WD domain, G-beta repeat, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ID60_LEIDO

TriTrypDb:

LdBPK_181440.1 , LdCL_180019800 , LDHU3_18.1840

Length:

910

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0005858	axonemal dynein complex	4	1
GO:0005875	microtubule associated complex	2	2
GO:0005929	cilium	4	2
GO:0030286	dynein complex	3	2
GO:0030990	intraciliary transport particle	2	1
GO:0032991	protein-containing complex	1	2
GO:0036064	ciliary basal body	3	1
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2
GO:1902494	catalytic complex	2	2
GO:0005840	ribosome	5	1
GO:0005868	cytoplasmic dynein complex	4	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3Q8ID60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID60

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	1
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2
GO:0006810	transport	3	1
GO:0010970	transport along microtubule	4	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0042073	intraciliary transport	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0099111	microtubule-based transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0045503	dynein light chain binding	3	2
GO:0045504	dynein heavy chain binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.498
CLV_C14_Caspase3-7	227	231	PF00656	0.698
CLV_C14_Caspase3-7	313	317	PF00656	0.648
CLV_C14_Caspase3-7	380	384	PF00656	0.674
CLV_C14_Caspase3-7	693	697	PF00656	0.618
CLV_NRD_NRD_1	126	128	PF00675	0.641
CLV_NRD_NRD_1	129	131	PF00675	0.657
CLV_NRD_NRD_1	15	17	PF00675	0.486
CLV_NRD_NRD_1	182	184	PF00675	0.530
CLV_NRD_NRD_1	19	21	PF00675	0.487
CLV_NRD_NRD_1	194	196	PF00675	0.492
CLV_NRD_NRD_1	203	205	PF00675	0.521
CLV_NRD_NRD_1	207	209	PF00675	0.574
CLV_NRD_NRD_1	268	270	PF00675	0.472
CLV_NRD_NRD_1	353	355	PF00675	0.639
CLV_NRD_NRD_1	609	611	PF00675	0.525
CLV_NRD_NRD_1	64	66	PF00675	0.600
CLV_NRD_NRD_1	72	74	PF00675	0.494
CLV_NRD_NRD_1	8	10	PF00675	0.482
CLV_NRD_NRD_1	844	846	PF00675	0.450
CLV_PCSK_KEX2_1	126	128	PF00082	0.668
CLV_PCSK_KEX2_1	14	16	PF00082	0.509
CLV_PCSK_KEX2_1	175	177	PF00082	0.511
CLV_PCSK_KEX2_1	184	186	PF00082	0.507
CLV_PCSK_KEX2_1	196	198	PF00082	0.537
CLV_PCSK_KEX2_1	203	205	PF00082	0.447
CLV_PCSK_KEX2_1	207	209	PF00082	0.543
CLV_PCSK_KEX2_1	268	270	PF00082	0.472
CLV_PCSK_KEX2_1	353	355	PF00082	0.639
CLV_PCSK_KEX2_1	635	637	PF00082	0.516
CLV_PCSK_KEX2_1	72	74	PF00082	0.528
CLV_PCSK_KEX2_1	79	81	PF00082	0.560
CLV_PCSK_KEX2_1	8	10	PF00082	0.497
CLV_PCSK_KEX2_1	844	846	PF00082	0.450
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.580
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.491
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.544
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.454
CLV_PCSK_PC1ET2_1	635	637	PF00082	0.516
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.573
CLV_PCSK_PC7_1	11	17	PF00082	0.606
CLV_PCSK_PC7_1	192	198	PF00082	0.472
CLV_PCSK_PC7_1	203	209	PF00082	0.451
CLV_PCSK_PC7_1	75	81	PF00082	0.614
CLV_PCSK_SKI1_1	175	179	PF00082	0.411
CLV_PCSK_SKI1_1	203	207	PF00082	0.572
CLV_PCSK_SKI1_1	234	238	PF00082	0.600
CLV_PCSK_SKI1_1	259	263	PF00082	0.640
CLV_PCSK_SKI1_1	347	351	PF00082	0.623
CLV_PCSK_SKI1_1	354	358	PF00082	0.638
CLV_PCSK_SKI1_1	401	405	PF00082	0.666
CLV_PCSK_SKI1_1	414	418	PF00082	0.437
CLV_PCSK_SKI1_1	573	577	PF00082	0.361
CLV_PCSK_SKI1_1	672	676	PF00082	0.426
DEG_APCC_DBOX_1	233	241	PF00400	0.551
DEG_SPOP_SBC_1	456	460	PF00917	0.503
DOC_MAPK_gen_1	467	477	PF00069	0.425
DOC_MAPK_MEF2A_6	470	479	PF00069	0.367
DOC_PP1_RVXF_1	267	274	PF00149	0.553
DOC_PP2B_LxvP_1	721	724	PF13499	0.436
DOC_PP4_FxxP_1	576	579	PF00568	0.302
DOC_USP7_MATH_1	104	108	PF00917	0.649
DOC_USP7_MATH_1	119	123	PF00917	0.571
DOC_USP7_MATH_1	34	38	PF00917	0.693
DOC_USP7_MATH_1	391	395	PF00917	0.741
DOC_USP7_MATH_1	456	460	PF00917	0.434
DOC_USP7_MATH_1	48	52	PF00917	0.770
DOC_USP7_MATH_1	55	59	PF00917	0.606
DOC_USP7_MATH_1	678	682	PF00917	0.561
DOC_USP7_MATH_1	683	687	PF00917	0.614
DOC_USP7_MATH_1	713	717	PF00917	0.464
DOC_USP7_MATH_1	737	741	PF00917	0.386
DOC_USP7_MATH_1	754	758	PF00917	0.521
DOC_USP7_MATH_2	638	644	PF00917	0.562
DOC_WW_Pin1_4	235	240	PF00397	0.648
DOC_WW_Pin1_4	35	40	PF00397	0.617
DOC_WW_Pin1_4	497	502	PF00397	0.580
DOC_WW_Pin1_4	517	522	PF00397	0.385
DOC_WW_Pin1_4	534	539	PF00397	0.340
DOC_WW_Pin1_4	642	647	PF00397	0.556
DOC_WW_Pin1_4	735	740	PF00397	0.542
DOC_WW_Pin1_4	798	803	PF00397	0.462
LIG_14-3-3_CanoR_1	167	177	PF00244	0.574
LIG_14-3-3_CanoR_1	263	271	PF00244	0.467
LIG_14-3-3_CanoR_1	523	531	PF00244	0.435
LIG_14-3-3_CanoR_1	563	571	PF00244	0.375
LIG_14-3-3_CanoR_1	849	855	PF00244	0.495
LIG_14-3-3_CanoR_1	899	909	PF00244	0.466
LIG_Actin_WH2_2	345	361	PF00022	0.552
LIG_Actin_WH2_2	883	901	PF00022	0.414
LIG_BIR_III_4	230	234	PF00653	0.568
LIG_BRCT_BRCA1_1	165	169	PF00533	0.577
LIG_Clathr_ClatBox_1	618	622	PF01394	0.302
LIG_eIF4E_1	668	674	PF01652	0.286
LIG_FHA_1	169	175	PF00498	0.469
LIG_FHA_1	402	408	PF00498	0.564
LIG_FHA_1	415	421	PF00498	0.372
LIG_FHA_1	589	595	PF00498	0.496
LIG_FHA_1	602	608	PF00498	0.539
LIG_FHA_1	715	721	PF00498	0.445
LIG_FHA_1	764	770	PF00498	0.418
LIG_FHA_1	789	795	PF00498	0.410
LIG_FHA_1	799	805	PF00498	0.413
LIG_FHA_2	239	245	PF00498	0.635
LIG_FHA_2	30	36	PF00498	0.667
LIG_FHA_2	317	323	PF00498	0.634
LIG_FHA_2	437	443	PF00498	0.713
LIG_FHA_2	517	523	PF00498	0.397
LIG_FHA_2	607	613	PF00498	0.589
LIG_FHA_2	66	72	PF00498	0.522
LIG_FHA_2	853	859	PF00498	0.406
LIG_FHA_2	861	867	PF00498	0.320
LIG_Integrin_isoDGR_2	360	362	PF01839	0.511
LIG_LIR_Gen_1	504	512	PF02991	0.325
LIG_LIR_Gen_1	612	621	PF02991	0.570
LIG_LIR_Gen_1	667	674	PF02991	0.286
LIG_LIR_Nem_3	287	292	PF02991	0.431
LIG_LIR_Nem_3	346	352	PF02991	0.603
LIG_LIR_Nem_3	504	509	PF02991	0.337
LIG_LIR_Nem_3	612	618	PF02991	0.547
LIG_LIR_Nem_3	667	671	PF02991	0.278
LIG_LIR_Nem_3	779	785	PF02991	0.363
LIG_NRBOX	506	512	PF00104	0.369
LIG_PCNA_yPIPBox_3	467	478	PF02747	0.461
LIG_PDZ_Wminus1_1	908	910	PF00595	0.392
LIG_REV1ctd_RIR_1	347	358	PF16727	0.604
LIG_SH2_NCK_1	753	757	PF00017	0.652
LIG_SH2_PTP2	668	671	PF00017	0.276
LIG_SH2_SRC	787	790	PF00017	0.331
LIG_SH2_STAP1	289	293	PF00017	0.432
LIG_SH2_STAP1	571	575	PF00017	0.477
LIG_SH2_STAP1	615	619	PF00017	0.434
LIG_SH2_STAT3	253	256	PF00017	0.459
LIG_SH2_STAT5	292	295	PF00017	0.449
LIG_SH2_STAT5	668	671	PF00017	0.276
LIG_SH2_STAT5	795	798	PF00017	0.352
LIG_SH3_3	303	309	PF00018	0.529
LIG_SH3_3	448	454	PF00018	0.530
LIG_SH3_3	478	484	PF00018	0.437
LIG_SH3_3	535	541	PF00018	0.306
LIG_SH3_3	764	770	PF00018	0.429
LIG_SUMO_SIM_anti_2	419	424	PF11976	0.418
LIG_SUMO_SIM_anti_2	504	511	PF11976	0.326
LIG_SUMO_SIM_anti_2	863	869	PF11976	0.452
LIG_SUMO_SIM_par_1	508	514	PF11976	0.415
LIG_SUMO_SIM_par_1	891	896	PF11976	0.347
LIG_TRAF2_1	122	125	PF00917	0.696
LIG_TRAF2_1	188	191	PF00917	0.489
LIG_TRAF2_1	309	312	PF00917	0.535
LIG_TRAF2_1	341	344	PF00917	0.619
LIG_TRAF2_1	68	71	PF00917	0.531
LIG_TRFH_1	661	665	PF08558	0.479
LIG_TYR_ITAM	612	632	PF00017	0.430
LIG_TYR_ITIM	773	778	PF00017	0.312
LIG_WRC_WIRS_1	503	508	PF05994	0.505
MOD_CDC14_SPxK_1	38	41	PF00782	0.613
MOD_CDC14_SPxK_1	537	540	PF00782	0.370
MOD_CDK_SPxK_1	35	41	PF00069	0.616
MOD_CDK_SPxK_1	517	523	PF00069	0.356
MOD_CDK_SPxK_1	534	540	PF00069	0.260
MOD_CK1_1	238	244	PF00069	0.682
MOD_CK1_1	37	43	PF00069	0.612
MOD_CK1_1	432	438	PF00069	0.701
MOD_CK1_1	44	50	PF00069	0.466
MOD_CK1_1	445	451	PF00069	0.472
MOD_CK1_1	459	465	PF00069	0.308
MOD_CK1_1	51	57	PF00069	0.541
MOD_CK1_1	527	533	PF00069	0.357
MOD_CK1_1	580	586	PF00069	0.346
MOD_CK1_1	606	612	PF00069	0.678
MOD_CK1_1	667	673	PF00069	0.530
MOD_CK1_1	714	720	PF00069	0.546
MOD_CK2_1	1	7	PF00069	0.512
MOD_CK2_1	119	125	PF00069	0.695
MOD_CK2_1	185	191	PF00069	0.566
MOD_CK2_1	29	35	PF00069	0.661
MOD_CK2_1	296	302	PF00069	0.599
MOD_CK2_1	316	322	PF00069	0.423
MOD_CK2_1	606	612	PF00069	0.640
MOD_CK2_1	65	71	PF00069	0.531
MOD_CK2_1	866	872	PF00069	0.487
MOD_CMANNOS	824	827	PF00535	0.298
MOD_Cter_Amidation	399	402	PF01082	0.515
MOD_GlcNHglycan	106	109	PF01048	0.724
MOD_GlcNHglycan	135	138	PF01048	0.497
MOD_GlcNHglycan	16	19	PF01048	0.551
MOD_GlcNHglycan	187	190	PF01048	0.620
MOD_GlcNHglycan	226	229	PF01048	0.699
MOD_GlcNHglycan	274	278	PF01048	0.586
MOD_GlcNHglycan	286	289	PF01048	0.475
MOD_GlcNHglycan	298	301	PF01048	0.499
MOD_GlcNHglycan	32	35	PF01048	0.516
MOD_GlcNHglycan	393	396	PF01048	0.668
MOD_GlcNHglycan	434	437	PF01048	0.681
MOD_GlcNHglycan	50	53	PF01048	0.630
MOD_GlcNHglycan	566	569	PF01048	0.430
MOD_GlcNHglycan	57	60	PF01048	0.714
MOD_GlcNHglycan	642	645	PF01048	0.660
MOD_GlcNHglycan	676	679	PF01048	0.566
MOD_GlcNHglycan	680	683	PF01048	0.566
MOD_GlcNHglycan	756	759	PF01048	0.668
MOD_GlcNHglycan	818	821	PF01048	0.341
MOD_GlcNHglycan	830	834	PF01048	0.301
MOD_GSK3_1	100	107	PF00069	0.678
MOD_GSK3_1	159	166	PF00069	0.576
MOD_GSK3_1	30	37	PF00069	0.613
MOD_GSK3_1	414	421	PF00069	0.531
MOD_GSK3_1	432	439	PF00069	0.549
MOD_GSK3_1	44	51	PF00069	0.629
MOD_GSK3_1	442	449	PF00069	0.574
MOD_GSK3_1	452	459	PF00069	0.320
MOD_GSK3_1	602	609	PF00069	0.533
MOD_GSK3_1	617	624	PF00069	0.262
MOD_GSK3_1	674	681	PF00069	0.481
MOD_GSK3_1	742	749	PF00069	0.557
MOD_GSK3_1	773	780	PF00069	0.299
MOD_GSK3_1	798	805	PF00069	0.395
MOD_GSK3_1	848	855	PF00069	0.384
MOD_GSK3_1	856	863	PF00069	0.312
MOD_N-GLC_1	429	434	PF02516	0.530
MOD_N-GLC_1	602	607	PF02516	0.603
MOD_N-GLC_2	552	554	PF02516	0.421
MOD_NEK2_1	273	278	PF00069	0.626
MOD_NEK2_1	296	301	PF00069	0.500
MOD_NEK2_1	416	421	PF00069	0.437
MOD_NEK2_1	457	462	PF00069	0.357
MOD_NEK2_1	511	516	PF00069	0.411
MOD_NEK2_1	564	569	PF00069	0.516
MOD_NEK2_1	621	626	PF00069	0.404
MOD_NEK2_1	850	855	PF00069	0.355
MOD_OFUCOSY	528	533	PF10250	0.393
MOD_PIKK_1	316	322	PF00454	0.627
MOD_PIKK_1	41	47	PF00454	0.628
MOD_PIKK_1	714	720	PF00454	0.474
MOD_PIKK_1	852	858	PF00454	0.401
MOD_PKA_1	14	20	PF00069	0.589
MOD_PKA_1	175	181	PF00069	0.474
MOD_PKA_1	27	33	PF00069	0.597
MOD_PKA_1	401	407	PF00069	0.437
MOD_PKA_1	65	71	PF00069	0.526
MOD_PKA_2	133	139	PF00069	0.699
MOD_PKA_2	14	20	PF00069	0.589
MOD_PKA_2	163	169	PF00069	0.570
MOD_PKA_2	175	181	PF00069	0.519
MOD_PKA_2	262	268	PF00069	0.456
MOD_PKA_2	466	472	PF00069	0.413
MOD_PKA_2	728	734	PF00069	0.505
MOD_PKA_2	848	854	PF00069	0.491
MOD_PKB_1	183	191	PF00069	0.536
MOD_Plk_1	429	435	PF00069	0.582
MOD_Plk_1	602	608	PF00069	0.454
MOD_Plk_2-3	442	448	PF00069	0.559
MOD_Plk_4	418	424	PF00069	0.471
MOD_Plk_4	429	435	PF00069	0.403
MOD_Plk_4	502	508	PF00069	0.378
MOD_Plk_4	664	670	PF00069	0.413
MOD_Plk_4	683	689	PF00069	0.463
MOD_Plk_4	737	743	PF00069	0.381
MOD_Plk_4	773	779	PF00069	0.427
MOD_ProDKin_1	235	241	PF00069	0.648
MOD_ProDKin_1	35	41	PF00069	0.620
MOD_ProDKin_1	497	503	PF00069	0.569
MOD_ProDKin_1	517	523	PF00069	0.384
MOD_ProDKin_1	534	540	PF00069	0.343
MOD_ProDKin_1	642	648	PF00069	0.552
MOD_ProDKin_1	735	741	PF00069	0.535
MOD_ProDKin_1	798	804	PF00069	0.455
MOD_SUMO_rev_2	179	186	PF00179	0.481
MOD_SUMO_rev_2	188	198	PF00179	0.532
MOD_SUMO_rev_2	23	30	PF00179	0.604
MOD_SUMO_rev_2	58	68	PF00179	0.733
MOD_SUMO_rev_2	71	81	PF00179	0.518
TRG_DiLeu_BaEn_1	201	206	PF01217	0.570
TRG_DiLeu_BaEn_1	429	434	PF01217	0.397
TRG_DiLeu_BaEn_4	201	207	PF01217	0.591
TRG_DiLeu_LyEn_5	201	206	PF01217	0.484
TRG_ENDOCYTIC_2	615	618	PF00928	0.478
TRG_ENDOCYTIC_2	629	632	PF00928	0.294
TRG_ENDOCYTIC_2	668	671	PF00928	0.475
TRG_ENDOCYTIC_2	775	778	PF00928	0.318
TRG_ER_diArg_1	183	186	PF00400	0.583
TRG_ER_diArg_1	203	205	PF00400	0.444
TRG_ER_diArg_1	206	208	PF00400	0.517
TRG_ER_diArg_1	267	269	PF00400	0.472
TRG_ER_diArg_1	326	329	PF00400	0.523
TRG_ER_diArg_1	352	354	PF00400	0.640
TRG_ER_diArg_1	470	473	PF00400	0.418
TRG_ER_diArg_1	72	75	PF00400	0.525
TRG_ER_diArg_1	8	11	PF00400	0.494
TRG_Pf-PMV_PEXEL_1	8	13	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PED2	Leptomonas seymouri	57%	100%
A0A0S4JR75	Bodo saltans	33%	100%
A0A1X0P8I2	Trypanosomatidae	41%	100%
A0A3R7KCG9	Trypanosoma rangeli	40%	100%
A4H9P9	Leishmania braziliensis	77%	100%
A4HY16	Leishmania infantum	100%	100%
E9ART0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4QDP3	Leishmania major	94%	100%
Q8C761	Mus musculus	23%	91%
Q8WVS4	Homo sapiens	23%	85%
V5BNK6	Trypanosoma cruzi	41%	100%