LeishMANIAdb
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tRNA synthetases class I (W and Y) family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
tRNA synthetases class I (W and Y) family protein
Gene product:
tyrosyl-tRNA synthetase, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8ID88_LEIDO
TriTrypDb:
LdBPK_141460.1 , LdCL_140020400 , LDHU3_14.1820
Length:
682

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

A0A3Q8ID88
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID88

PDB structure(s): 3p0h_A , 3p0h_B , 3p0i_A , 3p0i_B , 3p0j_A , 3p0j_B , 3p0j_C , 3p0j_D , 5usf_A , 5usf_B

Function

Biological processes
TermNameLevelCount
GO:0006082 organic acid metabolic process 3 12
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006399 tRNA metabolic process 7 12
GO:0006418 tRNA aminoacylation for protein translation 6 12
GO:0006520 amino acid metabolic process 3 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004812 aminoacyl-tRNA ligase activity 4 12
GO:0004831 tyrosine-tRNA ligase activity 5 6
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016874 ligase activity 2 12
GO:0016875 ligase activity, forming carbon-oxygen bonds 3 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 226 230 PF00656 0.503
CLV_C14_Caspase3-7 519 523 PF00656 0.539
CLV_NRD_NRD_1 185 187 PF00675 0.303
CLV_NRD_NRD_1 200 202 PF00675 0.303
CLV_NRD_NRD_1 217 219 PF00675 0.257
CLV_NRD_NRD_1 242 244 PF00675 0.309
CLV_NRD_NRD_1 353 355 PF00675 0.510
CLV_NRD_NRD_1 476 478 PF00675 0.374
CLV_NRD_NRD_1 576 578 PF00675 0.425
CLV_PCSK_KEX2_1 217 219 PF00082 0.257
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P3B3 Leptomonas seymouri 82% 100%
A0A0S4JQB1 Bodo saltans 61% 76%
A0A1X0NNR8 Trypanosomatidae 63% 98%
A0A422NFL4 Trypanosoma rangeli 61% 99%
A4H7V7 Leishmania braziliensis 89% 100%
A4HW83 Leishmania infantum 100% 100%
C9ZST4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 98%
E9APY5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
F4HWL4 Arabidopsis thaliana 37% 91%
Q4QFJ7 Leishmania major 97% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS