Protein phosphatase 2C-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 2C-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8ID61_LEIDO

TriTrypDb:

LdBPK_140960.1 , LdCL_140015200 , LDHU3_14.1210

Length:

851

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ID61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID61

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0004722	protein serine/threonine phosphatase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0017018	myosin phosphatase activity	5	6
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	350	354	PF00656	0.830
CLV_C14_Caspase3-7	372	376	PF00656	0.747
CLV_NRD_NRD_1	289	291	PF00675	0.755
CLV_NRD_NRD_1	477	479	PF00675	0.514
CLV_NRD_NRD_1	540	542	PF00675	0.389
CLV_NRD_NRD_1	605	607	PF00675	0.412
CLV_NRD_NRD_1	676	678	PF00675	0.478
CLV_NRD_NRD_1	73	75	PF00675	0.676
CLV_NRD_NRD_1	825	827	PF00675	0.697
CLV_NRD_NRD_1	95	97	PF00675	0.794
CLV_PCSK_FUR_1	538	542	PF00082	0.391
CLV_PCSK_KEX2_1	289	291	PF00082	0.755
CLV_PCSK_KEX2_1	477	479	PF00082	0.433
CLV_PCSK_KEX2_1	538	540	PF00082	0.355
CLV_PCSK_KEX2_1	605	607	PF00082	0.412
CLV_PCSK_KEX2_1	676	678	PF00082	0.478
CLV_PCSK_KEX2_1	73	75	PF00082	0.683
CLV_PCSK_KEX2_1	95	97	PF00082	0.819
CLV_PCSK_SKI1_1	124	128	PF00082	0.778
CLV_PCSK_SKI1_1	188	192	PF00082	0.745
CLV_PCSK_SKI1_1	307	311	PF00082	0.613
CLV_PCSK_SKI1_1	425	429	PF00082	0.658
CLV_PCSK_SKI1_1	514	518	PF00082	0.412
CLV_PCSK_SKI1_1	580	584	PF00082	0.412
CLV_PCSK_SKI1_1	606	610	PF00082	0.412
CLV_PCSK_SKI1_1	725	729	PF00082	0.412
CLV_PCSK_SKI1_1	838	842	PF00082	0.673
DEG_SPOP_SBC_1	195	199	PF00917	0.818
DOC_MAPK_DCC_7	382	390	PF00069	0.750
DOC_MAPK_gen_1	605	616	PF00069	0.412
DOC_MAPK_MEF2A_6	382	390	PF00069	0.750
DOC_MAPK_MEF2A_6	425	433	PF00069	0.601
DOC_PP2B_LxvP_1	191	194	PF13499	0.725
DOC_USP7_MATH_1	111	115	PF00917	0.729
DOC_USP7_MATH_1	150	154	PF00917	0.756
DOC_USP7_MATH_1	164	168	PF00917	0.583
DOC_USP7_MATH_1	195	199	PF00917	0.756
DOC_USP7_MATH_1	2	6	PF00917	0.682
DOC_USP7_MATH_1	249	253	PF00917	0.708
DOC_USP7_MATH_1	371	375	PF00917	0.741
DOC_USP7_MATH_1	391	395	PF00917	0.511
DOC_USP7_MATH_1	50	54	PF00917	0.656
DOC_USP7_MATH_1	670	674	PF00917	0.459
DOC_USP7_MATH_1	825	829	PF00917	0.636
DOC_USP7_UBL2_3	6	10	PF12436	0.607
DOC_WW_Pin1_4	144	149	PF00397	0.796
DOC_WW_Pin1_4	16	21	PF00397	0.711
DOC_WW_Pin1_4	203	208	PF00397	0.667
DOC_WW_Pin1_4	236	241	PF00397	0.715
DOC_WW_Pin1_4	245	250	PF00397	0.699
DOC_WW_Pin1_4	328	333	PF00397	0.801
DOC_WW_Pin1_4	636	641	PF00397	0.426
DOC_WW_Pin1_4	668	673	PF00397	0.473
DOC_WW_Pin1_4	728	733	PF00397	0.353
DOC_WW_Pin1_4	745	750	PF00397	0.353
LIG_14-3-3_CanoR_1	112	117	PF00244	0.688
LIG_14-3-3_CanoR_1	42	48	PF00244	0.669
LIG_14-3-3_CanoR_1	826	830	PF00244	0.692
LIG_14-3-3_CanoR_1	87	91	PF00244	0.746
LIG_14-3-3_CanoR_1	95	103	PF00244	0.769
LIG_Actin_WH2_2	119	136	PF00022	0.802
LIG_BIR_II_1	1	5	PF00653	0.574
LIG_BIR_III_3	1	5	PF00653	0.574
LIG_BIR_III_4	643	647	PF00653	0.330
LIG_BRCT_BRCA1_1	650	654	PF00533	0.514
LIG_FHA_1	17	23	PF00498	0.729
LIG_FHA_1	240	246	PF00498	0.762
LIG_FHA_1	281	287	PF00498	0.823
LIG_FHA_1	359	365	PF00498	0.685
LIG_FHA_1	39	45	PF00498	0.655
LIG_FHA_1	424	430	PF00498	0.555
LIG_FHA_1	719	725	PF00498	0.412
LIG_FHA_1	729	735	PF00498	0.412
LIG_FHA_1	87	93	PF00498	0.808
LIG_FHA_2	117	123	PF00498	0.798
LIG_FHA_2	444	450	PF00498	0.355
LIG_FHA_2	510	516	PF00498	0.412
LIG_Integrin_isoDGR_2	280	282	PF01839	0.760
LIG_Integrin_isoDGR_2	844	846	PF01839	0.694
LIG_LIR_Gen_1	449	460	PF02991	0.401
LIG_LIR_Gen_1	515	522	PF02991	0.402
LIG_LIR_Gen_1	68	77	PF02991	0.586
LIG_LIR_Gen_1	701	711	PF02991	0.412
LIG_LIR_LC3C_4	41	45	PF02991	0.656
LIG_LIR_Nem_3	449	455	PF02991	0.401
LIG_LIR_Nem_3	515	520	PF02991	0.412
LIG_LIR_Nem_3	68	72	PF02991	0.588
LIG_LIR_Nem_3	701	706	PF02991	0.412
LIG_LIR_Nem_3	709	715	PF02991	0.412
LIG_LIR_Nem_3	726	730	PF02991	0.260
LIG_MYND_1	128	132	PF01753	0.705
LIG_MYND_1	20	24	PF01753	0.795
LIG_Pex14_1	486	490	PF04695	0.412
LIG_Pex14_2	632	636	PF04695	0.353
LIG_Pex14_2	723	727	PF04695	0.412
LIG_PTAP_UEV_1	264	269	PF05743	0.700
LIG_SH2_CRK	69	73	PF00017	0.591
LIG_SH2_GRB2like	36	39	PF00017	0.716
LIG_SH2_STAP1	88	92	PF00017	0.736
LIG_SH2_STAT5	36	39	PF00017	0.717
LIG_SH2_STAT5	490	493	PF00017	0.412
LIG_SH2_STAT5	572	575	PF00017	0.412
LIG_SH2_STAT5	69	72	PF00017	0.792
LIG_SH2_STAT5	730	733	PF00017	0.394
LIG_SH2_STAT5	88	91	PF00017	0.737
LIG_SH3_3	18	24	PF00018	0.753
LIG_SH3_3	262	268	PF00018	0.706
LIG_SH3_3	313	319	PF00018	0.654
LIG_SH3_3	380	386	PF00018	0.825
LIG_SH3_3	42	48	PF00018	0.628
LIG_SH3_3	731	737	PF00018	0.412
LIG_SUMO_SIM_anti_2	466	472	PF11976	0.514
LIG_SUMO_SIM_anti_2	774	780	PF11976	0.430
LIG_SUMO_SIM_par_1	466	472	PF11976	0.514
LIG_SUMO_SIM_par_1	621	626	PF11976	0.412
LIG_SUMO_SIM_par_1	88	93	PF11976	0.588
LIG_SxIP_EBH_1	194	208	PF03271	0.819
LIG_TRAF2_1	645	648	PF00917	0.440
LIG_TRAF2_1	716	719	PF00917	0.412
LIG_UBA3_1	516	523	PF00899	0.412
LIG_WW_3	148	152	PF00397	0.769
MOD_CDK_SPK_2	203	208	PF00069	0.821
MOD_CDK_SPxxK_3	144	151	PF00069	0.816
MOD_CDK_SPxxK_3	236	243	PF00069	0.653
MOD_CK1_1	13	19	PF00069	0.818
MOD_CK1_1	167	173	PF00069	0.628
MOD_CK1_1	203	209	PF00069	0.659
MOD_CK1_1	239	245	PF00069	0.775
MOD_CK1_1	248	254	PF00069	0.698
MOD_CK1_1	366	372	PF00069	0.776
MOD_CK1_1	423	429	PF00069	0.520
MOD_CK1_1	664	670	PF00069	0.402
MOD_CK1_1	745	751	PF00069	0.478
MOD_CK1_1	820	826	PF00069	0.666
MOD_CK1_1	828	834	PF00069	0.688
MOD_CK2_1	263	269	PF00069	0.702
MOD_CK2_1	366	372	PF00069	0.798
MOD_CK2_1	509	515	PF00069	0.412
MOD_CK2_1	713	719	PF00069	0.412
MOD_CK2_1	828	834	PF00069	0.581
MOD_Cter_Amidation	475	478	PF01082	0.514
MOD_Cter_Amidation	536	539	PF01082	0.412
MOD_Cter_Amidation	93	96	PF01082	0.727
MOD_GlcNHglycan	103	106	PF01048	0.635
MOD_GlcNHglycan	152	155	PF01048	0.736
MOD_GlcNHglycan	191	194	PF01048	0.725
MOD_GlcNHglycan	251	254	PF01048	0.683
MOD_GlcNHglycan	265	268	PF01048	0.558
MOD_GlcNHglycan	322	326	PF01048	0.752
MOD_GlcNHglycan	368	371	PF01048	0.727
MOD_GlcNHglycan	401	405	PF01048	0.764
MOD_GlcNHglycan	422	425	PF01048	0.615
MOD_GlcNHglycan	436	439	PF01048	0.412
MOD_GlcNHglycan	535	538	PF01048	0.420
MOD_GlcNHglycan	552	555	PF01048	0.438
MOD_GlcNHglycan	663	667	PF01048	0.417
MOD_GlcNHglycan	699	703	PF01048	0.412
MOD_GlcNHglycan	740	743	PF01048	0.412
MOD_GlcNHglycan	793	796	PF01048	0.566
MOD_GlcNHglycan	799	802	PF01048	0.624
MOD_GlcNHglycan	819	822	PF01048	0.826
MOD_GlcNHglycan	91	95	PF01048	0.705
MOD_GlcNHglycan	99	102	PF01048	0.625
MOD_GSK3_1	112	119	PF00069	0.786
MOD_GSK3_1	196	203	PF00069	0.702
MOD_GSK3_1	222	229	PF00069	0.779
MOD_GSK3_1	245	252	PF00069	0.734
MOD_GSK3_1	263	270	PF00069	0.642
MOD_GSK3_1	371	378	PF00069	0.779
MOD_GSK3_1	419	426	PF00069	0.561
MOD_GSK3_1	505	512	PF00069	0.367
MOD_GSK3_1	552	559	PF00069	0.429
MOD_GSK3_1	586	593	PF00069	0.357
MOD_GSK3_1	664	671	PF00069	0.411
MOD_GSK3_1	738	745	PF00069	0.499
MOD_GSK3_1	805	812	PF00069	0.742
MOD_GSK3_1	813	820	PF00069	0.661
MOD_GSK3_1	86	93	PF00069	0.806
MOD_GSK3_1	97	104	PF00069	0.712
MOD_N-GLC_1	173	178	PF02516	0.825
MOD_N-GLC_1	455	460	PF02516	0.391
MOD_N-GLC_1	533	538	PF02516	0.440
MOD_N-GLC_1	661	666	PF02516	0.440
MOD_N-GLC_1	774	779	PF02516	0.431
MOD_N-GLC_2	757	759	PF02516	0.412
MOD_NEK2_1	312	317	PF00069	0.698
MOD_NEK2_1	357	362	PF00069	0.687
MOD_NEK2_1	363	368	PF00069	0.686
MOD_NEK2_1	455	460	PF00069	0.348
MOD_NEK2_1	505	510	PF00069	0.412
MOD_NEK2_1	623	628	PF00069	0.390
MOD_NEK2_1	684	689	PF00069	0.412
MOD_NEK2_1	817	822	PF00069	0.825
MOD_NEK2_1	833	838	PF00069	0.504
MOD_NEK2_1	90	95	PF00069	0.584
MOD_NEK2_2	164	169	PF00069	0.719
MOD_NEK2_2	173	178	PF00069	0.632
MOD_PIKK_1	358	364	PF00454	0.659
MOD_PIKK_1	809	815	PF00454	0.814
MOD_PKA_1	95	101	PF00069	0.715
MOD_PKA_2	111	117	PF00069	0.727
MOD_PKA_2	150	156	PF00069	0.824
MOD_PKA_2	222	228	PF00069	0.755
MOD_PKA_2	443	449	PF00069	0.392
MOD_PKA_2	769	775	PF00069	0.412
MOD_PKA_2	791	797	PF00069	0.614
MOD_PKA_2	825	831	PF00069	0.685
MOD_PKA_2	86	92	PF00069	0.772
MOD_PKA_2	95	101	PF00069	0.766
MOD_PKB_1	110	118	PF00069	0.691
MOD_PKB_1	398	406	PF00069	0.713
MOD_Plk_1	38	44	PF00069	0.709
MOD_Plk_1	455	461	PF00069	0.391
MOD_Plk_1	67	73	PF00069	0.591
MOD_Plk_1	698	704	PF00069	0.412
MOD_Plk_1	774	780	PF00069	0.430
MOD_Plk_2-3	769	775	PF00069	0.412
MOD_Plk_4	173	179	PF00069	0.753
MOD_Plk_4	196	202	PF00069	0.766
MOD_Plk_4	32	38	PF00069	0.759
MOD_Plk_4	463	469	PF00069	0.412
MOD_Plk_4	505	511	PF00069	0.412
MOD_Plk_4	557	563	PF00069	0.412
MOD_Plk_4	774	780	PF00069	0.430
MOD_Plk_4	828	834	PF00069	0.646
MOD_ProDKin_1	144	150	PF00069	0.794
MOD_ProDKin_1	16	22	PF00069	0.711
MOD_ProDKin_1	203	209	PF00069	0.656
MOD_ProDKin_1	236	242	PF00069	0.712
MOD_ProDKin_1	245	251	PF00069	0.700
MOD_ProDKin_1	328	334	PF00069	0.802
MOD_ProDKin_1	636	642	PF00069	0.426
MOD_ProDKin_1	668	674	PF00069	0.473
MOD_ProDKin_1	728	734	PF00069	0.353
MOD_ProDKin_1	745	751	PF00069	0.353
MOD_SUMO_rev_2	121	126	PF00179	0.804
MOD_SUMO_rev_2	593	598	PF00179	0.412
MOD_SUMO_rev_2	631	636	PF00179	0.412
MOD_SUMO_rev_2	641	651	PF00179	0.412
TRG_DiLeu_BaEn_1	39	44	PF01217	0.653
TRG_DiLeu_BaEn_3	718	724	PF01217	0.412
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.634
TRG_DiLeu_BaLyEn_6	212	217	PF01217	0.829
TRG_ENDOCYTIC_2	69	72	PF00928	0.589
TRG_ER_diArg_1	128	131	PF00400	0.708
TRG_ER_diArg_1	397	400	PF00400	0.648
TRG_ER_diArg_1	477	479	PF00400	0.514
TRG_ER_diArg_1	538	541	PF00400	0.412
TRG_ER_diArg_1	605	607	PF00400	0.412
TRG_ER_diArg_1	676	678	PF00400	0.478
TRG_ER_diArg_1	72	74	PF00400	0.583
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.801
TRG_Pf-PMV_PEXEL_1	627	631	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L7	Leptomonas seymouri	50%	81%
A4H7P3	Leishmania braziliensis	71%	100%
A4HW33	Leishmania infantum	100%	100%
E9APT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QFP5	Leishmania major	92%	100%