Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ID54_LEIDO

TriTrypDb:

LdBPK_262430.1 , LdCL_260030000 , LDHU3_26.3150

Length:

442

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ID54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID54

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.495
CLV_NRD_NRD_1	184	186	PF00675	0.452
CLV_NRD_NRD_1	207	209	PF00675	0.460
CLV_NRD_NRD_1	308	310	PF00675	0.446
CLV_NRD_NRD_1	51	53	PF00675	0.499
CLV_NRD_NRD_1	65	67	PF00675	0.546
CLV_NRD_NRD_1	96	98	PF00675	0.395
CLV_PCSK_FUR_1	182	186	PF00082	0.480
CLV_PCSK_FUR_1	306	310	PF00082	0.431
CLV_PCSK_KEX2_1	142	144	PF00082	0.535
CLV_PCSK_KEX2_1	184	186	PF00082	0.461
CLV_PCSK_KEX2_1	308	310	PF00082	0.430
CLV_PCSK_KEX2_1	51	53	PF00082	0.499
CLV_PCSK_KEX2_1	65	67	PF00082	0.550
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.535
CLV_PCSK_PC7_1	180	186	PF00082	0.453
CLV_PCSK_SKI1_1	139	143	PF00082	0.501
CLV_PCSK_SKI1_1	308	312	PF00082	0.430
CLV_PCSK_SKI1_1	98	102	PF00082	0.417
DEG_APCC_DBOX_1	210	218	PF00400	0.472
DEG_APCC_DBOX_1	361	369	PF00400	0.538
DEG_APCC_KENBOX_2	18	22	PF00400	0.458
DOC_CYCLIN_RxL_1	305	313	PF00134	0.423
DOC_MAPK_gen_1	409	418	PF00069	0.613
DOC_MAPK_gen_1	97	103	PF00069	0.491
DOC_MAPK_MEF2A_6	266	273	PF00069	0.355
DOC_PP1_RVXF_1	296	303	PF00149	0.287
DOC_PP4_FxxP_1	302	305	PF00568	0.346
DOC_USP7_MATH_1	134	138	PF00917	0.413
DOC_USP7_MATH_1	250	254	PF00917	0.513
DOC_USP7_MATH_1	319	323	PF00917	0.473
DOC_WW_Pin1_4	301	306	PF00397	0.456
LIG_14-3-3_CanoR_1	182	192	PF00244	0.485
LIG_14-3-3_CanoR_1	309	318	PF00244	0.499
LIG_Actin_WH2_2	248	264	PF00022	0.573
LIG_APCC_ABBA_1	361	366	PF00400	0.426
LIG_BIR_II_1	1	5	PF00653	0.551
LIG_BRCT_BRCA1_1	188	192	PF00533	0.485
LIG_CaM_IQ_9	167	182	PF13499	0.507
LIG_Clathr_ClatBox_1	242	246	PF01394	0.419
LIG_deltaCOP1_diTrp_1	125	131	PF00928	0.452
LIG_FHA_1	155	161	PF00498	0.461
LIG_FHA_1	22	28	PF00498	0.511
LIG_FHA_1	375	381	PF00498	0.494
LIG_FHA_1	86	92	PF00498	0.434
LIG_FHA_2	217	223	PF00498	0.432
LIG_FHA_2	330	336	PF00498	0.389
LIG_FHA_2	353	359	PF00498	0.474
LIG_FHA_2	39	45	PF00498	0.529
LIG_LIR_Apic_2	11	17	PF02991	0.375
LIG_LIR_Gen_1	125	134	PF02991	0.450
LIG_LIR_Gen_1	20	30	PF02991	0.403
LIG_LIR_Gen_1	229	237	PF02991	0.400
LIG_LIR_Gen_1	238	245	PF02991	0.341
LIG_LIR_Gen_1	267	276	PF02991	0.354
LIG_LIR_Gen_1	414	422	PF02991	0.561
LIG_LIR_Gen_1	74	83	PF02991	0.571
LIG_LIR_Gen_1	86	94	PF02991	0.432
LIG_LIR_Nem_3	110	115	PF02991	0.520
LIG_LIR_Nem_3	125	130	PF02991	0.372
LIG_LIR_Nem_3	20	25	PF02991	0.445
LIG_LIR_Nem_3	229	234	PF02991	0.394
LIG_LIR_Nem_3	238	244	PF02991	0.327
LIG_LIR_Nem_3	267	271	PF02991	0.346
LIG_LIR_Nem_3	274	279	PF02991	0.367
LIG_LIR_Nem_3	404	408	PF02991	0.521
LIG_LIR_Nem_3	414	418	PF02991	0.453
LIG_LIR_Nem_3	74	78	PF02991	0.630
LIG_LIR_Nem_3	86	90	PF02991	0.459
LIG_NRBOX	100	106	PF00104	0.444
LIG_NRBOX	306	312	PF00104	0.424
LIG_Pex14_1	127	131	PF04695	0.495
LIG_Pex14_2	192	196	PF04695	0.431
LIG_Pex14_2	226	230	PF04695	0.360
LIG_PTB_Apo_2	225	232	PF02174	0.503
LIG_PTB_Phospho_1	225	231	PF10480	0.498
LIG_RPA_C_Fungi	46	58	PF08784	0.492
LIG_SH2_CRK	14	18	PF00017	0.500
LIG_SH2_CRK	231	235	PF00017	0.473
LIG_SH2_CRK	276	280	PF00017	0.450
LIG_SH2_GRB2like	231	234	PF00017	0.516
LIG_SH2_NCK_1	231	235	PF00017	0.520
LIG_SH2_PTP2	415	418	PF00017	0.481
LIG_SH2_SRC	231	234	PF00017	0.385
LIG_SH2_STAP1	22	26	PF00017	0.405
LIG_SH2_STAT5	354	357	PF00017	0.390
LIG_SH2_STAT5	415	418	PF00017	0.540
LIG_SH2_STAT5	84	87	PF00017	0.504
LIG_SH3_3	153	159	PF00018	0.562
LIG_SH3_3	432	438	PF00018	0.638
LIG_SUMO_SIM_par_1	113	119	PF11976	0.558
LIG_SUMO_SIM_par_1	23	28	PF11976	0.590
LIG_SUMO_SIM_par_1	269	275	PF11976	0.473
LIG_SUMO_SIM_par_1	29	34	PF11976	0.476
LIG_TRAF2_1	188	191	PF00917	0.443
LIG_UBA3_1	270	278	PF00899	0.481
LIG_UBA3_1	418	426	PF00899	0.584
LIG_WRC_WIRS_1	100	105	PF05994	0.485
MOD_CDK_SPK_2	301	306	PF00069	0.389
MOD_CDK_SPxxK_3	301	308	PF00069	0.368
MOD_CK1_1	133	139	PF00069	0.429
MOD_CK1_1	186	192	PF00069	0.567
MOD_CK1_1	352	358	PF00069	0.419
MOD_CK1_1	374	380	PF00069	0.391
MOD_CK2_1	184	190	PF00069	0.506
MOD_CK2_1	287	293	PF00069	0.368
MOD_CK2_1	329	335	PF00069	0.496
MOD_CK2_1	352	358	PF00069	0.432
MOD_CK2_1	38	44	PF00069	0.448
MOD_CK2_1	394	400	PF00069	0.626
MOD_CK2_1	73	79	PF00069	0.565
MOD_GlcNHglycan	132	135	PF01048	0.413
MOD_GlcNHglycan	147	150	PF01048	0.588
MOD_GlcNHglycan	312	315	PF01048	0.587
MOD_GlcNHglycan	69	72	PF01048	0.635
MOD_GlcNHglycan	75	78	PF01048	0.486
MOD_GSK3_1	126	133	PF00069	0.499
MOD_GSK3_1	150	157	PF00069	0.530
MOD_GSK3_1	310	317	PF00069	0.512
MOD_GSK3_1	371	378	PF00069	0.464
MOD_GSK3_1	407	414	PF00069	0.610
MOD_GSK3_1	67	74	PF00069	0.509
MOD_GSK3_1	99	106	PF00069	0.371
MOD_N-GLC_1	226	231	PF02516	0.363
MOD_NEK2_1	103	108	PF00069	0.481
MOD_NEK2_1	196	201	PF00069	0.451
MOD_NEK2_1	226	231	PF00069	0.340
MOD_NEK2_1	310	315	PF00069	0.445
MOD_NEK2_1	329	334	PF00069	0.481
MOD_NEK2_1	372	377	PF00069	0.418
MOD_NEK2_1	385	390	PF00069	0.491
MOD_NEK2_1	422	427	PF00069	0.564
MOD_NEK2_2	134	139	PF00069	0.488
MOD_PIKK_1	196	202	PF00454	0.424
MOD_PIKK_1	407	413	PF00454	0.556
MOD_PKA_1	184	190	PF00069	0.477
MOD_PKA_1	65	71	PF00069	0.698
MOD_PKA_2	145	151	PF00069	0.527
MOD_PKA_2	183	189	PF00069	0.501
MOD_PKA_2	210	216	PF00069	0.469
MOD_PKA_2	65	71	PF00069	0.591
MOD_PKB_1	182	190	PF00069	0.478
MOD_Plk_1	115	121	PF00069	0.477
MOD_Plk_1	134	140	PF00069	0.411
MOD_Plk_1	226	232	PF00069	0.526
MOD_Plk_1	352	358	PF00069	0.425
MOD_Plk_4	126	132	PF00069	0.417
MOD_Plk_4	21	27	PF00069	0.538
MOD_Plk_4	226	232	PF00069	0.359
MOD_Plk_4	376	382	PF00069	0.382
MOD_Plk_4	411	417	PF00069	0.618
MOD_Plk_4	99	105	PF00069	0.415
MOD_ProDKin_1	301	307	PF00069	0.455
MOD_SUMO_for_1	368	371	PF00179	0.538
MOD_SUMO_rev_2	106	115	PF00179	0.541
MOD_SUMO_rev_2	322	330	PF00179	0.547
MOD_SUMO_rev_2	34	41	PF00179	0.605
MOD_SUMO_rev_2	401	410	PF00179	0.507
TRG_DiLeu_BaEn_1	110	115	PF01217	0.410
TRG_DiLeu_BaEn_1	326	331	PF01217	0.320
TRG_DiLeu_BaEn_2	98	104	PF01217	0.492
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.575
TRG_ENDOCYTIC_2	161	164	PF00928	0.392
TRG_ENDOCYTIC_2	22	25	PF00928	0.429
TRG_ENDOCYTIC_2	231	234	PF00928	0.444
TRG_ENDOCYTIC_2	276	279	PF00928	0.390
TRG_ENDOCYTIC_2	415	418	PF00928	0.486
TRG_ER_diArg_1	183	185	PF00400	0.476
TRG_ER_diArg_1	305	308	PF00400	0.426
TRG_ER_diArg_1	64	66	PF00400	0.572
TRG_NES_CRM1_1	162	173	PF08389	0.492
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM42	Leptomonas seymouri	64%	100%
A0A1X0P7I7	Trypanosomatidae	35%	92%
A0A3R7LDN5	Trypanosoma rangeli	31%	95%
A0A422MV92	Trypanosoma rangeli	27%	92%
A4HF86	Leishmania braziliensis	77%	100%
A4I2G9	Leishmania infantum	99%	100%
C9ZX27	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	95%
D0A343	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	91%
E9AYM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q8V0	Leishmania major	92%	100%
V5ATI0	Trypanosoma cruzi	30%	100%