N-terminal acetyltransferase complex ard1 subunit-like, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

n-terminal acetyltransferase complex ard1 subunit homolog, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ID89_LEIDO

TriTrypDb:

LdBPK_250020.1 , LdCL_250005100 , LDHU3_25.0030

Length:

227

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0031248	protein acetyltransferase complex	3	1
GO:0031414	N-terminal protein acetyltransferase complex	4	1
GO:0031416	NatB complex	5	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902493	acetyltransferase complex	4	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A0A3Q8ID89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID89

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	1
GO:0006474	N-terminal protein amino acid acetylation	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0017196	N-terminal peptidyl-methionine acetylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018206	peptidyl-methionine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0031365	N-terminal protein amino acid modification	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016407	acetyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0004596	peptide alpha-N-acetyltransferase activity	8	1
GO:0008080	N-acetyltransferase activity	6	1
GO:0016410	N-acyltransferase activity	5	1
GO:0034212	peptide N-acetyltransferase activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.241
CLV_NRD_NRD_1	153	155	PF00675	0.394
CLV_NRD_NRD_1	202	204	PF00675	0.386
CLV_NRD_NRD_1	207	209	PF00675	0.440
CLV_NRD_NRD_1	39	41	PF00675	0.476
CLV_NRD_NRD_1	46	48	PF00675	0.291
CLV_PCSK_KEX2_1	124	126	PF00082	0.241
CLV_PCSK_KEX2_1	202	204	PF00082	0.464
CLV_PCSK_KEX2_1	207	209	PF00082	0.457
CLV_PCSK_KEX2_1	38	40	PF00082	0.472
CLV_PCSK_KEX2_1	46	48	PF00082	0.270
CLV_PCSK_PC7_1	198	204	PF00082	0.457
CLV_PCSK_SKI1_1	125	129	PF00082	0.392
CLV_PCSK_SKI1_1	173	177	PF00082	0.334
CLV_PCSK_SKI1_1	198	202	PF00082	0.460
CLV_PCSK_SKI1_1	217	221	PF00082	0.408
CLV_PCSK_SKI1_1	30	34	PF00082	0.454
CLV_PCSK_SKI1_1	40	44	PF00082	0.501
CLV_PCSK_SKI1_1	46	50	PF00082	0.366
DOC_CYCLIN_yCln2_LP_2	215	221	PF00134	0.365
DOC_MAPK_gen_1	20	28	PF00069	0.421
DOC_MAPK_gen_1	205	215	PF00069	0.417
DOC_USP7_MATH_1	137	141	PF00917	0.374
DOC_USP7_MATH_1	187	191	PF00917	0.415
DOC_USP7_UBL2_3	185	189	PF12436	0.424
DOC_USP7_UBL2_3	205	209	PF12436	0.483
DOC_WW_Pin1_4	9	14	PF00397	0.398
LIG_14-3-3_CanoR_1	207	213	PF00244	0.357
LIG_14-3-3_CanoR_1	39	48	PF00244	0.523
LIG_AP2alpha_1	148	152	PF02296	0.241
LIG_FHA_1	3	9	PF00498	0.400
LIG_FHA_1	89	95	PF00498	0.363
LIG_FHA_2	47	53	PF00498	0.324
LIG_LIR_Gen_1	12	21	PF02991	0.423
LIG_LIR_Gen_1	162	172	PF02991	0.338
LIG_LIR_Gen_1	53	64	PF02991	0.373
LIG_LIR_Gen_1	82	90	PF02991	0.355
LIG_LIR_Nem_3	12	17	PF02991	0.442
LIG_LIR_Nem_3	122	126	PF02991	0.260
LIG_LIR_Nem_3	162	167	PF02991	0.294
LIG_LIR_Nem_3	53	59	PF02991	0.352
LIG_LIR_Nem_3	70	76	PF02991	0.371
LIG_LIR_Nem_3	78	83	PF02991	0.366
LIG_PDZ_Class_3	222	227	PF00595	0.435
LIG_PDZ_Wminus1_1	225	227	PF00595	0.475
LIG_Pex14_2	148	152	PF04695	0.241
LIG_PTB_Apo_2	142	149	PF02174	0.231
LIG_SH2_CRK	164	168	PF00017	0.241
LIG_SH2_CRK	172	176	PF00017	0.277
LIG_SH2_STAT5	147	150	PF00017	0.253
LIG_SH2_STAT5	169	172	PF00017	0.300
LIG_SH2_STAT5	76	79	PF00017	0.305
LIG_SH2_STAT5	98	101	PF00017	0.312
LIG_SH3_2	184	189	PF14604	0.535
LIG_SH3_3	181	187	PF00018	0.525
LIG_SH3_3	215	221	PF00018	0.396
LIG_SUMO_SIM_par_1	4	12	PF11976	0.393
LIG_TYR_ITIM	170	175	PF00017	0.283
MOD_CK1_1	115	121	PF00069	0.241
MOD_CK1_1	9	15	PF00069	0.409
MOD_GlcNHglycan	114	117	PF01048	0.241
MOD_GSK3_1	115	122	PF00069	0.249
MOD_GSK3_1	2	9	PF00069	0.404
MOD_GSK3_1	46	53	PF00069	0.444
MOD_GSK3_1	64	71	PF00069	0.348
MOD_N-GLC_1	68	73	PF02516	0.455
MOD_NEK2_1	128	133	PF00069	0.263
MOD_NEK2_1	50	55	PF00069	0.440
MOD_NEK2_1	64	69	PF00069	0.212
MOD_NEK2_1	96	101	PF00069	0.310
MOD_NEK2_2	68	73	PF00069	0.399
MOD_PK_1	208	214	PF00069	0.419
MOD_PKA_1	207	213	PF00069	0.411
MOD_PKA_1	46	52	PF00069	0.312
MOD_PKA_2	153	159	PF00069	0.259
MOD_PKA_2	207	213	PF00069	0.401
MOD_PKA_2	46	52	PF00069	0.424
MOD_PKB_1	38	46	PF00069	0.378
MOD_Plk_1	68	74	PF00069	0.450
MOD_Plk_4	128	134	PF00069	0.370
MOD_Plk_4	208	214	PF00069	0.364
MOD_Plk_4	6	12	PF00069	0.413
MOD_Plk_4	68	74	PF00069	0.361
MOD_ProDKin_1	9	15	PF00069	0.393
MOD_SUMO_for_1	219	222	PF00179	0.383
TRG_ENDOCYTIC_2	164	167	PF00928	0.292
TRG_ENDOCYTIC_2	172	175	PF00928	0.319
TRG_ENDOCYTIC_2	45	48	PF00928	0.412
TRG_ENDOCYTIC_2	83	86	PF00928	0.294
TRG_ER_diArg_1	123	125	PF00400	0.241
TRG_ER_diArg_1	17	20	PF00400	0.435
TRG_ER_diArg_1	201	203	PF00400	0.349
TRG_ER_diArg_1	38	40	PF00400	0.474
TRG_ER_diArg_1	45	47	PF00400	0.292

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I212	Leptomonas seymouri	91%	100%
A0A0S4JB69	Bodo saltans	28%	80%
A0A0S4KNL4	Bodo saltans	63%	100%
A0A1X0NYV1	Trypanosomatidae	77%	100%
A0A3R7M1B7	Trypanosoma rangeli	31%	90%
A0A422N4M9	Trypanosoma rangeli	77%	100%
A4HDU9	Leishmania braziliensis	92%	100%
A4I144	Leishmania infantum	100%	100%
C9ZKU0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
D0A6U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	85%
E9AXY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O61219	Caenorhabditis elegans	31%	100%
O74457	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	100%
P07347	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	95%
P36416	Dictyostelium discoideum	28%	100%
P41227	Homo sapiens	29%	97%
P61599	Homo sapiens	52%	100%
P61600	Mus musculus	52%	100%
Q05885	Leishmania donovani	99%	100%
Q06504	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
Q2KI14	Bos taurus	29%	97%
Q2PFM2	Macaca fascicularis	52%	100%
Q3UX61	Mus musculus	29%	100%
Q4QA94	Leishmania major	95%	100%
Q4V8K3	Rattus norvegicus	29%	92%
Q58ED9	Danio rerio	52%	100%
Q6P632	Xenopus tropicalis	51%	100%
Q7ZXR3	Xenopus laevis	52%	100%
Q8LGI8	Arabidopsis thaliana	53%	100%
Q8SSN5	Dictyostelium discoideum	51%	100%
Q9BSU3	Homo sapiens	28%	99%
Q9FKI4	Arabidopsis thaliana	33%	100%
Q9QY36	Mus musculus	29%	97%
Q9UTI3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
V5BDZ0	Trypanosoma cruzi	27%	88%