Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ID86_LEIDO

TriTrypDb:

LdBPK_250710.1 , LdCL_250012300 , LDHU3_25.0860

Length:

541

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ID86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID86

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.534
CLV_NRD_NRD_1	273	275	PF00675	0.574
CLV_NRD_NRD_1	366	368	PF00675	0.669
CLV_NRD_NRD_1	38	40	PF00675	0.705
CLV_NRD_NRD_1	97	99	PF00675	0.440
CLV_PCSK_FUR_1	364	368	PF00082	0.762
CLV_PCSK_FUR_1	506	510	PF00082	0.656
CLV_PCSK_KEX2_1	185	187	PF00082	0.550
CLV_PCSK_KEX2_1	273	275	PF00082	0.570
CLV_PCSK_KEX2_1	366	368	PF00082	0.825
CLV_PCSK_KEX2_1	508	510	PF00082	0.670
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.534
CLV_PCSK_PC1ET2_1	508	510	PF00082	0.670
CLV_PCSK_SKI1_1	14	18	PF00082	0.665
CLV_PCSK_SKI1_1	173	177	PF00082	0.525
CLV_PCSK_SKI1_1	203	207	PF00082	0.601
CLV_PCSK_SKI1_1	248	252	PF00082	0.510
CLV_PCSK_SKI1_1	387	391	PF00082	0.655
CLV_PCSK_SKI1_1	78	82	PF00082	0.419
CLV_PCSK_SKI1_1	98	102	PF00082	0.269
DEG_APCC_DBOX_1	172	180	PF00400	0.486
DEG_APCC_DBOX_1	247	255	PF00400	0.515
DEG_SPOP_SBC_1	308	312	PF00917	0.559
DEG_SPOP_SBC_1	65	69	PF00917	0.533
DOC_CDC14_PxL_1	333	341	PF14671	0.481
DOC_CKS1_1	458	463	PF01111	0.642
DOC_MAPK_MEF2A_6	387	394	PF00069	0.525
DOC_USP7_MATH_1	111	115	PF00917	0.497
DOC_USP7_MATH_1	197	201	PF00917	0.665
DOC_USP7_MATH_1	205	209	PF00917	0.564
DOC_USP7_MATH_1	23	27	PF00917	0.624
DOC_USP7_MATH_1	253	257	PF00917	0.510
DOC_USP7_MATH_1	269	273	PF00917	0.613
DOC_USP7_MATH_1	291	295	PF00917	0.706
DOC_USP7_MATH_1	309	313	PF00917	0.564
DOC_USP7_MATH_1	349	353	PF00917	0.592
DOC_USP7_MATH_1	484	488	PF00917	0.708
DOC_USP7_MATH_1	496	500	PF00917	0.587
DOC_USP7_MATH_1	65	69	PF00917	0.543
DOC_USP7_UBL2_3	181	185	PF12436	0.629
DOC_WW_Pin1_4	28	33	PF00397	0.652
DOC_WW_Pin1_4	312	317	PF00397	0.631
DOC_WW_Pin1_4	394	399	PF00397	0.509
DOC_WW_Pin1_4	448	453	PF00397	0.661
DOC_WW_Pin1_4	457	462	PF00397	0.643
DOC_WW_Pin1_4	463	468	PF00397	0.758
LIG_14-3-3_CanoR_1	359	363	PF00244	0.630
LIG_14-3-3_CanoR_1	453	457	PF00244	0.621
LIG_14-3-3_CanoR_1	509	515	PF00244	0.550
LIG_14-3-3_CanoR_1	78	84	PF00244	0.514
LIG_14-3-3_CanoR_1	98	104	PF00244	0.256
LIG_Actin_WH2_2	136	152	PF00022	0.553
LIG_Actin_WH2_2	319	334	PF00022	0.485
LIG_BIR_II_1	1	5	PF00653	0.678
LIG_BIR_III_2	290	294	PF00653	0.664
LIG_BRCT_BRCA1_1	231	235	PF00533	0.588
LIG_BRCT_BRCA1_1	293	297	PF00533	0.627
LIG_BRCT_BRCA1_1	497	501	PF00533	0.607
LIG_FHA_1	158	164	PF00498	0.413
LIG_FHA_1	345	351	PF00498	0.580
LIG_FHA_1	378	384	PF00498	0.706
LIG_FHA_1	453	459	PF00498	0.646
LIG_FHA_1	509	515	PF00498	0.684
LIG_FHA_2	395	401	PF00498	0.553
LIG_FHA_2	49	55	PF00498	0.570
LIG_Integrin_isoDGR_2	37	39	PF01839	0.607
LIG_LIR_Gen_1	101	112	PF02991	0.381
LIG_LIR_Gen_1	232	243	PF02991	0.567
LIG_LIR_Gen_1	54	63	PF02991	0.416
LIG_LIR_Nem_3	101	107	PF02991	0.392
LIG_LIR_Nem_3	232	238	PF02991	0.603
LIG_LIR_Nem_3	499	505	PF02991	0.604
LIG_LIR_Nem_3	54	59	PF02991	0.448
LIG_MLH1_MIPbox_1	498	502	PF16413	0.601
LIG_Pex14_2	401	405	PF04695	0.615
LIG_Pex14_2	497	501	PF04695	0.720
LIG_SH2_CRK	431	435	PF00017	0.580
LIG_SH2_NCK_1	431	435	PF00017	0.602
LIG_SH2_SRC	167	170	PF00017	0.410
LIG_SH2_STAT5	104	107	PF00017	0.380
LIG_SH2_STAT5	155	158	PF00017	0.392
LIG_SH2_STAT5	167	170	PF00017	0.410
LIG_SH2_STAT5	356	359	PF00017	0.730
LIG_SH2_STAT5	517	520	PF00017	0.672
LIG_SH2_STAT5	532	535	PF00017	0.474
LIG_SH3_3	259	265	PF00018	0.573
LIG_SH3_3	424	430	PF00018	0.735
LIG_SH3_3	474	480	PF00018	0.749
LIG_TRAF2_1	52	55	PF00917	0.580
MOD_CDK_SPK_2	448	453	PF00069	0.658
MOD_CK1_1	102	108	PF00069	0.309
MOD_CK1_1	189	195	PF00069	0.618
MOD_CK1_1	196	202	PF00069	0.627
MOD_CK1_1	263	269	PF00069	0.697
MOD_CK1_1	312	318	PF00069	0.534
MOD_CK1_1	377	383	PF00069	0.728
MOD_CK1_1	451	457	PF00069	0.625
MOD_CK1_1	466	472	PF00069	0.640
MOD_CK1_1	495	501	PF00069	0.666
MOD_CK1_1	513	519	PF00069	0.586
MOD_CK1_1	67	73	PF00069	0.619
MOD_CK2_1	171	177	PF00069	0.591
MOD_CK2_1	332	338	PF00069	0.480
MOD_CK2_1	369	375	PF00069	0.614
MOD_CK2_1	394	400	PF00069	0.497
MOD_CK2_1	48	54	PF00069	0.574
MOD_CK2_1	525	531	PF00069	0.533
MOD_Cter_Amidation	37	40	PF01082	0.611
MOD_GlcNHglycan	109	112	PF01048	0.370
MOD_GlcNHglycan	160	163	PF01048	0.514
MOD_GlcNHglycan	173	176	PF01048	0.573
MOD_GlcNHglycan	193	196	PF01048	0.646
MOD_GlcNHglycan	199	202	PF01048	0.647
MOD_GlcNHglycan	262	265	PF01048	0.602
MOD_GlcNHglycan	293	296	PF01048	0.587
MOD_GlcNHglycan	305	308	PF01048	0.489
MOD_GlcNHglycan	311	314	PF01048	0.645
MOD_GlcNHglycan	338	342	PF01048	0.565
MOD_GlcNHglycan	352	355	PF01048	0.582
MOD_GlcNHglycan	371	374	PF01048	0.679
MOD_GlcNHglycan	421	424	PF01048	0.634
MOD_GlcNHglycan	438	441	PF01048	0.681
MOD_GlcNHglycan	486	489	PF01048	0.714
MOD_GlcNHglycan	494	497	PF01048	0.625
MOD_GlcNHglycan	498	501	PF01048	0.588
MOD_GlcNHglycan	51	54	PF01048	0.626
MOD_GlcNHglycan	69	72	PF01048	0.646
MOD_GSK3_1	107	114	PF00069	0.374
MOD_GSK3_1	187	194	PF00069	0.594
MOD_GSK3_1	23	30	PF00069	0.630
MOD_GSK3_1	230	237	PF00069	0.623
MOD_GSK3_1	253	260	PF00069	0.520
MOD_GSK3_1	303	310	PF00069	0.706
MOD_GSK3_1	369	376	PF00069	0.677
MOD_GSK3_1	43	50	PF00069	0.624
MOD_GSK3_1	444	451	PF00069	0.785
MOD_GSK3_1	452	459	PF00069	0.517
MOD_GSK3_1	463	470	PF00069	0.640
MOD_GSK3_1	479	486	PF00069	0.654
MOD_GSK3_1	492	499	PF00069	0.580
MOD_GSK3_1	509	516	PF00069	0.459
MOD_GSK3_1	532	539	PF00069	0.647
MOD_GSK3_1	67	74	PF00069	0.453
MOD_GSK3_1	98	105	PF00069	0.533
MOD_LATS_1	330	336	PF00433	0.531
MOD_N-GLC_1	318	323	PF02516	0.607
MOD_N-GLC_1	369	374	PF02516	0.777
MOD_N-GLC_1	467	472	PF02516	0.658
MOD_N-GLC_1	520	525	PF02516	0.525
MOD_NEK2_1	107	112	PF00069	0.411
MOD_NEK2_1	229	234	PF00069	0.667
MOD_NEK2_1	279	284	PF00069	0.589
MOD_NEK2_1	331	336	PF00069	0.480
MOD_NEK2_1	79	84	PF00069	0.449
MOD_NEK2_2	243	248	PF00069	0.515
MOD_PIKK_1	279	285	PF00454	0.583
MOD_PIKK_1	93	99	PF00454	0.443
MOD_PK_1	332	338	PF00069	0.480
MOD_PKA_1	508	514	PF00069	0.632
MOD_PKA_1	98	104	PF00069	0.408
MOD_PKA_2	187	193	PF00069	0.560
MOD_PKA_2	291	297	PF00069	0.660
MOD_PKA_2	358	364	PF00069	0.618
MOD_PKA_2	452	458	PF00069	0.643
MOD_PKA_2	484	490	PF00069	0.779
MOD_PKA_2	508	514	PF00069	0.632
MOD_PKA_2	91	97	PF00069	0.446
MOD_PKB_1	184	192	PF00069	0.574
MOD_Plk_1	230	236	PF00069	0.603
MOD_Plk_1	520	526	PF00069	0.526
MOD_Plk_2-3	358	364	PF00069	0.618
MOD_Plk_4	429	435	PF00069	0.579
MOD_Plk_4	513	519	PF00069	0.667
MOD_Plk_4	71	77	PF00069	0.597
MOD_Plk_4	79	85	PF00069	0.390
MOD_Plk_4	99	105	PF00069	0.298
MOD_ProDKin_1	28	34	PF00069	0.654
MOD_ProDKin_1	312	318	PF00069	0.638
MOD_ProDKin_1	394	400	PF00069	0.507
MOD_ProDKin_1	448	454	PF00069	0.658
MOD_ProDKin_1	457	463	PF00069	0.644
MOD_ProDKin_1	467	473	PF00069	0.690
TRG_DiLeu_BaLyEn_6	75	80	PF01217	0.394
TRG_ENDOCYTIC_2	104	107	PF00928	0.380
TRG_ENDOCYTIC_2	431	434	PF00928	0.584
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEM3	Leptomonas seymouri	48%	98%
A4HE00	Leishmania braziliensis	78%	100%
A4I1B1	Leishmania infantum	100%	100%
E9AXE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QA25	Leishmania major	94%	100%