LeishMANIAdb
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Calpain-like cysteine peptidase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Calpain-like cysteine peptidase, putative
Gene product:
cysteine peptidase, Clan CA, family C2, putative (fragment)
Species:
Leishmania donovani
UniProt:
A0A3Q8ID62_LEIDO
TriTrypDb:
LdBPK_272520.1 * , LdCL_270010000 , LDHU3_27.0680
Length:
6403

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 27
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 16
NetGPI no yes: 0, no: 16
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 3
GO:0005929 cilium 4 3
GO:0042995 cell projection 2 3
GO:0043226 organelle 2 3
GO:0043227 membrane-bounded organelle 3 3
GO:0110165 cellular anatomical entity 1 3
GO:0120025 plasma membrane bounded cell projection 3 3
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Expansion

Sequence features

A0A3Q8ID62
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
TermNameLevelCount
GO:0006508 proteolysis 4 17
GO:0006807 nitrogen compound metabolic process 2 17
GO:0008152 metabolic process 1 17
GO:0019538 protein metabolic process 3 17
GO:0043170 macromolecule metabolic process 3 17
GO:0044238 primary metabolic process 2 17
GO:0071704 organic substance metabolic process 2 17
GO:1901564 organonitrogen compound metabolic process 3 17
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 15
GO:0004175 endopeptidase activity 4 14
GO:0004197 cysteine-type endopeptidase activity 5 14
GO:0004198 calcium-dependent cysteine-type endopeptidase activity 6 14
GO:0008233 peptidase activity 3 14
GO:0008234 cysteine-type peptidase activity 4 14
GO:0016787 hydrolase activity 2 15
GO:0140096 catalytic activity, acting on a protein 2 14
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 1329 1333 PF00656 0.375
CLV_C14_Caspase3-7 1514 1518 PF00656 0.426
CLV_C14_Caspase3-7 1608 1612 PF00656 0.652
CLV_C14_Caspase3-7 1656 1660 PF00656 0.286
CLV_C14_Caspase3-7 1857 1861 PF00656 0.386
CLV_C14_Caspase3-7 1951 1955 PF00656 0.447
CLV_C14_Caspase3-7 1999 2003 PF00656 0.324
CLV_C14_Caspase3-7 2200 2204 PF00656 0.367
CLV_C14_Caspase3-7 2294 2298 PF00656 0.416
CLV_C14_Caspase3-7 2342 2346 PF00656 0.471
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P313 Leptomonas seymouri 37% 100%
A0A1X0P3X6 Trypanosomatidae 40% 100%
A0A3Q8IHF4 Leishmania donovani 42% 100%
A0A3S7X0F6 Leishmania donovani 37% 100%
A4HFH5 Leishmania braziliensis 39% 100%
A4HFH6 Leishmania braziliensis 41% 100%
A4HFX3 Leishmania braziliensis 47% 100%
A4I2N5 Leishmania infantum 36% 100%
A4I2N6 Leishmania infantum 41% 100%
D0A5Q3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS