Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ID48_LEIDO

TriTrypDb:

LdBPK_281570.1 , LdCL_280020400 , LDHU3_28.2020

Length:

744

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ID48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID48

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.639
CLV_C14_Caspase3-7	159	163	PF00656	0.617
CLV_C14_Caspase3-7	723	727	PF00656	0.619
CLV_C14_Caspase3-7	732	736	PF00656	0.520
CLV_C14_Caspase3-7	79	83	PF00656	0.641
CLV_NRD_NRD_1	106	108	PF00675	0.563
CLV_NRD_NRD_1	211	213	PF00675	0.600
CLV_NRD_NRD_1	484	486	PF00675	0.533
CLV_NRD_NRD_1	495	497	PF00675	0.598
CLV_NRD_NRD_1	562	564	PF00675	0.550
CLV_NRD_NRD_1	73	75	PF00675	0.719
CLV_NRD_NRD_1	91	93	PF00675	0.502
CLV_PCSK_FUR_1	491	495	PF00082	0.582
CLV_PCSK_KEX2_1	106	108	PF00082	0.563
CLV_PCSK_KEX2_1	211	213	PF00082	0.600
CLV_PCSK_KEX2_1	484	486	PF00082	0.582
CLV_PCSK_KEX2_1	493	495	PF00082	0.594
CLV_PCSK_KEX2_1	564	566	PF00082	0.803
CLV_PCSK_KEX2_1	72	74	PF00082	0.745
CLV_PCSK_KEX2_1	91	93	PF00082	0.496
CLV_PCSK_PC1ET2_1	564	566	PF00082	0.692
CLV_PCSK_PC7_1	207	213	PF00082	0.661
CLV_PCSK_PC7_1	491	497	PF00082	0.699
CLV_PCSK_SKI1_1	207	211	PF00082	0.653
CLV_PCSK_SKI1_1	519	523	PF00082	0.689
CLV_PCSK_SKI1_1	542	546	PF00082	0.509
CLV_PCSK_SKI1_1	651	655	PF00082	0.594
CLV_PCSK_SKI1_1	667	671	PF00082	0.562
DEG_APCC_DBOX_1	301	309	PF00400	0.607
DEG_APCC_DBOX_1	532	540	PF00400	0.624
DEG_APCC_DBOX_1	541	549	PF00400	0.518
DEG_COP1_1	568	577	PF00400	0.636
DEG_Nend_Nbox_1	1	3	PF02207	0.593
DOC_CKS1_1	640	645	PF01111	0.643
DOC_MAPK_DCC_7	220	229	PF00069	0.623
DOC_MAPK_gen_1	289	298	PF00069	0.644
DOC_MAPK_gen_1	91	98	PF00069	0.681
DOC_MAPK_MEF2A_6	220	229	PF00069	0.699
DOC_MAPK_MEF2A_6	714	722	PF00069	0.489
DOC_MAPK_RevD_3	481	496	PF00069	0.585
DOC_MAPK_RevD_3	551	565	PF00069	0.494
DOC_PP1_RVXF_1	398	405	PF00149	0.439
DOC_PP2B_LxvP_1	588	591	PF13499	0.754
DOC_PP2B_LxvP_1	7	10	PF13499	0.604
DOC_PP2B_LxvP_1	739	742	PF13499	0.646
DOC_PP2B_PxIxI_1	717	723	PF00149	0.633
DOC_PP4_FxxP_1	640	643	PF00568	0.694
DOC_PP4_FxxP_1	690	693	PF00568	0.619
DOC_SPAK_OSR1_1	144	148	PF12202	0.585
DOC_USP7_MATH_1	17	21	PF00917	0.573
DOC_USP7_MATH_1	219	223	PF00917	0.653
DOC_USP7_MATH_1	329	333	PF00917	0.688
DOC_USP7_MATH_1	36	40	PF00917	0.611
DOC_USP7_MATH_1	408	412	PF00917	0.591
DOC_USP7_MATH_1	434	438	PF00917	0.575
DOC_USP7_MATH_1	448	452	PF00917	0.608
DOC_USP7_MATH_1	606	610	PF00917	0.604
DOC_USP7_MATH_1	665	669	PF00917	0.561
DOC_WW_Pin1_4	109	114	PF00397	0.613
DOC_WW_Pin1_4	11	16	PF00397	0.681
DOC_WW_Pin1_4	149	154	PF00397	0.651
DOC_WW_Pin1_4	190	195	PF00397	0.605
DOC_WW_Pin1_4	318	323	PF00397	0.683
DOC_WW_Pin1_4	512	517	PF00397	0.679
DOC_WW_Pin1_4	590	595	PF00397	0.719
DOC_WW_Pin1_4	602	607	PF00397	0.647
DOC_WW_Pin1_4	639	644	PF00397	0.691
DOC_WW_Pin1_4	689	694	PF00397	0.682
DOC_WW_Pin1_4	712	717	PF00397	0.674
LIG_14-3-3_CanoR_1	169	177	PF00244	0.647
LIG_14-3-3_CanoR_1	220	227	PF00244	0.617
LIG_14-3-3_CanoR_1	267	274	PF00244	0.567
LIG_14-3-3_CanoR_1	276	281	PF00244	0.564
LIG_14-3-3_CanoR_1	409	414	PF00244	0.598
LIG_14-3-3_CanoR_1	444	452	PF00244	0.546
LIG_14-3-3_CanoR_1	519	528	PF00244	0.721
LIG_14-3-3_CanoR_1	542	551	PF00244	0.539
LIG_14-3-3_CanoR_1	55	65	PF00244	0.735
LIG_14-3-3_CanoR_1	571	575	PF00244	0.551
LIG_14-3-3_CanoR_1	651	661	PF00244	0.668
LIG_14-3-3_CanoR_1	72	77	PF00244	0.615
LIG_14-3-3_CanoR_1	91	96	PF00244	0.610
LIG_Actin_WH2_2	399	416	PF00022	0.467
LIG_AP2alpha_1	461	465	PF02296	0.533
LIG_BIR_III_4	473	477	PF00653	0.497
LIG_BRCT_BRCA1_1	93	97	PF00533	0.675
LIG_Clathr_ClatBox_1	728	732	PF01394	0.501
LIG_EVH1_1	588	592	PF00568	0.624
LIG_FHA_1	150	156	PF00498	0.696
LIG_FHA_1	219	225	PF00498	0.703
LIG_FHA_1	396	402	PF00498	0.510
LIG_FHA_1	613	619	PF00498	0.633
LIG_FHA_1	85	91	PF00498	0.675
LIG_FHA_2	132	138	PF00498	0.587
LIG_FHA_2	495	501	PF00498	0.763
LIG_FHA_2	77	83	PF00498	0.816
LIG_GSK3_LRP6_1	590	596	PF00069	0.624
LIG_Integrin_RGD_1	622	624	PF01839	0.556
LIG_LIR_Apic_2	403	407	PF02991	0.492
LIG_LIR_Apic_2	576	580	PF02991	0.581
LIG_LIR_Apic_2	639	643	PF02991	0.685
LIG_LIR_Apic_2	689	693	PF02991	0.615
LIG_LIR_Gen_1	342	351	PF02991	0.460
LIG_LIR_Gen_1	593	601	PF02991	0.682
LIG_LIR_Nem_3	342	346	PF02991	0.455
LIG_LIR_Nem_3	462	468	PF02991	0.445
LIG_LIR_Nem_3	529	534	PF02991	0.545
LIG_LIR_Nem_3	593	598	PF02991	0.679
LIG_MYND_1	586	590	PF01753	0.651
LIG_Pex14_2	461	465	PF04695	0.533
LIG_Pex14_2	640	644	PF04695	0.646
LIG_SH2_STAP1	631	635	PF00017	0.624
LIG_SH2_STAT5	175	178	PF00017	0.623
LIG_SH2_STAT5	577	580	PF00017	0.650
LIG_SH2_STAT5	631	634	PF00017	0.626
LIG_SH3_1	622	628	PF00018	0.531
LIG_SH3_3	188	194	PF00018	0.654
LIG_SH3_3	316	322	PF00018	0.635
LIG_SH3_3	430	436	PF00018	0.500
LIG_SH3_3	583	589	PF00018	0.776
LIG_SH3_3	622	628	PF00018	0.594
LIG_SH3_3	7	13	PF00018	0.602
LIG_SUMO_SIM_anti_2	350	356	PF11976	0.465
LIG_SUMO_SIM_par_1	124	130	PF11976	0.635
LIG_SUMO_SIM_par_1	196	206	PF11976	0.651
LIG_SUMO_SIM_par_1	535	540	PF11976	0.525
LIG_SUMO_SIM_par_1	717	723	PF11976	0.558
LIG_SxIP_EBH_1	276	287	PF03271	0.553
LIG_TRAF2_1	44	47	PF00917	0.612
LIG_WRC_WIRS_1	128	133	PF05994	0.596
LIG_WW_1	9	12	PF00397	0.595
MOD_CDK_SPK_2	149	154	PF00069	0.651
MOD_CDK_SPxxK_3	512	519	PF00069	0.684
MOD_CK1_1	100	106	PF00069	0.630
MOD_CK1_1	133	139	PF00069	0.711
MOD_CK1_1	200	206	PF00069	0.642
MOD_CK1_1	213	219	PF00069	0.619
MOD_CK1_1	246	252	PF00069	0.615
MOD_CK1_1	347	353	PF00069	0.501
MOD_CK1_1	395	401	PF00069	0.436
MOD_CK1_1	554	560	PF00069	0.613
MOD_CK1_1	573	579	PF00069	0.616
MOD_CK1_1	593	599	PF00069	0.591
MOD_CK1_1	639	645	PF00069	0.681
MOD_CK1_1	689	695	PF00069	0.712
MOD_CK1_1	706	712	PF00069	0.613
MOD_CK1_1	83	89	PF00069	0.606
MOD_CK2_1	133	139	PF00069	0.560
MOD_CK2_1	29	35	PF00069	0.610
MOD_CK2_1	494	500	PF00069	0.773
MOD_CK2_1	593	599	PF00069	0.682
MOD_CK2_1	83	89	PF00069	0.615
MOD_GlcNHglycan	212	215	PF01048	0.692
MOD_GlcNHglycan	286	289	PF01048	0.605
MOD_GlcNHglycan	31	34	PF01048	0.608
MOD_GlcNHglycan	315	318	PF01048	0.768
MOD_GlcNHglycan	374	378	PF01048	0.493
MOD_GlcNHglycan	38	41	PF01048	0.607
MOD_GlcNHglycan	473	477	PF01048	0.500
MOD_GlcNHglycan	487	490	PF01048	0.599
MOD_GlcNHglycan	557	560	PF01048	0.642
MOD_GlcNHglycan	610	613	PF01048	0.609
MOD_GlcNHglycan	667	670	PF01048	0.560
MOD_GlcNHglycan	680	683	PF01048	0.554
MOD_GlcNHglycan	696	699	PF01048	0.503
MOD_GlcNHglycan	708	711	PF01048	0.592
MOD_GSK3_1	11	18	PF00069	0.649
MOD_GSK3_1	127	134	PF00069	0.672
MOD_GSK3_1	178	185	PF00069	0.783
MOD_GSK3_1	210	217	PF00069	0.723
MOD_GSK3_1	243	250	PF00069	0.749
MOD_GSK3_1	276	283	PF00069	0.751
MOD_GSK3_1	311	318	PF00069	0.662
MOD_GSK3_1	349	356	PF00069	0.457
MOD_GSK3_1	551	558	PF00069	0.509
MOD_GSK3_1	602	609	PF00069	0.622
MOD_GSK3_1	613	620	PF00069	0.651
MOD_GSK3_1	72	79	PF00069	0.642
MOD_GSK3_1	80	87	PF00069	0.599
MOD_LATS_1	309	315	PF00433	0.526
MOD_N-GLC_1	131	136	PF02516	0.565
MOD_N-GLC_1	56	61	PF02516	0.712
MOD_N-GLC_1	602	607	PF02516	0.537
MOD_N-GLC_2	334	336	PF02516	0.559
MOD_NEK2_1	21	26	PF00069	0.610
MOD_NEK2_1	210	215	PF00069	0.682
MOD_NEK2_1	315	320	PF00069	0.639
MOD_NEK2_1	330	335	PF00069	0.623
MOD_NEK2_1	461	466	PF00069	0.462
MOD_NEK2_1	551	556	PF00069	0.599
MOD_NEK2_1	63	68	PF00069	0.756
MOD_NEK2_1	670	675	PF00069	0.611
MOD_NEK2_1	76	81	PF00069	0.561
MOD_NEK2_2	156	161	PF00069	0.639
MOD_NEK2_2	301	306	PF00069	0.557
MOD_PIKK_1	76	82	PF00454	0.594
MOD_PK_1	276	282	PF00069	0.541
MOD_PK_1	91	97	PF00069	0.680
MOD_PKA_1	494	500	PF00069	0.600
MOD_PKA_1	72	78	PF00069	0.632
MOD_PKA_1	91	97	PF00069	0.575
MOD_PKA_2	210	216	PF00069	0.685
MOD_PKA_2	219	225	PF00069	0.571
MOD_PKA_2	246	252	PF00069	0.644
MOD_PKA_2	275	281	PF00069	0.623
MOD_PKA_2	29	35	PF00069	0.633
MOD_PKA_2	301	307	PF00069	0.615
MOD_PKA_2	408	414	PF00069	0.675
MOD_PKA_2	443	449	PF00069	0.521
MOD_PKA_2	494	500	PF00069	0.672
MOD_PKA_2	570	576	PF00069	0.637
MOD_PKA_2	63	69	PF00069	0.780
MOD_PKA_2	72	78	PF00069	0.661
MOD_PKA_2	91	97	PF00069	0.597
MOD_PKB_1	494	502	PF00069	0.465
MOD_PKB_1	563	571	PF00069	0.559
MOD_Plk_1	203	209	PF00069	0.576
MOD_Plk_1	292	298	PF00069	0.582
MOD_Plk_1	422	428	PF00069	0.640
MOD_Plk_1	461	467	PF00069	0.447
MOD_Plk_1	551	557	PF00069	0.528
MOD_Plk_4	17	23	PF00069	0.683
MOD_Plk_4	276	282	PF00069	0.577
MOD_Plk_4	292	298	PF00069	0.662
MOD_Plk_4	349	355	PF00069	0.455
MOD_Plk_4	387	393	PF00069	0.438
MOD_Plk_4	434	440	PF00069	0.469
MOD_Plk_4	573	579	PF00069	0.643
MOD_Plk_4	613	619	PF00069	0.633
MOD_Plk_4	91	97	PF00069	0.680
MOD_ProDKin_1	109	115	PF00069	0.611
MOD_ProDKin_1	11	17	PF00069	0.680
MOD_ProDKin_1	149	155	PF00069	0.648
MOD_ProDKin_1	190	196	PF00069	0.604
MOD_ProDKin_1	318	324	PF00069	0.683
MOD_ProDKin_1	512	518	PF00069	0.680
MOD_ProDKin_1	590	596	PF00069	0.710
MOD_ProDKin_1	602	608	PF00069	0.646
MOD_ProDKin_1	639	645	PF00069	0.689
MOD_ProDKin_1	689	695	PF00069	0.681
MOD_ProDKin_1	712	718	PF00069	0.668
TRG_DiLeu_BaEn_1	293	298	PF01217	0.579
TRG_DiLeu_BaLyEn_6	715	720	PF01217	0.581
TRG_ER_diArg_1	210	212	PF00400	0.588
TRG_ER_diArg_1	483	485	PF00400	0.582
TRG_ER_diArg_1	491	494	PF00400	0.637
TRG_ER_diArg_1	495	498	PF00400	0.545
TRG_ER_diArg_1	562	565	PF00400	0.550
TRG_ER_diArg_1	585	588	PF00400	0.659
TRG_ER_diArg_1	648	651	PF00400	0.690
TRG_ER_diArg_1	72	74	PF00400	0.643
TRG_ER_diArg_1	90	92	PF00400	0.585
TRG_NLS_MonoExtC_3	562	567	PF00514	0.551
TRG_NLS_MonoExtN_4	563	568	PF00514	0.608
TRG_Pf-PMV_PEXEL_1	267	271	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I813	Leptomonas seymouri	41%	100%
A4HGJ7	Leishmania braziliensis	73%	99%
A4I3M4	Leishmania infantum	99%	100%
E9AZW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q8C1	Leishmania major	91%	100%