Short chain dehydrogenase/reductase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

short chain dehydrogenase/reductase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ID46_LEIDO

TriTrypDb:

LdBPK_241890.1 , LdCL_240024500 , LDHU3_24.2320

Length:

507

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 32
NetGPI	no	yes: 0, no: 33

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	14
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8ID46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ID46

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006633	fatty acid biosynthetic process	5	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0016053	organic acid biosynthetic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0030497	fatty acid elongation	6	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046394	carboxylic acid biosynthetic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0072330	monocarboxylic acid biosynthetic process	6	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0008667	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity	5	1
GO:0016491	oxidoreductase activity	2	4
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	1
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	1
GO:0004312	fatty acid synthase activity	5	3
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	5	3
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	3
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	3
GO:0016740	transferase activity	2	3
GO:0016746	acyltransferase activity	3	3
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.221
CLV_NRD_NRD_1	169	171	PF00675	0.588
CLV_NRD_NRD_1	27	29	PF00675	0.438
CLV_NRD_NRD_1	324	326	PF00675	0.423
CLV_NRD_NRD_1	388	390	PF00675	0.529
CLV_NRD_NRD_1	48	50	PF00675	0.564
CLV_PCSK_KEX2_1	127	129	PF00082	0.221
CLV_PCSK_KEX2_1	169	171	PF00082	0.629
CLV_PCSK_KEX2_1	27	29	PF00082	0.450
CLV_PCSK_KEX2_1	388	390	PF00082	0.529
CLV_PCSK_KEX2_1	478	480	PF00082	0.514
CLV_PCSK_KEX2_1	48	50	PF00082	0.573
CLV_PCSK_PC1ET2_1	478	480	PF00082	0.594
CLV_PCSK_SKI1_1	175	179	PF00082	0.561
CLV_PCSK_SKI1_1	27	31	PF00082	0.466
CLV_PCSK_SKI1_1	274	278	PF00082	0.442
CLV_PCSK_SKI1_1	354	358	PF00082	0.561
CLV_PCSK_SKI1_1	478	482	PF00082	0.552
CLV_PCSK_SKI1_1	73	77	PF00082	0.560
DEG_APCC_DBOX_1	127	135	PF00400	0.477
DEG_APCC_DBOX_1	6	14	PF00400	0.566
DEG_Nend_Nbox_1	1	3	PF02207	0.700
DEG_SPOP_SBC_1	237	241	PF00917	0.381
DEG_SPOP_SBC_1	36	40	PF00917	0.566
DEG_SPOP_SBC_1	58	62	PF00917	0.649
DOC_CYCLIN_RxL_1	24	33	PF00134	0.573
DOC_CYCLIN_yCln2_LP_2	129	135	PF00134	0.351
DOC_MAPK_DCC_7	397	406	PF00069	0.385
DOC_MAPK_gen_1	127	135	PF00069	0.488
DOC_MAPK_gen_1	214	221	PF00069	0.292
DOC_MAPK_gen_1	299	308	PF00069	0.269
DOC_MAPK_gen_1	388	395	PF00069	0.314
DOC_MAPK_MEF2A_6	127	135	PF00069	0.483
DOC_MAPK_MEF2A_6	301	310	PF00069	0.367
DOC_MAPK_NFAT4_5	128	136	PF00069	0.349
DOC_MAPK_RevD_3	157	170	PF00069	0.227
DOC_PP1_RVXF_1	25	32	PF00149	0.663
DOC_PP1_RVXF_1	250	256	PF00149	0.270
DOC_PP2B_LxvP_1	129	132	PF13499	0.351
DOC_PP4_FxxP_1	310	313	PF00568	0.273
DOC_PP4_MxPP_1	78	81	PF00568	0.545
DOC_USP7_MATH_1	155	159	PF00917	0.427
DOC_USP7_MATH_1	209	213	PF00917	0.354
DOC_USP7_MATH_1	238	242	PF00917	0.488
DOC_USP7_MATH_1	36	40	PF00917	0.773
DOC_USP7_MATH_1	58	62	PF00917	0.680
DOC_USP7_MATH_1	74	78	PF00917	0.684
DOC_USP7_MATH_1	81	85	PF00917	0.691
DOC_USP7_MATH_1	86	90	PF00917	0.653
DOC_USP7_MATH_1	98	102	PF00917	0.550
DOC_USP7_UBL2_3	496	500	PF12436	0.407
DOC_WW_Pin1_4	240	245	PF00397	0.531
DOC_WW_Pin1_4	421	426	PF00397	0.378
LIG_14-3-3_CanoR_1	163	167	PF00244	0.320
LIG_14-3-3_CanoR_1	252	256	PF00244	0.246
LIG_14-3-3_CanoR_1	325	334	PF00244	0.333
LIG_14-3-3_CanoR_1	369	376	PF00244	0.271
LIG_14-3-3_CanoR_1	397	404	PF00244	0.387
LIG_14-3-3_CanoR_1	434	440	PF00244	0.329
LIG_APCC_ABBAyCdc20_2	170	176	PF00400	0.275
LIG_BRCT_BRCA1_1	59	63	PF00533	0.578
LIG_CSL_BTD_1	129	132	PF09270	0.270
LIG_eIF4E_1	194	200	PF01652	0.262
LIG_eIF4E_1	466	472	PF01652	0.305
LIG_FHA_1	154	160	PF00498	0.408
LIG_FHA_1	179	185	PF00498	0.262
LIG_FHA_1	186	192	PF00498	0.269
LIG_FHA_1	232	238	PF00498	0.547
LIG_FHA_1	315	321	PF00498	0.265
LIG_LIR_Apic_2	143	148	PF02991	0.367
LIG_LIR_Gen_1	120	129	PF02991	0.553
LIG_LIR_Gen_1	178	184	PF02991	0.308
LIG_LIR_Gen_1	254	261	PF02991	0.249
LIG_LIR_Nem_3	120	124	PF02991	0.524
LIG_LIR_Nem_3	178	183	PF02991	0.314
LIG_Pex14_2	310	314	PF04695	0.240
LIG_PTB_Apo_2	384	391	PF02174	0.382
LIG_PTB_Apo_2	459	466	PF02174	0.292
LIG_PTB_Phospho_1	384	390	PF10480	0.378
LIG_PTB_Phospho_1	459	465	PF10480	0.294
LIG_SH2_CRK	180	184	PF00017	0.316
LIG_SH2_GRB2like	145	148	PF00017	0.214
LIG_SH2_NCK_1	113	117	PF00017	0.660
LIG_SH2_NCK_1	154	158	PF00017	0.478
LIG_SH2_SRC	145	148	PF00017	0.214
LIG_SH2_STAP1	136	140	PF00017	0.362
LIG_SH2_STAP1	180	184	PF00017	0.316
LIG_SH2_STAP1	466	470	PF00017	0.284
LIG_SH2_STAT3	260	263	PF00017	0.310
LIG_SH2_STAT3	380	383	PF00017	0.227
LIG_SH2_STAT3	502	505	PF00017	0.324
LIG_SH2_STAT5	103	106	PF00017	0.613
LIG_SH2_STAT5	121	124	PF00017	0.576
LIG_SH2_STAT5	145	148	PF00017	0.328
LIG_SH2_STAT5	180	183	PF00017	0.265
LIG_SH2_STAT5	194	197	PF00017	0.201
LIG_SH2_STAT5	336	339	PF00017	0.265
LIG_SH2_STAT5	502	505	PF00017	0.456
LIG_SH3_3	15	21	PF00018	0.542
LIG_SH3_3	225	231	PF00018	0.440
LIG_SUMO_SIM_anti_2	262	268	PF11976	0.233
LIG_SUMO_SIM_anti_2	279	285	PF11976	0.265
LIG_TYR_ITSM	176	183	PF00017	0.317
LIG_UBA3_1	320	326	PF00899	0.225
MOD_CK1_1	112	118	PF00069	0.612
MOD_CK1_1	14	20	PF00069	0.719
MOD_CK1_1	240	246	PF00069	0.525
MOD_CK1_1	37	43	PF00069	0.739
MOD_CK1_1	474	480	PF00069	0.320
MOD_CK1_1	61	67	PF00069	0.618
MOD_CK2_1	209	215	PF00069	0.354
MOD_Cter_Amidation	167	170	PF01082	0.636
MOD_GlcNHglycan	114	117	PF01048	0.455
MOD_GlcNHglycan	13	16	PF01048	0.369
MOD_GlcNHglycan	142	145	PF01048	0.346
MOD_GlcNHglycan	188	191	PF01048	0.488
MOD_GlcNHglycan	211	214	PF01048	0.601
MOD_GlcNHglycan	240	243	PF01048	0.695
MOD_GlcNHglycan	32	35	PF01048	0.381
MOD_GlcNHglycan	371	374	PF01048	0.461
MOD_GlcNHglycan	39	42	PF01048	0.529
MOD_GlcNHglycan	473	476	PF01048	0.517
MOD_GlcNHglycan	50	53	PF01048	0.431
MOD_GlcNHglycan	64	67	PF01048	0.469
MOD_GlcNHglycan	83	86	PF01048	0.453
MOD_GlcNHglycan	99	103	PF01048	0.334
MOD_GSK3_1	178	185	PF00069	0.285
MOD_GSK3_1	233	240	PF00069	0.528
MOD_GSK3_1	30	37	PF00069	0.654
MOD_GSK3_1	320	327	PF00069	0.236
MOD_GSK3_1	40	47	PF00069	0.642
MOD_GSK3_1	57	64	PF00069	0.606
MOD_N-GLC_1	22	27	PF02516	0.369
MOD_N-GLC_1	34	39	PF02516	0.343
MOD_N-GLC_1	421	426	PF02516	0.615
MOD_N-GLC_2	453	455	PF02516	0.463
MOD_NEK2_1	123	128	PF00069	0.576
MOD_NEK2_1	153	158	PF00069	0.382
MOD_NEK2_1	22	27	PF00069	0.680
MOD_NEK2_1	29	34	PF00069	0.662
MOD_NEK2_1	324	329	PF00069	0.213
MOD_NEK2_1	364	369	PF00069	0.427
MOD_NEK2_1	413	418	PF00069	0.334
MOD_NEK2_1	427	432	PF00069	0.378
MOD_NEK2_1	494	499	PF00069	0.340
MOD_NEK2_1	59	64	PF00069	0.640
MOD_NEK2_2	86	91	PF00069	0.752
MOD_PIKK_1	445	451	PF00454	0.250
MOD_PKA_1	325	331	PF00069	0.315
MOD_PKA_1	48	54	PF00069	0.560
MOD_PKA_2	162	168	PF00069	0.329
MOD_PKA_2	251	257	PF00069	0.239
MOD_PKA_2	324	330	PF00069	0.232
MOD_PKA_2	396	402	PF00069	0.416
MOD_PKA_2	456	462	PF00069	0.384
MOD_PKA_2	47	53	PF00069	0.702
MOD_Plk_1	98	104	PF00069	0.602
MOD_Plk_2-3	215	221	PF00069	0.238
MOD_Plk_4	117	123	PF00069	0.600
MOD_Plk_4	155	161	PF00069	0.423
MOD_Plk_4	251	257	PF00069	0.261
MOD_Plk_4	427	433	PF00069	0.424
MOD_Plk_4	447	453	PF00069	0.246
MOD_Plk_4	74	80	PF00069	0.632
MOD_ProDKin_1	240	246	PF00069	0.523
MOD_ProDKin_1	421	427	PF00069	0.376
MOD_SUMO_rev_2	477	485	PF00179	0.295
MOD_SUMO_rev_2	89	98	PF00179	0.650
TRG_DiLeu_BaEn_1	353	358	PF01217	0.248
TRG_DiLeu_BaEn_2	216	222	PF01217	0.319
TRG_DiLeu_BaLyEn_6	25	30	PF01217	0.572
TRG_ENDOCYTIC_2	121	124	PF00928	0.526
TRG_ENDOCYTIC_2	139	142	PF00928	0.284
TRG_ENDOCYTIC_2	180	183	PF00928	0.283
TRG_ENDOCYTIC_2	194	197	PF00928	0.264
TRG_ENDOCYTIC_2	390	393	PF00928	0.331
TRG_ENDOCYTIC_2	501	504	PF00928	0.418
TRG_ER_diArg_1	127	129	PF00400	0.421
TRG_ER_diArg_1	27	29	PF00400	0.648
TRG_ER_diArg_1	388	390	PF00400	0.329
TRG_ER_diArg_1	6	9	PF00400	0.684
TRG_ER_FFAT_2	60	68	PF00635	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S7	Leptomonas seymouri	80%	99%
A0A0N1HZ81	Leptomonas seymouri	32%	91%
A0A0S4IWT0	Bodo saltans	46%	100%
A0A0S4IZG2	Bodo saltans	30%	100%
A0A0S4J1I6	Bodo saltans	31%	100%
A0A1X0NVT8	Trypanosomatidae	65%	100%
A0A3Q8IM89	Leishmania donovani	28%	100%
A0A3R7K071	Trypanosoma rangeli	32%	100%
A0A3R7N7S2	Trypanosoma rangeli	26%	100%
A0A3S5H7D5	Leishmania donovani	34%	100%
A0A3S7WQY1	Leishmania donovani	27%	100%
A0A422N2B6	Trypanosoma rangeli	63%	100%
A4H5Z1	Leishmania braziliensis	26%	100%
A4HDP2	Leishmania braziliensis	34%	100%
A4HDP3	Leishmania braziliensis	87%	100%
A4HMN7	Leishmania braziliensis	30%	100%
A4HUB6	Leishmania infantum	27%	100%
C9ZWC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
C9ZWC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZZF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZZF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AF39	Leishmania major	29%	100%
E9AH88	Leishmania infantum	34%	100%
E9AH89	Leishmania infantum	99%	100%
E9AHV6	Leishmania infantum	28%	100%
E9AN15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AX26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AX27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9B694	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4QAE9	Leishmania major	92%	100%
Q4QAF0	Leishmania major	34%	100%
Q4QHL1	Leishmania major	28%	100%
Q803A8	Danio rerio	25%	100%
V5BAF4	Trypanosoma cruzi	63%	100%
V5BJC7	Trypanosoma cruzi	25%	100%