Mitochondrial_RNA_binding_complex_1_subunit_putat ive/GeneDB:LmjF.28.1810

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ID67_LEIDO

TriTrypDb:

LdBPK_281930.1 , LdCL_280024300 , LDHU3_28.2540

Length:

176

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ID67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID67

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016553	base conversion or substitution editing	6	1
GO:0016554	cytidine to uridine editing	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031330	negative regulation of cellular catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043489	RNA stabilization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048255	mRNA stabilization	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902369	negative regulation of RNA catabolic process	7	1
GO:1902373	negative regulation of mRNA catabolic process	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903312	negative regulation of mRNA metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.582
CLV_NRD_NRD_1	61	63	PF00675	0.569
CLV_PCSK_KEX2_1	61	63	PF00082	0.569
CLV_PCSK_SKI1_1	19	23	PF00082	0.540
CLV_PCSK_SKI1_1	3	7	PF00082	0.451
DEG_APCC_DBOX_1	2	10	PF00400	0.456
DEG_Nend_Nbox_1	1	3	PF02207	0.450
DOC_CYCLIN_yCln2_LP_2	34	40	PF00134	0.460
DOC_PP2B_LxvP_1	34	37	PF13499	0.455
DOC_USP7_MATH_1	100	104	PF00917	0.610
DOC_USP7_MATH_1	119	123	PF00917	0.592
DOC_USP7_MATH_1	137	141	PF00917	0.280
DOC_USP7_MATH_1	44	48	PF00917	0.637
DOC_USP7_MATH_1	51	55	PF00917	0.629
DOC_USP7_MATH_1	7	11	PF00917	0.541
DOC_USP7_MATH_1	93	97	PF00917	0.707
DOC_USP7_UBL2_3	166	170	PF12436	0.479
DOC_WW_Pin1_4	85	90	PF00397	0.812
LIG_LIR_Gen_1	133	141	PF02991	0.496
LIG_LIR_Nem_3	133	138	PF02991	0.490
LIG_Pex14_2	164	168	PF04695	0.388
LIG_SH2_STAT5	163	166	PF00017	0.390
LIG_SH2_STAT5	64	67	PF00017	0.572
LIG_SH3_3	86	92	PF00018	0.732
LIG_TRFH_1	63	67	PF08558	0.574
MOD_CK1_1	96	102	PF00069	0.645
MOD_CK2_1	137	143	PF00069	0.501
MOD_GlcNHglycan	104	107	PF01048	0.510
MOD_GlcNHglycan	121	124	PF01048	0.626
MOD_GlcNHglycan	46	49	PF01048	0.686
MOD_GlcNHglycan	9	12	PF01048	0.595
MOD_GlcNHglycan	96	99	PF01048	0.632
MOD_GSK3_1	96	103	PF00069	0.617
MOD_N-GLC_1	100	105	PF02516	0.605
MOD_NEK2_1	22	27	PF00069	0.566
MOD_NEK2_1	5	10	PF00069	0.469
MOD_Plk_4	152	158	PF00069	0.398
MOD_ProDKin_1	85	91	PF00069	0.812
MOD_SUMO_rev_2	144	154	PF00179	0.443
TRG_ER_diArg_1	61	63	PF00400	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM51	Leptomonas seymouri	58%	98%
A0A3R7M7X7	Trypanosoma rangeli	54%	88%
A4HGN4	Leishmania braziliensis	79%	100%
A4I3Q7	Leishmania infantum	99%	100%
E9B000	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q885	Leishmania major	92%	100%