Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8ID76_LEIDO

TriTrypDb:

LdBPK_250520.1 , LdCL_250010300 , LDHU3_25.0610

Length:

561

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ID76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID76

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	353	357	PF00656	0.677
CLV_C14_Caspase3-7	401	405	PF00656	0.625
CLV_NRD_NRD_1	189	191	PF00675	0.751
CLV_NRD_NRD_1	362	364	PF00675	0.681
CLV_NRD_NRD_1	371	373	PF00675	0.435
CLV_NRD_NRD_1	498	500	PF00675	0.662
CLV_NRD_NRD_1	512	514	PF00675	0.448
CLV_NRD_NRD_1	90	92	PF00675	0.737
CLV_PCSK_KEX2_1	189	191	PF00082	0.751
CLV_PCSK_KEX2_1	362	364	PF00082	0.681
CLV_PCSK_KEX2_1	371	373	PF00082	0.435
CLV_PCSK_KEX2_1	498	500	PF00082	0.665
CLV_PCSK_KEX2_1	512	514	PF00082	0.446
CLV_PCSK_KEX2_1	90	92	PF00082	0.686
CLV_PCSK_PC7_1	367	373	PF00082	0.567
CLV_PCSK_SKI1_1	119	123	PF00082	0.527
CLV_PCSK_SKI1_1	134	138	PF00082	0.497
CLV_PCSK_SKI1_1	22	26	PF00082	0.602
CLV_PCSK_SKI1_1	248	252	PF00082	0.580
CLV_PCSK_SKI1_1	322	326	PF00082	0.542
CLV_PCSK_SKI1_1	362	366	PF00082	0.702
CLV_PCSK_SKI1_1	367	371	PF00082	0.587
CLV_PCSK_SKI1_1	541	545	PF00082	0.529
CLV_PCSK_SKI1_1	90	94	PF00082	0.532
CLV_Separin_Metazoa	459	463	PF03568	0.473
DEG_APCC_DBOX_1	118	126	PF00400	0.568
DEG_APCC_DBOX_1	247	255	PF00400	0.500
DEG_APCC_DBOX_1	321	329	PF00400	0.532
DEG_APCC_DBOX_1	366	374	PF00400	0.562
DEG_SPOP_SBC_1	490	494	PF00917	0.582
DOC_CYCLIN_RxL_1	166	175	PF00134	0.535
DOC_CYCLIN_RxL_1	19	29	PF00134	0.601
DOC_CYCLIN_RxL_1	359	366	PF00134	0.692
DOC_MAPK_gen_1	19	27	PF00069	0.639
DOC_MAPK_gen_1	371	378	PF00069	0.490
DOC_MAPK_gen_1	414	423	PF00069	0.476
DOC_MAPK_gen_1	512	519	PF00069	0.523
DOC_MAPK_gen_1	546	554	PF00069	0.535
DOC_MAPK_MEF2A_6	19	27	PF00069	0.518
DOC_MAPK_MEF2A_6	414	423	PF00069	0.523
DOC_PP1_RVXF_1	132	139	PF00149	0.631
DOC_PP2B_LxvP_1	171	174	PF13499	0.614
DOC_PP2B_LxvP_1	242	245	PF13499	0.470
DOC_PP2B_LxvP_1	25	28	PF13499	0.511
DOC_PP2B_LxvP_1	421	424	PF13499	0.598
DOC_PP2B_LxvP_1	517	520	PF13499	0.552
DOC_PP4_FxxP_1	241	244	PF00568	0.564
DOC_PP4_FxxP_1	377	380	PF00568	0.591
DOC_USP7_MATH_1	10	14	PF00917	0.595
DOC_USP7_MATH_1	310	314	PF00917	0.632
DOC_USP7_MATH_1	317	321	PF00917	0.467
DOC_USP7_MATH_1	470	474	PF00917	0.584
DOC_USP7_MATH_1	489	493	PF00917	0.545
DOC_USP7_MATH_1	529	533	PF00917	0.682
DOC_WW_Pin1_4	180	185	PF00397	0.683
DOC_WW_Pin1_4	221	226	PF00397	0.617
DOC_WW_Pin1_4	227	232	PF00397	0.655
DOC_WW_Pin1_4	308	313	PF00397	0.595
DOC_WW_Pin1_4	315	320	PF00397	0.561
DOC_WW_Pin1_4	472	477	PF00397	0.657
DOC_WW_Pin1_4	49	54	PF00397	0.487
DOC_WW_Pin1_4	71	76	PF00397	0.595
LIG_14-3-3_CanoR_1	134	139	PF00244	0.667
LIG_14-3-3_CanoR_1	14	21	PF00244	0.606
LIG_14-3-3_CanoR_1	140	145	PF00244	0.619
LIG_14-3-3_CanoR_1	195	199	PF00244	0.593
LIG_14-3-3_CanoR_1	248	254	PF00244	0.479
LIG_14-3-3_CanoR_1	387	397	PF00244	0.556
LIG_14-3-3_CanoR_1	448	453	PF00244	0.664
LIG_14-3-3_CanoR_1	553	557	PF00244	0.528
LIG_BIR_III_2	356	360	PF00653	0.603
LIG_BRCT_BRCA1_1	434	438	PF00533	0.679
LIG_eIF4E_1	116	122	PF01652	0.586
LIG_FHA_1	168	174	PF00498	0.630
LIG_FHA_1	257	263	PF00498	0.455
LIG_FHA_1	316	322	PF00498	0.629
LIG_FHA_1	364	370	PF00498	0.520
LIG_FHA_1	392	398	PF00498	0.664
LIG_FHA_1	80	86	PF00498	0.523
LIG_FHA_2	209	215	PF00498	0.489
LIG_FHA_2	424	430	PF00498	0.600
LIG_FHA_2	43	49	PF00498	0.625
LIG_GBD_Chelix_1	117	125	PF00786	0.574
LIG_Integrin_RGD_1	382	384	PF01839	0.597
LIG_LIR_Apic_2	238	244	PF02991	0.588
LIG_LIR_Gen_1	196	206	PF02991	0.577
LIG_LIR_Nem_3	196	201	PF02991	0.597
LIG_LIR_Nem_3	252	258	PF02991	0.643
LIG_LIR_Nem_3	48	54	PF02991	0.625
LIG_NRBOX	335	341	PF00104	0.470
LIG_NRBOX	456	462	PF00104	0.474
LIG_Pex14_1	194	198	PF04695	0.501
LIG_SH2_CRK	198	202	PF00017	0.580
LIG_SH2_CRK	326	330	PF00017	0.498
LIG_SH2_SRC	207	210	PF00017	0.557
LIG_SH2_STAP1	198	202	PF00017	0.620
LIG_SH2_STAP1	393	397	PF00017	0.539
LIG_SH2_STAT5	116	119	PF00017	0.723
LIG_SH2_STAT5	256	259	PF00017	0.545
LIG_SH2_STAT5	326	329	PF00017	0.499
LIG_SH2_STAT5	393	396	PF00017	0.544
LIG_SH2_STAT5	516	519	PF00017	0.531
LIG_SH3_1	179	185	PF00018	0.548
LIG_SH3_3	179	185	PF00018	0.681
LIG_SH3_3	219	225	PF00018	0.628
LIG_SH3_3	286	292	PF00018	0.708
LIG_SH3_3	515	521	PF00018	0.563
LIG_SH3_4	303	310	PF00018	0.543
LIG_SUMO_SIM_anti_2	261	268	PF11976	0.549
LIG_SUMO_SIM_anti_2	52	58	PF11976	0.532
LIG_SUMO_SIM_par_1	23	29	PF11976	0.512
LIG_SUMO_SIM_par_1	256	261	PF11976	0.457
LIG_TRAF2_1	108	111	PF00917	0.641
LIG_TRAF2_1	443	446	PF00917	0.697
LIG_TRFH_1	554	558	PF08558	0.521
LIG_TYR_ITIM	253	258	PF00017	0.534
LIG_TYR_ITIM	324	329	PF00017	0.546
LIG_TYR_ITIM	514	519	PF00017	0.569
LIG_WRC_WIRS_1	209	214	PF05994	0.483
MOD_CDK_SPxxK_3	315	322	PF00069	0.579
MOD_CK1_1	100	106	PF00069	0.665
MOD_CK1_1	193	199	PF00069	0.629
MOD_CK1_1	299	305	PF00069	0.656
MOD_CK1_1	311	317	PF00069	0.600
MOD_CK1_1	392	398	PF00069	0.635
MOD_CK1_1	400	406	PF00069	0.730
MOD_CK1_1	422	428	PF00069	0.715
MOD_CK1_1	43	49	PF00069	0.733
MOD_CK1_1	52	58	PF00069	0.532
MOD_CK1_1	8	14	PF00069	0.507
MOD_CK2_1	105	111	PF00069	0.627
MOD_CK2_1	208	214	PF00069	0.640
MOD_CK2_1	277	283	PF00069	0.612
MOD_CK2_1	423	429	PF00069	0.597
MOD_CK2_1	78	84	PF00069	0.703
MOD_GlcNHglycan	102	105	PF01048	0.615
MOD_GlcNHglycan	111	115	PF01048	0.576
MOD_GlcNHglycan	202	205	PF01048	0.549
MOD_GlcNHglycan	279	282	PF01048	0.508
MOD_GlcNHglycan	298	301	PF01048	0.636
MOD_GlcNHglycan	40	43	PF01048	0.690
MOD_GlcNHglycan	438	441	PF01048	0.607
MOD_GlcNHglycan	45	48	PF01048	0.610
MOD_GlcNHglycan	471	475	PF01048	0.628
MOD_GlcNHglycan	476	479	PF01048	0.651
MOD_GlcNHglycan	487	490	PF01048	0.608
MOD_GlcNHglycan	493	496	PF01048	0.618
MOD_GlcNHglycan	500	503	PF01048	0.526
MOD_GlcNHglycan	531	534	PF01048	0.668
MOD_GlcNHglycan	7	10	PF01048	0.635
MOD_GSK3_1	134	141	PF00069	0.627
MOD_GSK3_1	163	170	PF00069	0.541
MOD_GSK3_1	180	187	PF00069	0.645
MOD_GSK3_1	190	197	PF00069	0.602
MOD_GSK3_1	227	234	PF00069	0.681
MOD_GSK3_1	306	313	PF00069	0.719
MOD_GSK3_1	38	45	PF00069	0.708
MOD_GSK3_1	388	395	PF00069	0.666
MOD_GSK3_1	419	426	PF00069	0.605
MOD_GSK3_1	428	435	PF00069	0.649
MOD_GSK3_1	470	477	PF00069	0.625
MOD_GSK3_1	485	492	PF00069	0.611
MOD_GSK3_1	529	536	PF00069	0.651
MOD_GSK3_1	552	559	PF00069	0.605
MOD_GSK3_1	95	102	PF00069	0.595
MOD_LATS_1	132	138	PF00433	0.537
MOD_LATS_1	361	367	PF00433	0.563
MOD_N-GLC_1	49	54	PF02516	0.511
MOD_NEK2_1	167	172	PF00069	0.599
MOD_NEK2_1	298	303	PF00069	0.549
MOD_NEK2_1	552	557	PF00069	0.539
MOD_NEK2_1	85	90	PF00069	0.592
MOD_NEK2_1	95	100	PF00069	0.653
MOD_OFUCOSY	94	101	PF10250	0.563
MOD_PKA_1	498	504	PF00069	0.562
MOD_PKA_2	13	19	PF00069	0.605
MOD_PKA_2	194	200	PF00069	0.601
MOD_PKA_2	497	503	PF00069	0.626
MOD_PKA_2	552	558	PF00069	0.539
MOD_Plk_1	265	271	PF00069	0.565
MOD_Plk_4	134	140	PF00069	0.550
MOD_Plk_4	163	169	PF00069	0.611
MOD_Plk_4	208	214	PF00069	0.512
MOD_Plk_4	249	255	PF00069	0.547
MOD_Plk_4	324	330	PF00069	0.521
MOD_Plk_4	406	412	PF00069	0.584
MOD_Plk_4	52	58	PF00069	0.593
MOD_ProDKin_1	180	186	PF00069	0.684
MOD_ProDKin_1	221	227	PF00069	0.620
MOD_ProDKin_1	229	235	PF00069	0.666
MOD_ProDKin_1	308	314	PF00069	0.592
MOD_ProDKin_1	315	321	PF00069	0.551
MOD_ProDKin_1	472	478	PF00069	0.661
MOD_ProDKin_1	49	55	PF00069	0.479
MOD_ProDKin_1	71	77	PF00069	0.592
TRG_DiLeu_BaEn_1	332	337	PF01217	0.632
TRG_DiLeu_BaEn_1	459	464	PF01217	0.547
TRG_DiLeu_BaLyEn_6	360	365	PF01217	0.748
TRG_DiLeu_LyEn_5	459	464	PF01217	0.547
TRG_ENDOCYTIC_2	198	201	PF00928	0.589
TRG_ENDOCYTIC_2	255	258	PF00928	0.618
TRG_ENDOCYTIC_2	326	329	PF00928	0.547
TRG_ENDOCYTIC_2	516	519	PF00928	0.580
TRG_ER_diArg_1	139	142	PF00400	0.619
TRG_ER_diArg_1	362	364	PF00400	0.670
TRG_ER_diArg_1	370	372	PF00400	0.442
TRG_ER_diArg_1	512	514	PF00400	0.528
TRG_ER_diArg_1	89	91	PF00400	0.719
TRG_NES_CRM1_1	413	427	PF08389	0.513
TRG_NES_CRM1_1	455	469	PF08389	0.564
TRG_NES_CRM1_1	84	97	PF08389	0.522
TRG_Pf-PMV_PEXEL_1	462	467	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4J4	Leptomonas seymouri	29%	100%
A4HDZ3	Leishmania braziliensis	66%	100%
A4I192	Leishmania infantum	100%	100%
E9AXC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QA44	Leishmania major	87%	100%