Signal recognition particle subunit SRP72

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

signal recognition particle protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDA7_LEIDO

TriTrypDb:

LdBPK_190790.1 , LdCL_190012900 , LDHU3_19.0870

Length:

741

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	12
GO:0005786	signal recognition particle, endoplasmic reticulum targeting	4	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0048500	signal recognition particle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3Q8IDA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDA7

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	12
GO:0006612	protein targeting to membrane	5	12
GO:0006613	cotranslational protein targeting to membrane	6	12
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	12
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0033365	protein localization to organelle	5	12
GO:0045047	protein targeting to ER	6	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0051668	localization within membrane	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0070972	protein localization to endoplasmic reticulum	6	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0072594	establishment of protein localization to organelle	4	12
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	12
GO:0072657	protein localization to membrane	4	12
GO:0090150	establishment of protein localization to membrane	4	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0008312	7S RNA binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.438
CLV_C14_Caspase3-7	413	417	PF00656	0.671
CLV_NRD_NRD_1	11	13	PF00675	0.542
CLV_NRD_NRD_1	287	289	PF00675	0.525
CLV_NRD_NRD_1	324	326	PF00675	0.402
CLV_NRD_NRD_1	445	447	PF00675	0.572
CLV_NRD_NRD_1	483	485	PF00675	0.500
CLV_NRD_NRD_1	631	633	PF00675	0.624
CLV_NRD_NRD_1	659	661	PF00675	0.258
CLV_NRD_NRD_1	663	665	PF00675	0.253
CLV_NRD_NRD_1	693	695	PF00675	0.521
CLV_NRD_NRD_1	699	701	PF00675	0.550
CLV_NRD_NRD_1	710	712	PF00675	0.537
CLV_PCSK_FUR_1	657	661	PF00082	0.281
CLV_PCSK_KEX2_1	287	289	PF00082	0.525
CLV_PCSK_KEX2_1	447	449	PF00082	0.582
CLV_PCSK_KEX2_1	483	485	PF00082	0.541
CLV_PCSK_KEX2_1	582	584	PF00082	0.567
CLV_PCSK_KEX2_1	631	633	PF00082	0.610
CLV_PCSK_KEX2_1	657	659	PF00082	0.263
CLV_PCSK_KEX2_1	663	665	PF00082	0.257
CLV_PCSK_KEX2_1	693	695	PF00082	0.521
CLV_PCSK_KEX2_1	699	701	PF00082	0.550
CLV_PCSK_KEX2_1	709	711	PF00082	0.537
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.591
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.567
CLV_PCSK_PC1ET2_1	709	711	PF00082	0.588
CLV_PCSK_PC7_1	659	665	PF00082	0.295
CLV_PCSK_SKI1_1	114	118	PF00082	0.311
CLV_PCSK_SKI1_1	221	225	PF00082	0.493
CLV_PCSK_SKI1_1	260	264	PF00082	0.351
CLV_PCSK_SKI1_1	325	329	PF00082	0.420
CLV_PCSK_SKI1_1	385	389	PF00082	0.408
CLV_PCSK_SKI1_1	391	395	PF00082	0.466
CLV_PCSK_SKI1_1	412	416	PF00082	0.650
CLV_PCSK_SKI1_1	525	529	PF00082	0.371
CLV_PCSK_SKI1_1	563	567	PF00082	0.431
CLV_PCSK_SKI1_1	631	635	PF00082	0.655
CLV_PCSK_SKI1_1	664	668	PF00082	0.315
DEG_APCC_DBOX_1	113	121	PF00400	0.515
DEG_SCF_SKP2-CKS1_1	67	74	PF00560	0.476
DOC_CYCLIN_RxL_1	446	456	PF00134	0.466
DOC_MAPK_gen_1	287	294	PF00069	0.441
DOC_MAPK_gen_1	325	335	PF00069	0.530
DOC_MAPK_gen_1	446	454	PF00069	0.588
DOC_MAPK_gen_1	561	570	PF00069	0.446
DOC_MAPK_MEF2A_6	287	294	PF00069	0.406
DOC_MAPK_RevD_3	384	397	PF00069	0.561
DOC_PP2B_LxvP_1	242	245	PF13499	0.650
DOC_USP7_MATH_1	228	232	PF00917	0.555
DOC_USP7_MATH_1	301	305	PF00917	0.390
DOC_USP7_MATH_1	414	418	PF00917	0.642
DOC_USP7_MATH_1	438	442	PF00917	0.711
DOC_USP7_MATH_1	555	559	PF00917	0.480
DOC_USP7_MATH_1	623	627	PF00917	0.600
DOC_USP7_MATH_1	714	718	PF00917	0.633
DOC_USP7_MATH_1	736	740	PF00917	0.734
DOC_USP7_UBL2_3	9	13	PF12436	0.549
DOC_WW_Pin1_4	177	182	PF00397	0.537
DOC_WW_Pin1_4	254	259	PF00397	0.456
DOC_WW_Pin1_4	400	405	PF00397	0.746
DOC_WW_Pin1_4	68	73	PF00397	0.559
DOC_WW_Pin1_4	732	737	PF00397	0.653
LIG_14-3-3_CanoR_1	106	116	PF00244	0.516
LIG_14-3-3_CanoR_1	12	20	PF00244	0.576
LIG_14-3-3_CanoR_1	31	36	PF00244	0.540
LIG_14-3-3_CanoR_1	338	345	PF00244	0.434
LIG_14-3-3_CanoR_1	363	369	PF00244	0.500
LIG_14-3-3_CanoR_1	412	421	PF00244	0.665
LIG_14-3-3_CanoR_1	483	489	PF00244	0.509
LIG_14-3-3_CanoR_1	511	521	PF00244	0.527
LIG_14-3-3_CanoR_1	583	589	PF00244	0.360
LIG_14-3-3_CanoR_1	631	636	PF00244	0.586
LIG_BIR_II_1	1	5	PF00653	0.451
LIG_BRCT_BRCA1_1	316	320	PF00533	0.534
LIG_BRCT_BRCA1_1	52	56	PF00533	0.476
LIG_BRCT_BRCA1_1	75	79	PF00533	0.559
LIG_CtBP_PxDLS_1	680	684	PF00389	0.504
LIG_eIF4E_1	85	91	PF01652	0.515
LIG_FHA_1	155	161	PF00498	0.412
LIG_FHA_1	178	184	PF00498	0.449
LIG_FHA_1	187	193	PF00498	0.334
LIG_FHA_1	301	307	PF00498	0.401
LIG_FHA_1	349	355	PF00498	0.376
LIG_FHA_1	363	369	PF00498	0.420
LIG_FHA_1	379	385	PF00498	0.397
LIG_FHA_1	454	460	PF00498	0.535
LIG_FHA_1	564	570	PF00498	0.517
LIG_FHA_1	76	82	PF00498	0.504
LIG_FHA_2	13	19	PF00498	0.567
LIG_FHA_2	254	260	PF00498	0.491
LIG_FHA_2	411	417	PF00498	0.629
LIG_FHA_2	632	638	PF00498	0.654
LIG_GBD_Chelix_1	306	314	PF00786	0.469
LIG_LIR_Nem_3	627	633	PF02991	0.642
LIG_PDZ_Class_1	736	741	PF00595	0.674
LIG_SH2_CRK	311	315	PF00017	0.470
LIG_SH2_CRK	542	546	PF00017	0.504
LIG_SH2_CRK	630	634	PF00017	0.563
LIG_SH2_NCK_1	127	131	PF00017	0.515
LIG_SH2_NCK_1	197	201	PF00017	0.446
LIG_SH2_NCK_1	542	546	PF00017	0.477
LIG_SH2_SRC	127	130	PF00017	0.540
LIG_SH2_STAP1	127	131	PF00017	0.473
LIG_SH2_STAP1	134	138	PF00017	0.431
LIG_SH2_STAP1	156	160	PF00017	0.470
LIG_SH2_STAP1	428	432	PF00017	0.564
LIG_SH2_STAP1	519	523	PF00017	0.533
LIG_SH2_STAT3	41	44	PF00017	0.537
LIG_SH2_STAT5	156	159	PF00017	0.437
LIG_SH2_STAT5	275	278	PF00017	0.372
LIG_SH2_STAT5	311	314	PF00017	0.402
LIG_SH2_STAT5	686	689	PF00017	0.466
LIG_SH2_STAT5	85	88	PF00017	0.454
LIG_SH2_STAT5	93	96	PF00017	0.454
LIG_Sin3_3	567	574	PF02671	0.490
LIG_SUMO_SIM_anti_2	47	53	PF11976	0.526
LIG_SUMO_SIM_anti_2	566	572	PF11976	0.457
LIG_SUMO_SIM_par_1	386	392	PF11976	0.525
LIG_TYR_ITIM	309	314	PF00017	0.499
LIG_TYR_ITIM	628	633	PF00017	0.591
MOD_CDC14_SPxK_1	257	260	PF00782	0.408
MOD_CDK_SPxK_1	254	260	PF00069	0.456
MOD_CDK_SPxK_1	68	74	PF00069	0.532
MOD_CK1_1	253	259	PF00069	0.559
MOD_CK1_1	300	306	PF00069	0.377
MOD_CK1_1	403	409	PF00069	0.727
MOD_CK1_1	682	688	PF00069	0.479
MOD_CK2_1	24	30	PF00069	0.451
MOD_CK2_1	253	259	PF00069	0.575
MOD_CK2_1	58	64	PF00069	0.540
MOD_GlcNHglycan	109	112	PF01048	0.207
MOD_GlcNHglycan	160	163	PF01048	0.426
MOD_GlcNHglycan	299	302	PF01048	0.421
MOD_GlcNHglycan	303	306	PF01048	0.391
MOD_GlcNHglycan	316	319	PF01048	0.448
MOD_GlcNHglycan	356	359	PF01048	0.561
MOD_GlcNHglycan	405	408	PF01048	0.736
MOD_GlcNHglycan	416	419	PF01048	0.635
MOD_GlcNHglycan	52	55	PF01048	0.339
MOD_GlcNHglycan	596	599	PF01048	0.646
MOD_GlcNHglycan	649	652	PF01048	0.765
MOD_GlcNHglycan	738	741	PF01048	0.748
MOD_GlcNHglycan	75	78	PF01048	0.371
MOD_GSK3_1	154	161	PF00069	0.382
MOD_GSK3_1	20	27	PF00069	0.508
MOD_GSK3_1	215	222	PF00069	0.389
MOD_GSK3_1	244	251	PF00069	0.683
MOD_GSK3_1	292	299	PF00069	0.456
MOD_GSK3_1	408	415	PF00069	0.667
MOD_GSK3_1	483	490	PF00069	0.548
MOD_GSK3_1	513	520	PF00069	0.497
MOD_GSK3_1	594	601	PF00069	0.560
MOD_GSK3_1	732	739	PF00069	0.728
MOD_N-GLC_1	154	159	PF02516	0.418
MOD_NEK2_1	292	297	PF00069	0.480
MOD_NEK2_1	320	325	PF00069	0.418
MOD_NEK2_1	354	359	PF00069	0.413
MOD_NEK2_1	380	385	PF00069	0.427
MOD_NEK2_1	476	481	PF00069	0.542
MOD_NEK2_1	50	55	PF00069	0.543
MOD_NEK2_1	512	517	PF00069	0.501
MOD_NEK2_1	7	12	PF00069	0.537
MOD_NEK2_1	73	78	PF00069	0.540
MOD_NEK2_2	469	474	PF00069	0.379
MOD_PKA_1	12	18	PF00069	0.555
MOD_PKA_1	483	489	PF00069	0.454
MOD_PKA_1	631	637	PF00069	0.655
MOD_PKA_2	337	343	PF00069	0.416
MOD_PKA_2	362	368	PF00069	0.476
MOD_PKA_2	408	414	PF00069	0.712
MOD_PKA_2	483	489	PF00069	0.570
MOD_PKA_2	510	516	PF00069	0.522
MOD_PKA_2	631	637	PF00069	0.580
MOD_Plk_1	476	482	PF00069	0.556
MOD_Plk_1	555	561	PF00069	0.538
MOD_Plk_1	563	569	PF00069	0.425
MOD_Plk_1	7	13	PF00069	0.514
MOD_Plk_4	200	206	PF00069	0.470
MOD_Plk_4	484	490	PF00069	0.435
MOD_Plk_4	58	64	PF00069	0.493
MOD_Plk_4	631	637	PF00069	0.448
MOD_ProDKin_1	177	183	PF00069	0.529
MOD_ProDKin_1	254	260	PF00069	0.446
MOD_ProDKin_1	400	406	PF00069	0.748
MOD_ProDKin_1	68	74	PF00069	0.559
MOD_ProDKin_1	732	738	PF00069	0.656
MOD_SUMO_for_1	5	8	PF00179	0.490
MOD_SUMO_rev_2	174	181	PF00179	0.458
TRG_DiLeu_BaEn_1	148	153	PF01217	0.433
TRG_DiLeu_BaEn_1	564	569	PF01217	0.407
TRG_ENDOCYTIC_2	134	137	PF00928	0.454
TRG_ENDOCYTIC_2	275	278	PF00928	0.476
TRG_ENDOCYTIC_2	311	314	PF00928	0.459
TRG_ENDOCYTIC_2	542	545	PF00928	0.482
TRG_ENDOCYTIC_2	630	633	PF00928	0.572
TRG_ENDOCYTIC_2	88	91	PF00928	0.466
TRG_ER_diArg_1	279	282	PF00400	0.511
TRG_ER_diArg_1	286	288	PF00400	0.427
TRG_ER_diArg_1	448	451	PF00400	0.485
TRG_ER_diArg_1	483	485	PF00400	0.541
TRG_ER_diArg_1	630	632	PF00400	0.656
TRG_ER_diArg_1	657	660	PF00400	0.455
TRG_ER_diArg_1	662	664	PF00400	0.454
TRG_ER_diArg_1	698	700	PF00400	0.559
TRG_NES_CRM1_1	379	392	PF08389	0.423
TRG_NES_CRM1_1	497	510	PF08389	0.540
TRG_NLS_Bipartite_1	693	713	PF00514	0.598
TRG_NLS_MonoCore_2	393	398	PF00514	0.536
TRG_NLS_MonoExtC_3	393	398	PF00514	0.439
TRG_NLS_MonoExtC_3	445	450	PF00514	0.500
TRG_NLS_MonoExtN_4	391	398	PF00514	0.521
TRG_NLS_MonoExtN_4	446	451	PF00514	0.499
TRG_Pf-PMV_PEXEL_1	114	119	PF00026	0.315
TRG_Pf-PMV_PEXEL_1	221	225	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	31	36	PF00026	0.309
TRG_Pf-PMV_PEXEL_1	688	692	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I027	Leptomonas seymouri	63%	100%
A0A0S4J0A8	Bodo saltans	34%	100%
A0A1X0P6G4	Trypanosomatidae	41%	100%
A0A422NHC6	Trypanosoma rangeli	42%	100%
A4HA36	Leishmania braziliensis	83%	100%
A4HY99	Leishmania infantum	99%	100%
D0A0N5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AS31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O76094	Homo sapiens	23%	100%
P33731	Canis lupus familiaris	23%	100%
Q4QDE2	Leishmania major	93%	100%
Q54EP7	Dictyostelium discoideum	22%	100%
V5BJ44	Trypanosoma cruzi	43%	100%