Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8ID95_LEIDO

TriTrypDb:

LdBPK_251180.1 , LdCL_250017200 , LDHU3_25.1500

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ID95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID95

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	524	528	PF00656	0.651
CLV_NRD_NRD_1	12	14	PF00675	0.425
CLV_NRD_NRD_1	178	180	PF00675	0.609
CLV_PCSK_FUR_1	176	180	PF00082	0.613
CLV_PCSK_KEX2_1	12	14	PF00082	0.425
CLV_PCSK_KEX2_1	178	180	PF00082	0.609
CLV_PCSK_SKI1_1	529	533	PF00082	0.654
DEG_SCF_FBW7_1	244	251	PF00400	0.644
DEG_SPOP_SBC_1	109	113	PF00917	0.620
DOC_CDC14_PxL_1	184	192	PF14671	0.491
DOC_CKS1_1	245	250	PF01111	0.625
DOC_CKS1_1	53	58	PF01111	0.420
DOC_PP2B_LxvP_1	315	318	PF13499	0.578
DOC_PP2B_LxvP_1	74	77	PF13499	0.582
DOC_PP2B_PxIxI_1	363	369	PF00149	0.511
DOC_PP4_FxxP_1	214	217	PF00568	0.625
DOC_USP7_MATH_1	103	107	PF00917	0.599
DOC_USP7_MATH_1	140	144	PF00917	0.621
DOC_USP7_MATH_1	152	156	PF00917	0.607
DOC_USP7_MATH_1	222	226	PF00917	0.615
DOC_USP7_MATH_1	236	240	PF00917	0.669
DOC_USP7_MATH_1	248	252	PF00917	0.565
DOC_USP7_MATH_1	271	275	PF00917	0.568
DOC_USP7_MATH_1	329	333	PF00917	0.620
DOC_USP7_MATH_1	340	344	PF00917	0.572
DOC_USP7_MATH_1	410	414	PF00917	0.790
DOC_USP7_MATH_1	534	538	PF00917	0.672
DOC_USP7_MATH_1	8	12	PF00917	0.492
DOC_USP7_MATH_1	93	97	PF00917	0.625
DOC_USP7_UBL2_3	138	142	PF12436	0.656
DOC_WW_Pin1_4	128	133	PF00397	0.614
DOC_WW_Pin1_4	238	243	PF00397	0.634
DOC_WW_Pin1_4	244	249	PF00397	0.644
DOC_WW_Pin1_4	280	285	PF00397	0.657
DOC_WW_Pin1_4	289	294	PF00397	0.559
DOC_WW_Pin1_4	308	313	PF00397	0.427
DOC_WW_Pin1_4	344	349	PF00397	0.671
DOC_WW_Pin1_4	387	392	PF00397	0.594
DOC_WW_Pin1_4	414	419	PF00397	0.664
DOC_WW_Pin1_4	424	429	PF00397	0.599
DOC_WW_Pin1_4	509	514	PF00397	0.616
DOC_WW_Pin1_4	52	57	PF00397	0.426
DOC_WW_Pin1_4	530	535	PF00397	0.574
LIG_14-3-3_CanoR_1	47	53	PF00244	0.496
LIG_14-3-3_CanoR_1	529	534	PF00244	0.605
LIG_Actin_WH2_2	464	482	PF00022	0.484
LIG_BIR_III_2	395	399	PF00653	0.647
LIG_BRCT_BRCA1_1	412	416	PF00533	0.780
LIG_EVH1_1	214	218	PF00568	0.655
LIG_EVH1_2	431	435	PF00568	0.647
LIG_FHA_1	26	32	PF00498	0.460
LIG_FHA_1	388	394	PF00498	0.665
LIG_FHA_1	488	494	PF00498	0.506
LIG_FHA_1	5	11	PF00498	0.456
LIG_FHA_1	509	515	PF00498	0.668
LIG_FHA_1	533	539	PF00498	0.609
LIG_FHA_2	218	224	PF00498	0.689
LIG_FHA_2	522	528	PF00498	0.654
LIG_FHA_2	53	59	PF00498	0.419
LIG_FHA_2	67	73	PF00498	0.585
LIG_LIR_Apic_2	211	217	PF02991	0.611
LIG_LIR_Apic_2	225	231	PF02991	0.614
LIG_LIR_Apic_2	332	336	PF02991	0.612
LIG_LIR_Gen_1	438	449	PF02991	0.448
LIG_LIR_Gen_1	466	475	PF02991	0.495
LIG_LIR_Gen_1	69	78	PF02991	0.610
LIG_LIR_Nem_3	300	305	PF02991	0.527
LIG_LIR_Nem_3	438	444	PF02991	0.437
LIG_LIR_Nem_3	466	471	PF02991	0.507
LIG_LIR_Nem_3	473	478	PF02991	0.453
LIG_LIR_Nem_3	69	74	PF02991	0.592
LIG_MYND_1	313	317	PF01753	0.567
LIG_NRBOX	58	64	PF00104	0.454
LIG_NRP_CendR_1	543	545	PF00754	0.652
LIG_PTAP_UEV_1	131	136	PF05743	0.653
LIG_SH2_CRK	305	309	PF00017	0.511
LIG_SH2_CRK	333	337	PF00017	0.613
LIG_SH2_CRK	454	458	PF00017	0.422
LIG_SH2_PTP2	361	364	PF00017	0.515
LIG_SH2_SRC	361	364	PF00017	0.515
LIG_SH2_STAT3	61	64	PF00017	0.398
LIG_SH2_STAT5	18	21	PF00017	0.399
LIG_SH2_STAT5	194	197	PF00017	0.606
LIG_SH2_STAT5	200	203	PF00017	0.575
LIG_SH2_STAT5	29	32	PF00017	0.474
LIG_SH2_STAT5	361	364	PF00017	0.515
LIG_SH2_STAT5	441	444	PF00017	0.428
LIG_SH2_STAT5	478	481	PF00017	0.415
LIG_SH2_STAT5	61	64	PF00017	0.398
LIG_SH3_2	428	433	PF14604	0.662
LIG_SH3_3	129	135	PF00018	0.662
LIG_SH3_3	182	188	PF00018	0.505
LIG_SH3_3	212	218	PF00018	0.649
LIG_SH3_3	239	245	PF00018	0.654
LIG_SH3_3	247	253	PF00018	0.615
LIG_SH3_3	310	316	PF00018	0.606
LIG_SH3_3	388	394	PF00018	0.659
LIG_SH3_3	425	431	PF00018	0.649
LIG_SH3_3	50	56	PF00018	0.444
LIG_SH3_3	515	521	PF00018	0.625
LIG_SH3_3	87	93	PF00018	0.686
LIG_SUMO_SIM_par_1	96	102	PF11976	0.549
LIG_WW_3	421	425	PF00397	0.566
MOD_CDC14_SPxK_1	417	420	PF00782	0.629
MOD_CDC14_SPxK_1	430	433	PF00782	0.532
MOD_CDK_SPK_2	244	249	PF00069	0.644
MOD_CDK_SPxK_1	414	420	PF00069	0.625
MOD_CDK_SPxK_1	427	433	PF00069	0.550
MOD_CK1_1	108	114	PF00069	0.628
MOD_CK1_1	192	198	PF00069	0.507
MOD_CK1_1	252	258	PF00069	0.815
MOD_CK1_1	283	289	PF00069	0.676
MOD_CK1_1	297	303	PF00069	0.430
MOD_CK1_1	311	317	PF00069	0.492
MOD_CK1_1	319	325	PF00069	0.609
MOD_CK1_1	343	349	PF00069	0.640
MOD_CK1_1	414	420	PF00069	0.651
MOD_CK1_1	512	518	PF00069	0.646
MOD_CK1_1	533	539	PF00069	0.629
MOD_CK2_1	52	58	PF00069	0.407
MOD_CK2_1	66	72	PF00069	0.481
MOD_DYRK1A_RPxSP_1	424	428	PF00069	0.574
MOD_GlcNHglycan	105	108	PF01048	0.669
MOD_GlcNHglycan	124	127	PF01048	0.638
MOD_GlcNHglycan	142	145	PF01048	0.586
MOD_GlcNHglycan	273	276	PF01048	0.663
MOD_GlcNHglycan	285	288	PF01048	0.555
MOD_GlcNHglycan	302	305	PF01048	0.414
MOD_GlcNHglycan	321	324	PF01048	0.515
MOD_GlcNHglycan	353	356	PF01048	0.520
MOD_GlcNHglycan	524	527	PF01048	0.618
MOD_GlcNHglycan	83	86	PF01048	0.650
MOD_GlcNHglycan	93	96	PF01048	0.548
MOD_GSK3_1	103	110	PF00069	0.667
MOD_GSK3_1	111	118	PF00069	0.601
MOD_GSK3_1	136	143	PF00069	0.679
MOD_GSK3_1	189	196	PF00069	0.527
MOD_GSK3_1	234	241	PF00069	0.644
MOD_GSK3_1	244	251	PF00069	0.665
MOD_GSK3_1	267	274	PF00069	0.638
MOD_GSK3_1	339	346	PF00069	0.802
MOD_GSK3_1	4	11	PF00069	0.529
MOD_GSK3_1	410	417	PF00069	0.764
MOD_GSK3_1	466	473	PF00069	0.489
MOD_GSK3_1	48	55	PF00069	0.620
MOD_GSK3_1	508	515	PF00069	0.612
MOD_GSK3_1	529	536	PF00069	0.792
MOD_GSK3_1	66	73	PF00069	0.417
MOD_GSK3_1	77	84	PF00069	0.605
MOD_GSK3_1	93	100	PF00069	0.579
MOD_N-GLC_1	411	416	PF02516	0.562
MOD_N-GLC_1	66	71	PF02516	0.463
MOD_NEK2_1	160	165	PF00069	0.529
MOD_NEK2_1	190	195	PF00069	0.505
MOD_NEK2_1	378	383	PF00069	0.548
MOD_NEK2_1	435	440	PF00069	0.569
MOD_NEK2_1	48	53	PF00069	0.494
MOD_NEK2_2	18	23	PF00069	0.438
MOD_PIKK_1	160	166	PF00454	0.559
MOD_PIKK_1	234	240	PF00454	0.681
MOD_PKA_2	386	392	PF00069	0.658
MOD_PKA_2	48	54	PF00069	0.490
MOD_Plk_1	411	417	PF00069	0.652
MOD_Plk_4	297	303	PF00069	0.492
MOD_ProDKin_1	128	134	PF00069	0.612
MOD_ProDKin_1	238	244	PF00069	0.630
MOD_ProDKin_1	249	255	PF00069	0.672
MOD_ProDKin_1	280	286	PF00069	0.661
MOD_ProDKin_1	289	295	PF00069	0.552
MOD_ProDKin_1	308	314	PF00069	0.434
MOD_ProDKin_1	344	350	PF00069	0.668
MOD_ProDKin_1	387	393	PF00069	0.596
MOD_ProDKin_1	414	420	PF00069	0.669
MOD_ProDKin_1	424	430	PF00069	0.595
MOD_ProDKin_1	509	515	PF00069	0.616
MOD_ProDKin_1	52	58	PF00069	0.420
MOD_ProDKin_1	530	536	PF00069	0.576
MOD_SUMO_rev_2	438	447	PF00179	0.438
TRG_DiLeu_BaEn_1	58	63	PF01217	0.447
TRG_DiLeu_BaEn_2	155	161	PF01217	0.525
TRG_ENDOCYTIC_2	305	308	PF00928	0.517
TRG_ENDOCYTIC_2	441	444	PF00928	0.408
TRG_ENDOCYTIC_2	454	457	PF00928	0.424
TRG_ER_diArg_1	12	14	PF00400	0.425
TRG_ER_diArg_1	175	178	PF00400	0.618
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Z7	Leptomonas seymouri	52%	100%
A4HE58	Leishmania braziliensis	70%	99%
A4I1F6	Leishmania infantum	99%	100%
E9AXJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4Q9X9	Leishmania major	91%	100%