Cation transporter, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cation transporter, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IDA3_LEIDO

TriTrypDb:

LdBPK_271160.1 , LdCL_270018100 , LDHU3_27.1820

Length:

610

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	9
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	9

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Expansion

Sequence features

A0A3Q8IDA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDA3

Function

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Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	1
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0006812	monoatomic cation transport	5	2
GO:0006829	zinc ion transport	8	1
GO:0006873	intracellular monoatomic ion homeostasis	4	7
GO:0006875	obsolete intracellular metal ion homeostasis	6	7
GO:0006882	intracellular zinc ion homeostasis	7	7
GO:0009987	cellular process	1	8
GO:0019725	cellular homeostasis	2	7

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	9
GO:0005385	zinc ion transmembrane transporter activity	7	8
GO:0008324	monoatomic cation transmembrane transporter activity	4	9
GO:0015075	monoatomic ion transmembrane transporter activity	3	9
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	8
GO:0022857	transmembrane transporter activity	2	9
GO:0022890	inorganic cation transmembrane transporter activity	4	8
GO:0046873	metal ion transmembrane transporter activity	5	8
GO:0046915	transition metal ion transmembrane transporter activity	6	8

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	272	276	PF00656	0.629
CLV_NRD_NRD_1	108	110	PF00675	0.413
CLV_NRD_NRD_1	313	315	PF00675	0.330
CLV_NRD_NRD_1	582	584	PF00675	0.327
CLV_PCSK_FUR_1	106	110	PF00082	0.393
CLV_PCSK_KEX2_1	108	110	PF00082	0.423
CLV_PCSK_SKI1_1	112	116	PF00082	0.237
CLV_PCSK_SKI1_1	269	273	PF00082	0.422
CLV_PCSK_SKI1_1	314	318	PF00082	0.276
CLV_PCSK_SKI1_1	519	523	PF00082	0.271

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB11	Leptomonas seymouri	58%	100%
A4HFQ2	Leishmania braziliensis	78%	100%
A4HJM3	Leishmania braziliensis	23%	100%
A4I2S7	Leishmania infantum	99%	100%
E9ADA5	Leishmania major	90%	100%
E9AZ30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q622	Leishmania major	23%	100%

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