SET domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

D-ala D-ala ligase C-terminus/SET domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ID63_LEIDO

TriTrypDb:

LdBPK_262590.1 , LdCL_260031800 , LDHU3_26.3350

Length:

516

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ID63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID63

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003824	catalytic activity	1	19
GO:0005488	binding	1	16
GO:0005524	ATP binding	5	16
GO:0008716	D-alanine-D-alanine ligase activity	5	16
GO:0016740	transferase activity	2	16
GO:0016874	ligase activity	2	16
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	16
GO:0016881	acid-amino acid ligase activity	4	16
GO:0017076	purine nucleotide binding	4	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0035639	purine ribonucleoside triphosphate binding	4	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0043169	cation binding	3	16
GO:0046872	metal ion binding	4	16
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16
GO:0008168	methyltransferase activity	4	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.456
CLV_C14_Caspase3-7	488	492	PF00656	0.684
CLV_NRD_NRD_1	349	351	PF00675	0.491
CLV_PCSK_KEX2_1	269	271	PF00082	0.350
CLV_PCSK_KEX2_1	349	351	PF00082	0.458
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.350
CLV_PCSK_PC7_1	265	271	PF00082	0.350
CLV_PCSK_SKI1_1	265	269	PF00082	0.261
CLV_PCSK_SKI1_1	291	295	PF00082	0.316
CLV_PCSK_SKI1_1	55	59	PF00082	0.414
DOC_CKS1_1	33	38	PF01111	0.384
DOC_CYCLIN_yCln2_LP_2	5	11	PF00134	0.424
DOC_MAPK_MEF2A_6	217	226	PF00069	0.468
DOC_MAPK_MEF2A_6	496	505	PF00069	0.506
DOC_PP1_RVXF_1	289	295	PF00149	0.494
DOC_PP4_FxxP_1	483	486	PF00568	0.531
DOC_PP4_FxxP_1	99	102	PF00568	0.436
DOC_USP7_MATH_1	432	436	PF00917	0.486
DOC_USP7_MATH_1	438	442	PF00917	0.442
DOC_USP7_UBL2_3	115	119	PF12436	0.353
DOC_WW_Pin1_4	32	37	PF00397	0.411
DOC_WW_Pin1_4	482	487	PF00397	0.491
DOC_WW_Pin1_4	489	494	PF00397	0.555
LIG_Actin_WH2_2	435	450	PF00022	0.485
LIG_BRCT_BRCA1_1	68	72	PF00533	0.444
LIG_EH1_1	171	179	PF00400	0.550
LIG_FHA_1	102	108	PF00498	0.406
LIG_FHA_1	46	52	PF00498	0.485
LIG_FHA_1	492	498	PF00498	0.627
LIG_FHA_2	209	215	PF00498	0.520
LIG_LIR_Apic_2	481	486	PF02991	0.522
LIG_LIR_Apic_2	97	102	PF02991	0.444
LIG_LIR_Gen_1	129	139	PF02991	0.311
LIG_LIR_Gen_1	158	165	PF02991	0.448
LIG_LIR_Gen_1	187	197	PF02991	0.551
LIG_LIR_Gen_1	327	336	PF02991	0.361
LIG_LIR_Gen_1	395	403	PF02991	0.486
LIG_LIR_Gen_1	69	76	PF02991	0.372
LIG_LIR_Nem_3	129	135	PF02991	0.311
LIG_LIR_Nem_3	147	153	PF02991	0.494
LIG_LIR_Nem_3	158	163	PF02991	0.425
LIG_LIR_Nem_3	187	193	PF02991	0.551
LIG_LIR_Nem_3	230	235	PF02991	0.452
LIG_LIR_Nem_3	327	331	PF02991	0.355
LIG_LIR_Nem_3	395	399	PF02991	0.482
LIG_LIR_Nem_3	409	415	PF02991	0.453
LIG_LIR_Nem_3	457	463	PF02991	0.458
LIG_LIR_Nem_3	58	63	PF02991	0.392
LIG_LIR_Nem_3	69	75	PF02991	0.380
LIG_MAD2	291	299	PF02301	0.471
LIG_Pex14_2	235	239	PF04695	0.443
LIG_SH2_CRK	160	164	PF00017	0.457
LIG_SH2_CRK	60	64	PF00017	0.385
LIG_SH2_GRB2like	124	127	PF00017	0.397
LIG_SH2_NCK_1	125	129	PF00017	0.438
LIG_SH2_NCK_1	160	164	PF00017	0.457
LIG_SH2_PTP2	132	135	PF00017	0.419
LIG_SH2_STAT3	386	389	PF00017	0.419
LIG_SH2_STAT5	103	106	PF00017	0.434
LIG_SH2_STAT5	132	135	PF00017	0.481
LIG_SH2_STAT5	347	350	PF00017	0.441
LIG_SH2_STAT5	39	42	PF00017	0.473
LIG_SH2_STAT5	396	399	PF00017	0.506
LIG_SH3_3	131	137	PF00018	0.511
LIG_SH3_3	215	221	PF00018	0.450
LIG_SH3_4	115	122	PF00018	0.369
LIG_SUMO_SIM_anti_2	441	446	PF11976	0.511
LIG_TRAF2_1	95	98	PF00917	0.423
LIG_TYR_ITIM	275	280	PF00017	0.467
LIG_TYR_ITSM	56	63	PF00017	0.408
LIG_UBA3_1	316	321	PF00899	0.388
MOD_CDK_SPxxK_3	489	496	PF00069	0.536
MOD_CK1_1	158	164	PF00069	0.472
MOD_CK1_1	208	214	PF00069	0.544
MOD_CK1_1	366	372	PF00069	0.475
MOD_CK1_1	485	491	PF00069	0.580
MOD_CK1_1	492	498	PF00069	0.594
MOD_CK1_1	499	505	PF00069	0.566
MOD_CK2_1	18	24	PF00069	0.453
MOD_CK2_1	195	201	PF00069	0.465
MOD_CK2_1	208	214	PF00069	0.497
MOD_GlcNHglycan	157	160	PF01048	0.248
MOD_GlcNHglycan	197	200	PF01048	0.274
MOD_GlcNHglycan	310	314	PF01048	0.352
MOD_GlcNHglycan	68	71	PF01048	0.449
MOD_GSK3_1	101	108	PF00069	0.385
MOD_GSK3_1	14	21	PF00069	0.371
MOD_GSK3_1	155	162	PF00069	0.447
MOD_GSK3_1	485	492	PF00069	0.592
MOD_N-GLC_1	426	431	PF02516	0.247
MOD_N-GLC_1	432	437	PF02516	0.230
MOD_N-GLC_2	77	79	PF02516	0.324
MOD_NEK2_1	165	170	PF00069	0.475
MOD_NEK2_1	245	250	PF00069	0.511
MOD_NEK2_1	463	468	PF00069	0.422
MOD_NEK2_1	66	71	PF00069	0.428
MOD_NEK2_2	45	50	PF00069	0.501
MOD_PIKK_1	208	214	PF00454	0.472
MOD_PIKK_1	245	251	PF00454	0.531
MOD_PIKK_1	496	502	PF00454	0.708
MOD_PKA_1	55	61	PF00069	0.419
MOD_PKA_2	179	185	PF00069	0.511
MOD_Plk_1	200	206	PF00069	0.464
MOD_Plk_1	363	369	PF00069	0.569
MOD_Plk_1	432	438	PF00069	0.465
MOD_Plk_1	454	460	PF00069	0.448
MOD_Plk_1	464	470	PF00069	0.423
MOD_Plk_2-3	454	460	PF00069	0.432
MOD_Plk_4	200	206	PF00069	0.444
MOD_Plk_4	366	372	PF00069	0.468
MOD_Plk_4	499	505	PF00069	0.529
MOD_ProDKin_1	32	38	PF00069	0.413
MOD_ProDKin_1	482	488	PF00069	0.499
MOD_ProDKin_1	489	495	PF00069	0.559
MOD_SUMO_for_1	451	454	PF00179	0.505
MOD_SUMO_for_1	82	85	PF00179	0.540
MOD_SUMO_rev_2	112	121	PF00179	0.362
MOD_SUMO_rev_2	228	235	PF00179	0.484
MOD_SUMO_rev_2	94	102	PF00179	0.449
TRG_DiLeu_BaLyEn_6	341	346	PF01217	0.533
TRG_ENDOCYTIC_2	110	113	PF00928	0.374
TRG_ENDOCYTIC_2	124	127	PF00928	0.257
TRG_ENDOCYTIC_2	132	135	PF00928	0.439
TRG_ENDOCYTIC_2	160	163	PF00928	0.469
TRG_ENDOCYTIC_2	242	245	PF00928	0.472
TRG_ENDOCYTIC_2	277	280	PF00928	0.471
TRG_ENDOCYTIC_2	396	399	PF00928	0.479
TRG_ENDOCYTIC_2	412	415	PF00928	0.432
TRG_ENDOCYTIC_2	460	463	PF00928	0.382
TRG_ENDOCYTIC_2	60	63	PF00928	0.371
TRG_ER_diArg_1	348	350	PF00400	0.473
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILV0	Leptomonas seymouri	78%	100%
A0A0S4JLQ2	Bodo saltans	60%	100%
A0A0S4JPH7	Bodo saltans	37%	80%
A0A1X0P879	Trypanosomatidae	65%	100%
A0A1X0P8J8	Trypanosomatidae	29%	100%
A0A3R7MWC4	Trypanosoma rangeli	63%	100%
A0A3R7P2U3	Trypanosoma rangeli	27%	100%
A4HFA0	Leishmania braziliensis	87%	100%
A4I1M6	Leishmania infantum	37%	100%
A4I2H5	Leishmania infantum	100%	100%
C9ZK70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	67%
C9ZX10	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
D0A2I3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AYN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q8T5	Leishmania major	94%	100%
V5B7P8	Trypanosoma cruzi	65%	100%
V5BHW2	Trypanosoma cruzi	37%	100%