HECT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ID57_LEIDO

TriTrypDb:

LdBPK_321870.1 , LdCL_320024200 , LDHU3_32.2360

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ID57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID57

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	250	254	PF00656	0.579
CLV_C14_Caspase3-7	576	580	PF00656	0.500
CLV_MEL_PAP_1	126	132	PF00089	0.312
CLV_NRD_NRD_1	118	120	PF00675	0.496
CLV_NRD_NRD_1	392	394	PF00675	0.262
CLV_NRD_NRD_1	459	461	PF00675	0.312
CLV_NRD_NRD_1	607	609	PF00675	0.584
CLV_PCSK_KEX2_1	118	120	PF00082	0.496
CLV_PCSK_KEX2_1	392	394	PF00082	0.262
CLV_PCSK_KEX2_1	458	460	PF00082	0.321
CLV_PCSK_SKI1_1	100	104	PF00082	0.291
CLV_PCSK_SKI1_1	23	27	PF00082	0.365
CLV_PCSK_SKI1_1	284	288	PF00082	0.484
CLV_PCSK_SKI1_1	45	49	PF00082	0.395
CLV_PCSK_SKI1_1	460	464	PF00082	0.329
CLV_PCSK_SKI1_1	482	486	PF00082	0.281
CLV_PCSK_SKI1_1	609	613	PF00082	0.681
DEG_APCC_DBOX_1	22	30	PF00400	0.349
DEG_APCC_DBOX_1	481	489	PF00400	0.354
DOC_CKS1_1	341	346	PF01111	0.397
DOC_CKS1_1	4	9	PF01111	0.656
DOC_CYCLIN_RxL_1	281	291	PF00134	0.527
DOC_CYCLIN_yCln2_LP_2	242	248	PF00134	0.418
DOC_CYCLIN_yCln2_LP_2	29	35	PF00134	0.416
DOC_MAPK_gen_1	332	340	PF00069	0.288
DOC_MAPK_gen_1	392	399	PF00069	0.275
DOC_MAPK_gen_1	458	465	PF00069	0.346
DOC_MAPK_gen_1	597	604	PF00069	0.417
DOC_MAPK_HePTP_8	184	196	PF00069	0.441
DOC_MAPK_MEF2A_6	119	128	PF00069	0.474
DOC_MAPK_MEF2A_6	148	156	PF00069	0.500
DOC_MAPK_MEF2A_6	187	196	PF00069	0.449
DOC_MAPK_MEF2A_6	332	340	PF00069	0.288
DOC_PP1_RVXF_1	198	204	PF00149	0.334
DOC_PP2B_LxvP_1	242	245	PF13499	0.510
DOC_PP2B_LxvP_1	29	32	PF13499	0.462
DOC_PP2B_LxvP_1	370	373	PF13499	0.412
DOC_PP2B_LxvP_1	538	541	PF13499	0.464
DOC_PP4_FxxP_1	110	113	PF00568	0.409
DOC_PP4_FxxP_1	341	344	PF00568	0.372
DOC_USP7_MATH_1	2	6	PF00917	0.592
DOC_USP7_MATH_1	269	273	PF00917	0.577
DOC_USP7_MATH_1	301	305	PF00917	0.606
DOC_USP7_MATH_1	377	381	PF00917	0.341
DOC_USP7_MATH_1	507	511	PF00917	0.641
DOC_USP7_MATH_1	56	60	PF00917	0.511
DOC_WW_Pin1_4	262	267	PF00397	0.736
DOC_WW_Pin1_4	296	301	PF00397	0.518
DOC_WW_Pin1_4	3	8	PF00397	0.713
DOC_WW_Pin1_4	340	345	PF00397	0.382
DOC_WW_Pin1_4	412	417	PF00397	0.406
DOC_WW_Pin1_4	505	510	PF00397	0.547
DOC_WW_Pin1_4	549	554	PF00397	0.586
DOC_WW_Pin1_4	568	573	PF00397	0.435
LIG_14-3-3_CanoR_1	100	107	PF00244	0.502
LIG_14-3-3_CanoR_1	129	134	PF00244	0.384
LIG_14-3-3_CanoR_1	282	287	PF00244	0.539
LIG_14-3-3_CanoR_1	460	466	PF00244	0.377
LIG_ActinCP_TwfCPI_2	110	119	PF01115	0.356
LIG_APCC_ABBA_1	441	446	PF00400	0.357
LIG_APCC_ABBA_1	70	75	PF00400	0.420
LIG_APCC_ABBAyCdc20_2	284	290	PF00400	0.406
LIG_BIR_II_1	1	5	PF00653	0.613
LIG_BIR_III_1	1	5	PF00653	0.535
LIG_BIR_III_3	1	5	PF00653	0.535
LIG_CAP-Gly_1	614	620	PF01302	0.507
LIG_CtBP_PxDLS_1	373	377	PF00389	0.422
LIG_deltaCOP1_diTrp_1	104	110	PF00928	0.372
LIG_deltaCOP1_diTrp_1	518	525	PF00928	0.537
LIG_FHA_1	145	151	PF00498	0.618
LIG_FHA_1	164	170	PF00498	0.464
LIG_FHA_1	357	363	PF00498	0.426
LIG_FHA_1	605	611	PF00498	0.601
LIG_FHA_2	290	296	PF00498	0.635
LIG_FHA_2	341	347	PF00498	0.394
LIG_FHA_2	514	520	PF00498	0.600
LIG_GBD_Chelix_1	18	26	PF00786	0.386
LIG_LIR_Apic_2	339	344	PF02991	0.360
LIG_LIR_Apic_2	528	532	PF02991	0.548
LIG_LIR_Gen_1	104	115	PF02991	0.369
LIG_LIR_Gen_1	131	140	PF02991	0.363
LIG_LIR_Gen_1	518	527	PF02991	0.567
LIG_LIR_Nem_3	104	110	PF02991	0.361
LIG_LIR_Nem_3	138	143	PF02991	0.369
LIG_LIR_Nem_3	41	47	PF02991	0.341
LIG_LIR_Nem_3	518	523	PF02991	0.493
LIG_LYPXL_S_1	564	568	PF13949	0.486
LIG_LYPXL_yS_3	565	568	PF13949	0.486
LIG_MYND_3	71	75	PF01753	0.375
LIG_NRBOX	484	490	PF00104	0.383
LIG_PCNA_PIPBox_1	221	230	PF02747	0.466
LIG_PCNA_PIPBox_1	391	400	PF02747	0.370
LIG_PCNA_yPIPBox_3	384	398	PF02747	0.365
LIG_PCNA_yPIPBox_3	487	500	PF02747	0.521
LIG_PDZ_Class_3	615	620	PF00595	0.464
LIG_Pex14_1	520	524	PF04695	0.578
LIG_Pex14_2	140	144	PF04695	0.352
LIG_REV1ctd_RIR_1	586	596	PF16727	0.354
LIG_SH2_CRK	419	423	PF00017	0.460
LIG_SH2_SRC	560	563	PF00017	0.479
LIG_SH2_SRC	73	76	PF00017	0.526
LIG_SH2_STAP1	320	324	PF00017	0.370
LIG_SH2_STAT3	421	424	PF00017	0.405
LIG_SH2_STAT5	404	407	PF00017	0.349
LIG_SH2_STAT5	421	424	PF00017	0.334
LIG_SH2_STAT5	439	442	PF00017	0.250
LIG_SH2_STAT5	505	508	PF00017	0.641
LIG_SH2_STAT5	560	563	PF00017	0.430
LIG_SH2_STAT5	73	76	PF00017	0.517
LIG_SH3_3	1	7	PF00018	0.641
LIG_SH3_3	147	153	PF00018	0.559
LIG_SH3_3	189	195	PF00018	0.449
LIG_SH3_3	44	50	PF00018	0.404
LIG_SH3_3	560	566	PF00018	0.531
LIG_SUMO_SIM_anti_2	359	365	PF11976	0.425
LIG_SUMO_SIM_par_1	151	158	PF11976	0.483
LIG_SUMO_SIM_par_1	334	339	PF11976	0.435
LIG_SUMO_SIM_par_1	358	365	PF11976	0.425
LIG_TRAF2_1	139	142	PF00917	0.532
LIG_TRAF2_1	155	158	PF00917	0.505
LIG_TRAF2_1	516	519	PF00917	0.594
LIG_TRAF2_1	66	69	PF00917	0.447
LIG_TYR_ITIM	417	422	PF00017	0.332
LIG_UBA3_1	310	317	PF00899	0.381
LIG_UBA3_1	601	609	PF00899	0.484
LIG_WRC_WIRS_1	130	135	PF05994	0.388
LIG_WRC_WIRS_1	137	142	PF05994	0.310
MOD_CDK_SPxxK_3	296	303	PF00069	0.496
MOD_CK1_1	259	265	PF00069	0.662
MOD_CK1_1	270	276	PF00069	0.699
MOD_CK1_1	38	44	PF00069	0.372
MOD_CK1_1	478	484	PF00069	0.374
MOD_CK2_1	135	141	PF00069	0.435
MOD_CK2_1	152	158	PF00069	0.497
MOD_CK2_1	171	177	PF00069	0.533
MOD_CK2_1	289	295	PF00069	0.508
MOD_CK2_1	340	346	PF00069	0.389
MOD_CK2_1	512	518	PF00069	0.532
MOD_CK2_1	63	69	PF00069	0.509
MOD_GlcNHglycan	267	270	PF01048	0.721
MOD_GlcNHglycan	272	275	PF01048	0.707
MOD_GlcNHglycan	303	306	PF01048	0.622
MOD_GlcNHglycan	36	40	PF01048	0.356
MOD_GlcNHglycan	364	367	PF01048	0.307
MOD_GlcNHglycan	501	504	PF01048	0.496
MOD_GlcNHglycan	509	512	PF01048	0.599
MOD_GlcNHglycan	547	550	PF01048	0.524
MOD_GSK3_1	265	272	PF00069	0.754
MOD_GSK3_1	545	552	PF00069	0.639
MOD_GSK3_1	573	580	PF00069	0.494
MOD_N-GLC_2	231	233	PF02516	0.362
MOD_NEK2_1	128	133	PF00069	0.430
MOD_NEK2_1	144	149	PF00069	0.466
MOD_NEK2_1	35	40	PF00069	0.473
MOD_NEK2_1	376	381	PF00069	0.399
MOD_NEK2_1	477	482	PF00069	0.448
MOD_NEK2_1	604	609	PF00069	0.420
MOD_NEK2_2	461	466	PF00069	0.336
MOD_PIKK_1	217	223	PF00454	0.341
MOD_PK_1	539	545	PF00069	0.445
MOD_PKA_1	392	398	PF00069	0.392
MOD_PKA_2	128	134	PF00069	0.311
MOD_PKA_2	392	398	PF00069	0.422
MOD_PKA_2	80	86	PF00069	0.500
MOD_Plk_1	35	41	PF00069	0.435
MOD_Plk_1	400	406	PF00069	0.332
MOD_Plk_1	427	433	PF00069	0.405
MOD_Plk_1	448	454	PF00069	0.523
MOD_Plk_1	581	587	PF00069	0.596
MOD_Plk_2-3	577	583	PF00069	0.551
MOD_Plk_4	202	208	PF00069	0.362
MOD_Plk_4	214	220	PF00069	0.400
MOD_Plk_4	400	406	PF00069	0.446
MOD_Plk_4	427	433	PF00069	0.366
MOD_Plk_4	539	545	PF00069	0.445
MOD_ProDKin_1	262	268	PF00069	0.736
MOD_ProDKin_1	296	302	PF00069	0.512
MOD_ProDKin_1	3	9	PF00069	0.704
MOD_ProDKin_1	340	346	PF00069	0.389
MOD_ProDKin_1	412	418	PF00069	0.401
MOD_ProDKin_1	505	511	PF00069	0.551
MOD_ProDKin_1	549	555	PF00069	0.582
MOD_ProDKin_1	568	574	PF00069	0.433
MOD_SUMO_for_1	611	614	PF00179	0.402
MOD_SUMO_rev_2	247	256	PF00179	0.768
MOD_SUMO_rev_2	590	598	PF00179	0.584
TRG_DiLeu_BaEn_2	599	605	PF01217	0.372
TRG_DiLeu_BaEn_4	177	183	PF01217	0.418
TRG_DiLeu_BaLyEn_6	197	202	PF01217	0.475
TRG_DiLeu_BaLyEn_6	366	371	PF01217	0.259
TRG_DiLeu_BaLyEn_6	484	489	PF01217	0.430
TRG_ENDOCYTIC_2	320	323	PF00928	0.353
TRG_ENDOCYTIC_2	419	422	PF00928	0.319
TRG_ENDOCYTIC_2	524	527	PF00928	0.465
TRG_ENDOCYTIC_2	560	563	PF00928	0.479
TRG_ENDOCYTIC_2	565	568	PF00928	0.495
TRG_ER_diArg_1	117	119	PF00400	0.485
TRG_ER_diArg_1	281	284	PF00400	0.420
TRG_ER_diArg_1	392	394	PF00400	0.262
TRG_ER_diArg_1	457	460	PF00400	0.316
TRG_ER_diArg_1	605	608	PF00400	0.523
TRG_Pf-PMV_PEXEL_1	100	104	PF00026	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2G9	Leptomonas seymouri	62%	98%
A0A0S4IM38	Bodo saltans	38%	100%
A0A1X0NUS4	Trypanosomatidae	43%	100%
A0A422NH67	Trypanosoma rangeli	45%	100%
A4HKG6	Leishmania braziliensis	81%	100%
D0AA61	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B2V5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q5A1	Leishmania major	93%	100%