Expression site-associated gene (ESAG-like) protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ID98_LEIDO

TriTrypDb:

LdBPK_150020.1 , LdCL_150005100 , LDHU3_15.0020

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3Q8ID98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID98

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.434
CLV_C14_Caspase3-7	530	534	PF00656	0.379
CLV_NRD_NRD_1	477	479	PF00675	0.627
CLV_NRD_NRD_1	545	547	PF00675	0.564
CLV_NRD_NRD_1	561	563	PF00675	0.506
CLV_NRD_NRD_1	578	580	PF00675	0.615
CLV_NRD_NRD_1	92	94	PF00675	0.608
CLV_PCSK_FUR_1	409	413	PF00082	0.574
CLV_PCSK_FUR_1	49	53	PF00082	0.378
CLV_PCSK_KEX2_1	411	413	PF00082	0.574
CLV_PCSK_KEX2_1	476	478	PF00082	0.626
CLV_PCSK_KEX2_1	51	53	PF00082	0.386
CLV_PCSK_KEX2_1	545	547	PF00082	0.696
CLV_PCSK_KEX2_1	560	562	PF00082	0.645
CLV_PCSK_KEX2_1	578	580	PF00082	0.501
CLV_PCSK_KEX2_1	92	94	PF00082	0.563
CLV_PCSK_KEX2_1	98	100	PF00082	0.713
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.574
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.289
CLV_PCSK_PC1ET2_1	560	562	PF00082	0.657
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.581
CLV_PCSK_SKI1_1	401	405	PF00082	0.577
CLV_PCSK_SKI1_1	51	55	PF00082	0.331
CLV_PCSK_SKI1_1	546	550	PF00082	0.582
CLV_PCSK_SKI1_1	579	583	PF00082	0.625
CLV_PCSK_SKI1_1	595	599	PF00082	0.450
CLV_PCSK_SKI1_1	93	97	PF00082	0.587
CLV_Separin_Metazoa	36	40	PF03568	0.524
DEG_APCC_DBOX_1	33	41	PF00400	0.617
DEG_APCC_DBOX_1	477	485	PF00400	0.407
DOC_CKS1_1	357	362	PF01111	0.370
DOC_CKS1_1	512	517	PF01111	0.448
DOC_CYCLIN_RxL_1	49	57	PF00134	0.487
DOC_MAPK_DCC_7	265	275	PF00069	0.370
DOC_MAPK_gen_1	31	40	PF00069	0.573
DOC_MAPK_gen_1	448	458	PF00069	0.447
DOC_MAPK_gen_1	490	497	PF00069	0.422
DOC_MAPK_MEF2A_6	196	204	PF00069	0.388
DOC_MAPK_MEF2A_6	451	460	PF00069	0.439
DOC_PP1_RVXF_1	138	144	PF00149	0.397
DOC_PP1_RVXF_1	27	33	PF00149	0.529
DOC_PP4_FxxP_1	313	316	PF00568	0.364
DOC_PP4_FxxP_1	454	457	PF00568	0.311
DOC_PP4_FxxP_1	497	500	PF00568	0.372
DOC_PP4_FxxP_1	512	515	PF00568	0.343
DOC_PP4_FxxP_1	617	620	PF00568	0.418
DOC_USP7_MATH_1	320	324	PF00917	0.417
DOC_USP7_MATH_1	506	510	PF00917	0.426
DOC_USP7_MATH_1	556	560	PF00917	0.459
DOC_WW_Pin1_4	223	228	PF00397	0.395
DOC_WW_Pin1_4	256	261	PF00397	0.527
DOC_WW_Pin1_4	312	317	PF00397	0.364
DOC_WW_Pin1_4	356	361	PF00397	0.469
DOC_WW_Pin1_4	511	516	PF00397	0.442
DOC_WW_Pin1_4	612	617	PF00397	0.409
LIG_14-3-3_CanoR_1	167	171	PF00244	0.357
LIG_14-3-3_CanoR_1	308	314	PF00244	0.455
LIG_14-3-3_CanoR_1	52	62	PF00244	0.306
LIG_14-3-3_CanoR_1	578	582	PF00244	0.443
LIG_14-3-3_CanoR_1	6	15	PF00244	0.610
LIG_Actin_WH2_2	385	403	PF00022	0.348
LIG_Actin_WH2_2	581	597	PF00022	0.276
LIG_AP2alpha_2	452	454	PF02296	0.274
LIG_BRCT_BRCA1_1	427	431	PF00533	0.316
LIG_BRCT_BRCA1_1	508	512	PF00533	0.375
LIG_Clathr_ClatBox_1	460	464	PF01394	0.349
LIG_deltaCOP1_diTrp_1	151	154	PF00928	0.332
LIG_deltaCOP1_diTrp_1	569	575	PF00928	0.318
LIG_eIF4E_1	298	304	PF01652	0.329
LIG_EVH1_2	271	275	PF00568	0.350
LIG_FHA_1	129	135	PF00498	0.493
LIG_FHA_1	298	304	PF00498	0.327
LIG_FHA_1	470	476	PF00498	0.425
LIG_FHA_1	512	518	PF00498	0.435
LIG_FHA_1	55	61	PF00498	0.398
LIG_FHA_2	209	215	PF00498	0.420
LIG_FHA_2	347	353	PF00498	0.434
LIG_FHA_2	357	363	PF00498	0.299
LIG_FHA_2	496	502	PF00498	0.504
LIG_FHA_2	528	534	PF00498	0.499
LIG_FHA_2	587	593	PF00498	0.339
LIG_LIR_Apic_2	280	286	PF02991	0.398
LIG_LIR_Apic_2	312	316	PF02991	0.359
LIG_LIR_Apic_2	452	457	PF02991	0.370
LIG_LIR_Apic_2	494	500	PF02991	0.385
LIG_LIR_Apic_2	509	515	PF02991	0.344
LIG_LIR_Apic_2	615	620	PF02991	0.346
LIG_LIR_Gen_1	151	162	PF02991	0.316
LIG_LIR_Gen_1	174	183	PF02991	0.401
LIG_LIR_Gen_1	288	299	PF02991	0.478
LIG_LIR_Gen_1	551	557	PF02991	0.332
LIG_LIR_Gen_1	56	66	PF02991	0.319
LIG_LIR_Nem_3	151	157	PF02991	0.322
LIG_LIR_Nem_3	174	180	PF02991	0.352
LIG_LIR_Nem_3	184	189	PF02991	0.390
LIG_LIR_Nem_3	288	294	PF02991	0.434
LIG_LIR_Nem_3	325	330	PF02991	0.523
LIG_LIR_Nem_3	551	555	PF02991	0.426
LIG_LIR_Nem_3	56	62	PF02991	0.319
LIG_LIR_Nem_3	569	574	PF02991	0.279
LIG_LIR_Nem_3	580	584	PF02991	0.436
LIG_PCNA_PIPBox_1	118	127	PF02747	0.359
LIG_Pex14_1	570	574	PF04695	0.329
LIG_Pex14_2	218	222	PF04695	0.461
LIG_Pex14_2	571	575	PF04695	0.385
LIG_SH2_CRK	283	287	PF00017	0.419
LIG_SH2_CRK	330	334	PF00017	0.381
LIG_SH2_GRB2like	379	382	PF00017	0.356
LIG_SH2_NCK_1	225	229	PF00017	0.390
LIG_SH2_SRC	379	382	PF00017	0.356
LIG_SH2_SRC	83	86	PF00017	0.415
LIG_SH2_STAP1	177	181	PF00017	0.332
LIG_SH2_STAP1	183	187	PF00017	0.285
LIG_SH2_STAP1	427	431	PF00017	0.316
LIG_SH2_STAT3	124	127	PF00017	0.358
LIG_SH2_STAT3	282	285	PF00017	0.331
LIG_SH2_STAT5	124	127	PF00017	0.434
LIG_SH2_STAT5	136	139	PF00017	0.423
LIG_SH2_STAT5	186	189	PF00017	0.398
LIG_SH2_STAT5	298	301	PF00017	0.443
LIG_SH2_STAT5	379	382	PF00017	0.347
LIG_SH2_STAT5	488	491	PF00017	0.430
LIG_SH2_STAT5	564	567	PF00017	0.425
LIG_SH2_STAT5	574	577	PF00017	0.335
LIG_SH2_STAT5	59	62	PF00017	0.236
LIG_SH2_STAT5	83	86	PF00017	0.544
LIG_SH3_3	265	271	PF00018	0.383
LIG_SH3_3	447	453	PF00018	0.329
LIG_SH3_3	70	76	PF00018	0.379
LIG_SUMO_SIM_anti_2	528	533	PF11976	0.380
LIG_SUMO_SIM_par_1	197	207	PF11976	0.393
LIG_SUMO_SIM_par_1	459	464	PF11976	0.425
LIG_SUMO_SIM_par_1	62	68	PF11976	0.430
LIG_WRC_WIRS_1	549	554	PF05994	0.331
LIG_WW_3	522	526	PF00397	0.361
MOD_CDK_SPxxK_3	356	363	PF00069	0.419
MOD_CK1_1	147	153	PF00069	0.368
MOD_CK1_1	175	181	PF00069	0.357
MOD_CK1_1	226	232	PF00069	0.353
MOD_CK1_1	312	318	PF00069	0.425
MOD_CK1_1	486	492	PF00069	0.508
MOD_CK1_1	535	541	PF00069	0.375
MOD_CK2_1	346	352	PF00069	0.427
MOD_CMANNOS	570	573	PF00535	0.544
MOD_Cter_Amidation	96	99	PF01082	0.563
MOD_GlcNHglycan	249	252	PF01048	0.527
MOD_GlcNHglycan	508	511	PF01048	0.711
MOD_GlcNHglycan	540	543	PF01048	0.607
MOD_GSK3_1	128	135	PF00069	0.359
MOD_GSK3_1	252	259	PF00069	0.449
MOD_GSK3_1	293	300	PF00069	0.306
MOD_GSK3_1	482	489	PF00069	0.446
MOD_GSK3_1	534	541	PF00069	0.402
MOD_GSK3_1	582	589	PF00069	0.385
MOD_GSK3_1	612	619	PF00069	0.364
MOD_N-GLC_1	128	133	PF02516	0.583
MOD_N-GLC_1	147	152	PF02516	0.434
MOD_N-GLC_1	347	352	PF02516	0.613
MOD_N-GLC_1	600	605	PF02516	0.603
MOD_NEK2_1	117	122	PF00069	0.384
MOD_NEK2_1	252	257	PF00069	0.415
MOD_NEK2_1	346	351	PF00069	0.422
MOD_NEK2_1	384	389	PF00069	0.352
MOD_NEK2_1	438	443	PF00069	0.344
MOD_NEK2_1	469	474	PF00069	0.360
MOD_NEK2_1	527	532	PF00069	0.456
MOD_NEK2_1	53	58	PF00069	0.323
MOD_NEK2_1	64	69	PF00069	0.335
MOD_NEK2_1	7	12	PF00069	0.674
MOD_OFUCOSY	155	161	PF10250	0.513
MOD_PIKK_1	123	129	PF00454	0.336
MOD_PIKK_1	8	14	PF00454	0.558
MOD_PKA_2	166	172	PF00069	0.365
MOD_PKA_2	320	326	PF00069	0.452
MOD_PKA_2	538	544	PF00069	0.397
MOD_PKA_2	577	583	PF00069	0.433
MOD_PKA_2	8	14	PF00069	0.660
MOD_Plk_1	150	156	PF00069	0.327
MOD_Plk_1	173	179	PF00069	0.402
MOD_Plk_1	347	353	PF00069	0.404
MOD_Plk_1	416	422	PF00069	0.343
MOD_Plk_1	527	533	PF00069	0.359
MOD_Plk_1	600	606	PF00069	0.402
MOD_Plk_4	132	138	PF00069	0.309
MOD_Plk_4	166	172	PF00069	0.320
MOD_Plk_4	309	315	PF00069	0.466
MOD_Plk_4	416	422	PF00069	0.343
MOD_Plk_4	483	489	PF00069	0.517
MOD_Plk_4	527	533	PF00069	0.436
MOD_Plk_4	54	60	PF00069	0.486
MOD_Plk_4	548	554	PF00069	0.332
MOD_Plk_4	586	592	PF00069	0.372
MOD_ProDKin_1	223	229	PF00069	0.397
MOD_ProDKin_1	256	262	PF00069	0.527
MOD_ProDKin_1	312	318	PF00069	0.366
MOD_ProDKin_1	356	362	PF00069	0.468
MOD_ProDKin_1	511	517	PF00069	0.440
MOD_ProDKin_1	612	618	PF00069	0.396
MOD_SUMO_for_1	410	413	PF00179	0.400
TRG_DiLeu_BaEn_2	351	357	PF01217	0.424
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.376
TRG_ENDOCYTIC_2	177	180	PF00928	0.397
TRG_ENDOCYTIC_2	19	22	PF00928	0.575
TRG_ENDOCYTIC_2	330	333	PF00928	0.386
TRG_ENDOCYTIC_2	334	337	PF00928	0.348
TRG_ENDOCYTIC_2	427	430	PF00928	0.356
TRG_ENDOCYTIC_2	574	577	PF00928	0.382
TRG_ENDOCYTIC_2	59	62	PF00928	0.236
TRG_ENDOCYTIC_2	85	88	PF00928	0.377
TRG_ER_diArg_1	29	32	PF00400	0.618
TRG_ER_diArg_1	475	478	PF00400	0.401
TRG_ER_diArg_1	544	546	PF00400	0.379
TRG_ER_diArg_1	561	563	PF00400	0.297
TRG_ER_diArg_1	577	579	PF00400	0.395
TRG_NLS_Bipartite_1	545	564	PF00514	0.307
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGZ4	Leptomonas seymouri	32%	97%
A0A0N1PDD7	Leptomonas seymouri	24%	100%
A0A3Q8IM92	Leishmania donovani	32%	93%
A4H7X2	Leishmania braziliensis	77%	100%
A4HLI8	Leishmania braziliensis	33%	100%
A4HLJ0	Leishmania braziliensis	32%	100%
A4HLJ2	Leishmania braziliensis	30%	99%
A4HW99	Leishmania infantum	100%	100%
A4I8Z8	Leishmania infantum	33%	100%
E9APZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B3W7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q4Q457	Leishmania major	34%	100%
Q4QFI2	Leishmania major	91%	100%