RNA polymerase Rpb6 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IDA2_LEIDO

TriTrypDb:

LdBPK_250140.1 , LdCL_250006500 , LDHU3_25.0200

Length:

129

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	9
GO:0030880	RNA polymerase complex	3	9
GO:0032991	protein-containing complex	1	9
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	9
GO:0140535	intracellular protein-containing complex	2	9
GO:1902494	catalytic complex	2	9
GO:1990234	transferase complex	3	9
GO:0005665	RNA polymerase II, core complex	4	1
GO:0005666	RNA polymerase III complex	4	1
GO:0005736	RNA polymerase I complex	4	1
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3Q8IDA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IDA2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006351	DNA-templated transcription	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009059	macromolecule biosynthetic process	4	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0018130	heterocycle biosynthetic process	4	10
GO:0019438	aromatic compound biosynthetic process	4	10
GO:0032774	RNA biosynthetic process	5	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034654	nucleobase-containing compound biosynthetic process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:0097659	nucleic acid-templated transcription	6	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901362	organic cyclic compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0003824	catalytic activity	1	10
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	6	10
GO:0005488	binding	1	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016779	nucleotidyltransferase activity	4	10
GO:0034062	5'-3' RNA polymerase activity	5	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097747	RNA polymerase activity	4	10
GO:0140098	catalytic activity, acting on RNA	3	10
GO:0140640	catalytic activity, acting on a nucleic acid	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	5	9	PF00656	0.561
CLV_C14_Caspase3-7	63	67	PF00656	0.472
CLV_NRD_NRD_1	102	104	PF00675	0.326
CLV_NRD_NRD_1	28	30	PF00675	0.413
CLV_NRD_NRD_1	94	96	PF00675	0.241
CLV_PCSK_KEX2_1	102	104	PF00082	0.366
CLV_PCSK_KEX2_1	28	30	PF00082	0.470
CLV_PCSK_PC7_1	98	104	PF00082	0.432
DEG_Nend_Nbox_1	1	3	PF02207	0.497
DEG_SCF_FBW7_2	22	27	PF00400	0.497
DOC_ANK_TNKS_1	102	109	PF00023	0.396
DOC_MAPK_DCC_7	78	87	PF00069	0.501
DOC_MAPK_gen_1	28	34	PF00069	0.421
DOC_MAPK_gen_1	95	101	PF00069	0.569
DOC_MAPK_RevD_3	80	96	PF00069	0.501
DOC_USP7_MATH_1	54	58	PF00917	0.524
DOC_WW_Pin1_4	20	25	PF00397	0.516
LIG_APCC_ABBA_1	22	27	PF00400	0.586
LIG_EH1_1	36	44	PF00400	0.428
LIG_FHA_1	110	116	PF00498	0.467
LIG_FHA_2	121	127	PF00498	0.538
LIG_FHA_2	33	39	PF00498	0.449
LIG_SH2_CRK	90	94	PF00017	0.501
LIG_SH2_STAP1	18	22	PF00017	0.522
LIG_SH2_STAT5	33	36	PF00017	0.418
LIG_SUMO_SIM_par_1	117	123	PF11976	0.525
MOD_CK1_1	67	73	PF00069	0.462
MOD_CK2_1	32	38	PF00069	0.269
MOD_GlcNHglycan	29	32	PF01048	0.497
MOD_GlcNHglycan	51	54	PF01048	0.328
MOD_GlcNHglycan	62	65	PF01048	0.256
MOD_GSK3_1	16	23	PF00069	0.571
MOD_GSK3_1	54	61	PF00069	0.489
MOD_GSK3_1	72	79	PF00069	0.332
MOD_NEK2_1	32	37	PF00069	0.390
MOD_PKA_2	27	33	PF00069	0.411
MOD_PKA_2	72	78	PF00069	0.444
MOD_Plk_1	120	126	PF00069	0.543
MOD_Plk_4	120	126	PF00069	0.530
MOD_ProDKin_1	20	26	PF00069	0.511
TRG_ENDOCYTIC_2	90	93	PF00928	0.501
TRG_ER_diArg_1	101	103	PF00400	0.343
TRG_NES_CRM1_1	117	128	PF08389	0.527
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.260
TRG_Pf-PMV_PEXEL_1	78	83	PF00026	0.301

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7X7	Leptomonas seymouri	82%	100%
A0A1X0P4L0	Trypanosomatidae	53%	98%
A0A3Q8IKT1	Leishmania donovani	31%	81%
A0A422NF56	Trypanosoma rangeli	50%	99%
A4HAK2	Leishmania braziliensis	33%	81%
A4HDW1	Leishmania braziliensis	92%	100%
A4I156	Leishmania infantum	100%	100%
A4I9P6	Leishmania infantum	31%	81%
A8WSV7	Caenorhabditis briggsae	29%	93%
D0A5E1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AX90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B4R0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	81%
P20435	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	83%
P36595	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	91%
Q17684	Caenorhabditis elegans	33%	94%
Q4Q3B6	Leishmania major	31%	81%
Q4QA82	Leishmania major	98%	100%