NOL1/NOP2/sun family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NOL1/NOP2/sun family, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ID92_LEIDO

TriTrypDb:

LdBPK_322580.1 , LdCL_320031300 , LDHU3_32.3210

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000315	organellar large ribosomal subunit	5	1
GO:0005762	mitochondrial large ribosomal subunit	3	1
GO:0015934	large ribosomal subunit	4	1
GO:0032991	protein-containing complex	1	1
GO:0044391	ribosomal subunit	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3Q8ID92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID92

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0032259	methylation	2	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000154	rRNA modification	6	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0031167	rRNA methylation	5	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.477
CLV_C14_Caspase3-7	346	350	PF00656	0.733
CLV_C14_Caspase3-7	351	355	PF00656	0.723
CLV_MEL_PAP_1	65	71	PF00089	0.494
CLV_NRD_NRD_1	212	214	PF00675	0.263
CLV_NRD_NRD_1	60	62	PF00675	0.468
CLV_NRD_NRD_1	96	98	PF00675	0.426
CLV_PCSK_FUR_1	210	214	PF00082	0.260
CLV_PCSK_KEX2_1	212	214	PF00082	0.257
CLV_PCSK_KEX2_1	47	49	PF00082	0.441
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.441
CLV_PCSK_SKI1_1	255	259	PF00082	0.260
CLV_PCSK_SKI1_1	284	288	PF00082	0.278
CLV_PCSK_SKI1_1	328	332	PF00082	0.352
CLV_PCSK_SKI1_1	345	349	PF00082	0.422
CLV_PCSK_SKI1_1	377	381	PF00082	0.465
CLV_PCSK_SKI1_1	62	66	PF00082	0.401
DEG_SPOP_SBC_1	104	108	PF00917	0.527
DEG_SPOP_SBC_1	404	408	PF00917	0.737
DOC_CKS1_1	363	368	PF01111	0.612
DOC_CYCLIN_RxL_1	374	383	PF00134	0.488
DOC_MAPK_gen_1	322	329	PF00069	0.455
DOC_PP2B_LxvP_1	340	343	PF13499	0.513
DOC_PP2B_LxvP_1	378	381	PF13499	0.460
DOC_PP4_FxxP_1	191	194	PF00568	0.510
DOC_USP7_MATH_1	250	254	PF00917	0.509
DOC_USP7_MATH_1	28	32	PF00917	0.648
DOC_USP7_MATH_1	350	354	PF00917	0.778
DOC_USP7_MATH_1	405	409	PF00917	0.609
DOC_USP7_UBL2_3	23	27	PF12436	0.732
DOC_USP7_UBL2_3	29	33	PF12436	0.666
DOC_WW_Pin1_4	190	195	PF00397	0.510
DOC_WW_Pin1_4	261	266	PF00397	0.484
DOC_WW_Pin1_4	305	310	PF00397	0.460
DOC_WW_Pin1_4	362	367	PF00397	0.700
LIG_14-3-3_CanoR_1	299	309	PF00244	0.485
LIG_14-3-3_CanoR_1	68	74	PF00244	0.529
LIG_BIR_III_4	145	149	PF00653	0.494
LIG_BIR_III_4	354	358	PF00653	0.691
LIG_CtBP_PxDLS_1	265	269	PF00389	0.527
LIG_FHA_1	274	280	PF00498	0.483
LIG_FHA_1	291	297	PF00498	0.388
LIG_FHA_1	302	308	PF00498	0.417
LIG_FHA_1	363	369	PF00498	0.687
LIG_FHA_1	76	82	PF00498	0.521
LIG_FHA_2	171	177	PF00498	0.554
LIG_FHA_2	197	203	PF00498	0.465
LIG_FHA_2	227	233	PF00498	0.472
LIG_FHA_2	321	327	PF00498	0.498
LIG_FHA_2	34	40	PF00498	0.487
LIG_FHA_2	344	350	PF00498	0.748
LIG_LIR_Apic_2	235	239	PF02991	0.452
LIG_LIR_Gen_1	38	45	PF02991	0.366
LIG_LIR_Nem_3	36	40	PF02991	0.393
LIG_LIR_Nem_3	373	378	PF02991	0.396
LIG_Pex14_1	387	391	PF04695	0.450
LIG_Rb_LxCxE_1	193	206	PF01857	0.535
LIG_SH2_CRK	375	379	PF00017	0.479
LIG_SH2_NCK_1	41	45	PF00017	0.481
LIG_SH2_SRC	237	240	PF00017	0.517
LIG_SH2_STAP1	41	45	PF00017	0.481
LIG_SH2_STAT5	153	156	PF00017	0.362
LIG_SH2_STAT5	223	226	PF00017	0.467
LIG_SH3_3	244	250	PF00018	0.449
LIG_SH3_3	338	344	PF00018	0.703
LIG_SH3_3	360	366	PF00018	0.688
LIG_SUMO_SIM_par_1	264	270	PF11976	0.527
LIG_TRAF2_1	73	76	PF00917	0.571
MOD_CK1_1	261	267	PF00069	0.550
MOD_CK1_1	272	278	PF00069	0.512
MOD_CK1_1	303	309	PF00069	0.455
MOD_CK1_1	353	359	PF00069	0.713
MOD_CK1_1	406	412	PF00069	0.678
MOD_CK2_1	196	202	PF00069	0.469
MOD_CK2_1	264	270	PF00069	0.494
MOD_CK2_1	305	311	PF00069	0.474
MOD_CK2_1	320	326	PF00069	0.508
MOD_CK2_1	33	39	PF00069	0.539
MOD_CK2_1	353	359	PF00069	0.762
MOD_CK2_1	404	410	PF00069	0.618
MOD_CK2_1	79	85	PF00069	0.549
MOD_Cter_Amidation	45	48	PF01082	0.323
MOD_GlcNHglycan	112	115	PF01048	0.671
MOD_GlcNHglycan	158	161	PF01048	0.414
MOD_GlcNHglycan	260	263	PF01048	0.308
MOD_GlcNHglycan	30	33	PF01048	0.611
MOD_GlcNHglycan	333	336	PF01048	0.480
MOD_GlcNHglycan	354	358	PF01048	0.691
MOD_GSK3_1	269	276	PF00069	0.479
MOD_GSK3_1	301	308	PF00069	0.460
MOD_GSK3_1	75	82	PF00069	0.543
MOD_GSK3_1	99	106	PF00069	0.716
MOD_N-GLC_1	99	104	PF02516	0.650
MOD_NEK2_1	258	263	PF00069	0.492
MOD_NEK2_1	320	325	PF00069	0.436
MOD_NEK2_1	4	9	PF00069	0.607
MOD_NEK2_2	290	295	PF00069	0.497
MOD_PIKK_1	226	232	PF00454	0.460
MOD_PIKK_1	67	73	PF00454	0.503
MOD_PKA_2	226	232	PF00069	0.559
MOD_PKA_2	4	10	PF00069	0.638
MOD_PKA_2	67	73	PF00069	0.462
MOD_Plk_1	370	376	PF00069	0.434
MOD_Plk_2-3	232	238	PF00069	0.531
MOD_Plk_4	170	176	PF00069	0.398
MOD_Plk_4	232	238	PF00069	0.475
MOD_Plk_4	364	370	PF00069	0.641
MOD_Plk_4	85	91	PF00069	0.476
MOD_ProDKin_1	190	196	PF00069	0.510
MOD_ProDKin_1	261	267	PF00069	0.484
MOD_ProDKin_1	305	311	PF00069	0.460
MOD_ProDKin_1	362	368	PF00069	0.687
MOD_SUMO_rev_2	396	404	PF00179	0.577
TRG_DiLeu_BaEn_1	85	90	PF01217	0.567
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.492
TRG_ENDOCYTIC_2	152	155	PF00928	0.369
TRG_ENDOCYTIC_2	375	378	PF00928	0.400
TRG_ENDOCYTIC_2	41	44	PF00928	0.428
TRG_ER_diArg_1	210	213	PF00400	0.464
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.252
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.249
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.249
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	377	382	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK00	Leptomonas seymouri	67%	100%
A0A0S4J448	Bodo saltans	41%	100%
A0A1X0NJV9	Trypanosomatidae	29%	73%
A0A1X0NRJ9	Trypanosomatidae	40%	100%
A0A3R7K4S3	Trypanosoma rangeli	47%	100%
A4HKN4	Leishmania braziliensis	80%	100%
A4I865	Leishmania infantum	100%	100%
D0AAD3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B323	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q0P5D8	Bos taurus	30%	100%
Q0V8R7	Bos taurus	28%	100%
Q4KMK0	Danio rerio	32%	100%
Q4Q532	Leishmania major	92%	100%
Q5M7E3	Xenopus laevis	30%	100%
Q66KI9	Xenopus tropicalis	29%	100%
Q8CCT7	Mus musculus	31%	100%
Q96CB9	Homo sapiens	27%	100%
Q9CZ57	Mus musculus	29%	100%
V5B8C1	Trypanosoma cruzi	44%	100%