Elongation of fatty acids protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fatty acid elongase, puatative

Species:

Leishmania donovani

UniProt:

A0A3Q8ID51_LEIDO

TriTrypDb:

LdBPK_140770.1 , LdCL_140013200 , LdCL_140013300 , LDHU3_14.1020

Length:

397

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 36

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 70
NetGPI	no	yes: 0, no: 71

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	62
GO:0110165	cellular anatomical entity	1	65
GO:0005737	cytoplasm	2	3

Expansion

Sequence features

A0A3Q8ID51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID51

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	72
GO:0006629	lipid metabolic process	3	72
GO:0006631	fatty acid metabolic process	4	72
GO:0006633	fatty acid biosynthetic process	5	72
GO:0008152	metabolic process	1	72
GO:0008610	lipid biosynthetic process	4	72
GO:0009058	biosynthetic process	2	72
GO:0009987	cellular process	1	72
GO:0016053	organic acid biosynthetic process	4	72
GO:0019752	carboxylic acid metabolic process	5	72
GO:0032787	monocarboxylic acid metabolic process	6	72
GO:0043436	oxoacid metabolic process	4	72
GO:0044237	cellular metabolic process	2	72
GO:0044238	primary metabolic process	2	72
GO:0044249	cellular biosynthetic process	3	72
GO:0044255	cellular lipid metabolic process	3	72
GO:0044281	small molecule metabolic process	2	72
GO:0044283	small molecule biosynthetic process	3	72
GO:0046394	carboxylic acid biosynthetic process	5	72
GO:0071704	organic substance metabolic process	2	72
GO:0072330	monocarboxylic acid biosynthetic process	6	72
GO:1901576	organic substance biosynthetic process	3	72
GO:0000038	very long-chain fatty acid metabolic process	5	10
GO:0006643	membrane lipid metabolic process	4	10
GO:0006665	sphingolipid metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0019367	fatty acid elongation, saturated fatty acid	7	10
GO:0019368	fatty acid elongation, unsaturated fatty acid	7	10
GO:0030148	sphingolipid biosynthetic process	5	10
GO:0030497	fatty acid elongation	6	10
GO:0034625	fatty acid elongation, monounsaturated fatty acid	8	10
GO:0034626	fatty acid elongation, polyunsaturated fatty acid	8	10
GO:0042761	very long-chain fatty acid biosynthetic process	6	10
GO:0046467	membrane lipid biosynthetic process	4	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901566	organonitrogen compound biosynthetic process	4	10
GO:0001676	long-chain fatty acid metabolic process	5	2
GO:0042759	long-chain fatty acid biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	72
GO:0004312	fatty acid synthase activity	5	72
GO:0009922	fatty acid elongase activity	6	72
GO:0016740	transferase activity	2	72
GO:0016746	acyltransferase activity	3	72
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	72
GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity	5	72

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.474
CLV_NRD_NRD_1	180	182	PF00675	0.339
CLV_NRD_NRD_1	235	237	PF00675	0.299
CLV_NRD_NRD_1	364	366	PF00675	0.464
CLV_NRD_NRD_1	54	56	PF00675	0.320
CLV_PCSK_FUR_1	14	18	PF00082	0.467
CLV_PCSK_KEX2_1	16	18	PF00082	0.613
CLV_PCSK_KEX2_1	354	356	PF00082	0.353
CLV_PCSK_KEX2_1	54	56	PF00082	0.330
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.342
CLV_PCSK_SKI1_1	146	150	PF00082	0.474
CLV_PCSK_SKI1_1	24	28	PF00082	0.590
CLV_PCSK_SKI1_1	88	92	PF00082	0.534
DEG_Nend_UBRbox_2	1	3	PF02207	0.426
DOC_CKS1_1	166	171	PF01111	0.501
DOC_CKS1_1	384	389	PF01111	0.589
DOC_CYCLIN_RxL_1	345	353	PF00134	0.404
DOC_MAPK_gen_1	54	61	PF00069	0.461
DOC_MAPK_MEF2A_6	240	248	PF00069	0.513
DOC_MAPK_MEF2A_6	54	61	PF00069	0.575
DOC_MAPK_NFAT4_5	54	62	PF00069	0.411
DOC_MAPK_RevD_3	40	55	PF00069	0.213
DOC_PP1_RVXF_1	180	187	PF00149	0.508
DOC_PP4_FxxP_1	46	49	PF00568	0.369
DOC_USP7_MATH_1	206	210	PF00917	0.352
DOC_USP7_MATH_1	305	309	PF00917	0.231
DOC_WW_Pin1_4	138	143	PF00397	0.365
DOC_WW_Pin1_4	165	170	PF00397	0.498
DOC_WW_Pin1_4	383	388	PF00397	0.751
LIG_14-3-3_CanoR_1	181	187	PF00244	0.562
LIG_14-3-3_CanoR_1	54	60	PF00244	0.524
LIG_Actin_WH2_2	223	238	PF00022	0.462
LIG_BRCT_BRCA1_1	154	158	PF00533	0.258
LIG_BRCT_BRCA1_1	315	319	PF00533	0.236
LIG_eIF4E_1	225	231	PF01652	0.426
LIG_FHA_1	139	145	PF00498	0.368
LIG_FHA_1	166	172	PF00498	0.363
LIG_FHA_1	301	307	PF00498	0.221
LIG_FHA_1	384	390	PF00498	0.582
LIG_FHA_1	75	81	PF00498	0.409
LIG_GBD_Chelix_1	193	201	PF00786	0.228
LIG_Integrin_isoDGR_2	22	24	PF01839	0.460
LIG_KLC1_Yacidic_2	349	353	PF13176	0.428
LIG_LIR_Gen_1	173	184	PF02991	0.345
LIG_LIR_Gen_1	195	206	PF02991	0.480
LIG_LIR_Gen_1	222	231	PF02991	0.432
LIG_LIR_Gen_1	261	270	PF02991	0.428
LIG_LIR_Gen_1	338	347	PF02991	0.349
LIG_LIR_Nem_3	173	179	PF02991	0.344
LIG_LIR_Nem_3	195	201	PF02991	0.410
LIG_LIR_Nem_3	222	228	PF02991	0.351
LIG_LIR_Nem_3	261	266	PF02991	0.352
LIG_LIR_Nem_3	277	283	PF02991	0.265
LIG_LIR_Nem_3	28	33	PF02991	0.321
LIG_LIR_Nem_3	288	294	PF02991	0.396
LIG_LIR_Nem_3	338	342	PF02991	0.333
LIG_LIR_Nem_3	76	81	PF02991	0.400
LIG_LIR_Nem_3	9	13	PF02991	0.328
LIG_LYPXL_SIV_4	35	43	PF13949	0.183
LIG_PDZ_Class_1	392	397	PF00595	0.596
LIG_Pex14_1	200	204	PF04695	0.287
LIG_Pex14_2	219	223	PF04695	0.456
LIG_Pex14_2	279	283	PF04695	0.224
LIG_Pex14_2	343	347	PF04695	0.362
LIG_PTB_Apo_2	273	280	PF02174	0.227
LIG_Rb_pABgroove_1	146	154	PF01858	0.188
LIG_REV1ctd_RIR_1	277	285	PF16727	0.215
LIG_SH2_CRK	339	343	PF00017	0.493
LIG_SH2_CRK	36	40	PF00017	0.376
LIG_SH2_GRB2like	274	277	PF00017	0.224
LIG_SH2_PTP2	198	201	PF00017	0.501
LIG_SH2_PTP2	259	262	PF00017	0.488
LIG_SH2_STAP1	274	278	PF00017	0.383
LIG_SH2_STAP1	36	40	PF00017	0.404
LIG_SH2_STAT5	165	168	PF00017	0.365
LIG_SH2_STAT5	198	201	PF00017	0.392
LIG_SH2_STAT5	218	221	PF00017	0.297
LIG_SH2_STAT5	225	228	PF00017	0.366
LIG_SH2_STAT5	259	262	PF00017	0.366
LIG_SH2_STAT5	263	266	PF00017	0.350
LIG_SH2_STAT5	294	297	PF00017	0.225
LIG_SH2_STAT5	339	342	PF00017	0.345
LIG_SH2_STAT5	351	354	PF00017	0.488
LIG_SH2_STAT5	41	44	PF00017	0.339
LIG_SH2_STAT5	47	50	PF00017	0.360
LIG_SH3_3	238	244	PF00018	0.482
LIG_SH3_3	28	34	PF00018	0.394
LIG_SH3_3	381	387	PF00018	0.578
LIG_TRFH_1	268	272	PF08558	0.232
LIG_UBA3_1	162	167	PF00899	0.399
LIG_UBA3_1	175	182	PF00899	0.350
LIG_UBA3_1	232	237	PF00899	0.423
LIG_UBA3_1	342	348	PF00899	0.357
LIG_WRC_WIRS_1	220	225	PF05994	0.240
LIG_WRC_WIRS_1	93	98	PF05994	0.379
MOD_CK1_1	299	305	PF00069	0.230
MOD_CK1_1	324	330	PF00069	0.372
MOD_CK1_1	73	79	PF00069	0.385
MOD_CK1_1	92	98	PF00069	0.176
MOD_CK2_1	137	143	PF00069	0.319
MOD_CK2_1	96	102	PF00069	0.251
MOD_GlcNHglycan	106	109	PF01048	0.515
MOD_GlcNHglycan	153	157	PF01048	0.465
MOD_GlcNHglycan	18	21	PF01048	0.555
MOD_GlcNHglycan	208	211	PF01048	0.499
MOD_GSK3_1	152	159	PF00069	0.283
MOD_GSK3_1	296	303	PF00069	0.230
MOD_GSK3_1	70	77	PF00069	0.388
MOD_GSK3_1	92	99	PF00069	0.328
MOD_NEK2_1	103	108	PF00069	0.365
MOD_NEK2_1	171	176	PF00069	0.376
MOD_NEK2_1	219	224	PF00069	0.383
MOD_NEK2_1	235	240	PF00069	0.567
MOD_NEK2_1	258	263	PF00069	0.385
MOD_NEK2_1	26	31	PF00069	0.332
MOD_NEK2_1	335	340	PF00069	0.325
MOD_NEK2_1	70	75	PF00069	0.367
MOD_NEK2_1	96	101	PF00069	0.357
MOD_NEK2_2	274	279	PF00069	0.386
MOD_OFUCOSY	322	328	PF10250	0.420
MOD_PIKK_1	305	311	PF00454	0.212
MOD_PKA_1	16	22	PF00069	0.273
MOD_PKA_2	16	22	PF00069	0.273
MOD_PKA_2	235	241	PF00069	0.441
MOD_PKB_1	14	22	PF00069	0.269
MOD_Plk_1	146	152	PF00069	0.277
MOD_Plk_1	357	363	PF00069	0.692
MOD_Plk_2-3	147	153	PF00069	0.188
MOD_Plk_4	147	153	PF00069	0.280
MOD_Plk_4	171	177	PF00069	0.324
MOD_Plk_4	182	188	PF00069	0.496
MOD_Plk_4	200	206	PF00069	0.327
MOD_Plk_4	219	225	PF00069	0.312
MOD_Plk_4	261	267	PF00069	0.339
MOD_Plk_4	274	280	PF00069	0.320
MOD_Plk_4	296	302	PF00069	0.230
MOD_Plk_4	35	41	PF00069	0.347
MOD_Plk_4	357	363	PF00069	0.691
MOD_Plk_4	70	76	PF00069	0.370
MOD_ProDKin_1	138	144	PF00069	0.365
MOD_ProDKin_1	165	171	PF00069	0.498
MOD_ProDKin_1	383	389	PF00069	0.752
MOD_SUMO_for_1	375	378	PF00179	0.527
MOD_SUMO_rev_2	367	375	PF00179	0.696
TRG_ENDOCYTIC_2	190	193	PF00928	0.373
TRG_ENDOCYTIC_2	198	201	PF00928	0.397
TRG_ENDOCYTIC_2	204	207	PF00928	0.342
TRG_ENDOCYTIC_2	227	230	PF00928	0.353
TRG_ENDOCYTIC_2	259	262	PF00928	0.416
TRG_ENDOCYTIC_2	263	266	PF00928	0.396
TRG_ENDOCYTIC_2	339	342	PF00928	0.338
TRG_ENDOCYTIC_2	36	39	PF00928	0.347
TRG_ENDOCYTIC_2	78	81	PF00928	0.374
TRG_ENDOCYTIC_2	84	87	PF00928	0.318
TRG_ER_diArg_1	13	16	PF00400	0.272
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5E5	Leptomonas seymouri	32%	100%
A0A0N0P7D1	Leptomonas seymouri	30%	100%
A0A0N0P7D6	Leptomonas seymouri	27%	100%
A0A0N1HZJ8	Leptomonas seymouri	30%	100%
A0A0N1I9H5	Leptomonas seymouri	30%	100%
A0A0N1PDR8	Leptomonas seymouri	30%	100%
A0A0S4IVS6	Bodo saltans	32%	100%
A0A0S4IW98	Bodo saltans	32%	100%
A0A1X0NNK7	Trypanosomatidae	32%	100%
A0A1X0NNM5	Trypanosomatidae	32%	100%
A0A3Q8I8T7	Leishmania donovani	71%	100%
A0A3Q8I9T2	Leishmania donovani	75%	100%
A0A3Q8I9U9	Leishmania donovani	31%	93%
A0A3Q8I9X8	Leishmania donovani	30%	92%
A0A3Q8IC05	Leishmania donovani	32%	82%
A0A3Q8IIA9	Leishmania donovani	30%	100%
A0A3R7KG78	Trypanosoma rangeli	32%	100%
A0A3R7MJR2	Trypanosoma rangeli	28%	100%
A0A3S5H6R7	Leishmania donovani	30%	100%
A0A3S7WSY8	Leishmania donovani	30%	100%
A0A3S7WSZ1	Leishmania donovani	31%	100%
A0A3S7WT03	Leishmania donovani	31%	100%
A0A3S7WT16	Leishmania donovani	27%	100%
A0A422NNP1	Trypanosoma rangeli	30%	100%
A4H7M2	Leishmania braziliensis	30%	100%
A4H7M3	Leishmania braziliensis	29%	100%
A4H7M4	Leishmania braziliensis	28%	100%
A4H7M6	Leishmania braziliensis	30%	88%
A4H7M7	Leishmania braziliensis	29%	96%
A4H7M8	Leishmania braziliensis	69%	100%
A4H7M9	Leishmania braziliensis	62%	100%
A4H7N0	Leishmania braziliensis	34%	80%
A4HW07	Leishmania infantum	30%	100%
A4HW08	Leishmania infantum	30%	100%
A4HW09	Leishmania infantum	30%	100%
A4HW12	Leishmania infantum	31%	91%
A4HW13	Leishmania infantum	31%	93%
A4HW14	Leishmania infantum	27%	96%
A4HW15	Leishmania infantum	76%	100%
A4HW16	Leishmania infantum	99%	100%
A4HW17	Leishmania infantum	73%	100%
A4HW18	Leishmania infantum	32%	81%
C9ZT16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E8NHR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E8NHR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
E9AGL0	Leishmania infantum	31%	88%
E9AGL2	Leishmania infantum	31%	88%
E9APQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9APR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9APR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9APR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	89%
E9APR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	89%
E9APR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	92%
E9APR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	93%
E9APR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	98%
E9APR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
E9APR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	89%
Q4QFQ9	Leishmania major	32%	80%
Q4QFR0	Leishmania major	69%	100%
Q4QFR1	Leishmania major	95%	100%
Q4QFR2	Leishmania major	74%	100%
Q4QFR3	Leishmania major	28%	96%
Q4QFR4	Leishmania major	30%	93%
Q4QFR5	Leishmania major	31%	100%
Q4QFR6	Leishmania major	30%	88%
Q4QFR9	Leishmania major	31%	100%
Q4QFS0	Leishmania major	30%	100%
V5BE99	Trypanosoma cruzi	31%	100%
V5BIX9	Trypanosoma cruzi	29%	100%
V5BND3	Trypanosoma cruzi	30%	100%