Poly(A) polymerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Poly(A) polymerase

Gene product:

poly(A) polymerase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ID77_LEIDO

TriTrypDb:

LdBPK_141260.1 , LdCL_140018500 , LDHU3_14.1600

Length:

709

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	14
GO:0005737	cytoplasm	2	14
GO:0043226	organelle	2	14
GO:0043227	membrane-bounded organelle	3	14
GO:0043229	intracellular organelle	3	14
GO:0043231	intracellular membrane-bounded organelle	4	14
GO:0110165	cellular anatomical entity	1	14
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8ID77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID77

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	14
GO:0006396	RNA processing	6	14
GO:0006397	mRNA processing	7	14
GO:0006725	cellular aromatic compound metabolic process	3	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009987	cellular process	1	14
GO:0016070	RNA metabolic process	5	14
GO:0016071	mRNA metabolic process	6	14
GO:0031123	RNA 3'-end processing	7	14
GO:0034641	cellular nitrogen compound metabolic process	3	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043631	RNA polyadenylation	6	14
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0046483	heterocycle metabolic process	3	14
GO:0071076	RNA 3' uridylation	8	14
GO:0071704	organic substance metabolic process	2	14
GO:0090304	nucleic acid metabolic process	4	14
GO:1901360	organic cyclic compound metabolic process	3	14
GO:0006378	mRNA polyadenylation	7	2
GO:0031124	mRNA 3'-end processing	8	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	14
GO:0003676	nucleic acid binding	3	14
GO:0003723	RNA binding	4	14
GO:0003824	catalytic activity	1	14
GO:0004652	obsolete polynucleotide adenylyltransferase activity	6	14
GO:0005488	binding	1	14
GO:0005524	ATP binding	5	14
GO:0016740	transferase activity	2	14
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	14
GO:0016779	nucleotidyltransferase activity	4	14
GO:0017076	purine nucleotide binding	4	14
GO:0030554	adenyl nucleotide binding	5	14
GO:0032553	ribonucleotide binding	3	14
GO:0032555	purine ribonucleotide binding	4	14
GO:0032559	adenyl ribonucleotide binding	5	14
GO:0035639	purine ribonucleoside triphosphate binding	4	14
GO:0036094	small molecule binding	2	14
GO:0043167	ion binding	2	14
GO:0043168	anion binding	3	14
GO:0043169	cation binding	3	14
GO:0046872	metal ion binding	4	14
GO:0050265	RNA uridylyltransferase activity	4	14
GO:0070566	adenylyltransferase activity	5	14
GO:0070569	uridylyltransferase activity	5	14
GO:0097159	organic cyclic compound binding	2	14
GO:0097367	carbohydrate derivative binding	2	14
GO:0140098	catalytic activity, acting on RNA	3	14
GO:0140640	catalytic activity, acting on a nucleic acid	2	14
GO:1901265	nucleoside phosphate binding	3	14
GO:1901363	heterocyclic compound binding	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	302	306	PF00656	0.314
CLV_C14_Caspase3-7	388	392	PF00656	0.293
CLV_C14_Caspase3-7	625	629	PF00656	0.799
CLV_C14_Caspase3-7	649	653	PF00656	0.805
CLV_NRD_NRD_1	434	436	PF00675	0.351
CLV_NRD_NRD_1	50	52	PF00675	0.335
CLV_NRD_NRD_1	655	657	PF00675	0.694
CLV_PCSK_KEX2_1	434	436	PF00082	0.339
CLV_PCSK_KEX2_1	49	51	PF00082	0.336
CLV_PCSK_KEX2_1	598	600	PF00082	0.657
CLV_PCSK_KEX2_1	657	659	PF00082	0.765
CLV_PCSK_PC1ET2_1	598	600	PF00082	0.657
CLV_PCSK_PC1ET2_1	657	659	PF00082	0.765
CLV_PCSK_SKI1_1	204	208	PF00082	0.325
CLV_PCSK_SKI1_1	212	216	PF00082	0.340
CLV_PCSK_SKI1_1	51	55	PF00082	0.326
CLV_PCSK_SKI1_1	9	13	PF00082	0.507
DEG_APCC_DBOX_1	207	215	PF00400	0.307
DEG_APCC_DBOX_1	50	58	PF00400	0.303
DEG_SPOP_SBC_1	604	608	PF00917	0.789
DOC_CKS1_1	312	317	PF01111	0.298
DOC_MAPK_DCC_7	140	149	PF00069	0.314
DOC_MAPK_FxFP_2	228	231	PF00069	0.314
DOC_MAPK_gen_1	300	309	PF00069	0.314
DOC_MAPK_HePTP_8	53	65	PF00069	0.436
DOC_MAPK_MEF2A_6	140	149	PF00069	0.320
DOC_MAPK_MEF2A_6	378	387	PF00069	0.355
DOC_MAPK_MEF2A_6	56	65	PF00069	0.391
DOC_PP1_RVXF_1	405	411	PF00149	0.321
DOC_PP2B_LxvP_1	108	111	PF13499	0.457
DOC_PP2B_PxIxI_1	544	550	PF00149	0.314
DOC_PP4_FxxP_1	228	231	PF00568	0.314
DOC_PP4_FxxP_1	436	439	PF00568	0.416
DOC_PP4_FxxP_1	73	76	PF00568	0.314
DOC_USP7_MATH_1	299	303	PF00917	0.314
DOC_USP7_MATH_1	456	460	PF00917	0.463
DOC_USP7_MATH_1	487	491	PF00917	0.403
DOC_USP7_MATH_1	584	588	PF00917	0.683
DOC_USP7_MATH_1	627	631	PF00917	0.823
DOC_USP7_MATH_1	647	651	PF00917	0.629
DOC_USP7_MATH_1	675	679	PF00917	0.726
DOC_USP7_MATH_1	681	685	PF00917	0.695
DOC_USP7_MATH_1	688	692	PF00917	0.630
DOC_USP7_MATH_1	89	93	PF00917	0.477
DOC_USP7_MATH_2	299	305	PF00917	0.314
DOC_USP7_UBL2_3	215	219	PF12436	0.298
DOC_WW_Pin1_4	311	316	PF00397	0.298
LIG_14-3-3_CanoR_1	126	131	PF00244	0.313
LIG_14-3-3_CanoR_1	208	212	PF00244	0.427
LIG_14-3-3_CanoR_1	258	264	PF00244	0.381
LIG_14-3-3_CanoR_1	288	297	PF00244	0.436
LIG_14-3-3_CanoR_1	417	422	PF00244	0.349
LIG_14-3-3_CanoR_1	49	54	PF00244	0.345
LIG_14-3-3_CanoR_1	525	531	PF00244	0.421
LIG_14-3-3_CanoR_1	66	70	PF00244	0.298
LIG_BIR_II_1	1	5	PF00653	0.565
LIG_BRCT_BRCA1_1	224	228	PF00533	0.314
LIG_EH1_1	194	202	PF00400	0.334
LIG_FHA_1	171	177	PF00498	0.328
LIG_FHA_1	238	244	PF00498	0.436
LIG_FHA_1	312	318	PF00498	0.295
LIG_FHA_2	272	278	PF00498	0.405
LIG_FHA_2	3	9	PF00498	0.587
LIG_FHA_2	37	43	PF00498	0.405
LIG_FHA_2	418	424	PF00498	0.436
LIG_FHA_2	546	552	PF00498	0.300
LIG_LIR_Apic_2	225	231	PF02991	0.314
LIG_LIR_Apic_2	265	269	PF02991	0.335
LIG_LIR_Apic_2	71	76	PF02991	0.314
LIG_LIR_Gen_1	117	127	PF02991	0.486
LIG_LIR_Gen_1	526	534	PF02991	0.391
LIG_LIR_Nem_3	117	123	PF02991	0.486
LIG_LIR_Nem_3	157	163	PF02991	0.324
LIG_LIR_Nem_3	257	263	PF02991	0.436
LIG_LIR_Nem_3	393	398	PF02991	0.339
LIG_LIR_Nem_3	422	427	PF02991	0.358
LIG_LIR_Nem_3	526	530	PF02991	0.391
LIG_MYND_1	311	315	PF01753	0.354
LIG_PDZ_Class_2	704	709	PF00595	0.531
LIG_Pex14_2	213	217	PF04695	0.298
LIG_Pex14_2	375	379	PF04695	0.366
LIG_PTB_Apo_2	318	325	PF02174	0.298
LIG_PTB_Phospho_1	318	324	PF10480	0.334
LIG_REV1ctd_RIR_1	373	382	PF16727	0.436
LIG_RPA_C_Fungi	580	592	PF08784	0.569
LIG_SH2_CRK	424	428	PF00017	0.436
LIG_SH2_GRB2like	224	227	PF00017	0.314
LIG_SH2_SRC	398	401	PF00017	0.344
LIG_SH2_STAP1	224	228	PF00017	0.321
LIG_SH2_STAT3	247	250	PF00017	0.436
LIG_SH2_STAT3	700	703	PF00017	0.437
LIG_SH2_STAT5	282	285	PF00017	0.314
LIG_SH2_STAT5	382	385	PF00017	0.298
LIG_SH2_STAT5	503	506	PF00017	0.302
LIG_SH2_STAT5	700	703	PF00017	0.437
LIG_SH3_3	309	315	PF00018	0.338
LIG_SH3_3	366	372	PF00018	0.446
LIG_SH3_3	490	496	PF00018	0.385
LIG_SUMO_SIM_par_1	545	551	PF11976	0.285
LIG_TRAF2_1	43	46	PF00917	0.384
LIG_TRAF2_1	572	575	PF00917	0.593
LIG_UBA3_1	197	204	PF00899	0.314
LIG_WRC_WIRS_1	524	529	PF05994	0.391
LIG_WRC_WIRS_1	555	560	PF05994	0.436
MOD_CK1_1	112	118	PF00069	0.435
MOD_CK1_1	159	165	PF00069	0.298
MOD_CK1_1	184	190	PF00069	0.328
MOD_CK1_1	222	228	PF00069	0.499
MOD_CK1_1	450	456	PF00069	0.352
MOD_CK1_1	459	465	PF00069	0.306
MOD_CK1_1	468	474	PF00069	0.331
MOD_CK1_1	491	497	PF00069	0.430
MOD_CK1_1	587	593	PF00069	0.717
MOD_CK1_1	603	609	PF00069	0.690
MOD_CK1_1	610	616	PF00069	0.764
MOD_CK1_1	617	623	PF00069	0.738
MOD_CK1_1	650	656	PF00069	0.676
MOD_CK2_1	271	277	PF00069	0.334
MOD_CK2_1	29	35	PF00069	0.408
MOD_CK2_1	349	355	PF00069	0.513
MOD_CK2_1	36	42	PF00069	0.467
MOD_CK2_1	387	393	PF00069	0.298
MOD_CK2_1	49	55	PF00069	0.153
MOD_CK2_1	574	580	PF00069	0.729
MOD_CK2_1	627	633	PF00069	0.768
MOD_GlcNHglycan	17	20	PF01048	0.439
MOD_GlcNHglycan	231	234	PF01048	0.298
MOD_GlcNHglycan	351	354	PF01048	0.520
MOD_GlcNHglycan	470	473	PF01048	0.400
MOD_GlcNHglycan	489	493	PF01048	0.350
MOD_GlcNHglycan	514	517	PF01048	0.391
MOD_GlcNHglycan	577	580	PF01048	0.579
MOD_GlcNHglycan	602	605	PF01048	0.782
MOD_GlcNHglycan	616	619	PF01048	0.727
MOD_GlcNHglycan	624	627	PF01048	0.673
MOD_GlcNHglycan	628	632	PF01048	0.618
MOD_GlcNHglycan	644	647	PF01048	0.595
MOD_GlcNHglycan	683	686	PF01048	0.707
MOD_GlcNHglycan	690	693	PF01048	0.608
MOD_GlcNHglycan	99	102	PF01048	0.324
MOD_GSK3_1	413	420	PF00069	0.366
MOD_GSK3_1	443	450	PF00069	0.399
MOD_GSK3_1	477	484	PF00069	0.411
MOD_GSK3_1	487	494	PF00069	0.436
MOD_GSK3_1	508	515	PF00069	0.414
MOD_GSK3_1	599	606	PF00069	0.673
MOD_GSK3_1	607	614	PF00069	0.693
MOD_GSK3_1	616	623	PF00069	0.779
MOD_GSK3_1	642	649	PF00069	0.649
MOD_GSK3_1	677	684	PF00069	0.675
MOD_LATS_1	654	660	PF00433	0.579
MOD_N-GLC_1	324	329	PF02516	0.287
MOD_N-GLC_1	412	417	PF02516	0.391
MOD_N-GLC_1	585	590	PF02516	0.771
MOD_N-GLC_2	321	323	PF02516	0.298
MOD_NEK2_1	1	6	PF00069	0.657
MOD_NEK2_1	119	124	PF00069	0.324
MOD_NEK2_1	207	212	PF00069	0.441
MOD_NEK2_1	259	264	PF00069	0.457
MOD_NEK2_1	283	288	PF00069	0.298
MOD_NEK2_1	349	354	PF00069	0.491
MOD_NEK2_1	481	486	PF00069	0.437
MOD_NEK2_2	319	324	PF00069	0.366
MOD_NEK2_2	523	528	PF00069	0.366
MOD_PK_1	219	225	PF00069	0.366
MOD_PK_1	49	55	PF00069	0.334
MOD_PKA_1	49	55	PF00069	0.363
MOD_PKA_1	656	662	PF00069	0.642
MOD_PKA_2	112	118	PF00069	0.296
MOD_PKA_2	139	145	PF00069	0.357
MOD_PKA_2	207	213	PF00069	0.316
MOD_PKA_2	299	305	PF00069	0.314
MOD_PKA_2	446	452	PF00069	0.361
MOD_PKA_2	462	468	PF00069	0.352
MOD_PKA_2	49	55	PF00069	0.344
MOD_PKA_2	575	581	PF00069	0.599
MOD_PKA_2	584	590	PF00069	0.551
MOD_PKA_2	65	71	PF00069	0.298
MOD_PKB_1	445	453	PF00069	0.436
MOD_Plk_1	156	162	PF00069	0.285
MOD_Plk_1	181	187	PF00069	0.296
MOD_Plk_1	29	35	PF00069	0.460
MOD_Plk_1	324	330	PF00069	0.307
MOD_Plk_1	566	572	PF00069	0.629
MOD_Plk_1	675	681	PF00069	0.754
MOD_Plk_2-3	170	176	PF00069	0.298
MOD_Plk_4	181	187	PF00069	0.344
MOD_Plk_4	262	268	PF00069	0.352
MOD_Plk_4	477	483	PF00069	0.437
MOD_Plk_4	494	500	PF00069	0.456
MOD_Plk_4	526	532	PF00069	0.353
MOD_Plk_4	554	560	PF00069	0.419
MOD_Plk_4	65	71	PF00069	0.298
MOD_ProDKin_1	311	317	PF00069	0.298
MOD_SUMO_for_1	127	130	PF00179	0.436
MOD_SUMO_for_1	673	676	PF00179	0.771
MOD_SUMO_rev_2	298	304	PF00179	0.316
MOD_SUMO_rev_2	352	358	PF00179	0.404
TRG_ENDOCYTIC_2	382	385	PF00928	0.315
TRG_ENDOCYTIC_2	424	427	PF00928	0.436
TRG_ER_diArg_1	287	290	PF00400	0.366
TRG_ER_diArg_1	405	408	PF00400	0.393
TRG_ER_diArg_1	433	435	PF00400	0.332
TRG_ER_diArg_1	444	447	PF00400	0.330
TRG_ER_diArg_1	49	51	PF00400	0.343
TRG_NLS_MonoExtC_3	655	660	PF00514	0.746
TRG_Pf-PMV_PEXEL_1	332	336	PF00026	0.298
TRG_Pf-PMV_PEXEL_1	532	536	PF00026	0.314
TRG_Pf-PMV_PEXEL_1	636	640	PF00026	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2K1	Leptomonas seymouri	71%	96%
A0A0S4JIG5	Bodo saltans	47%	100%
A0A1X0NP17	Trypanosomatidae	60%	100%
A0A3R7KE83	Trypanosoma rangeli	63%	100%
A4H7T8	Leishmania braziliensis	86%	100%
A4HW64	Leishmania infantum	100%	100%
A4I4T6	Leishmania infantum	26%	100%
C9ZSW0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AEC2	Leishmania major	26%	100%
E9APW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QFL6	Leishmania major	94%	99%
V5BKK6	Trypanosoma cruzi	59%	87%