	439	446	PF00069	0.566
MOD_GSK3_1	46	53	PF00069	0.638
MOD_GSK3_1	522	529	PF00069	0.497
MOD_GSK3_1	569	576	PF00069	0.475
MOD_GSK3_1	580	587	PF00069	0.364
MOD_GSK3_1	712	719	PF00069	0.699
MOD_GSK3_1	73	80	PF00069	0.424
MOD_GSK3_1	766	773	PF00069	0.778
MOD_GSK3_1	846	853	PF00069	0.773
MOD_GSK3_1	860	867	PF00069	0.647
MOD_NEK2_1	212	217	PF00069	0.519
MOD_NEK2_1	246	251	PF00069	0.403
MOD_NEK2_1	276	281	PF00069	0.435
MOD_NEK2_1	353	358	PF00069	0.511
MOD_NEK2_1	376	381	PF00069	0.610
MOD_NEK2_1	395	400	PF00069	0.540
MOD_NEK2_1	454	459	PF00069	0.466
MOD_NEK2_1	498	503	PF00069	0.421
MOD_NEK2_1	584	589	PF00069	0.518
MOD_NEK2_1	644	649	PF00069	0.481
MOD_NEK2_1	709	714	PF00069	0.714
MOD_NEK2_1	77	82	PF00069	0.405
MOD_NEK2_1	800	805	PF00069	0.665
MOD_PIKK_1	156	162	PF00454	0.825
MOD_PIKK_1	366	372	PF00454	0.559
MOD_PIKK_1	390	396	PF00454	0.624
MOD_PIKK_1	787	793	PF00454	0.745
MOD_PK_1	96	102	PF00069	0.515
MOD_PKA_1	16	22	PF00069	0.501
MOD_PKA_1	186	192	PF00069	0.717
MOD_PKA_1	517	523	PF00069	0.598
MOD_PKA_2	16	22	PF00069	0.556
MOD_PKA_2	185	191	PF00069	0.760
MOD_PKA_2	301	307	PF00069	0.511
MOD_PKA_2	380	386	PF00069	0.634
MOD_PKA_2	517	523	PF00069	0.598
MOD_PKA_2	645	651	PF00069	0.472
MOD_PKA_2	723	729	PF00069	0.702
MOD_PKA_2	800	806	PF00069	0.665
MOD_PKA_2	886	892	PF00069	0.778
MOD_PKA_2	95	101	PF00069	0.496
MOD_Plk_1	128	134	PF00069	0.368
MOD_Plk_1	212	218	PF00069	0.454
MOD_Plk_1	276	282	PF00069	0.436
MOD_Plk_1	371	377	PF00069	0.608
MOD_Plk_1	522	528	PF00069	0.499
MOD_Plk_1	894	900	PF00069	0.706
MOD_Plk_2-3	32	38	PF00069	0.574
MOD_Plk_2-3	586	592	PF00069	0.453
MOD_Plk_4	135	141	PF00069	0.361
MOD_Plk_4	172	178	PF00069	0.729
MOD_Plk_4	194	200	PF00069	0.546
MOD_Plk_4	270	276	PF00069	0.406
MOD_Plk_4	522	528	PF00069	0.473
MOD_Plk_4	563	569	PF00069	0.473
MOD_Plk_4	573	579	PF00069	0.397
MOD_Plk_4	618	624	PF00069	0.493
MOD_Plk_4	639	645	PF00069	0.618
MOD_Plk_4	66	72	PF00069	0.429
MOD_Plk_4	784	790	PF00069	0.712
MOD_ProDKin_1	120	126	PF00069	0.523
MOD_ProDKin_1	265	271	PF00069	0.490
MOD_ProDKin_1	318	324	PF00069	0.545
MOD_ProDKin_1	398	404	PF00069	0.547
MOD_ProDKin_1	686	692	PF00069	0.763
MOD_SUMO_for_1	841	844	PF00179	0.712
TRG_DiLeu_BaEn_1	747	752	PF01217	0.690
TRG_DiLeu_BaEn_1	778	783	PF01217	0.732
TRG_DiLeu_BaEn_2	745	751	PF01217	0.778
TRG_DiLeu_BaEn_4	894	900	PF01217	0.706
TRG_DiLeu_BaLyEn_6	789	794	PF01217	0.776
TRG_ENDOCYTIC_2	534	537	PF00928	0.446
TRG_ENDOCYTIC_2	590	593	PF00928	0.507
TRG_ENDOCYTIC_2	678	681	PF00928	0.580
TRG_ENDOCYTIC_2	735	738	PF00928	0.775
TRG_ENDOCYTIC_2	74	77	PF00928	0.429
TRG_ENDOCYTIC_2	888	891	PF00928	0.716
TRG_ER_diArg_1	360	362	PF00400	0.518
TRG_ER_diArg_1	516	518	PF00400	0.583
TRG_NES_CRM1_1	145	155	PF08389	0.502
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.680
TRG_Pf-PMV_PEXEL_1	604	609	PF00026	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE25	Leptomonas seymouri	43%	97%
A4HFJ3	Leishmania braziliensis	66%	100%
E9AD46	Leishmania major	89%	100%
E9AHE0	Leishmania infantum	99%	100%
E9AYX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%